周 专 教授
Ph.D. 博士生导师
细胞生物物理研究室主任
分子医学研究所学术委员会主任
联系电话：010-6276-7850
E-mail：zzhou@pku.edu.cn
通讯地址：北京大学英杰交流中心337室 100871
1984年获同济大学电子仪器与测量技术（5年制）专业学士学位；1990年获华中科技大学生物医学工程博士学位；1990-1993德国马普生物物理化学研究所Erwin Neher（1991年诺贝尔奖得主）实验室博士后；1993-1995年美国华盛顿大学生理和医学系讲师；1995-1997美国芝加哥Loyola大学生理系研究助理教授；1993-2000华中科技大学生物物理与化学研究所所长、教授；1997-1999中国科技大学神经与生物物理系常务副主任、教授；1999-2004上海中国科学院神经科学研究所研究员、实验室主任。2005起任北京大学分子医学研究所教授、高级研究员。
学术/期刊服务和任职情况
中国生物物理学会副理事长，兼神经生物物理专业委员会主任
《Journal of Physiology--London》编委
《NeuroMolecular Medicine》编委
《Cell Calcium》编委
《生理学报》编委；
《生物物理学报》编委；
国际嗜铬细胞生物学理事会执委（2006-）；
美国生物理学会会员
美国神经科学会会员
奖励情况
1995年 国家基金委“杰出青年基金”；
1996年 中科院“百人计划”；
1998年 The Li Foundation Heritage Prize（美国）；
1999年 中国科技大学优秀教师“东方通讯奖”；
2002年 中科院优秀研究生导师奖；
2004年 中科院优秀毕业研究生导师；
2004年 新世纪百千万人才国家级人选；
2005年 全国优秀博士论文(张晨)指导教师；
2006年 复旦大学“九源生命科学”谈家桢（一等奖陈晓科）导师奖；
2006年 张锡均基金会第九届全国青年优秀生理学论文一等奖（王烈成）指导教师.
代表文章：
英文论文：
109.Huang R, Wang Y, Li J, Jiang X, Li YL, Liu B, Wu X, Du X, Hang Y, Jin M, Zhu F, Wang C, Chai Z and Zhou Z (2019) Ca2+-Independent but Voltage-Dependent Quantal Catecholamine Secretion (CiVDS) in the Mammalian Sympathetic Nervous System. PNAS, pii: . doi:10.1073/pnas.. [Epub ahead of print].
108.Li M, Xu H, Chen G, Sun S, Wang Q, Liu B, Wu X, Zhou L, Chai Z, Sun X, Lu Y, Younus M, Zheng L, Zhu F, Jia H, Chen X, Wang C, Zhou Z. (2019) Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson's disease. Brain,142:3099-3115. Preprint doi:10.1093/brain/awz243 BRAIN.
107.Zhang QF, Liu Bin, Wu QH, Liu Bing, Li YL, Sun SH, Wang Y, Wu X, Chai ZY, Jiang XH, Liu XY, Hu MQ, Wang YS, Yang YT, Wang L, Kang XJ, Xiong YF, Zhou Y, Chen XK, Zheng LH, Zhang B, Wang CH, Zhu FP and Zhou Z (2019) Differential controls of two native transmitters from a vesicle fusion pore in adrenal chromaffin cells. Neuron，102：173-183
106.Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, Jin L, Chen G, Jiang P, Zhang S, Song R, Peng W, Liu F, Guo J, Tang L, He Y, Shan D, Huang J, Zhou Z, Wang D, Lv F, Xiao RP. (2019) Glucose-sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis. Circulation, 139(7):901-914. doi:10.1161/CIRCULATIONAHA.118.037216.
105. Wu QH, Zhang QF, Liu B, Li YL, Wu X, Kuo ST, Zheng LH, Wang CH, Zhu FP andZhou Z*(2018) Dynamin-1 restrains vesicular release to a sub-quantal mode in mammalian adrenal chromaffin cells. Journal of Neuroscience, 39(2):199 -211..
104.Zhuan Zhou*, Zuying Chai, Changhe Wang (2018) From structure to function: unveiling the structure of Nav channel-toxin complex. National Science Review, nwy090,https://doi.org/10.1093/nsr/nwy090, Published: 14 September 2018
103. Xiong Y, Sun S, Teng S, Jin M* andZhou Z*(2018) Ca2+-Dependent and Ca2+-Independent ATP Release in Astrocytes. Front. Mol. Neurosci. 11:224 (pp1-5). doi: 10.3389/fnmol.2018.00224
102. Dou HQ* andZhou Z*(2018) Action potential-induced Ca2+ influx for both acute and sustained insulin secretion in pancreatic beta cells. In: Lemos J and Dayanithi G (Eds) International Neuroendocrine Federation (INF) Master class in Neuroendocrinology Series Neurosecretion: Secretory Mechanisms. Chapter 8. Springer, in press.
101. Bingying Chen, Xiaoshuai Huang, Dongzhou Gou, Jianzhi Zeng, Guoqing Chen, Meijun Pang, Yanhui Hu, Zhe Zhao, Yunfeng Zhang,Zhuan Zhou, Haitao Wu, Heping Cheng, Zhigang Zhang, Chris Xu, Yulong Li, Liangyi Chen, and Aimin Wang (2018) Rapid volumetric imaging with Bessel-Beam three-photon microscopy. Biomedical Optics Express, 9: 1992-2000
100. Xiong Y., Teng S., Zheng L., Sun S., Li J., Guo N, Li ML, Wang L, Zhu F, Wang C, Rao Z., andZhou Z*. (2018). Stretch-induced Ca2+-independent ATP release in hippocampal astrocytes. Journal of Physiology, 596: 1931–1947. PMID: ** DOI: 10.1113/JP275805
99. Liu B, Wu QH, Wang YS, Hu MQ, Zhu FP, Zheng LH, Wang CH and Zhou Z (2017) Differential controls of two native transmitters from a vesiclefusion pore in adrenal chromaffin cells. Neuron, in revision.
