纪建国 Emailjijg（AT）pku.edu.cn
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所在院系北京大学生命科学学院
实验室主页


详细描述
研究方向
1.衰老及退行性病变等细胞增殖异常模型中相关蛋白质群及其调控网络研究
2.神经细胞核蛋白质的动态修饰与功能研究
3.体内外蛋白质动态修饰与功能研究
代表性科研论文
1. Lu X, Shi Y, Lu Q, Ma Y, Luo J, Wang Q, Ji J, Jiang Q, Zhang C , Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit , J Biol Chem , 2014 , 285, 33281-93　　
2. An M, Dai J, Wang Q, Tong Y, Ji J , Efficient and clean charge derivatization of peptides for analysis by mass spectrometry. Rapid Commun Mass Spectrom , Rapid Commun Mass Spectrom , 2014 , 24, 1869-74　　
3. Wang Q, Zhao X, He S, Liu Y, An M, Ji J , Differential proteomics analysis of specific carbonylated proteins in the temporal cortex of aged rats: the deterioration of antioxidant system , Neurochem Res , 2014 , 35, 13-21　　
4. Ma Y, Bao J, Zhao X, Shen H, Lv J, Ma S, Zhang X, Li Z, Wang S, Wang Q, Ji J , ctivated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression , Mol Cell Proteomics , 2013 , 12, 2833-44　　
5. Zhao X, Wang Q, Wang S, Zou X, An M, Zhang X, Ji J , Citric acid-assisted two-step enrichment with TiO2 enhances the separation of multi- and monophosphorylated peptides and increases phosphoprotein profiling , J Proteome Res , 2013 , 12, 2467-76　　
6. An M, Zou X, Wang Q, Zhao X, Wu J, Xu LM, Shen HY, Xiao X, He D, Ji J , High-confidence de novo peptide sequencing using positive charge derivatization and tandem MS spectra merging , Anal Chem , 2013 , 85, 4530-7　　
7. Lai W, Wu J, Zou X, Xie J, Zhang L, Zhao X, Zhao M, Wang Q, Ji J , Secretome analyses of Aβ(1-42) stimulated hippocampal astrocytes reveal that CXCL10 is involved in astrocyte migration , J Proteome Res , 2013 , 12, 832-43　　
8. Zou X, Zhao M, Shen H, Zhao X, Tong Y, Wang Q, Wei S, Ji J , MilQuant: a free, generic software tool for isobaric tagging-based quantitation , J Proteomics , 2013 , 75, 5516-22　　
9. Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, Hu Y, Wang Q, Xu W, Sun F, Ji J, Murray JM, Carr AM, Kong D , The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing , Cell , 2012 , 149, 1221-32　　
10. Zhao M, An M, Wang Q, Liu X, Lai W, Zhao X, Wei S, Ji J , Quantitative proteomic analysis of human osteoblast-like MG-63 cells in response to bioinert implant material titanium and polyetheretherketone , J Proteomics , 2012 , 75, 3560-73　　
11. Lin X, Wang Q, Cheng Y, Ji J, Yu LC , Changes of protein expression profiles in the amygdala during the process of morphine-induced conditioned place preference in rats , Behav Brain Res , 2011 , 221, 197-206　　
12. Hong J, Huang Y, Li J, Yi F, Zheng J, Huang H, Wei N, Shan Y, An M, Zhang H, Ji J, Zhang P, Xi Z, Du Q, Liang Z , Comprehensive analysis of sequence-specific stability of siRNA , FASEB J , 2010 , 24, 4844-55　　
13. Lin X, Wang Q, Ji J, Yu LC , Role of MEK-ERK pathway in morphine-induced conditioned place preference in ventral tegmental area of rats , J Neurosci Res , 2010 , 88, 1595-604　　
14. Wu J, An Y, Pu H, Shan Y, Ren X, An M, Wang Q, Wei S, Ji J , Enrichment of serum low-molecular-weight proteins using C18 absorbent under urea/dithiothreitol denatured environment , Anal Biochem , 2010 , 398, 34-44　　
15. Wang Q, He J, Meng L, Liu Y, Pu H, Ji J , A proteomics analysis of rat liver membrane skeletons: the investigation of actin- and cytokeratin-based protein components , J Proteome Res , 2010 , 9, 22-9　　
16. Wang Q, He J, Meng L, Liu Y, Pu H, Ji J , A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components , J Proteome Res , 2009 , May 8. [Epub ahead of print]　　
17. Wang Q, He J, Meng L, Liu Y, Pu H, Ji J , A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components , J Proteome Res , 2009 , May 8. [Epub ahead of print]　　
18. Liu Y, He J, Wang Q, Ji S, Pu H, Jiang T, Meng L, Yang X, Ji J , Comparative studies of early liver dysfunction in senescence-accelerated mouse using mitochondrial proteomics approaches , Mol Cell Proteomics , 2008 , 7: 1755-1762.　　
