郑晓峰 邮  箱：xiaofengz@pku.edu.cn
职  称：教授
办公室地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼，100871
实验室地址：北京市海淀区颐和园路5号，北京大学，金光生命科学大楼，100871


个人简介
科研领域
代表性论文
个人介绍: 日本东京农工大学获得博士学位，美国宾西法尼亚州立大学博士后研究员。北京大学生命科学学院教授，博士生导师，学位委员会委员。担任国家自然科学基金医学科学领域学科评审组成员，北京市自然科学基金生物学科组会议评审专家。中国生物化学与分子生物学会酶学专业委员会委员、常务委员，中国生物物理学会女科学家分会理事。北京市生物化学与分子生物学学会副理事长。 研究组主要利用生化分子生物学、细胞生物学、免疫学和结构生物学等技术方法，鉴定新的调控肿瘤细胞生长、炎症和固有免疫性疾病的蛋白，包括影响肿瘤转移和耐药的外泌体蛋白，研究这些蛋白发挥作用的信号通路和分子机制。探讨泛素化、类泛素化和磷酸化等蛋白质翻译后修饰在DNA 损伤应答、炎症、肿瘤发生发展中的调控作用及机制，明确蛋白质功能的失调与炎症、肿瘤等重大疾病的发生和发展的关系。 先后主持、承担了20余项国家自然科学基金重点项目、面上项目，国际合作ICGEB课题，教育部博士点基金和优先发展基金、国家“重大科学研究计划”课题，科技部863课题、973课题等多项课题的研究。已经发表72篇SCI文章，其中作为通讯作者发表了50篇文章（Nature Comm,PNAS, PLoS Pathogen, Oncogene, Nucleic Acid Res, Cell Res, J Cell Sci, JBC等），合作发表包括Science和PNAS等在内的16篇SCI论文，作为第一作者发表6篇文章。
教育经历:1994 - 1998 , 理学博士 , 生化与分子生物学 , 东京农工大学
荣誉奖励:北京大学优秀共产党员，2016
北京大学优秀班主任，2016
北京大学东宝教师奖 , 2013
北京大学东宝教师奖 , 2009
北京大学青年教师教学基本功优秀奖 , 2007
北京大学东宝教师奖 , 2006
北京市优秀辅导员 , 2006
谈家桢基金生命科学九源导师奖 , 2006
北京大学优秀班主任 , 2005
工作经历:2008年6月 - 至今 , 教授 , 北京大学 生命科学学院
2002年5月 - 2008年5月 , 副教授 , 北京大学 生命科学学院
1998年4月 - 2002年4月, 博士后研究员 , 美国 宾夕法尼亚州大学
社会服务工作:北京大学优秀共产党员，2016
北京大学优秀班主任，2016
北京大学东宝教师奖 , 2013
北京大学东宝教师奖 , 2009
北京大学青年教师教学基本功优秀奖 , 2007
北京大学东宝教师奖 , 2006
北京市优秀辅导员 , 2006
谈家桢基金生命科学九源导师奖 , 2006
北京大学优秀班主任 , 2005
学术任职:1998年-至今　　美国生物化学学会会员
2003年-至今　　中国生物化学与分子生物学会会员
2003年-至今　　中国生物物理学会会员
2005年-至今　　中国细胞生物学会会员
2015年-至今　　中国生物化学与分子生物学会酶学专业委员会委员、常务委员，
2015年-至今　　中国生物物理学会女科学家分会理事。杂志任职:2012年-至今 World Journal of Biological Chemistry 编委评审任职:2005年-至今 中国博士后基金 评审专家2006年-至今 国家自然科学基金生命学部 评审专家2006年-至今 山东省自然科学基金生命科学 评审专家2015年-至今 国家自然科学基金医学科学领域学科评审组成员，2015年-至今 北京市自然科学基金生物学科组会议评审专家，2017年-至今 国家自然科学基金生命科学领域学科评审组成员。会议发言与组织:2017 12-02~12-03 南方科技大学国际肿瘤转化医学高峰论坛，中国深圳大会报告2017 12-01~12-02 第六届广州国际肿瘤学会议，中国广州大会报告2017 10-27~10-29 8th International symposium on DNA Damage Response and Human Diseases. 中国深圳大会报告2017 09-21~09-24 第六届广州跨学科蛋白质研究会议，中国广州大会报告2017 08-18~08-21 第十三届全国酶学学术讨论会，中国长春大会报告2017 05-27~05-29 Cullin RING ligases and Protein NEDDylation：Biology and Therapeutics.中国杭州大会报告2017 05-12~05-14 中华医学会医学细胞生物学分会第六次全国学术大会中国西安大会报告.2016 06-24~06-26 The Second Trilateral Workshop for Frontier Protein Studies. 日本 大阪 大会报告2016-10-21~10-23 8th International Conference SUMO, Ubiquitin, UBL Proteins：Implications for Human Diseases中国 上海大会报告：hCINAP, a novel regulator of ubiquitin-like protein modifications in various signaling pathways, is essential for tumor growth中美肿瘤论坛, 大会报告：hCINAP, an atypical enzyme, is a novel player in tumorigenesis.哈尔滨，2016.1.15-17.第十四次中国暨国际生物物理大会，分会报告：Human NADPH sensor HSCARG plays important roles in fundamental cellular processes.昆明，2015-11-17.第十二届全国酶学学术讨论会，大会报告：腺苷酸激酶hCINAP的结构和功能研究。威海，2015-9-19.2015蛋白质修饰与降解论坛，大会报告：组蛋白H2A泛素化、类泛素化修饰调控的新机制，上海，2015.6.The Seventh International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases.