席建忠 Emailxi(AT)coe.pku.edu.cn
联系电话
所在院系北京大学工学院
实验室主页http://www2.coe.pku.edu.cn/subpaget.asp?id=19


详细描述
研究方向：

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1、功能细胞芯片：利用微纳米技术开发各种高通量集成芯片，包括肌肉细胞芯片、细胞迁移芯片等。
2、miRNA：定量检测方法、生理功能以及调控机制的研究。
3、大规模siRNA 筛选以及药物的研发。
4、TALE技术开发以及应用
代表性科研论文：

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1. Yueguang Rong, Mei Liu, Liang Ma, Wanqing Du, Hanshuo Zhang, Yuan Tian, Yin Li, He Ren , Chuanmao Zhang, Lin Li, She Chen,Jianzhong Xi& Li Yu, Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation.Nature Cell Biology2012, Aug.
2. Zhao Wang, Juan Li, Gancheng, Wang, Mingjun Jiang, Shenyi Yin, Changhong Sun, Hanshuo, Zhang, Fengfeng Zhuang andJianzhong, Jeff Xi,An Integrated Chip for the High-throughput Manufacture of TAL Effectors.Angew. Chem. Int. Ed.2012, Aug.
3. Zhao Wang, Huang Huang, Hanshuo Zhang, Chang Hong Sun, Yang Hao, Junyu Yang, Yu Fan, andJianzhong Jeff Xi, A Magnetic Bead-Integrated Chip for the Large Scale Manufacture of Normalized esiRNAs,PLoS ONE2012.
4. Hanshuo Zhang, Yang Hao, Junyu Yang, Ying Zhuo, Juan Li, Changhong Sun, Shenyi Yin, Yanyi Huang andJianzhong Xi, Genome-wide Functional Screening of miR-23b as a Pleiotropic Modulator Suppressing Cancer Metastasis.Nature Communication2011 2,554 DOI: doi:10.1038/ncomms1555.
5. Huang Huang, Qing Chang, Changhong Sun, Shenyi Yin, Juan Li andJianzhong Xi, A polyacrylamide microbead-integrated chip for the large-scale manufacture of ready-to-use esiRNA,Lab Chip2011, 11 (6), 1036-1040
6. Huiping Yuan, Xiaoyong Zhang, Xiuqing Huang, Yonggang Lu, Weiqing Tang, Yong Man, Shu Wang,Jianzhong Xi, Jian Li, NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of b-Cells via JNK, p38 MAPK and p53 Pathways.PLoS ONE2011, 5(12): e15726. doi:10.1371
7. Li J, et al.Jianhzhong Xi, Real-Time Polymerase Chain Reaction MicroRNA Detection Based on Enzymatic Stem-Loop Probes Ligation.Anal. Chem.2009, 81: 5446-5451
8. Wang J,et al.Xi J, Huang Y, A Chip-to-chip Nanoliter Microfluidic Dispenser.Lab Chip2009, 9:1831-1835
9. Yao B, Li J, et al.Xi J, Quantitative analysis of zeptomole microRNAs based on isothermal ramification amplification.RNA2009, 15: 1787-1794
10.Xi J, Jacob J, Montemagno C, Self-assembled microdevices driven by muscle,Nature Materials2005, 4:180-184