秦跟基 邮  箱：qingenji@pku.edu.cn
职  称：教授
办公室电话：**
办公室地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼，100871
实验室电话：**
实验室地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼，100871


个人简介
科研领域
代表性论文
个人介绍:北京大学生命科学学院教授，博士生导师，国家杰青。课题组致力于通过研究叶片发育，寻找控制植物器官发育的重要共有保守调控机制，主要通过遗传、生化和分子生物学等手段发掘调控叶片发育和侧枝形成的重要基因，并研究其作用机制和分子调控机理，揭示叶片等器官形态适应性的分子机制。近年来已发现了多个基因在调控叶片发育中起重要作用，其中包括发现的转录因子、转录抑制因子和E3泛素连接酶形成TCP/TIE/TEAR调控模块来精细调控叶片、分枝和胚珠发育的新机制。已在Plant Cell、PNAS、Cell Res、New Phytol等国际主流期刊上发表论文30多篇。参与主译了植物科学优秀教材《植物生物学》。
教育经历:2007 - 2009, 访问学者 , 生物科学系 , 美国加州大学圣地亚哥分校
2001 - 2003, 博士后 , 北京大学生命科学学院
1996 - 2001, 毕业 , 植物遗传育种 , 南京农业大学农学院，农学博士
1992 - 1996, 毕业 , 植物遗传育种 , 南京农业大学农学院，农学学士
荣誉奖励:2017年获国家杰出青年基金资助
2010年教育部新世纪优秀人才
2012年北京大学绿叶生物医药杰出青年学者奖工作经历:2015 - 至今，教授，北京大学生命科学学院
2006 - 2015，副教授，北京大学生命科学学院
2001 - 2006， 讲师，北京大学生命科学学院 学术任职:2013-至今 中国植物学会植物生理及分子生物学专业委员会，委员
2018-至今 北京市植物学会第十届理事会，理事评审任职:国家自然科学基金、教育部学位中心以及包括New Phytol、Plant Physiol等多个专业杂志的同行评审专家。教材编撰:《植物生物学》执教课程:生物技术制药基础，教学，北京大学，秋季学期
现代植物学实验技术，教学，北京大学，春季学期
植物激素与信号转导，教学，北京大学，春季学期


植物叶片发育保守转录调控分子机制的研究：
　　 叶片是光合作用的主要器官。叶片在地球上的出现彻底改变了地球表面和大气的环境，也改变了植物和动物的进化方向。早在300多年前，德国著名的自然科学家兼哲学家戈特弗里德?威廉?莱布尼茨 (Gottfried Wilhelm Leibniz) 就指出世界上没有两片完全相同叶片的自然现象，叶片形态的多样性使其成为重要的分类依据，但叶片也有统一性，比如很多叶片都是平整的。叶片如何进化而来？叶片如何根据不同的环境形成多种多样的大小和形态？又怎样形成平整的结构为进行光合作用来高效捕获光能？这些科学问题还远没有研究清楚。本课题组的研究方向主要是根据这些科学问题，以模式植物拟南芥和水稻为材料，利用遗传学、分子生物学和生物化学的方法，寻找和克隆调控叶片发育相关的重要保守关键基因，研究重要转录因子TCP、EXB蛋白家族、转录抑制因子TIE蛋白家族以及与染色质重塑因子相关的TPL/TPRs蛋白家族在调控叶片和其他器官发育中的保守分子机制，完善调控叶片发育的分子调控网络，为叶片与侧枝间的进化关系提供可能的分子证据，加深理解叶片形成平整以及不同形态和大小的分子机理，为通过分子设计育种改造植物株型和叶片大小和形态来提高农作物产量提供理论基础。
1.Rongrong Yuan, Jingqiu Lan, Yuxing Fang, Hao Yu, Jinzhe Zhang, Jiaying Huang and Genji Qin* (2018) The Arabidopsis USL1 controls multiple aspects of development by affecting late endosome morphology. New Phytologist 219(4):1388-1405.
2.Yan Yang#, Michael Nicolas#, Jinzhe Zhang, Hao Yu, Dongshu Guo, Rongrong Yuan, Tiantian Zhang, Jianzhao Yang, Pilar Cubas*, Genji Qin* (2018) The TIE1 transcriptional repressor controls shoot branching by directly repressing BRANCHED1 in Arabidopsis. PLoS Genetics 14(3): e**.