98. Yingfei Xiong, Sasa Teng, suhua Sun, Huadong Xu, Ning Guo, Yang Zhou, Tao Liu, Li Wang, Xiaoke Chen, Bin Liu, Changhe Wang, Lianghong Zheng, Jin Lu, Claire Xi Zhang, Zhiren Rao and Zhuan Zhou (2017) Direct recording of non-vesicular ATP release from a hippocampal astrocyte. J Physiol, 2^nd in revision.
97. Wang CH, Kang XJ, Chai ZY, Wu QH1, Huang R, Hu MQ, Liu B1, Zhu FP, Zhang QF, Zhou L, Jiao RY, Xu HD, Shang SJ, Zuo PL, Wang L, Zheng LH, Yue ZY, and Zhou Z (2017) Synaptotagmin-11 mediates parkin-linked pathogenesis in Parkinson’s disease. Nature Communications, in press.
96. Chai ZY, Zhang XY, Huang R, Wang Y, Zhou R, Wu QH, Hu MQ, Wu X, Liu HW, Liu T, Wang YS, Guo W, Zheng H, Xiong W, Zhang C, Zheng LH, Zhang CX, Ding JP, Wang CH, Zhou Z (2017) CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons, Neuron, 96：1-10. https://doi.org/10.1016/j.neuron.2017.10.028; Highlighted by 4 Commentaries: (1) Natasha B (2017) Nature Review Neuroscience, doi:10.1038/nrn.2017.162; (2) Yang Y (2017) F1000Prime DOI: 10.3410/f..; (3) Holz R (2018) F1000Prime DOI: 10.3410/f..; (4) Colmers W (2018) F1000Prime DOI: 10.3410/f...
95. Feipeng Zhu, Qihui Wu, Jie Li, Katarzyna Grycel, Bing Liu, Xiaoxuan Sun, Li Zhou, Ruiyin Jiao, Rui Song, Younus M. Khan, Qinglong Wang, Lun Wang, Yongxin Xu, Jin Li, Bo Zhang, Zhuan Zhou (2017) A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. Cell Calcium (IF 4), 67 : 11-20.
94. Chae-Seok Lim, Cheng Wen, Yanghui Sheng, Guangfu Wang, Zhuan Zhou, Shiqiang Wang, Huaye Zhang, Anpei Ye and J. Julius Zhu (2017) Piconewton-scale analysis of Ras-BRaf signal transduction with single-molecule force spectroscopy. Small (IF 8.3), in press
93. Wang YS, Wu QH, Hu MQ, Liu B, Chai ZY, Xu HD, Zhou L, Zheng LH, Wang CH, Zhou Z (2017) Ligand-gated and voltage-gated calcium channels differentially regulate “kiss-and-run” vesicular neuropeptide release in mammalian sensory neurons. Science Signaling, 10(484) pii: eaal1683. doi: 10.1126/scisignal.aal1683. Highlighted by Ferrarelli LK. (2017) Kiss-and-run or a full commitment?, Science , 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p.
92. Zong W#, Wu R#, Li M#, Wu H, Jia H, Fan M, Zhou Z, Zhang Y, Wang A, Chen L, Cheng H (2017) Fast High-resolution Miniature Two-photon Microscopy for Brain Imaging in Freely-behaving Mice. Nature Methods, 14(7):713-719. doi: 10.1038/nmeth.4305. (#equal contributors, this “Engineering + Biology” work, we did biology)
91. Yu-Zhen Chen*, Xiao-Cun Li, Zhenquan Guo, Li Zhou, Zhuan Zhou*, Song-Ping Liang, Cai-Hong Wu (2017) Porcine diazepam-binding inhibitor and bovine diazepam-binding inhibitor affect morphine antinociception via different receptors. Protein & Cell, 8(2):140-143. doi: 10.1007/s13238-016-0355-5 (* co-corresponding authors)
90. Chunhua Liu, Zheng Gong, Zong-Lai Liang, Zhi-Xin Liu, Fan Yang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Chao-Ran Ji, Yu-Hong Wang, Mei Jie Wang, Fu-Ai Cui, Amy Lin, Wen-Shuai Zheng, Dong-fang He, Chang-xiu Qu, Peng Xiao, Chuanyong Liu, Alex Thomsen, Thomas Cahill III, Alem Kahsai, Fan Yi, Kunhong Xiao, Tian Xue, Zhuan Zhou, Xiao Yu, and Jinpeng Sun (2017) Arrestin biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nature Communications, 8:14335
89. Shang SJ, Zhu FP, Liu B, Chai ZY, Wu QH, Hu MQ, Wang Y, Huang R, Zhang XY, Wu X, Sun L, Wang Y, Wang L, Xu HD, Teng SS, Liu B, Zheng LH, Zhang C, Zhang F, Feng X, Zhu DS, Wang CH, Liu T, Zhu MX, Zhou Z(2016) Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons. J Cell Biol , 215(3):369-381. DOI:10.1083/jcb.. Highlighted by Gu M and Xu HX (2016) A painful TR(i)P to lysosomes, J Cell Biol , 215(3):309-312 DOI: 10.1083/jcb.
88. Zhang K, Chen C, Yang Z, He W, Liao X, Ma Q, Deng P, Lu J, Li J, Wang M, Li M, Zheng L, Zhou Z, Sun W, Wang L, Jia H, Yu Z, Zhou Z, Chen X (2016) Sensory Response of Transplanted Astrocytes in Adult Mammalian Cortex In Vivo. Cerebral Cortex, 26:3690-704
87. Wang CH, Wang YS, Hu MQ, Chai ZY, Wu QH, Huang R, Han WP, Zhang CX and Zhou Z (2016) Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports, 17(1):47-63. DOI: 10.15252/embr.
