曲红 邮  箱：quh@mail.cbi.pku.edu.cn
职  称：副教授


个人简介
科研领域
代表性论文
教育经历:1993 - 1996 , 工学博士 , 应用化学 , 北京理工大学
1990 - 1993 , 理学硕士 , 物理化学 , 吉林大学
1986 - 1990 , 理学学士 , 有机化学 , 辽宁大学
工作经历:2000 - 至今 , 副教授 , 北京大学生命科学学院
1998 - 2000 , 讲师 , 北京大学生命科学学院
1996 - 1998 , 博士后 , 军事医学科学院药物与毒物研究所 教材编撰:实用生物统计(第2版), 李松岗、曲红编,北大出版社, 2007执教课程:生物统计 , 主讲 , 北京大学 , 2003-今
计算概论 , 主讲 , 北京大学 , 1999-2003
1. 利用泛癌基因组数据整合分析复杂疾病中的遗传机制;
2. 系统注释和分析转运蛋白的功能及与复杂疾病的关系;
3. 构建和拓扑分析代谢转运网络;
4. 计算模拟分析生物大分子的结构和功能;
5. 验证MSKCC Nomogram预后分析模型在中国结肠癌和胃癌人群中的的适用度
6. 研究circular RNA作为竞争性内源RNA在癌症转移中的调控作用
1.Yining Liu*, Mingyu Luo*, Qijun Li, Jiachun Lu, Min Zhao#, and Hong Qu#, CIGene: a literature-based online resource for cancer initiation genes. BMC Genomics. 2018; 19: 552.
2.Yining Liu*, Mingyu Luo*, Zhaochen Jin, Min Zhao#, and Hong Qu#, dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence. Database (Oxford). 2018. doi: 10.1093/database/bay062.
3.Yining Liu, Zhe Li, Jiachun Lu, Min Zhao*, Hong Qu*. CMGene: A literature-based database and knowledge resource for cancer metastasis genes, Journal of Genetics and Genomics 44(5): 277-279 (2017).
4.Min Zhao, Yining Liu, Fuda Huang, Hong Qu*. A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes. Sci. Rep. 6: 30624 (2016).
5.Min Zhao, Luming Chen, Yining Liu, Hong Qu*. GCGene: a gene resource for gastric cancer with literature evidence. Oncotarget. 7(23): 33983-93 (2016).
6.Aidong Wang, Ming Cui, Hong Qu, Jiabo Di, Zaozao Wang, Jiadi Xing, Fan Wu, Wei Wu, Xicheng Wang, Lin Shen, Beihai Jiang, Xiangqian Su. Induction of anti-EGFR immune response with mimotopes identified from a phage display peptide library by panitumumab. Oncotarget, 7(46): 75293-75306 (2016).
7.Min Zhao, Di Liu, Hong Qu*. Systematic review of next-generation sequencing simulators: computational tools, features and perspectives. Briefings in Functional Genomics, 16(3): 121-128 (2016).
8.Chao Yang, Yu Xia, Hong Qu, An-Dong Li, Ruihua Liu, Yubo Wang, Tong Zhang. Discovery of new cellulases from the metagenome by a metagenomics-guided strategy. Biotechnol Biofuels, 9:138 (2016).
9.Min Zhao, Yining Liu, Hong Qu*, Expression of epithelial-mesenchymal transition-related genes increases with copy number in multiple cancer types. Oncotarget, 7(17): 24688-99 (2016).
10.M Zhao, L Chen and H Qu*, CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases. Cell Death and Disease, 7: e2053 (2016).
11.Min Zhao, Zhe Li, Hong Qu*. An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis. Sci. Rep., 5: 15478 (2015).
12.Min Zhao, Lei Kong, Yining Liu & Hong Qu*. dbEMT: an epithelial-mesenchymal transition associated gene resource. Sci. Rep., 5: 11459 (2015).
13.Min Zhao, Lei Ma, Yining Liu & Hong Qu*. PediCan: an online gene resource for pediatric cancers with literature evidence. Sci. Rep., 5, 11435 (2015).
14.Min Zhao, Yanming Chen, Dacheng Qu*, Hong Qu*. METSP: a maximum-entropy classifier based text mining tool for transporter-substrate identification with semi-structured text. BioMed Research Internationa, 2015: 254838 (2015).
15.Xueying Chen, Min Zhao, Hong Qu*. Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum. BioMed Research International, 2015: 328568 (2015).
16.Jianghong Dai*, Hong Qu*, Zhisheng Yu, Jiangke Yang, Hongxun Zhang. Computational analysis of AnmK-like kinase: New insights into the cell wall metabolism of fungi. Journal of Theoretical Biology, 379: 59-65 (2015).