大会报告： HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1. 上海，2014.5.中国生物化学与分子生物学会第十一届会员代表大会暨2014年全国学术会议，RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. 厦门，2014.8.2012年全国生物化学与分子生物学学术大会，报告题目：hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway via controlling NEDDylation of ribosomal protein S14成都， 2012.8.The 17th IBC (IUPAB). 报告题目：Structural insight into the regulatory mechanism of human UDP-glucose pyrophosphorylase，北京，2011.10.中国细胞生物学学会第十二次全体会员代表大会暨学术大会. 报告题目：Crystal structure of PACSIN F-BAR domain reveals a novel membrane curvature sensing mechanism.北京，2011.7.The Inaugural Xiamen Winter Symposium “Molecular Mechanisms and Signalling in Cancer Biology”，报告题目：USP7 deubiquitinates NEMO through the interaction with HSCARG，厦门，2011.2.2010年中国生物化学与分子生物学会第十届全国会员代表大会暨全国学术会议. 报告题目：Crystal structure of PACSIN F-BAR domain reveals a novel membrane curvature sensing mechanism. 南京，2010.8.第三届中国结构生物学学术讨论会，报告题目：人类分泌蛋白SI-CLP通过巨噬细胞调节固有免疫反应，三亚，2010.3.21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology（第21届国际生物化学与分子生物学联盟学术大会暨第12届亚洲大洋洲生物化学家与分子生物学家学术大会），上海，2009.8.2009年北京同步辐射装置用户学术年会暨专家会，分会报告：NADPH是HSCARG的变构调节因子，分会报告，太原，2009.8.10th Sino-Singapore Symposium in Biology，大会报告：HSCARG inhibits activation of NF-κB by interacting with IκB kinase-β. 厦门，2009.11.第二届全国“跨学科蛋白质研究”学术讨论会，NADPH sensor protein HSCARG down-regulates NO synthesis and is essential for cell viability. 烟台，2008.7.北京生物化学学会2007年年会 , 2007.12 International Symposium on Synchrotron Radiation and Biology, Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein, 上海，2007.11 Serum presence of preS antigen in chronic hepatitis B: a significant serological marker in HBV prognosis,Advances in Protein Sciences, Hongkong , 2005.12 Activation of the protein kinase PKR by small double-stranded RNAs flanked by single-stranded regions.,The 3rd Annual Meeting of the China RNA Society & 1st International RNA Workshop in China , 2003.7 Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR,Second International Conference: Proteins that bind RNA , 2001.2 执教课程:基础分子生物学 , 主讲, 北京大学, 秋季、2004-至今
研究生科研规范训练,主持，北京大学, 秋季、2014-至今
蛋白质的翻译后修饰及其调控作用，主持, 北京大学, 春季、2015-
现代生物学实验技术原理及其应用，主持, 北京大学, 秋季、2015-
生化与分子生物学进展，主讲，北京大学, 秋季、2006-至今
蛋白质晶体学，主讲，北京大学, 秋季、2012-2014
　　一些参与基本生物学过程的重要蛋白质的功能失调会影响细胞的正常生理功能，并可能导致炎症、肿瘤在内的多种疾病，因此，对这些蛋白的结构和功能开展研究具有重要的生物学意义。我们实验室利用生化分子生物学、细胞生物学、免疫学和结构生物学等技术方法，发现并鉴定调控肿瘤细胞生长、炎症和固有免疫性疾病的新的调控蛋白，研究这些蛋白发挥作用的信号通路和分子机制。研究泛素化、类泛素化和磷酸化等蛋白质翻译后修饰在DNA 损伤应答、炎症、肿瘤发生发展中的调控作用及机制，明确蛋白质功能的失调与炎症、肿瘤等重大疾病的发生和发展的关系。我们还通过研究流感病毒和乙肝病毒蛋白的结构和功能，了解病毒的致病机理。
本实验室主要兴趣在于：
1. 炎症和肿瘤发生发展重要调控蛋白的鉴定和作用机制。
2. 蛋白质的泛素化、类泛素化、磷酸化等修饰对NF-κB、p53等信号通路以及DNA损伤应答的调节作用及其机制。
3. 流感、乙肝等病毒重要蛋白的结构和功能研究。
