智旭 硕导，副研究员

  妇产科生殖医学与肿瘤学，胚胎植入前遗传学诊断，蛋白泛素化修饰
  北京大学第三医院生殖医学中心医师。2004-2008年于日本大阪市立大学医学部攻读妇产科博士，期间深造生殖医学临床与科研工作，科研重点为妇产科生殖与肿瘤相关生理病理的分子生物学机制研究。随后，在美国的博士后及工作期间，致力于蛋白泛素化研究，以及Prop1基因突变小鼠的泌乳素与卵巢功能变化等生殖内分泌相关的分子生物学研究。相关论文发表在Cancer Research, The American Journal of Pathology, Oncotarget, Cellular and Molecular Life Sciences: CMLS.，Carcinogenesis等杂志。共发表SCI论文20余篇，其中第一作者8篇。此外，多次参加国际学术会议，会议发表共8次。曾为美国老龄化协会，美国肿瘤协会，日本妇产科协会，日本东洋医学会会员。教育经历：1999年毕业于中国医科大学临床医学系2002年考入首都医科大学北京妇产医院硕士研究生2004年考取日本大阪市立大学医学部妇产科博士，2008年取得博士学位工作经历：1999年毕业后就职于北京第二炮兵总医院，任妇产科医师2008-2013年先后于美国Albany Medical Center和University of Central Florida从事博士后及助理研究员工作2013年归国就职于北京大学第三医院生殖医学中心获奖情况：2006年 日本ROTARY YONEYAMA优秀博士生奖项2007年 中国国家优秀自费留学生奖项主要论文：1.Zhi X, Lamperska K, Golusinski P, Schork NJ, Luczewski L, Kolenda T, Golusinski W, Masternak MM. Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence. Oncotarget. 2015; 6(1):547-55.2. Zhi X, Lamperska K, Golusinski P, Schork NJ, Luczewski L, Golusinski W, Masternak MM. Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma. Growth Horm IGF Res. 2014; 24(4):137-41.3. Zhi X, Zhao D, Wang Z, Zhou Z, Wang C, Chen W, Liu R, Chen C. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. Cancer Research. 2013; 73(1):385-94.4. Zhi X, Zhao D, Zhou Z, Liu R, Chen C. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. The American Journal of Pathology. 2012; 180(6):2452-61.5. Zhi X, Chen C. WWP1: a versatile E3 ubiquitin ligase in signaling and diseases. Cellular and molecular life sciences : CMLS. 2012; 69(9):1425-34.6. Zhao D, Zhi X (并列第一作者), Zhou Z, Chen C. TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis. Carcinogenesis. 2012; 33(1):59-67.7. Zhi X (第一作者并通讯作者), Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H, Ishiko O. Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. International Journal of Oncology. 2007 Dec;31(6):1333-8.8. Zhi X, Honda K, Ozaki K, Misugi T, Sumi T, Ishiko O. Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice. International Journal of Molecular Medicine. 2007 Sep;20(3):287-92. 9.Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F, Qiao J. The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells. Cell. 2015 Jun 4;161(6):1437-52. 10.Do A, Menon V, Zhi X, Gesing A, Wiesenborn DS, Spong A, Sun L, Bartke A, Masternak MM. Thyroxine modifies the effects of growth hormone in Ames dwarf mice. Aging (Albany NY). 2015; 7(4):241-55.11. Zhang L, Yan LY, Zhi X, Yan J, Qiao J. Female Fertility: Is it Safe to "Freeze?" Chin Med J (Engl). 2015; 128(3):390-397. 12. Schneider A, Zhi X, Moreira F, Lucia T, Mondadori R, Masternak MM. Primordial follicle activation in the ovary of Ames dwarf mice. J Ovarian Res. 2014; 7(1):284. 13. Wiesenborn DS, Menon V, Zhi X, Do A, Gesing A, Wang Z, Bartke A, Altomare DA, Masternak MM. The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice. Aging (Albany NY). 2014; 6(10):900-12. 14. Xia X, Yin T, Yan J, Yan L, Jin C, Lu C, Wang T, Zhu X, Zhi X, Wang J, Tian L, Liu J, Li R, Qiao J. Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation. Cell Transplant. 2014 Oct 28. [Epub ahead of print]15. Schneider A, Zhi X, Bartke A, Kopchick JJ, Masternak MM. Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries. Age (Dordr). 2014;36(4):9701. 16. Menon V, Zhi X, Hossain T, Bartke A, Spong A, Gesing A, Masternak MM. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging Cell. 2014; 13(3):497-506. doi: 10.1111/acel.12201. 17. List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology. 2014; 155(5):1793-805. 18. Wang X, Hu G, Gao X, Wang Y, Zhang W, Harmon EY, Zhi X, Xu Z, Lennartz MR, Barroso M, Trebak M, Chen C, Zhou J. The Induction of Yes-Associated Protein Expression After Arterial Injury Is Crucial for Smooth Muscle Phenotypic Modulation and Neointima Formation. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(11):2662-9.19. Honda K, Kajitani K, Nobeyama K, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida Y, Matsumoto Y, Ichimura Y, Yaui T, Sumi T, Ishiko O. An Upstream Estrogen Response Element Linked to Exogenous p53 Tumor Suppressor Gene Expression Differentiates Effects of the Codon 72 Polymorphism. Asian Pacific Journal of Cancer Prevention : APJCP. 2011;12(4):865-8. 20. Yoshida H, Sumi T, Zhi X, Yasui T, Honda K, and Ishiko O. Claudin-4: a potential therapeutic target in chemotherapy-resistant ovarian cancer. Anticancer Research. 2011 Apr;31(4):1271-7. 21. Noriyuki M, Sumi T, Zhi X, Misugi F, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T, Honda K, and Ishiko O. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. International Journal of Oncology. 2007 Sep;31(3):
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