86. Shang CF, Li XQ, Yin C, Liu B, Wang YF, Zhou Z*, Du JL* （2015）Amperometric Monitoring of Sensory-Evoked Dopamine Release in Awake Larval Zebrafish. J Neurosci. 35(46):15291-4. doi: 10.1523/JNEUROSCI.3050-15.2015
85. He LL, Wang LC, Dai JX, and Zheng LH, Zhou Z (2015) Muscarine inhibition of Nicotinic Transmission in Superior Cervical Ganglion Neurons. Philosophical Transactions B, 370(1672). pii: **. doi: 10.1098/rstb.2014.0188.
84. Xu H, Zuo P, Wang S, Zhou L, Sun X, Hu M, Liu B, Wu Q, Dou H, Liu B, Zhu F, Teng S, Zhang X, Wang L, Li Q, Jin M, Kang X, Xiong W, Wang C, Zhou Z (2015) Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst, 140:3840 - 3845.
83. Hao ZH, Wei LS, Feng YQ, Chen XW, Du W, Ma J, Zhou Z, Chen LY, Li W (2015) Impaired maturation of large dense core vesicles in muted-deficient adrenal chromaffin cells. Journal of Cell Science, 128:1365–1374.
82. Dou HQ, Wang CH, Wu X, Yao LJ, Zhang XY, Teng SS, Xu HD, Liu B, Wu QH, Zhang QF, Hu MQ, Wang YS, Wang L, Wu Y, Shang SJ, Kang XJ, Zheng LH, Zhang J, Raoux M, Lang J, Li Q, Su J, Yu X, Chen LY and Zhou Z (2014) Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia,58:324–333
81. Kang XJ, Wang CH, Xu HD, Shang SJ, Zhang XY, Zuo PL, Zhou L, Deng ZJ, Liu B, Liu B, Wu QH, Wang L, Hu MQ, Dou HQ, Liu W, Zhu FP, Li Q, Guo S, Gu JL, Lei Q, Lü J, Jin M, Jiang W, Wang SR, Liu K, Li WL, Zhang K, Zhou Z (2014) Rescuing dopamine release and parkinsonian behavior by neural stem cells. PNAS, Epub ahead www.pnas.org/cgi/doi/10.1073/pnas.
80. Zong WJ, Zhao J, Chen XY, Lin Y, Ren HX, Zhang YF, Fan M, Zhou Z, Cheng HP, Sun YJ and Chen LY (2014) Large-field high-resolution two-photon digital scanned light-sheet microscopy. Cell Research, Epub ahead, http://www.nature.com/cr/journal/vaop/ncurrent/full/cr**a.html
79. Li YT, Zhang SH, Wang L, Xiao RR, Liu W, Zhang XW, Zhou Z, Amatore C, Huang WH (2014) Nanoelectrode for Amperometric Monitoring of Individual Vesicular Exocytosis Inside Single Synapses. Angew. Chem. Int. Ed., Epub ahead, DOI: 10.1002/anie.
78. Yang YM, Wang W, Fedchyshyn MJ, Zhou Z, Ding JP, Wang LY (2014) Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic K+ currents. Nature Communications, doi:10.1038/ncomms5564
77. Liu T, Li HY, Gounko N, Zhou Z, Xu AM, Hong WJ, and Han WP (2014) Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3 knockout mice. Am J Physiol-Endo M, 307(7):E611-8
76. Shang SJ, Wang CH, Liu B, Wu QH, Zhang QF, Liu W, Zheng LH, Xu HD, Kang XJ, Zhang XY, Wang YS, Zheng H, Wang SR, Xiong W, Liu T, Zhou Z (2014) Extracellular Ca2+ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. Cell Calcium, 56:202–207.
75. Wang L, Zhang XY, Xu HD, Zhou L, Jiao RY, Liu W, Zhu FP, Kang XJ, Liu B, Teng SS, Wu QH, Li ML, Dou HQ, Wang CH, Zuo PL, Wang SR and Zhou Z (2014) Temporal components of synapse-synapse transmission in dorsal striatum brain slices of mice. Journal of Physiology, 592:3559–3576.
74. Wang L, Shang SJ, Kang XJ , Teng SS, Zhu FP, Liu B, Wu QH, Li ML, Liu W, Xu HD, Zhou L, Jiao RY, Dou HQ, Zuo PL, Zhang XY, Zheng LH, Wang SR, Wang CH and Zhou Z (2014) A mechanism of modulating dopamine release in the striatum by smoking-level nicotine. Nature Communications, DOI: 10.1038/ncomms4925.
73. Kuo ST, Wu QH, Liu B, Xie ZL, Wu X, Shang SJ, Zhang XY, Kang XJ, Liu LN, Zhu FP, Wang YS, Hu MQ, Xu HD, Zhou L, Liu B, Chai ZY, Zhang QF, Liu W, Teng SS, Wang CH, Guo N, Dou HQ, Zuo PL1, Zheng LH, Zhang CX1, Zhu DS, Wang L, Wang SR, and Zhou Z. (2014). Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese University. J Mol Neurosci, 53(3):487-92.
