刘小云（生物质谱、细菌与宿主相互作用）
E-mail: xiaoyun.liu@bjmu.edu.cn
教育与工作经历：
2019- 北京大学基础医学院 研究员
2012-2019 北京大学化学学院研究员
2009-2012 耶鲁大学医学院 博士后
2003-2009 印第安那大学化学系博士
2001-2003 密歇根州立大学化学系 硕士
1997-2001 吉林大学化学系 学士
研究方向：
课题组致力于发展高通量蛋白质组学方法以解决感染生物学领域一些因传统技术手段受限的重要科学问题。我们发展了高效、普适的胞内病原细菌蛋白质组分析新策略，为从整体层次揭示致病菌适应宿主的分子机制提供了新颖的视角。与病原微生物实验室紧密合作，我们运用高精度质谱在细菌毒力因子催化的蛋白质翻译后修饰研究中取得了一系列突破性进展，包括发现了全新磷酸胆碱化修饰（Nature2011），单酶催化的蛋白质泛素化（Nature2016&2018）及细菌毒素介导的新型蛋白质脂化修饰（Science2017）。课题组于2016年获得国家优秀青年科学基金的支持。
代表性论文：
Li Z, Liu Y, Fu J, Zhang B, Cheng S, Wu M, Wang Z, Jiang J, Chang C, Liu X. (2019) Salmonella proteomic profiling during infection distinguishes the intracellular environment of host cells. mSystems, 4, e00314-18.
Wang Z, Sun J, Tian M, Xu Z, Liu Y, Fu J, Yan A, Liu X. (2019) Proteomic analysis of FNR-regulated anaerobiosis in Salmonella Typhimurium. J. Am. Soc. Mass Spectrom., doi: 10.1007/s13361-019-02145-2.
Wang Z, McCloskey A, Cheng S, Wu M, Xue C, Fu J, Liu Y, Luo ZQ, Liu X. (2018) Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase. Cell Discov., 4, 53.
Wang Z, Sun J, Xia T, Liu Y, Fu J, Lo YK, Chang C, Yan A, Liu X. (2018) Proteomic delineation of the ArcA regulon in Salmonella Typhimurium during anaerobiosis. Mol. Cell. Proteomics, 17, 1937-1947.
Zhang B, Ran L, Wu M, Li Z, Jiang J, Wang Z, Cheng S, Fu J, Liu X. (2018)Shigella flexneriregulator SlyA controls bacterial acid resistance by directly activating the glutamate decarboxylation system. Front. Microbiol.,9, 2071.
Cheng S, Wang L, Liu Q, Qi L, Yu K, Wang Z, Wu M, Liu Y, Fu J, Hu M, Li M, Zhou D, Liu X. (2017) Identification of a novel Salmonella type III effector by quantitative secretome profiling. Mol. Cell. Proteomics, 16, 2219-2228.
Liu Y, Liu Q, Qi L, Ding T, Wang Z, Fu J, Hu M, Li M, Song J, Liu X. (2017) Temporal regulation of a Salmonella Typhimurium virulence factor by the transcriptional regulator YdcR. Mol. Cell. Proteomics, 16, 1683-1693.
Liu Y, Yu K, Zhou F, Ding T, Yang Y, Hu M, Liu X. (2017) Quantitative proteomics charts the landscape of Salmonella carbon metabolism within host epithelial cells. J. Proteome Res., 16, 788-797. 8.
Zhou Y, Huang C, Yin L, Wan M, Wang X, Li L, Liu Y, Wang Z, Fu P, Zhang N, Chen S, Liu X, Shao F, Zhu Y. (2017) Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science, 358, 528-531.
Qiu J, Sheedlo MJ, Yu K, Tan Y, Nakayasu ES, Das C, Liu X, Luo ZQ. (2016) Ubiquitination independent of E1 and E2 enzymes by bacterial effectors. Nature, 533, 120-124.
了解更多信息，请访问我们的主页：http://www.chem.pku.edu.cn/proteomics/