凌笑梅 Emailpkulxm（AT）126.com
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所在院系北京大学医学部药学院
实验室主页


详细描述
研究方向：
1、药物分析新技术和新方法研究及其在生物医药领域中的应用研究:采用毛细管电泳方法研究分子间相互作用研究，如生物大分子和小分子、生物大分子与生物大分子相互作用；手性物质的拆分及与生物大分子相互作用研究；毛细管色谱柱固定化技术研究（固定蛋白、细胞等）及在药物研究中的应用。
2、药物代谢动力学及代谢组学研究:采用现代仪器和色谱联用技术，进行药物体内的生物转化、血药浓度-时间曲线、吸收、分布、排泄、与血浆蛋白结合、对药物代谢酶活性影响和药物-药物相互作用及代谢组学研究等。
3、新药质量标准及稳定性研究:创新药物质量标准建立和稳定性研究。


代表性科研论文：
1. Jing Li^, Wensi Lin, Weiwei Lin, Peng Xu, Jianmei Zhang, Haisong Yang, Xiaomei Ling^？, Metabolic profiling study on potential toxicity and immunotoxicity-biomarker discovery in rats treated with cyclophosphamide using HPLC-ESI-IT-TOF-MS，Biomedical Chromatography, 2015, 29(5): 768-776
2. Zhongjie Li, Yiran Zhao, Weiwei Li, Xiaobo Hu, MinYe, Xiaodan Zhang, Xiaomei Ling*，Rapid screening and identification of active ingredients in licoriceextract interacting with V3 loop region of HIV-1 gp120 using ACE andCE-MS，Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmaceutical and Biomedical Analysis, 2015, 111: 28–35
3. Peng Xu, MinLi, Yanping Βai, WeiLu, Xiaomei Ling*,WeidongLi, The effects of piracetam on heroin-induced CPP and neuronal apoptosis in rats，Drug and Alcohol Dependence, 2015.150: 141-146
4. Zhongjie Li, Li Li, Xiaowei Wang, Junyi Liu, Xiaomei Ling*，Interactions of carrageenan or its degradation with R15K by affinity capillary electrophoresis，Journal of Chinese Pharmaceutical Sciences，2015,24（6）: 400-404
5. Peng Xu, Yanping Βai, Haisong Yang, Jing Li, Wei Lu, Xiaomei Ling*，High-performance liquid chromatography with fluorescence detection method for simultaneous quantitation of monoamine neurotransmitters and their metabolites in subregions of rat brain, Journal of Chinese Pharmaceutical Sciences，2015,24(7):458-466
6. Yiran Zhao, Zhongjie Li, Yong Jiang, Xiaodan Zhang,Xiaomei Ling*，Rapid screening of anti-HIV ingredients in Artemisia rupestris L. extracts interacting with V3 loop region of HIV-1 gp120 and reverse transcriptase by affinity capillary electrophoresis and capillary zone electrophoresis，Journal of Chinese Pharmaceutical Sciences，2015,24(6):625-629
7. Lu Yang, Pazilaiti.Yakufu, Meina Li, Xiaomei Ling*, Zhongjie Li, Ying Wang,Study on Interactions between Ligands (Compound A/22) and CCR4, ML40, 3 Extracellular Loops by ACE and CZE，Journal of Chinese Pharmaceutical Sciences，2014，23(3)186-189
8. Meina Li,·Lei Lei,·Linghan Jia, Xiaomei Ling*, Jianmei Zhang, Yiran Zhao, Kewei Wang, Quantitative evaluation of interactions between Kv4.3 N-terminus and its auxilary subunit KchIPs by affinity capillary electrophoresis, Analytical Biochemistry, 2014,449:99-105
9. Haisong Yang, Wensi Lin, Jianmei Zhang, Weiwei Lin, Peng Xu, Jing Li, Xiaomei Ling*，Urine metabonomics analysis of the toxic effects of TM208 in rats by HPLC-IT-TOF/MS, Journal of Chromatography B, 2014, 959: 49-54
10. Jing Li, Weiwei Lin, Dai Li, Yingfang Ao, Haisong Yang, Xiaomei Ling*A validated HPLC method for the determination of cefazolin sodium level in rabbit synovial fluid, Journal of Chinese Pharmaceutical Sciences 2014,23(9):649-653