72. Liu LN, Zhu FP, Song MY, Zhang B, Kuo ST, Liu W, Li ML, Zhou L, Jiao RY, Liu B, Zhang XY, Wang CH, Wang SR and Zhou Z. (2014). Cocaine modulation of ion channels and action potentials in locus coeruleus brain slices. J Mol Neurosci, 53(3):345-51
71. Zhang XY, Wen JG, Yang W, Wang C, Gao L, Zheng LH, Wang T, Ran KK, Li YL, Li, Ming Xu XY, Luo JY, Feng SL, Ma XX, Ma HY, Chai ZY, Zhou Z, Yao J, Zhang X, Liu JY (2013) Gain-of-function mutations in SCN11A cause familial episodic pain. American Journal of Human Genetics, 93(5):957-66
70. Zhang H, Shang W, Zhang X, Gu J, Wang X, Zheng M, Wang Y, Zhou Z, Cao JM, Ji G, Zhang R, Cheng H. (2013) β-Adrenergic-stimulated l-type channel Ca(2+) entry mediates hypoxic Ca(2+) overload in intact heart. Journal of Molecular and Cellular Cardiology. 65: 51–58
69. Liang-Hong Zheng, Shujiang Zhang, Changhe Wang, Meiqin Hu, Yeshi Wang, Xiaoyu Zhang, Zuyin Chai, Xi Wu, Hui Zheng, Chen Zhang, Lie-Cheng Wang, Wei Xiong, and Zhuan Zhou. (2013) Real Time Endocytosis Imaging as Rapid Assay of Ligand-GPCR Binding in Single Cells. Am J Physiol, 305: C751–C760
68. Zuo PL, Yao W, Sun L, Kuo ST, Li Q, Wang SR, Dou HQ, Xu HD, Zhang CX, Kang XJ, Zhou Z* and Zhang B*. (2013) Impulse-dependent extracellular resting dopamine concentration in rat striatum in vivo, Neurochemistry International, 62:50-7.
67. Loh YP, Zhou Z, Kao LS. (2012) Proceedings of the 16th international symposium on chromaffin cell biology. J Mol Neurosci. 48(2):313-314.
66. Carbone E, Guérineau NC, Loh YP and Zhou Z. (2012) Commentary: Ion Channels, Fusion Pores and Exocytosis. J Mol Neurosci. 48(2):313-314.
65. Jing Lü, Xue Gao, Jingli Gu, Lan Zhou, Shu Guo, Wei Hao, Zhuan Zhou, Ji-Min Cao. (2012) Nerve sprouting contributes to increased severity of ventricular tachyarrhythmias by upregulating iGluRs in rats with healed myocardial necrotic injury. J Mol Neurosci, 48:448–455
64. Huang HP, Zhu FP, Chen XW, Xu ZQD, Zhang CX and Zhou Z（2012）Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus. Frontiers in Molecular Neuroscience, 5(29):1-5
63. Guo N, Yao W, Wang SR , Zhu J, Huang D, Zuo PL, Kang XJ, Fu CL, Zhou Z*, Zhang B* (2012) Nicotine dynamically modulates dopamine clearance in rat striatum in vivo. Neurochemistry International, 60: 55-359
62. Dou HQ, Xu YF, Sun JP, Shang SJ, GuoS, Zheng LH, Chen CC, Bruce IC, Yu X, and Zhou Z (2012) Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. American Journal of Physiology-Cell, 302:C796-C803
61. Zhang B, Zhang XY, Huang W, Luo PF, Zhu FP, Liu T, Du YR, Wu QH, Lü J, Xiu Y, Liu LN, Huang HP, Guo S, Zheng H, Zhang CX, and Zhou Z (2012) Action potential triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices. Journal of Physiology, 590: 753–762.
60. Wang SR, Yao W, Huang HP, Zhang B, Zuo PL, Sun L, Dou HQ, Li Q, Kang XJ, Xu HD, Hu MQ, Jin M, Zhang L, Mu Y, Peng JY, Zhang CX, Ding JP, Li BM, Zhou Z (2011) Role of vesicle pools in action potential pattern-dependent dopamine overflow in rat striatum in vivo. Journal of Neurochemistry, 119:342–353
59. Xiong W, Liu T, Wang YS, Chen XW, Sun L, Guo N, Zheng H, Zheng LH, Ruat M, Han WP, Zhang CX, and Zhou Z (2011) Extracellular Ca2+ directly inhibits neuronal exocytosis in cell body. PloS One, 6: e24573
58. Tao Liu, Lei Sun, Yingfei Xiong, Shujiang Shang, Ning Guo, Sasa Teng, Yeshi Wang, Bing Liu, Changhe Wang, Li Wang, Lianghong Zheng, Claire Xi Zhang, Weiping Han, and Zhuan Zhou (2011) Calcium triggers quantal release simultaneously from two types of vesicles in a single astrocyte. Journal of Neuroscience，31:10593–10601.
57. Tao Liu, Shu-Jiang Shang, Bin Liu, Chang-He Wang, Ye-Shi Wang, Wei Xiong, Liang-Hong Zheng, Claire Xi Zhang, and Zhuan Zhou (2011) Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons, Journal of Physiology, 589:3507–3515.
56. Bo Zhang, Liang Sun, Yi-Mei Yang, Hong-Ping Huang, Fei-Peng Zhu, Li Wang, Xiao-Yu Zhang, Shu Guo, Pan-Li Zuo, Claire X. Zhang, Jiu-Ping Ding, Lu-Yang Wang, and Zhuan Zhou (2011) Action potential bursts enhance transmitter release at a giant central synapse. Journal of Physiology，589:2213–2227.
55. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW and Wang Y (2010) The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit. Journal of Neuroscience, 30(22):7575–7586
54. Huang H, Wei ZW, Huang YY, Zhao DY, Zheng LY, Cai TJ, Wu MX, Wang W, Ding XF, Zhou Z, Du Q, Li ZH and Liang ZC (2010) An efficient and high-throughput electroporation microchip applicable for siRNA delivery. Lab on a Chip, 11:163-172
53. Huang H, Wei N, Xiong YF, Yang F, Fang HQ, Xie WJ, Zhou Z, Cheng HP, Liang ZC, Du Q (2010) Exogenous nucleic acids aggregate in non-P-body cytoplasmic granules when transfected into cultured cells. Front Biol, 5(3):272-281.