3.Shaoman Zhang, Cong Li, Yangyang Zhou, Xiaoji Wang, Hong Li, Ziyi Feng, Haodong Chen, Genji Qin, Dan Jin, William Terzaghi, Hongya Gu, Li-Jia Qu, Dingming Kang, Xing Wang Deng, Jigang Li (2018) TANDEM ZINC-FINGER/PLUS3 Is a Key Component of Phytochrome A Signaling. Plant Cell 30(4): 835-852.
4.Wenxing Han, Danlu Han, Zhipeng He, Huan Hu, Qian Wu, Juanjuan Zhang Jieming Jiang, Genji Qin, Yuhai Cui, Jianbin Lai, Chengwei Yang (2018). The SWI/SNF subunit SWI3B regulates IAMT1 expression via chromatin remodeling in Arabidopsis leaf development. Plant Science 271: 127-132.
5.Jinzhe Zhang, Baoye Wei, Rongrong Yuan, Jianhui Wang, Mingxin Ding, Zhuoyao Chen, Hao Yu, Genji Qin* (2017). The Arabidopsis RING-type E3 ligase TEAR1 controls leaf development by targeting the TIE1 transcriptional repressor for degradation. Plant Cell 29(2): 243-259.
6.Dongshu Guo, Genji Qin* (2016). EXB1/WRKY71 transcription factor regulates both shoot branching and responses to abiotic stresses. Plant Signaling & Behavior. 11(3): e**.
7.Shibai Li, Xiaochen Wang, Shan He, Jieru Li, Qingpei Huang, Takato Imaizumi, Leqing Qu, Genji Qin, Li-Jia Qu, and Hongya Gu* (2016). CFLAP1 and CFLAP2 Are Two bHLH Transcription Factors Participating in Synergistic Regulation of AtCFL1-Mediated Cuticle Development in Arabidopsis. PLoS Genetics. 12(1): e**.
8.Dongshu Guo, Jinzhe Zhang, Xinlei Wang, Xiang Han, Baoye Wei, Jianqiao Wang, Boxun Li, Hao Yu, Qingpei Huang, Hongya Gu, Li-Jia Qu, Genji Qin* (2015). The WRKY transcription factor WRKY71/EXB1 controls shoot branching by transcriptionally regulating RAX genes in Arabidopsis. Plant Cell 27: 3112-3127. (cover story)
9.Qing Liu, Gezhi Shen, Keqin Peng, Zhigang Huang, Jianhua Tong, Mohammed Humayun Kabir, Jianhui Wang, Jingzhe Zhang, Genji Qin* and Langtao Xiao* (2015). The alteration in the architecture of a T-DNA insertion rice mutant osmtd1 is caused by up-regulation of MicroRNA156f. Journal of Integrative Plant Biology 57(10):819-829.
10.Baoye Wei, Jinzhe Zhang, Changxu Pang, Hao Yu, Dongshu Guo, Hao Jiang, Mingxin Ding, Zhuoyao Chen, Qing Tao, Hongya Gu, Li-Jia Qu, Genji Qin* (2015). The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development. Cell Research 25:121-134.
11.Yan Yang, Bin Ou, Jinzhe Zhang, Hongya Gu, Genji Qin and Li-Jia Qu (2014). The Arabidopsis Mediator subunit MED16 regulates iron homeostasis by associating with EIN3/EIL1 through subunit MED25. Plant Journal 77(6):838-851.
12.Ruixi Li, Jieru Li, Shibai Li, Genji Qin, Ondrej Novak, Ales Pencik, Karin Ljung，Takashi Aoyama, Jingjing Liu, Angus Murphy, Hongya Gu, Tomohiko Tsuge, Li-Jia Qu (2014). ADP1 Affects Plant Architecture by Regulating Local Auxin Biosynthesis. PLOS Genetics 10(1): e**.
13.Jin Miao#, Dongshu Guo#, Jinzhe Zhang#, Qingpei Huang#, Genji Qin#, Xin Zhang,Jianmin Wan, Hongya Gu, Li-Jia Qu* (2013). Targeted mutagenesis in rice using CRISPR-Cas system. Cell Research 23(10):1233-1236.
