梁德海　教授

生命体的基本构成单元，如DNA、蛋白质和多糖，都携带有电离和可电离集团，可归属为聚电解质；它们的生理功能往往在组装成特定的结构以后才会得以实现。　
　　 我们课题组的宗旨是利用各种现代物理手段来阐明带电生物大分子在生理环境下的行为规律，揭示组装背后的物理作用和过程；以获得的信息为指导，进一步开发高效生物医用材料。
研究方向:

·高分子物理：重点研究聚电解质的溶液行为和嵌段共聚物的组装行为
·生物物理: 生物大分子，如DNA/RNA、蛋白质/多肽、多糖以及脂质体，之间的相互作用研究
·生物材料: 多糖等材料以及复合物在生物医学中的应用
在研项目:

·嵌段共聚物在非选择性溶剂中的缔和行为研究。
　　　　研究人员：周继寒，苏翠翠
·聚电解质的慢模式及其对复合过程的影响。
　　　　研究人员：郑萃，周继寒
·DNA与聚阳离子或脂质体在平衡及非平衡条件下的复合行为研究。
　　　　研究人员：牛林
·脂质体在多价离子或多肽引导下的出芽、裂殖或融合机理研究。
　　　　研究人员：夏玉琼，孙建波
·水凝胶与脂质体复合过程及其在可控药物缓释中的应用研究。
　　　　研究人员：刘赟