52. Zheng H, Fan J, Xiong W, Zhang C, Wang XB, Liu T, Liu HJ, Sun L, Wang YS, Zheng LH, Wang BR, Zhang CX, Zhou Z (2009) Fractional contributions of Ca-dependent and Ca-independent secretion induced by action potentials in single sensory neurons. Biophysical Journal. 96:2449–2456
51. Misler S, Zhou Z, Dickey AS, Silva AM, Pressel DM, Barnett DW (2009) Biphasic insulin secretion from ?-cells of canine islets of Langerhans: tuning two modes of exocytosis to two modes of glucose-induced electrical activity?, Channels, 3(3): 181 - 193
50. Fan J, Zhang B, Shu HF, Zhang XY, Wang X, Kuang F, Liu L, Peng ZW, Wu R, Zhou Z, Wang BR (2009) IL-6 Increases [Ca2+]i Level and Induces Catecholamine Secretion in the Rat Carotid Body Glomus Cells. Journal of Neuroscience Research, 87(12):2757-62
49. Li B, Chen F, Ye JN, Chen XW, Yan J, Li Y, Xiong Y, Zhou Z, Xia JX and Hu ZA（2009）The Modulation of Orexin A on HCN Currents of Pyramidal Neurons in Mouse Prelimbic Cortex. Cerebral Cortex, 20:1756-1767
48. Chen XW, Feng YQ, Hao CJ, Guo XL, He X, Zhou ZY, Guo N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W, Zhou Z（2008）A Schizophrenia-Susceptible Gene Affects Quanta Size of Transmitter Release. J Cell Biol, 181: 791-801
47. Chen XW, Mu Y, Huang HP, Guo N, Zhang B, Fan SY, Xiong JX, Wang SR, Xiong W, Huang W, Liu T, Zheng LH, Zhang CX, Li LH, Yu ZP, Hu ZA, Zhou Z (2008) Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus coeruleus neurons. J. Neurosci., 28:3202-08.
46. Chen XW, Huang W, Yan JA, Fan HX, Guo N, Lü J, Xiu Y, Gu JL, Zhang CX, Ruan HZ, Hu ZA, Yu ZP, Zhou Z (2008) Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells. Neuroscience Letters, 436:181-184.
45. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Zhang B, Xiong W, Chen XW, Zheng LH, Wang LY, Marc Landry, Hokfelt T, Xu ZQD and Zhou Z (2007) Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci U S A., 104(4):1401-1406
44. Zhang W, Zhang Y, Zheng H, Zhang C, Xiong W, Olyarchuk JG, Walker M, Xu W, Zhao M, Zhao S, Zhou Z*, Wei L*. (2007) SynDB: A Synapse protein DataBase based on Synapse Ontology. Nucl. Acid Res., 35: D737–D741.
43. Shu HF, Wang BR, Wang SR, Yao W, Huang HP, Zhou Z, Wang X, Fan J, Wang T, Ju G. (2007) IL-1beta inhibits IK and increases [Ca2+]i in the carotid body glomus cells and increases carotid sinus nerve firings in the rat. Eur J Neurosci. 25(12):3638-47.
42. Yu X, Chen XW, Zhou P, Yao LJ, Liu T, Zhang B, Li Y, Zheng H, Zheng LH, Zhang CX, Bruce I, Ge JB, Wang SQ, Hu ZA, Yu HG and Zhou Z (2007) Calcium influx through If channels in rat ventricular myocytes. Am J Physiol-Cell. Am J Physiol-Cell, 292: C1147-1155.
41. Yao LJ, Wang G, Ou-Yang KF, Wei CL, Wang XH, Wang SR, Yao W, Huang HP, Luo JH, Wu CH, Liu J, Zhou Z*, Cheng HP*（2006）Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons. Acta Pharmacologica Sinica, 27 (7): 848–852
40. Chen XK, Xiong YF, and Zhou Z (2006) “Kiss-and-Run” Exocytosis in Astrocytes. Neuroscientist, 12(5): 375–378.
39. Wang LC, Xiong W, Zheng J, Zhou Y, Zheng H, Zhang C, Zheng LH, Zhu XL, Xiong ZQ, Wang LY, Cheng HP, Zhou Z (2006) The timing of endocytosis following activation of a G-protein-coupled receptor in a sensory neuron. Biophysical Journal, 90:3590-3598
38. Chen XK, Wang LC, Zhou Y, Zheng LH and Zhou Z (2005) “Kiss-and-Run” Glutamate Secretion in Cultured and Freshly Isolated Rat Hippocampal Astrocytes J. Neurosci., 25(40):9236 –9243
a) Highlighted in Nature Reviews Neuroscience (2005) DIO 10.1038. （http://www.nature.com/nrn/journal/v6/n12/full/nrn1815.html）
37. Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z (2005) Activation of GPCRs modulates quantal size in chromaffin cells through Gbc and PKC. Nature Neuroscience, 8(9):1160 - 1168.
36. Ouyang K, Zheng H, Qin X, Zhang C, Yang D, Wang X, Wu C, Zhou Z*, Cheng H* （2005）Ca2+ Sparks and Secretion in Dorsal Root Ganglion Neurons. Proc Natl Acad Sci U S A., 102:12259-64.
35. Yang H, Zhang C, Zheng H, Xiong W, Zhou Z, Xu T, Ding JP (2005) A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons. Eur. Biophy. J., 34:1007-16
34. Yao J, Chen X, Li H, Zhou Y, Yao L, Wu G, Chen X, Zhang N, Zhou Z, Xu T, Wu H, Ding J (2005) BmP09, a ‘Long-Chain’ Scorpion Peptide Blocker of BK Channels. J. Biol. Chem. 280(15):14819-28
33. Wu B, Wang YM, Xiong W, Zheng LH, Fu CL, Bruce I, Zhang C and Zhou Z (2005) Optimization of a multi-channel puffer system for rapid delivery of solutions during patch-clamp experiments. Frontiers in Bioscience. 10:761-7
32. Xiao RP, Cheng HP, Zhou Z, Chen YQ, Wu CH & Gu XC (2004) Can China Join in main stream of Molecular Medicine? Nature, 432: A44-47
31. Xu CQ, He LL, Brone B, Martin-Eauclaire MF, Van Kerkhove E, Zhou Z, Chi CW. (2004) A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel. Toxicon. 43, 961-71.