14.Tong Wei, Bin Ou, Jinbin Li, Yang Zhao, Dongshu Guo, Youyong Zhu, Zhangliang Chen, Hongya Gu, Chengyun Li*, Genji Qin* and Li-Jia Qu* (2013). Transcriptional profiling of rice early response to Magnaporthe oryzae identified OsWRKYs as important regulators in rice blast resistance. PLoS ONE 8(3): e59720.
15.Qing Tao, Dongshu Guo, Baoye Wei, Fan Zhang, Changxu Pang, Hao Jiang, Jinzhe Zhang, Tong Wei, Hongya Gu, Li-Jia Qu, Genji Qin* (2013). The TIE1 Transcriptional Repressor Links TCP Transcription Factors with TOPLESS/TOPLESS-RELATED Corepressors and Modulates Leaf Development in Arabidopsis. Plant Cell 25: 421-437
16.Yan Chen, Zhangliang Chen, Juqing Kang, Dingming Kang, Hongya Gu, Genji Qin* (2013). AtMYB14 Regulates Cold Tolerance in Arabidopsis. Plant Molecular Biology Reporter 31: 87-97.
17.Mingqiu Dai, Chen Zhang, Urszula Kania, Fang Chen, Qin Xue, Tyra Mccray, Gang Li, Genji Qin, Michelle Wakeley, William Terzaghi, ,Jianmin Wan, Yunde Zhao, Jian Xu, Ji?í Friml, Xing Wang Deng and Haiyang Wang (2012). A novel PP6-type phosphatase holoenzyme directly regulates PIN phosphorylation and auxin efflux in Arabidopsis. Plant Cell 24: 2497-2514.
18.Wei-ying Wang, Li Zhang, Shufan Xing, Zhiqiang Ma, Jingjing Liu, Hongya Gu, Genji Qin* and Li-jia Qu* (2012). Arabidopsis AtVPS15 plays essential roles in pollen germination possibly by interacting with AtVPS34. Journal of Genetics and Genomics 39: 81-92.
19.Yang Zhao, Tong Wei, Kang-Quan Yin, Zhangliang Chen, Hongya Gu, Li-Jia Qu and Genji Qin*（2012）. Arabidopsis RAP2.2 plays an important role in plant resistance to Botrytis cinerea and ethylene responses. New Phytologist 195: 450-460.
20.Renhong Wu, Shibai Li, Shan He, Friedrich Wa?mann, Caihong Yu, Genji Qin, Lukas Schreiber, Li-Jia Qu, and Hongya Gu (2011). CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a Class IV homeodomain transcription factor, in rice and Arabidopsis. Plant Cell 23(9): 3392-3411.
21.Yu Luo, Genji Qin, Jun Zhang, Yuan Liang,Yingqi Song,Meiping Zhao,Tomohiko Tsuge,Takashi Aoyama,Jingjing Liu,Hongya Gu, and Li-Jia Qu (2011). D-myo-Inositol-3-Phosphate Affects Phosphatidylinositol-Mediated Endomembrane Function in Arabidopsis and Is Essential for Auxin-Regulated Embryogenesis. Plant Cell 23(4): 1352-72.
22.Yanxia Zhang, Renhong Wu, Genji Qin, Zhangliang Chen, Hongya Gu, Li-Jia Qu (2011). Over-expression of WOX1 leads to defects in meristem development and polyamine homeostasis in Arabidopsis. Journal of Integrative Plant Biology 53: 493-506.
23.Lihua Han, Genji Qin, Dingming Kang, Zhangliang Chen, Hongya Gu, Li-Jia Qu （2010）. A nuclear-encoded mitochondrial gene AtCIB22 is essential for plant development in Arabidopsis. Journal of Genetics and Genomics 37: 667-683.
24.Shufan Xing, Jin Miao, Shuang Li, Genji Qin, Si Tang, Haoni Li, Hongya Gu, Li-Jia Qu, (2010) Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis. Cell Research 20:688-700.