17.Maoxing Liu*, Hong Qu*, Zhaode Bu*, Donglai Chen, Beihai Jiang, Ming Cui, Jiadi Xing, Hong Yang, Zaozao Wang, Jiabo Di, Lei Chen, Chenghai Zhang, Zhendan Yao, Nan Zhang, Fei Tan, Jin Gu, Ziyu Li, and Xiangqian Su. Validation of the Memorial Sloan-Kettering Cancer Center Nomogram to Predict Overall Survival After Curative Colectomy in a Chinese Colon Cancer Population. Ann Surg Oncol., 22(12):3881-7 (2015).
18.Hai-Ying Zhang, Guo-Hua Bi, Xia Li, Jie Li, Hong Qu, Shi-Jian Zhang, Chuan-Yun Li, Emmanuel S Onaivi, Eliot L Gardner, Zheng-Xiong Xi and Qing-Rong Liu. Species Differences in Cannabinoid Receptor 2 and Receptor Responses to Cocaine Self-Administration in Mice and Rats. Neuropsychopharmacology, 40(4):1037-51 (2015).
19.Ye AY, Liu Q-R, Li C-Y, Zhao M*, Qu H*. Human Transporter Database: Comprehensive Knowledge and Discovery Tools in the Human Transporter Genes. PLoS ONE, 9(2): e88883 (2014).
20.Zhao, M., Kong, L. & Qu, H*. A systems biology approach to identify intelligence quotient score-related genomic regions, and pathways relevant to potential therapeutic treatments. Sci. Rep., 4: 4176 (2014).
21.Zhao M, Li X M, Qu H*. EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder. Sci China Life Sci, 56(12): 1086–96 (2013).
22.He H, Han D, Feng H, Qu H, Song S, Baojing Bai, Zhenting Zhang. Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population. PLoS ONE, 8(11): e80393 (2013).
23.Kong,L., Cheng,L., Fan,L.Y., Zhao,M.*, and Qu,H*. IQdb: an intelligence quotient score-associated gene resource for human intelligence. Database(Oxford), 2013: bat063 (2013).
24.Chen D, Jiang B, Xing J, Liu M, Cui M, Liu Y, Wang Z, Chen L, Yang H, Zhang C, Yao Z, Zhang N, Ji J, Qu H*, Su X*., Validation of the memorial sloan-kettering cancer center nomogram to predict disease-specific survival after r0 resection in a chinese gastric cancer population. PLoS One, 8(10):e76041 (2013).
25.Fang K. Du, Fang Xu, Hong Qu, Sisi Feng, Jijun Tang, Rongling Wu, Exploiting the Transcriptome of Euphrates Poplar, Populus euphratica (Salicaceae) to Develop and Characterize New EST-SSR Markers and Construct an EST-SSR Database. PLoS One, 8(4): e61337 (2013).
26.Mei-Qin Chen, Ai-Hong Zhang, Quan Zhang, Bao-Cai Zhang, Jie Nan, Xia Li, Na Liu, Hong Qu, Cong-Ming Lu, Sudmorgen, Yi-Hua Zhou, Zhi-Hong Xu, Shu-Nong Bai*, Arabidopsis NMD3 Is Required for Nuclear Export of 60S Ribosomal Subunits and Affects Secondary Cell Wall Thickening, PLoS One, 7(4): e35904 (2012).
27.Min Zhao, Hong Qu*, High similarity of phylogenetic profiles of rate-limiting enzymes with inhibitory relation in Human, Mouse, Rat, budding Yeast and E. coli, BMC Genomics, 12 (S3): S10 (2011).
28.Taochao Tan, Xi Xiang, Hong Qu, Shenggeng Zhu, Qun Bi, The study on venom proteins of Lapemis hardwickii by cDNA phage display, Toxicology Letters, 206(3): 252-7 (2011).
29.Yong-Kang Yang, Hong Qu, Dong Gao, Wei Di, Hai-Wei Chen, Xin Guo, Zhong-He Zhai, and Dan-Ying Chen, ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner, J. Biol. Chem., 286(12): 10568-80 (2011)..
30.Min Zhao, YanMing Chen, DaCheng Qu and Hong Qu*，TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates，Science China. Life sciences, 54(1), 60-4 (2011).
31.Zhicheng Lin, Juan J. Canales, Thr?stur Bj?rgvinsson, Morgane Thomsen, Hong Qu, Qing-Rong Liu, Gonzalo E. Torres, and S. Barak Caine, Monoamine Transporters: Vulnerable and Vital Doorkeepers. In Shafiqur Rahman, editor: Progress in Molecular Biology and Translational Science, Burlington: Academic Press, 98: 1-46 (2011).
32.Min Zhao and Hong Qu*, PathLocdb: a comprehensive database for subcellular localization of metabolic pathway and its application for multiple localization analysis，BMC Genomics, 11(Suppl 4): S13 (2010).
33.Beihai Jiang, Tingting Ren, Bin Dong, Like Qu, Genglin Jin, Jianning Li, Hong Qu, Lin Meng, Caiyun Liu, Jian Wu and Chengchao Shou. Peptide Mimic Isolated by Autoantibody Reveals Human Arrest Defective 1 Overexpression Is Associated with Poor Prognosis for Colon Cancer Patients, The American Journal of Pathology, 177(3): 1095-103 (2010).