30. Zhang C, Xiong W, Zheng H, Wang L, Lu B and Zhou Z (2004) Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons. Neuron, 42: 225–236
29. Yu X, Duan KL, Shang CF, Yu HG and Zhou Z (2004) Calcium influx through hyperpolarization-activated cation channels ( Ih channels) contributes to activity-evoked neuronal secretion. Proc Natl Acad Sci U S A., 101:1051-1056.
28. Duan KL, Yu X, Zhang C, and Zhou Z (2003) Control of Secretion by Temporal Patterns of Action Potentials in Adrenal Chromaffin Cells. J. Neurosci., 23(35):11235-43
27. Lou XL, Yu X, Chen XK, Duan KL, He LM, Qu AL, Xu T, Zhou Z (2003) Na channel inactivation: a comparison study between pancreatic islet ?-cells and adrenal chromaffin cells in rat. J. Physiol (Lond) 548: 191-202.
26. Fan CX, Chen XK, Zhang C, Wang LX, Duan KL, He LL, Cao Y, Liu SY, Zhong MN, Ulens C, Tytgat J, Chen JS, Chi CW, Zhou Z (2003) A Novel Conotoxin from Conus betulinus, ?-BtX, unique in Cysteine Pattern and in Function as a specific BK Channel Modulator. J. Biol. Chem. 278:12624-33
25. Bao L, Jin SX, Zhang C, Wang LH, Xu ZZ, Zhang FX, Wang LC, Ning FS, Cai HJ, Guan JS, Xiao HS, Xu ZQ, He C, Hokfelt T, Zhou Z*, Zhang X* (2003) Activation of delta-Opioid Receptors on Dorsal Root Ganglion Neurons Induces Receptor Insertion and Neuropeptide Secretion. Neuron, 37:121-133.
24. Ji YH, Wang WX, Ye JG, He LL, Li YJ, Yan YP, Zhou Z (2003) BmTX3, a Novel Specific Blocker of Ca2+-Activated K+ Channel from Asian Scorpion Venom: Purification, Genomic Organization and Function Assessment. J. Neurochem. 84(2):325-35.
23. Song P, Lie-Cheng W, Wang GD, Zhou Z, Zhao ZQ (2003) Interleukin-2 regulates calcium current and intracellular calcium via Mu opioid receptors in rat dorsal root ganglion neurons. Neuropharmacology, 43(8):1324-1329
22. He LM, Chen LY, Lou XL, Qu AL, Zhou Z, Xu T. (2003) Rapid inhibitory effects of corticosterone on calcium influx rat dorsal root ganglion neurons. Neuroscience, 116(2):325-33.
21. Zhou Z*, Bers DM (2002) Time Course of Mitochondrial Antagonists Blockade in Intact Cells. European Journal of Physiology, 445:132-138
20. Wu JJ, He LL, Zhou Z, and Chi ZW (2002) Gene Expression, Mutation and Structure-Function Relationship of Scorpion Toxin BmP05 Active on SKCa Channels. Biochemistry, 41(8):2844-9
19. Zhang C & Zhou Z (2002) Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nature Neuroscience, 5(5):425-30
18. He L, Chen L, Lou X, Qu A, Zhou Z, Xu T. (2002) Evaluation of beta-amyloid peptide 25-35 on calcium homeostasis in cultured rat dorsal root ganglion neurons. Brain Res 939(1-2):65-75
17. Lou XL, Zeng, XH, Qu AL and Zhou Z (2001) Glucose induced Ca signals in rat pancreatic ? cells. Progress in Natural Sciences, 11:109-114 (Chinese version: 10:812-817)
16. Zhou.Z & Bers.DM (2000) Ca influx via L-type Ca channel at voltages positive to the reversal potential in ventricular myocytes. Journal of Physiology (London) 523: 57-66
15. Zeng XH, Qu AL, Lou XL, Xu JH, Wang JJ, Wu HX and Zhou Z (2000) Ca signals induced from calcieum stores in pancreatic islets ?-cells. Chinese Science Bulletin, 45:51-56 (Chinese version: 44:2058-2063)
14. Zhou.Z , Matlib.MA & Bers.DM (1998) Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes. Journal of Physiology (London), 507：379-403
13. Matlib MA, Zhou Z, Knight S, Ahmed S, Choi KM, Krause-Bauer J, Phillips R, Altschuld R, Katsube Y, Sperelakis N, Bers DM (1998) Oxo-Bridged Dinuclear ruthenium Ammine Complex Specifically inhibits Ca2+ Uptake into mitochendria in vitro and in situ in single cardiac myocytes. J. Biol. Chem.273(17):10223-31,
12. Elhamdani A, Zhou Z, Arttalejo CR (1998) Timing of dense-core vesicle exocytosis depends on the facilitation L-type Ca channel in adrenal chromaffin cells. J. Neurosci. 18(16):6230-40
11. Wei Shun-hui, Anlian Qu, Hongxiu Wu, Zhuan Zhou (1998). A kinetic model of control on secretion in neuroendocrine cells. IEEE/EMBS, 20: 3083-3086
10. Zhou.Z, Misler.S & Chow .RH (1996) Rapid fluctuations in transmitter release from single vesicles in bovine adrenal chromaffin cells. Biophysical Journal, 70:1543-52
9. Zhou.Z, Misler.S (1996) Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells. J Biol Chem 271(1):270-7
8. Zhou.Z, Misler.S (1995) Amperometric detection of stimulus-induced quantal release of catecholamines from cultured superior cervical ganglion neurons. Proc Natl Acad Sci USA 92(15):6938-42
7. Burnashev, N., Zhou, Z., Neher, E. & Sakmann, B. (1995) Calcium flux and fractional calcium currents through recombinant GluR channels of NMDA-R, AMPA-R and KA-R Subtypes. J. Physiol. (London), 485:403-418
6. Zhuan Zhou & Stanley Misler (1995) Action potential induced catecholamine secretion in rat chromaffin cells. Journal of Biological Chemistry, 270: 3498-3505.
