Ying Liu, Ph.D.
Principal Investigator
Laboratory of Mitochondrial and Aging Research
Room 228, Integrated Science Research Center,
Peking University, Beijing, China 100871
E-mail: ying.liu@pku.edu.cn
Dr. Ying Liu received her B.S. in Biochemistry from Nanjing University in 2006 and her Ph.D. in Biochemistry from the University of Texas Southwestern Medical Center in 2011. She then obtained her postdoctoral training in Massachusetts General Hospital and Harvard Medical School as a Helen Hay Whitney Research Fellow from 2011 to 2013. In December 2013, she joined IMM as a full-time investigator.
Selected Publications:
1. Gao K, Li Y, Hu SM andLiu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.eLife(2019)e41792
2. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A andLiu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation.Nature Cell Biology(2018) doi: 10.1038/s41556-018-0238-5.
3. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y andLiu Y*. KLHL22 activates amino-acid-dependent mTORC1 signaling to promote tumorigenesis and ageing.Nature557(2018) 585-589.
4. Chen J^#, Ou Y^#, Li Y, Hu S, Shao LW andLiu Y*. Metformin ExtendsC. elegansLifespan through Lysosomal Pathway.eLife6 (2017)e31268.
5. Shao LW, Niu R andLiu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response.Cell Res.11 (2016) 1182-1196. (cover story)
6. Berendzen K, Durieux J, Shao L, Tian Y, Kim H, Wolff S,Liu Yand Dillin A. Neuroendocrine coordination of mitochondrial stress signaling and proteostasis.Cell166 (2016) 1553-1563.
7.Liu Y,Samuel B, Breen P, and Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria.Nature508 (2014) 406-410.
8.Liu Y,Tan H, Tian H, Liang C, Chen S and Liu Q. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis.Mol. Cell44 (2011) 502-508.
9. Ye X*, Huang N*,Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q and Zhang H. Structure of C3PO and mechanism of Human RISC activation.Nat. Struct. Mol. Biol. 18 (2011) 650-657.
10.Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.Science5941 (2009) 750-753.