1.Yang CZ, Zang WC, Tang ZF, Ji YP, Xu RD, Yang YF, Luo AP, Hu B, Zhang ZM, Liu ZH, Zheng XF*. (2018) A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy. Cancer Research. 78, 1069-1082. Doi: 10.1158/0008-5472.CAN-17-2143.
2.Guan JH, Yu SY, Zheng XF*. (2017) NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage. Protein Cell. DOI 10.1007/s13238-017-0455-x.
3.Ji YP, Yang CZ, Tang ZF, Yang YF, Tian YL, Yao HW, Zhu X, Zhang ZM, Ji JF, Zheng XF*. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells in a glycolysis-dependent manner by facilitating LDHA phosphorylation. Nature Communications. 8:15308. Doi.10.1038/ncomms15308.
4. Dong XD, GuanJH, ZhengCF, Zheng XF*. (2017) Herpes simplex virus-1 UL36USP suppresses translesion synthesis pathway by deubiquitinating PCNA. J Biol Chem. Accepted.
5. Bai DM, Zheng XF*. (2017) PML-RARA mutations confer varying arsenic trioxide resistance. Protein & Cell. 8(4):296–301. DOI: 10.1007/s13238-016-0356-4.
6. Bai DM, Zhang J, Li T, Hang R, Liu Y, TianY, Huang D, Qu L, Cao XF, Ji J-F, Zheng XF*. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumor growth. Nature Communications.7: 12310.
7. Severin C,, Rocha de Moura T, Liu Y, Li K, Zheng XF*, Luo M*. (2016) The cap binding site of influenza virus protein PB2 as a drug target. Acta Cryst. D72, 245-253.
8. Qu LL, Ji YP, Zhu X, Zheng XF*. (2015) hCINAP Negatively Regulates NF-κB Signaling by Recruiting the Phosphatase PP1 to Deactivate the IKK Complex. Journal of Molecular Cell Biology. 7 (6): 529-542. doi: 10.1093/jmcb/mjv041.
9. Liu Y, Yang YF, Fan JL, He RN, Luo M, Zheng XF*. (2015) The Crystal Structure of PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism. J Biol. Chem. 290(14): 9141-9149.
10. Li TT, Guan J, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. Cell Difference & Diseases.5: e1229. Doi: 10.1038/cddis.2014.197.
11. Hu B, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acid Res. 42, 5582-5593
12. Li G, Qu L, Ma S, Wu Y, J CW, Zheng XF*. (2014) Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity. Acta crystallographica section D. D70, 1812-1822.
13. Peng YY, Xu RD, Zheng XF*. (2014) HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. PloS Pathogens. 10(4): e**.
14. Li TT, Guan JH, Huang ZJ, Hu X, Zheng XF*. (2014) RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. J Cell Sci. 127: 2238-2248.
15. Zhang JF, Bai DM, Ma XW, Guan JH, Zheng XF*. (2014) hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14. Oncogene. 33, 246-254. doi: 10.1038/onc.2012.560.
16. Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z, Zheng XF*. (2014) Human SI-CLP aggravates the inflammation of the arthritis and is a potential macrophage inflammatory regulator. Arthritis Rheumatol. 66(5):1141-1152.
