职称：教授
所在部门：统计学教研室

1579E 67562 dengmh at math dot pku dot edu dot cn


工作经历
2009.8-至今北京大学数学科学学院 教授
2003.8-2009.7北京大学数学科学学院 副教授
2009.8-2010.1耶鲁大学医学院生物统计学分部 访问助理教授
2001.2-2003.8南加州大学生物科学系，分子和计算生物学 博士后

代表作
1. 杨群峰，邓明华，表示张量积与量子对称，数学进展，24：532-539, 1995.
2. Minghua Deng, Minping Qian, Segmentation of Connected Image Based on Phase-locking. Communications in Nonlinear Science & Numerical Simulation. Vol.1, No.3, pp.32-36, 1996.
3. Qian, M.P. and Deng, M. The Exploratory Statistics and Neural Networks. Proc. 3rd Asia Statistics Conference, 1998.
4. 邓明华，钱敏平，基于隐马氏模型(HMM)的手写体汉字识别方法及其实现。第三届中国计算机智能接口与智能应用学术会议论文集，204-208, 1997.
5. 朱学庆，钱敏平，邓明华，数据融合在手写体汉字识别中的应用。第四届中国计算机智能接口与智能应用学术会议论文集，23-27, 1998.
6. Feng Qi, Minghua Deng, Minping Qian, Xueqing Zhu. A Novel Algorithm for Handwritten Chinese Character Recognition. Proceedings of Third International Conference:Advances in Multimodal Interfaces (ICMI 2000), Beijing, China, October 2000, 379-385.
7. Deng, M., Mehta, S., Sun, F. and Chen, T. Inferring domain-domain interactions from protein-protein interactions. Genome Research 12: 1540-1548, 2002. See also The ACM-SIGACT 6th Annual International Conference on Computational Molecular Biology (RECOMB02), 95-103, 2002.
8. Zhang, K., Deng, M., Chen, T., Waterman, M.S. and Sun, F. A dynamic programming approach for haplotype partitioning. The Proceeding of National Academy of Sciences (PNAS), 99(11): 7335-9, May 28 2002.
9. Deng, M., Sun, F. and Chen, T. Assessment of the reliability of protein-protein interactions and protein function prediction. Pacific Symposium on Biocomputing(PSB2003). 140-151, 2003.
10. Deng, M., Zhang, K., Mehta, S., Chen, T. and Sun F. Prediction of protein function using protein-protein interaction data. Journal of Computational Biology 10: 947-960, 2003. See also Proceeding of IEEE Computer Society Bioinformatics Conference (ISCB2002), 197-206, 2002.
11. Lanckriet,G.R.G, Deng, M., Cristianini, N. Jordan, M.I. and Noble, W.S. Kernel-based data fusion and its application to protein function prediction in yeast. Pac. Symp. Biocomputing(PSB2004), 300-311, 2004.
12. Deng, M., Tu, Z., Chen, T. and Sun, F. Mapping Gene Ontology to proteins based on protein-protein interaction data, Bioinformatics, 20: 895-902, 2004.
13. Deng, M., Chen, T. and Sun F. An integrative analysis of protein function prediction. Journal of Computational Biology 11: 463-475, 2004. See also The ACM-SIGACT 7th Annual International Conference on Computational Molecular Biology (RECOMB03), 95-103, 2003.
14. Feng Xiucheng, Qian Minping, Deng Minghua, Ma Xiaotu, Yan Xiting. Application of hidden semi-Markov model to 3-prime splice sites identification. Progress in Biochemistry and Biophysics, 31(5), 455-458, 2004.
15. Xiting Yan, Minghua Deng, Wing K. Fung, Minping Qian. Detecting differentially expressed genes by relative entropy. Journal of Theoretical Biology 234: 395-402, 2005
16. 马尽文，邓明华。生物医学信息处理－DNA微阵列数据在医学中的应用。物理 34(5): 371-380, 2005
17. Huan Yu, Minping Qian and Minghua Deng. Understanding protein-protein interactions: from domain level to motif Level. Proceeding of Sino-Germany conference: Network, from biology to theory 247-263, 2005.
18. Xiucheng Feng, Lin Wan, Minghua Deng, Fengzhu Sun and Minping Qian. An efficient algorithm for deciphering regulatory motifs. Proceeding of Sino-Germany conference: Network, from biology to theory 265-285, 2005.
19. Huan Yu and Minghua Deng. ClustalY: Speed up the guide tree building for ClustalW. Proceeding of Eighth international conference on high-performance computing in Asia-Pacific region. 608-610. Nov.30-Dec.3, 2005. Beijing.
20. Lee H, Tu Z, Deng M, Sun F and Chen T. Diffusion kernel based logistic regression models for protein function prediction. OMICS: Integrative Biology.10(1):40-55, 2006.
21. Lee H, Deng M, Sun F and Chen T. Inferring domain-domain interactions from multiple biological data sources. BMC Bioinformatics.25;7(1):269, 2006.
22. Yuping Zhang, Minping Qian, Qi Ouyang, Minghua Deng, Fangting Liand Chao Tang. Stochastic model of yeast cell-cycle network. Physica D 219:35-39, 2006.