19. Liu Y, He J, Wang Q, Ji S, Pu H, Jiang T, Meng L, Yang X, Ji J , Comparative studies of early liver dysfunction in senescence-accelerated mouse using mitochondrial proteomics approaches , Mol Cell Proteomics , 2008 , 7: 1755-1762.　　
20. He J, Liu Y, He S, Wang Q, Pu H, Tong Y and Ji J , Comparison of two-dimensional gel electrophoresis based and shotgun strategies in the study of plasma membrane proteome. , Proteomics-Clinical Application , 2007 , 1: 231-241.　　
21. He J, Liu Y, He S, Wang Q, Pu H and Ji J, , Proteomic analysis of a membrane skeleton fraction from human liver. , Journal of Proteome Research , 2007 , 6: 3509-3518.　　
22. He J, Liu Y, He S, Wang Q, Pu H, Tong Y and Ji J , Comparison of two-dimensional gel electrophoresis based and shotgun strategies in the study of plasma membrane proteome. , Proteomics-Clinical Application , 2007 , 1: 231-241.　　
23. He J, Liu Y, He S, Wang Q, Pu H and Ji J, , Proteomic analysis of a membrane skeleton fraction from human liver. , Journal of Proteome Research , 2007 , 6: 3509-3518.　　
24. Diao W, Chen W, Wu Y, Liu P, Xie X, Li S, Shen P, Ji J , Serum, liver, and kidney proteomic analysis for the alloxan-induced type I diabetic mice after insulin gene transfer of naked plasmid through electroporation. , Protoemics , 2006 , 6: 5837-5845.　　
25. He S, Wang Q, He J, Pu H, Yang W and Ji J , Proteomic analysis and comparison of the biopsy and autopsy specimen of human brain temporal lobe. , Proteomics , 2006 , 18: 4987-4996.　　
26. Yang W, Liu P, Liu Y, Wang Q, Tong Y and Ji J , A proteomics profiling of rat pheochromocytoma PC12 cells , Proteomics , 2006 , 10:2982-2990.　　
27. Diao W, Chen W, Wu Y, Liu P, Xie X, Li S, Shen P, Ji J , Serum, liver, and kidney proteomic analysis for the alloxan-induced type I diabetic mice after insulin gene transfer of naked plasmid through electroporation. , Protoemics , 2006 , 6: 5837-5845.　　
28. He S, Wang Q, He J, Pu H, Yang W and Ji J , Proteomic analysis and comparison of the biopsy and autopsy specimen of human brain temporal lobe. , Proteomics , 2006 , 18: 4987-4996.　　
29. Yang W, Liu P, Liu Y, Wang Q, Tong Y and Ji J , A proteomics profiling of rat pheochromocytoma PC12 cells , Proteomics , 2006 , 10:2982-2990.　　
30. Chen T, Wang Q, Cui J, Yang W, Shi Q, Ji J and Shen P, 2005. . , Induction of apoptosis in mice liver by microcystin-LR: a combined transcriptomic, proteomic and simulation strategy , Molecular & Cellular Proteomics , 2005 , 4: 958-974.　　
31. Chen T, Wang Q, Cui J, Yang W, Shi Q, Ji J and Shen P, 2005. . , Induction of apoptosis in mice liver by microcystin-LR: a combined transcriptomic, proteomic and simulation strategy , Molecular & Cellular Proteomics , 2005 , 4: 958-974.　　
32. Zhou B, Yang W, Ji J and Ru B , Differential display proteome analysis of PC-12 cells transiently transfected with metallothionein-3 gene , Journal of Proteome Research , 2004 , 3: 126-131.　　
33. Zhou B, Yang W, Ji J and Ru B , Differential display proteome analysis of PC-12 cells transiently transfected with metallothionein-3 gene , Journal of Proteome Research , 2004 , 3: 126-131.　　
34. Zhao R, Ji J, Tong Y, Pu H, Ru B , Use of serological proteomic methods to find biomarkers associated with breast cancer , Proteomics , 2003 , 3: 433-439.　　
35. Zhao R, Ji J, Tong Y, Pu H, Ru B , Use of serological proteomic methods to find biomarkers associated with breast cancer , Proteomics , 2003 , 3: 433-439.　
详细介绍