5. Zhuan Zhou & Erwin Neher (1993). Mobile and immobile Ca buffers in bovine adrenal chromaffin cells. J. Physiol. (London). 469: 245-273
4. Schneggenburger,R., Zhou,Z., Konnerth,A. & Neher,E. (1993). Fractional contribution of calcium to the cation current through glutamate receptors. Neuron, 11: 133-143
3. Zhuan Zhou & Erwin Neher (1993). Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells. Pflugers Arch, 425: 511-517.
2. Zhuan Zhou & Huaguang Kang (1990) patch clamp noise from seal impedance and the pipette capacitance. Proc. IEEE/EMBS, 12(4):1679-1680.
1. H.G. Kang & Zhuan Zhou (1990) Low noise design of patch clamp amplifier, Proc. IEEE/EMBS, 12(3):1103-1104.
Papers in Chinese:
1. 关兵才，周 专，张海林 (2015) “Handbook of Ion Channels (Zheng J, Trudeau M, Eds, CRC, 2015)”--系统介绍离子通道的一部新书问世. 生理学报, in press.
2. 周专 （2015） 李之望--当代中国生命科学黎明前的一位铺路人，生理学报, in press.
3. 廉和，张勃，左盼莉， 汪世溶， 姚 伟，孙晓娟， 陆启韶，张曦， 周 专 (2010)小鼠大脑纹状体诱发多巴胺信号分析--Monte Carlo模拟. 生物物理学报. 26（1）:49-60.
4. 树海峰, 汪世溶，姚伟，王 曦，周 专, 王百忍 (2007) IL-1β对实验性急性缺氧诱导的大鼠窦神经放电的影响. 生物物理学报. 23(5): 377-382
5. 黄 维，黄宏平，穆 玉，张 磊，金 木，吕 靖，古靓丽，修 云，张 勃，郭 宁，刘 涛，孙 蕾，宋美英，张 曦，阮怀珍，周 专 (2007)中枢神经系统去甲肾上腺素分泌的实时检测. 生理学报, 59 (6): 865-870.
6. 徐太湘，吕辉，王强，伍龙军，刘进，周专, 徐天乐. （2003）机械分离的果蝇幼虫中枢神经元全细胞钾电流的特性. 生理学报 54(5):411-416.
7. 周专 （2003）单个细胞分泌的实时记录方法。In：范明，王晓民， 周 专，饶毅，丘小庆,徐天乐 (主 编) 《神经科学进展（二）》高等教育出版社, pp:409-420.
8. 吴政星，娄雪林, 周专，瞿安连， 徐涛 (2002) 胰岛素分泌及调节的分子机制. 生物化学与生物物理进展. 29（3）：342-347.
9. 何立铭，段开来，张晨，何林玲，熊巍，李洁，周 专 (2002) 微碳纤电极与细胞量子化分泌的记录方法, 生物物理学报, 18:147-155
10. 娄雪林，何立铭，龚非力，于晓， 徐 涛， 周 专 (2002) 免疫细胞分泌研究进展. 生理学报，54(3):183-188
11. 吴政星，周专，徐 涛 (2001) 单通道和全细胞记录技术. 中国医疗器械杂志， 2001, 24(4): 221-226.
12. 娄雪林,徐涛,瞿安连,周专(2001) 细胞分泌的分子机制研究进展. 科学通报。46:1-8
13. 娄雪林, 周专 (2001) 谷氨酸对海马神经元钙信号的影响. 中国应用生理学杂志. 17（1）：17-23.
14. Ye Q, Qu AL, Zhang CG & Zhou Z (2001) Effects of toosendanin on the [Ca]I in rat chromaffin cells. Chin. J. Neurosci. 17(2): 105-108
15. 娄雪林, 徐涛，周专 (2001) 胰腺Beta细胞的离子通道和分泌活动, 生命的化学， 21（2）：150-152.
16. 娄雪林,曾旭辉,瞿安连,周专(2000) 大鼠胰腺?细胞内葡萄糖钙信号调控机制.自然科学进展，10：812-817 (English version: Lou et al (2001), vol. 11: 109-114)
17. 曾旭辉,娄雪林,瞿安连,吴鸿修,周专. (2000)大鼠胰腺?细胞离子通道的一些特性. 生理学报，52(2)：98-102 (English version: 45:51-56)
18. 徐建华，曾旭辉，瞿安连，周专 (1999)乙酰胆碱对肾上腺嗜铬细胞内钙库释放和激素分泌的诱导作用。生理学报，51(5):564-570
19. 蔡东, 瞿安连, 王晓民, 周专, 徐建华, 韩济生 (1999) 一种实用的碳纤电极制作方法. 生理学报. 51(6):692-9.