23. Huan Yu, Minping Qian and Minghua Deng. Using a stochastic Adaboost algorithm to discover interactome motif pairs from sequence. Computational Intelligence and Bioinformatics.International Conference on Intelligent Computing, ICIC 2006, Kunming, China, August 16-19, 2006. Proceedings, Part III.622-630, 2006.
24. Yuping Zhang, Huan Yu, Minghua Deng and Minping Qian. Nonequilibrium Model for Yeast Cell Cycle. Computational Intelligence and Bioinformatics. International Conference on Intelligent Computing, ICIC 2006, Kunming, China, August 16-19, 2006. Proceedings, Part III, 786-791, 2006.
25. 杨良怀, 吕丕明, 陈立军，邓明华。k-gram方法识别MicroRNA前体。生物化学和生物物理进展 34(2): 154-161, 2007.
26. 谈效俊, 张永新, 钱敏平, 张幼怡,邓明华. 芯片数据标准化方法比较. 生物化学与生物物理进展 34(6):625-633,2007.
27. Lourdes Pena-Castillo, Murat Tasan, Chad L Myers, Hyunju Lee, Trupti Joshi, Chao Zhang, Yuanfang Guan, Michele Leone, Andrea Pagnani, Wan Kyu Kim, Chase Krumpelman, Weidong Tian, Guillaume Obozinski, Yanjun Qi, Sara Mostafavi, Guan Ning Lin, Gabriel F Berriz, Francis D Gibbons, Gert Lanckriet, Jian Qiu, Charles Grant, Zafer Barutcuoglu, David P Hill, DavidWarde-Farley, Chris Grouios, Debajyoti Ray, Judith A Blake, Minghua Deng, Michael I Jordan, William S Noble, Quaid Morris, Judith Klein-Seetharaman, Ziv Bar-Joseph, Ting Chen, Fengzhu Sun, Olga G Troyanskaya, Edward M Marcotte, Dong Xu, Timothy R Hughes and Frederick P Roth. A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biology 9:S2, 2008.
28. Lin Wan, Wenjiang J. Fu, Minghua Deng and Minping Qian. A Method to Correct Systematic Bias in Affymetrix SNP Arrays. Proceedings of the 2008 International Conference on BioMedical Engineering and Informatics, BMEI 2008, May 28-30, 2008, Sanya, Hainan, China - Volume 1, 442-446.
29. Wenjiang J. Fu, Ming Li, Lin Wan, Minghua Deng, Minping Qian. On Design of Oligonucleotide SNP Arrays and Methods for Genotype Calling. Proceedings of the 2008 International Conference on BioMedical Engineering and Informatics, BMEI 2008, May 28-30, 2008, Sanya, Hainan, China - Volume 1, 453-458.
39.Fugui Wang, Lin Hou, Jiangfeng Xu, Minping Qian, Minghua Deng. A robust empirical Bayesian method for detecting differentially expressed genes. Proceedings of the 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Oct 17-19, 2009, Tianjin, China - Volume 4, 1824-1828.
38.Wei Wei, Lin Wan, Minping Qian, Minghua Deng. The Implementation and Application of the Microarray Preprocessing Generalized PDNN Model. Proceedings of the 2nd International Conference on BioMedical Engineering and Informatics, BMEI 2009, Oct 17-19, 2009, Tianjin, China - Volume 3, 1536-1540, 2009.
30. Lin Wan, Dayong Li, Donglei Zhang, Xue Liu, Wenjiang J. Fu, Lihuang Zhu, Minghua Deng, Fengzhu Sun and Minping Qian. Conservation and Implications of Eukaryote Transcriptional Regulatory Regions across Multiple Species. BMC Genomics 9:623, 2008.
31. Hao Zheng, Xingyi Hang, Ji Zhu, Minping Qian, Wubin Qu, Chenggang Zhang, Minghua Deng. REMAS: a new regression model to identify alternative splicing events from exon array data. BMC Bioinformatics 10 (Suppl 1):S18, 2009. APBC2009 Best Paper Award.
32. Quan Wang, Lin Wan, Dayong Li, Lihuang Zhu, Minping Qian, Minghua Deng. Searching for bidirectional promoters in Arabidopsis thaliana. BMC Bioinformatics 10 (Suppl 1): S29, 2009.
33. Shaojin Duan, Lin Wan, Wenjiang J. Fu, Hong Pan, Qi Ding, Chang Chen, Peiwei Han, Xiaoyan Zhu, Liying Du, Hongxiao Liu, Yuxia Chen, Ximing Liu, Xiting Yan, Minghua Deng and Minping Qian. Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: A quantitative approach with cross-platform validation. Apoptosis 14(2):236-245, 2009.
34. 韩放, 吴晶辰, 徐江峰, 邓明华. 利用PLS-VIP方法筛选差异表达基因. 北京大学学报 45(1):1-5, 2009.
35. 侯琳, 钱敏平, 朱云平, 邓明华. 转录因子结合位点生物信息学研究进展. 遗传 31(4): 365-373, 2009.
37.Hao Zheng, Fugui Wang, Jiangfeng Xu, Nengfeng Zhou, Minping Qian, Ji Zhu and Minghua Deng. Pathway Detection Based on Hierarchical LASSO Regression Model. Proceedings of the 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Oct 17-19, 2009, Tianjin, China - Volume 4, 1893-1899, 2009.
36. Hang, X., Li, P., Li, Z., Qu, W., Yu, Y., Li, H., Shen, Z., Zheng, H., Gao, Y.,Wu, Y.,Deng, M., Sun, Z., Zhang, C.Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array. BMC Genomics 10:126,2009.