17. Bai DM, Zhang J, Xiao WC, Zheng XF*. (2014) Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. Nucleic Acid Res. 42(3):1799-1811.
18. Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R, Zheng XF*. (2013) The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding. Protein & Cell. 4(12):897-900.
19. Bai XY, Zheng XF*. (2013) Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity. Protein & Cell. 4(3): 211–219.
20. Xiao WC, Peng YY, Liu Y, Li Z, Li SL, Zheng XF*. (2013) HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. PLoS One. 8(3): e59301.
21. Liu Y, Qin K, Meng G, Zhang J, Zhou JF, Zhao GY, Luo M, Zheng XF*. (2013) Structural and Functional Characterization of K339T Substitution Identified in the PB2 subunit Cap-binding Pocket of Influenza A Virus. J Biol. Chem. 288(16): 11013-11023.
22. Liu Y, Meng G, Luo M, Zheng XF*. (2013) Crystallization and X-ray crystallographic analysis on the cap binding domain of influenza A virus H1N1 polymerase subunit PB2. Acta crystallgrophy F. 69: 280-283.
23. Feng X, Yang R, Zheng XF*, Zhang F. (2012) Identification of a novel nuclear-localized adenylate kinase 6 from Arabidopsis thaliana as an essential stem growth factor. Plant Physiol Biochem. 61: 180-186.
24. Bai X, Meng G, Luo,M, Zheng XF*. (2012) Rigidity of the Wedge Loop in PACSIN 3 is a Key Factor in Dictating the Diameters of Tubules. J Biol. Chem. 287(26):22387-22396.
25. Zhang M, Hu B, Li T, Peng Y, Guan J, Lai S, Li Z, Zheng XF*. (2012) A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity. Traffic. 13(6):790-799.
26. Yu Q, Zheng XF*. (2012) The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect important for regulating pyrophosphorylase activity. Biochemical J. 442(2): 283-291.
27. Bai X, Meng G, Zheng XF*. (2012) Cloning, purification, crystallization and preliminary X-ray diffraction analysis of mouse PACSIN 3 protein from Escherichia coli. Acta crystallgrophy F68, 159-162.
28. Ding Q, Meng G, Wang S-F, Zheng XF,Yang H, Gong Q-H. (2011) Ultrafast Solvation Dynamics of Subtilisin-Polyethylene Glycol Interaction for Protein Crystallization. CHIN. PHYS. LETT. Vol. 28, No. 6 (2011) 067804.
29. Zhu WZ, Meng G, Liu Y, Zhang FY, Zheng XF* (2011) Protein Expression, Crystallization and Preliminary X-Ray Crystallographic Studies on LidA from Legionella pneumophila. Acta crystallgrophy F67, 637-639.
30. Li GM, Qiang Chen, Dai KS, Zheng XF*. (2011) The Ca2+-dependent multimerization of Homo sapiens S100 domain in Cornulin protects cells from injury. Progress in Biochemistry and Biophysics. 38(3): ~9.
31. Meng G, Zhao YM, Bai XY, Liu Y, Todd J Green, Luo M, Zheng XF*. (2010) Structure of Human Stabilin-1 Interacting Chitinase-like Protein (SI-CLP) Reveals a Saccharide-binding Cleft with Lower Sugar-binding Selectivity. J Biol. Chem. 285, 39898-39904.
32. Li GM, Qu L, Meng G, Bai Xiaoyun, Dai KS, Zheng XF*. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. (2010). Acta crystallgrophy F. 66: 935-937.
33. Li, C.Y. Zhang, Y. Wang, Z. Cao, C. Zhang, P.W. Lu, S.J. Li, X.M. Yu, Q. Zheng, X. Du, Q, Uhl, GR., Liu, QR, Wei, L. (2010) A human-specific de novo protein-coding gene associated with human brain functions. PLoS computational biology. 6(3):e**.
34. Cui Y, Jiao Z, Gong J, Yu Q, Zheng X, Quan J, Luo M, Yang Z. (2010) Development of new stereodiverse diaminocyclitols as inhibitors of influenza virus neuraminidase. Org. Lett. 12, 4-7.
35. Zhang JF, Zhang FY, Zheng XF*. (2010) Deficiency of hCINAP causes defects in Cajal body formation,histone transcrIption, and cell viability. Cellular and Molecular Life Sciences. 67:1907–1918.