25.Yong Guo, Genji Qin, Hongya Gu, and Li-Jia Qu (2009). Dof5.6/HCA2, a Dof transcription factor gene, regulates interfascicular cambium formation and vascular tissue development in Arabidopsis. Plant Cell 21: 3518-3534.
26.Jingjing Liu, Yiyue Zhang, Genji Qin, Tomohiko Tsuge, Norihiro Sakaguchi, Guo Luo, Kangtai Sun, Dongqiao Shi, Shiori Aki, Nuoyan Zheng, Takashi Aoyama, Atsuhiro Oka, Weicai Yang, Masaaki Umeda, Qi Xie, Hongya Gua, and Li-Jia Qu, (2008). Targeted Degradation of the Cyclin-Dependent Kinase Inhibitor ICK4/KRP6 by RING-Type E3 Ligases Is Essential for Mitotic Cell Cycle Progression during Arabidopsis Gametogenesis. Plant Cell 20: 1538-1554.
27.Youfa Cheng, Genji Qin, Xinhua Dai, and Yunde Zhao (2008). NPY genes and AGC kinases define two key steps in auxin-mediated organogenesis in Arabidopsis. Proceedings of the National Academy of Sciences, USA 105 (52): 21017-21022.
28.Lin-Chuan Li#, Genji Qin#, Tomohiko Tsuge, Xian-Hui Hou, Mao-Yu Ding, Takashi Aoyama,Atsuhiro Oka, Zhangliang Chen, Hongya Gu, Yunde Zhao and Li-Jia Qu (2008). aSPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis. New Phytologist 179(3): 751-764. (co-first author).
29.Xin Li, Genji Qin, Zhangliang Chen, Hongya Gu, and Li-Jia Qu (2008). A gain-of-function mutation of transcriptional factor PTL results in curly leaves, dwarfism and male sterility by affecting auxin homeostasis. Plant Molecular Biology 66: 315-327.
30.Youfa Cheng#, Genji Qin#, Xinhua Dai, and Yunde Zhao (2007). NPY1, a BTB-NPH3-like protein, plays a critical role in auxin-regulated organogenesis in Arabidopsis. Proceedings of the National Academy of Sciences, USA 104(47): 18825-18829 (co-first author).
31.Shufan Xing, Genji Qin, Yan Shi, Zhiqiang Ma, Zhangliang Chen, Hongya Gu and Li-Jia Qu (2007). GAMT2 encodes a methyltransferase of gibberellic acid that is involved in seed maturation and germination in arabidopsis. Journal of Integrative Plant Biology 49 (3): 368-381.
32.Genji Qin, Hongya Gu, Ligeng Ma, Yiben Peng, Xing Wang Deng, Zhangliang Chen, Li-Jia Qu (2007). Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis. Cell Research 17:471-482.
33.Genji Qin, Zhiqiang Ma, Li Zhang, Shufan Xing, Xianhui Hou, Jie Deng, Jingjing Liu, Zhangliang Chen, Li-Jia Qu, Hongya Gu (2007). Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development. Cell Research 17: 249-263.
34.Genji Qin, Hongya Gu, Yunde Zhao, Zhiqiang Ma, Guanglu Shi, Yue Yang, Eran Pichersky, Haodong Chen, Meihua Liu, Zhangliang Chen, and Li-Jia Qu. (2005). An indole-3-acetic acid carboxyl methyltransferase regulate Arabidopsis leaf development. Plant Cell, 17:2693-2704.
35.Gaofeng Jia, Peidu Chen, Genji Qin, Guihua Bai, Xiue Wang, Suling Wang, Bo Zhou, Shouzhong Zhang, Dajun Liu (2005). QTLs for Fusarium head blight response in a wheat DH population of Wangshuibai/Alondra‘s’. Euphytica, 146: 183-191.
36.Genji Qin, Dingming Kang, Yiyu Dong, Yunping Shen, Li Zhang, Xiaohui Deng, Yao Zhang, Song Li, Nan Chen, Weiran Niu, Cong Chen, Peicheng Liu, Haodong Chen, Jigang Li, Yanfei Ren, Hongya Gu, Xingwang Deng, Li-Jia Qu and Zhangliang Chen (2003). Obtaining and analysis of flanking sequences from T-DNA transformants in Arabidopsis. Plant Science, 165: 941-949.