科研项目
2009.1-2013.12基于蛋白质结构与相互作用的计算生物学研究（子课题：蛋白质相互作用网络形成的结构基础与动力学分析）973(蒋华良-刘莹)

2009.1-2011.12基于探针杂交机制的生物芯片数据预处理统计方法研究基金委面上（邓明华）

2008.1-2010.12蛋白质复杂网络构建与分析及其在肝癌疾病中的应用863生物(邓明华)

2007.1-2008.12构建基于生物学功能的跨物种转录组比较和进化研究的平台863生物（陈良标）

2006.1-2008.12转录因子结合位点(TSBS)研究基金委面上(邓明华)

2004.1-2008.12基因功能预测的生物信息学理论与应用(子课题三)973(来鲁华-钱敏平)

2003.1-2005.12基因组注释系统的标准建立和软件开发863生物(陈良标)

2003.1-2005.12复杂系统的统计力学研究及在计算分子生物学中的应用基金委面上(钱敏平)

2003.1-2005.12真核生物基因及其编码蛋白的信息基础基金委重大(钱敏平)

主讲课程
99年秋高等数学B城环、地质99

98年秋,00春数学分析习题计算机系99，98

98,99,00年春数学模型习题本院三年级本科生

08年春数学模型本院06级本科生

08年秋非参数统计本院本研合上

08年秋非参数统计本研合上(30人)

08年秋非参数统计本院本研合上

07年春数学模型本院05级本科生

07年秋非参数统计本院本研合上

06年春数学模型本院04级本科生

06年秋非参数统计本院本研合上

05年春数学模型本院02级本科生

05年秋数学模型本院03级本科生

04年春数学模型本系01级

04年秋生物信息中的数学模型与方法研究生

03年秋生物信息中的数学模型与方法全校通选(本、研)

00年春线性代数社会学98

00年秋高等数学C生命学院医预00

指导研究生
吴昌晶（13博），王伟楠（14博），何顺（16博），陈思羽（16硕），兰添（16硕），马磊（16硕），罗霄（17博）

社会兼职
99年秋-01年春99级二班班主任班主任

98年-01年数学模型竞赛组织

04年秋－07年春04级硕士二班班主任班主任

荣誉获奖
99年优秀主干基础课及教学优秀奖（高等数学B，郑志明）