34.Min Zhao and Hong Qu*, Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors, BMC Genomics, 10(Suppl 3): S31 (2009).
35.S. Song, D. Han, H. Qu, Y. Gong, H. Wu, X. Zhang, N. Zhong and H. Feng , EDA gene mutations underlie non-syndromic oligodontia, J DENT RES, 88(2): 126-31 (2009).
36.Dong Han, Yu Gong, Hua Wu, Xiaoxia Zhang, Ming Yan, Xiaozhu Wang, Hong Qu, Hailan Feng and Shujuan Song, Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis, European Journal of Medical Genetics, 51(6): 536-46 (2008).
37.Bingjun Jiang, Hong Qu, Yuanlei Hu, Ting Ni, Zhongping Lin, Computational analysis of the relationship between allergenicity and digestibility of allergenic proteins in simulated gastric fluid, BMC Bioinformatics, 8:375 (2007).
38.Feng Cui, Hong Qu, Jian Cong, Xiao-Li Liu, and Chuan-Ling Qiao , Do mosquitoes acquire organophosphate resistance by functional changes in carboxylesterases?, FASEB J, 21(13): 3584-91 (2007).
39.Hong Jiang, Chao Yang, Hong Qu, Zheng Liu, Q. S. Fu, and Chuanling Qiao, Cloning of a Novel Aldo-Keto Reductase Gene from Klebsiella sp. Strain F51-1-2 and Its Functional Expression in Escherichia coli, Appl. Environ. Microbiol., 73(15):4959-65 (2007).
40.Qun Bi, Xue Zhou, Xiaodong Cen, Hong Qu, Jingchu Luo, Yixiu Huang and Shenggeng Zhu , Efficient targeted anticoagulant with active RGD motif , Thromb Res., 120(4):541-7 (2007).
41.Xiaobo Lei, Yingyu Chen, Guanhua Du, Wenyu Yu, Xiaohui Wang, Hong Qu, Bin Xia, Hongping He, Jianhua Mao, Weixing Zong, Xudong Liao, Maryam Mehrpour, Xiaojiang Hao and Quan Chen, Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2., FASEB J, 20(12):2147-9 (2006).
42.Beihai Jiang, Wenbin Liu, Hong Qu, Lin Meng, Shumei Song, Tao Ouyang, and Chengchao Shou, A Novel Peptide Isolated from a Phage Display Peptide Library with Trastuzumab Can Mimic Antigen Epitope of HER-2, J. Biol. Chem., 280(6): 4656 - 62 (2005).
43.由德林,曲红,陈强,邢阳,顾孝诚,罗明. 次黄嘌呤-鸟嘌呤磷酸核糖转移酶突变体的基因构建、表达和性质. 生物化学与生物物理学报, 35(9):853-8 (2003).
44.罗敏,米志勇,曲红,唐朝荣,梁卫红,吴乃虎. 水稻Rac家族新成员osRACB基因的克隆及结构分析. 中国科学(C辑), 33(3): 202-14 (2003).
45.许云哲,米志勇,曲红,尤瑞麟,吴乃虎. 水稻osRACD基因编码蛋白质的生化特性分析. 自然科学进展, 13(9): 923-7 (2003).
46.周建军,曲红,吴才宏,韩卫东,李志伟,丰美福. 中国人HLA-G1的cDNA克隆、序列分析、表达和蛋白质空间结构预测. 北京大学学报(自然科学版), 38(2): 212-20 (2002).
47.Yanhui Su, Hong Qu, Vachon Vincent, Jingchu Luo, Jie Zhang, Raynald Laprade, Yuxian Zhu, The toxicity test and hypothetical model of Bacillus thuringiensis Cry1Aa helix4, Science China Life sciences, 45(6): 561-68 (2002).
48.吴小平,阎锡蕴,杨东玲,曲红. 人单链抗体亲和力成熟研究. 中华微生物学和免疫学杂志, 21(2): 156-9 (2001).
49.王建民,罗静初,李毅,曲红,吴光耀,顾孝诚. 水稻矮缩病毒基因组数据库的构建. 微生物学报, 40(1): 43-8 (2001).
50.任蕴芳,曲红,冯健男,李松,沈倍奋. 人介素-6受体胞外区配基结合功能域活性部位的设定. 科学通报, 45(3): 301-6 (2000).
51.Runfang Ren, Jiannan Feng, Hong Qu, Song Li, Beifen Shen, Three-dimensional structure and function study on the active region in the extracellular ligand-binding domain of human IL-6 receptor, Science China Life sciences, 43(4): 425-32 (2000).
52.邓鹏翅,吕善运,罗静初,Sandor Pongor,刘修才,曲红,梁宋平,韩汝珊,顾孝诚. ?_淀粉酶抑制剂AAI的核磁共振氢谱谱峰归属及结构分析.生物物理学报, 16(3), 444-52 (2000).