杨秀伟 Emailxwyang(AT)bjmu.edu.cn
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所在院系北京大学医学部药学院
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详细描述
研究方向：主要研究领域包括天然药物化学、天然药物化学成分及其生物转化与创新药物发现、中药复杂体系科学问题研究和药物的ADMET/Act.研究平台建设。
代表性科研论文：1.Ma Li-Yuan, Zhang You-Bo, Zhou Qi-Le, Yang Yan-Fang, Yang Xiu-Wei*. Simultaneousdetermination of eight ginsenosides in rat plasma by liquidchromatography–electrospray ionization tandem mass spectrometry: Application totheir pharmacokinetics. Molecules, 2015, 20(12):21597–21608. 2014-IF2.416
2.Ma Li-Yuan, Zhou Qi-Le, Yang Xiu-Wei*. New SIRT1 activator from alkalinehydrolysate of total saponins in the stems-leaves of Panax ginseng. Bioorganic& Medicinal Chemistry Letters, 2015, 25(22):5321–5325. 2014-IF2.42
3.Wu Shuai, Xu Wei, Wang Fu-Rong, Yang Xiu-Wei*. Study of the biotransformation ofTongmai Formula by human intestinal flora and its intestinal permeability acrossthe Caco-2 cell monolayer. Molecules, 2015, 20(10):18704-18716. 2014-IF2.416
4.Ma Li-Yuan, Yang Xiu-Wei*. Six new dammarane-type triterpenes from acidichydrolysate of the stems-leaves of Panax ginseng and their inhibitory–activitiesagainst three human cancer cell lines. Phytochemistry Letters, 2015,13:406-412. 2014-IF 1.45
5.Wei Wei, Rena Kasimu, Yang Xiu-Wei*. New salicin derivatives from the leaves ofPopulus euphratica. Journal of Asian Natural Products Research, 2015,17(5):491-496. 2014-IF 0.913
6.Zhou Qi-Le, Yang Xiu-Wei*. Four new ginsenosides from red ginseng withinhibitory activity on melanogenesis in melanoma cells. Bioorganic &Medicinal Chemistry Letters, 2015, 25:3112–3116. 2014-IF2.42
7.Yang Yan-Fang, Xu Wei, Song Wei, Ye Min, Yang Xiu-Wei*. Transport of twelvecoumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR cellmonolayer—An in vitro model for blood-brain barrier permeability. Molecules,2015, 20(7):11719-11732 2014-IF 2.416
8.Li Fei, Yang Xiu-Wei*, Krausz Kristopher, Nichols Robert, Xu Wei, PattersonAndrew, Gonzalez Frank J.*. Modulation of colon cancer by nutmeg. Journal ofProteome Research (J. Proteome Res.), 2015, 14 (4):1937-1946. 2014-IF4.245
9.Deng Gai-Gai, Wei Wei, Yang Xiu-Wei*, ZhangYou-Bo, Xu Wei, Gong Ning-Bo, LüYang, Wang Feng-Feng. New coumarins from the roots of Angelica dahurica var.formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activatedRAW264.7 cells. Fitoterapia, 2015, 101:194-200. 2014-IF2.345
10.Cao Gui-Yun, Xu Wei, Yang Xiu-Wei*, Gonzalez FJ, Li Fei. New neolignans from theseeds of Myristica fragrans that inhibit nitric oxide production. FoodChemistry, 2015, 173:231–237. 2014-IF 3.391