36. Bai XY, Meng G, Li GM, Luo M, Zheng XF*. (2010) Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein. Acta crystallgrophy F. 66: 73-75.
37. Li GM, Tang ZT, Meng G, Dai KD, Zhao JD, Zheng XF*. (2009) Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from the Anabaena Pcc 7120. Acta crystallgrophy F. 65(10): 1039-1041.
38. Zhang Y, Lu S, Zhao S, Zheng XF, Long M, Wei L. (2009) Positive selection for the male functionality of a co-retroposed gene in the hominoids. BMC Evol Biol. 9: 252.
39. Gan QN, Li TT, Hu B, Lian M, Zheng XF* (2009) HSCARG inhibits activation of NF-κB by interacting with IκB kinase-β. J Cell Sci. 122(22): 4081-4088.
40. Heinicke LA, Wong J, Lary J, Nallagatla SR, Diegelman-Parente A, Zheng XF, Cole JL, Philip C Bevilacqua. (2009) RNA dimerization promotes PKR dimerization and activation. J Mol Biol. 390(2): 319-338.
41. Lian M, Zheng XF* (2009) HSCARG regulates NF-κB activation by promoting the ubiquitination of RelA or COMMD1 in response to changes of cellular NADPH/NADP+. J Biol. Chem. 284(27): 17998-18006.
42. Dai XY, Li YY, Meng G, Yao S, Zhao YM, Yu Q, Zhang JF, Luo M and Zheng XF* (2009) NADPH is an allosteric regulator of HSCARG. J Mol. Biol. 387, 1277–1285.
43. Meng G, Bai X, Green TJ, Luo M, Zheng XF* (2009) Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain–containing protein. Protein & Peptide Letter. 16(3): 336-338.
44. Chen B, Lian M, Luo M, Zheng XF* (2008) A chemical lipid modification of recombinant preS antigen to study the mechanism of HBV attachment to the host cell. J Biotechnology. 137: 8-13.
45. Zhao YM, Zhang JF, Li HY, Li YY, Ren J, Luo M and Zheng XF* (2008). An NADPH sensor protein (HSCARG) downregulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. J Biol. Chem. 283(16):11004-11013.
46. Hwang J, Nallagatla SR, Toroney RU, Zheng XF, Bevilacqua PC, Cameron CE (2008). Activation of PKR by 5 `-triphosphorylated, single-stranded RNA. FASEB J. 22
47. Meng G, Zhai RT, Liu B and Zheng XF* (2008). Identification of a novel nuclear-localized adenylate kinase from Drosophila melanogaster. Biochemistry (Moscow). 37: 38-43.
48. Lian M, Zhou X, Chen B, Li C, Gu X, Luo M and Zheng XF* (2008). Identification of the critical regions in HBV preS required for its stability. J Peptide Science. 14(3): 307-312.
49. Nallagatla SR, Hwang J, Toroney R, Zheng XF, Cameron CE and Bevilacqua PC. (2007) 5`-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science, 318: 1455-1458.
50. Chen Q, You DL, Liang YH, Su XD, Gu X, Luo M and Zheng XF* (2007). Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design. FEBS J. 274: 4408-4415.
51. Zheng XF*, Dai XY, Zhao YM, Chen Q, Lu F, Yao DQ, Yu Q, Liu XP, Zhang CM, Gu X and Luo M (2007). Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein. Proc.Natl.Acad.Sci.USA. 104(21): 8809-8814.
52. Lian M, Zhou X, Wei L, Qiu SH, Zhou T, Li L, Gu X, Luo M and Zheng XF* (2007). Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients. Virology J. 4: 93.
53. Li CY, Yu Q, Ye ZQ, Sun Y, He QY, Li XM, Zhang WX, Luo JC, Gu X, Zheng XF* and Wei LP (2007). A Nonsynonymous SNP in Human Cytosolic Sialidase in a Small Asian Population Results in Reduced Enzyme Activity: Potential Link with Severe Adverse Reactions to Oseltamivir. Cell Research. 17(4):357-362.
54. Dai X, Gu X, Luo M and Zheng XF* (2006). Protein expression, crystallization and preliminary X-ray crystallographic studies on HSCARG from Homo sapiens. Protein & Peptide Letter. 13(9):955-957.
55. Zhai RT, Meng G, Zhao YM, Liu B, Zhang GF and Zheng XF* (2006). A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans. FEBS Letters. 580: 3811-3817.
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