20. 韦顺会，徐建华，瞿安连，吴鸿修，周专，叶琴。（1999）大鼠嗜铬细胞分泌的膜电容和微碳纤电极检测。生物物理学报。15:40-46
21. 周专 （1999）细胞内的Ca2+平衡机制。复旦神经生物学讲座。Vol.15:147-158
22. 曾旭辉, 娄雪林，瞿安连, 徐建华，王君健，吴鸿修，周专 (1999) 大鼠胰腺?细胞内的一些诱发Ca2+信号。科学通报。44:2058-2063 (English version: Zeng et al (2000) Chinese Science Bulletin, 45:51-56)
23. 蔡东，王晓民，瞿安连，韩松平，于英心，周专，康华光，韩济生 (1999) 重复膜片钳法研究MPPP＋对神经元钙电流的作用。生物化学与生物物理进展， 26: 158~161
24. Wei Shun-hui, Anlian Qu, Hongxiu Wu, Zhuan Zhou (1998). A kinetic model of control on secretion in neuroendocrine cells IEEE/EMBS,Vol.20: 3083-3086
25. 韦顺会，瞿安连，吴鸿修，周专。（1998）嗜铬细胞分泌的模型研究。华中理工大学学报。26（10）：97－99
26. 曾旭辉，徐建华，周专，瞿安连。（1998）大鼠胰腺β细胞原代培养的一种实用方法。华中理工大学学报。26（5）：24－26
27. 陈良怡，叶琴，瞿安连，邹寿彬，康国新，周专, 康华光（1998）SH－SY5Y细胞上的钙库和钙振荡机理研究。生物物理学报。14（2）：215－220
28. 蔡东，王晓民，瞿安连，韩松年，于英心，康华光，韩济生，周专。（1998） 用突起切断法分析MPP+对于多巴胺能神经细胞的损伤。生物物理学报。14（2）：227-232
29. 韦顺会，瞿安连，吴鸿修，周专（1998）大鼠嗜铬细胞分泌的膜片钳和Fura-2联合检测。华中理工大学学报。26（9）：100－102
30. 徐建华，瞿安连，叶琴，康华光，周专。（1997）大鼠肾上腺嗜铬细胞分泌儿茶酚胺的电化学检测。生物物理学报。13（3）：405－409
31. 叶琴，瞿安连，康华光，周专。（1997）大鼠肾上腺嗜铬细胞原代培养的一种实用方法。华中理工大学学报25（6）：1－3
32. 徐涛，刘乃江，瞿安连，康华光，周专，韩济生。（1995）细胞膜离子通道电流及胞内游离钙离子浓度的同时定量检测。武汉大学学报。2（生物物理专刊）：24－28
33. 周专，康华光 （1992）膜片钳系统的噪声分析。中国生物医学工程学报，11（2）：129-137
34. 曹忠升，康华光，邹寿彬，周专 (1992) 应用膜片钳技术研究细胞分泌. 生物学和生物物理进展, 19:14-19
35. 周专，康华光 (1990) 国产膜片钳仪研制成功。 生物化学和生物物理进展, 17(3): 326-328
36. 周专，康华光，周小萍，李之望 (1990) 大鼠背根神经节DRG细胞的单通道记录技术. 华中理工大学学报. 8:115-122
37. 周专，康华光 （1990）膜片钳系统的低噪声设计。华中理工大学学报。 8:123-130
38. 周专（1990）细胞膜离职单通道电流检测技术与实验方法研究 (On the techniques of single channel recording from cell membrane and the experiment method).华中理工大学博士论文. July 1990， Wuhan，pp:1-150
Book & chapters:
39. 吴政星，王昌河，周专 (2016) “胞饮-胞吞-胞吐” （in： （杨雄里）“神经生物学条目”in：（许智宏）《中国大百科全书》第三版, in press.
40. Peng Loh, Zhuan Zhou and Lung-Sen Kao. (Editors) Special issue “Proceedings of the 16th international symposium on chromaffin cell biology”. J Mol Neurosci. 2012, October, Volume 48（issue 2): 313-471
41. 吴政星、张晨、周专（2012）细胞分泌. (in：王建军，王晓民 (主编）《生理科学进展》). 高等教育出版社，in press.
42. Douglas L. Jones and Zhuan Zhou. (2009) (Eds). Special issue on Calcium Signaling. Canadian Journal of Physiology and Pharmacology. NRC Research Press, New York. Volume 88 (No.2): 83-110.
43. 吴政星，徐涛，周 专. (2009) 神经递质的释放及其调控. (In: 韩济生 主编. 神经科学. 第三版)。北京医科大学出版社。pp:220-241
44. 汪萌芽, 周 专. (2006) 离子通道与胞内钙离子平衡. (In: 寿天德 编. 神经生物学. 第二版)。高等教育出版社。pp:86-110
45. 周 专，尚春峰，丁瑜，姚伟，李洁 (2006) 脑内微环境的化学监测生物传感器，微透析及相关技术. In: 赵志奇，陈军(主编译)：《现代神经科学研究技术》，中国科学出版社, pp:928-977。 原著：JAN KEHR. Monitoring Chemistry of Brain Microenvironment: Biosensors, Microdialysis and Related Techniques. In: U. Windhorst，H. Johansson (Eds) 《Modern Techniques in Neuroscience Research》, Springer, 2001. pp:1149-1198
46. 范明，王晓民， 周 专，饶毅，丘小庆,徐天乐 (主 编) 《神经科学进展（二）》高等教育出版社, pp:1-431, 2003.
47. 徐天乐， 王晓民， 周 专， 曹河圻 (主 编) 《神经科学进展（一）》(81.5 万字) 科学出版社, pp:1-550, 2002.
48. 蔡东，周专，邓英，徐辉碧（1998）中药复杂体系中药效成份的细胞药理基础研究。（王小如主编）中药复杂体系中的重大基础理论问题。厦门大学出版社。pp:223-232
专利：
1. Zhuan Zhou* and He-Ping Cheng: "METHODS AND SYSTEMS FOR SCREENING LIGAND-RECEPTOR BINDING in living cells" (USA patent No. 1.9 awarded 2010-9-18, Euro patent awarded 2011; Chinese patent (发明专利) ZL **.6 awarded 2016 )
2. Mu-Min Poo, Zhuan Zhou*, Shu-Ming Duan, Xin-Qiao He and Qian Hu (2004): " A X-Y stage for combined confocal microscopy electrophysiology"， Chinese patent (发明专利) ZL **.6 (*correspondence author)
3. Zhuan Zhou (2003): "A magnetic button for wiring on stage". Chinese patent (实用新型) ZL **.0