专利:
2011
2
 Yun Liu, Xuyan Yang, Yuqiong Xia, Cui Zheng, Jihan Zhou, Lin Niu, Jianbo Sun, Dehai Liang, a method for separation and purification of lipid contained encapsulations, Application Number or Patent Number: 201110045389.8 (under review)
1
 Dehai Liang, Xuyan Yang, Lin Niu, Yuqiong Xia, Yun Liu, Cui Zheng, Jihan Zhou, CuiCui Su, Jianbo Sun, a method for preparation of DNA/RNA complex, Application Number or Patent Number: 201110150739.7（under review）
论文:
2012
52
 Zhang, Y. S.; Zhong, L. W.; Yang, S.; Liang, D. H.; Chen, E. Q. Memory effect on solution crystallization of high molecular weight poly(ethylene oxide) , Polymer, 2012, 52, 3621-3628 Abstract pdf
51
 Liu, S. J.; Dong, Y. T.; Zhao, W. B.; Xie, X.; Ji, T. R.; Yin, X. H.; Liu, Y.; Liang, Z. W.; Momotenko, D.; Liang, D. H.; Girault, H. H.; Shao, Y. H. Studies of Ionic Current Rectification Using Polyethyleneimines Coated Glass Nanopipettes Anal. Chem., 2012, 84, 5565-5573 Abstract pdf
50
 Ma, Z. Y.; Zheng, C.; Shen, Z. H.; Liang, D. H.; Fan, X. H. Synthesis and properties of comb polymers with semirigid mesogen-jacketed polymers as side chains J. Polym. Sci. Part A-Polym. Chem. 2012,50, 918-922Abstract pdf
49
 Chen, Y.; Ke, F. Y.; Wang, H. P.; Zhang, Y. M.; Liang, D. H. Phase Separation in Mixtures of Ionic Liquids and Water ChemPhysChem, 2012,13, 160-167Abstract pdf
48
 Zheng, C.; Niu, L.; Yan, J. J.; Liu, J.; Luo, Y.; Liang, D. H. Structure and stability of the complex formed by oligonucleotides Phys. Chem. Chem. Phys. 2012,14, 7352-7359 Abstract pdf
47
 Liu, Y.; Li, Z. C.; Liang, D. H. Behaviors of liposomes in a thermo-responsive poly(N-isopropylacrylamide) hydrogel Soft Matter , 2012, 8, 4517-4523 Abstract pdf
46  Lei, T.; Cheng, C. Y.; Guo, Z. H.; Zheng, C.; Zhou, Y.; Liang, D. H.; Pei, J. Supramolecular polymeric nanowires: preparation and orthogonal modification of their photophysical propertiesJ. Mater. Chem. , 2012, 22, 4306-4311 Abstract pdf
45
 Guo, Z. H.; Zheng, C.; Cao, Y.; Liang, D. H.; Pei, J. How does a supramolecular polymeric nanowire form in solution? Chemical Science, 2012, 3, 1162-1168 Abstract pdf
2011
44
 Chen, Y.; Ke,F.Y.; Wang, H.P.; Zhang,Y.M.; Liang, D.H. Phase Separation in Mixtures of Ionic Liquids and Water ChemPhysChem, 2011, Abstract pdf
43
 Zhou, J. H., Ke, F. Y., Tong, Y. Y., Li, Z. C.,Liang, D. H. Solution behavior of copolymers with poly(ethylene oxide) as the "hydrophobic" block Soft Matter, 2011, 7, 9956-9961 Abstract pdf
42
 Liu, Y., Zhang, G., Niu, L., Gan, L. B., Liang, D. H., Assembly of Janus fullerenol: a novel approach to prepare rich carbon structures , J. Mater. Chem., 2011, 21, 14864-14868 Abstract pdf
41
 Cheng, Y.H.; Chen, W.P.; Zheng, C.; Qu, W.; Wu, H.L.; Shen, Z. H.; Liang, D.H.; Fan, X.H.; Zhu, M.F.; Zhou, Q.F. Synthesis and Phase Structures of Mesogen-Jacketed Liquid Crystalline Polyelectrolytes and Their Ionic Complexes Macromolecules, 2011, 44, 3973-3980 Abstract pdf
40
 Xia, Y. Q., Gao, M., Chen, Y., Jia, X. R., Liang, D. H. Mimic of Protein: A Highly pH-Sensitive and Thermoresponsive Polyampholyte Macromolecular Chemistry and Physics 2011, 212, 2268-2274Abstract pdf
39
 Yang, X. Y., Tong, Y. Y., Li, Z. C., Liang, D. H. Aggregation-induced microgelation: a new approach to prepare gels in solution. Soft Matter, 2011, 7, 978-985Abstract pdf
38
 Chen, Y., Zhang, Y. M., Ke, F. Y., Wang, H. P., Liang, D. H. Solubility of Neutral and Charged Polymers in Ionic Liquids Studied by Laser Light Scattering Polymer 2011, 52, 481-488 Abstract pdf
37
 Li, W; Guo, Y.L.*; He, P.; Yang, R.; Li, X.G.; Chen, Y; Liang, D. H.; Kidowaki, M.; Ito, K. Preparation and study of alkyl carbamylated polyrotaxanes with large hysteresis during sol-gel phase transition Polymer Chemistry , 2011, 2, 1797-1802 Abstract pdf
36
 Qiao, Z. Y.; Zhang, R.; Du, F.S.; Liang, D.H.; Li, Z.C. Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs Journal of Controlled Release, 2011, 152, 57-66 Abstract pdf
35
 Wang, Y.; Zhang, R.; Xu, N.; Du, F.S.; Wang, Y.L.; Tan, Y.X.; Ji, S.P.; Liang, D.H.; Li, Z.C. Reduction-Degradable Linear Cationic Polymers as Gene Carriers Prepared by Cu(I)-Catalyzed Azide-Alkyne Cycloaddition Biomacromolecules, 2011, 12, 66-74 Abstract pdf
2010
34
 Ke, F. Y., Luu, Y. K, Hadjiargyrou, M., Liang, D. H. Characterizing DNA condensation and Conformational Changes in Organic Solvents. PLoS ONE 2010, 5(10), e13308 DOI: 10.1371/journal.pone.0013308 pdf
33
 Zhou, J. H., Ke, F. Y., Liang, D. H. Kinetic Study on the Reentrant Condensation of Oligonucleotide in Trivalent Salt Solution The Journal of Physical Chemistry B, 2010, 114, 13675–13680 Abstract pdf
32
 Xia, Y. Q., Chen, E. Q. Liang, D. H. Recognition of Single- and Double-Stranded Oligonucleotides by Bovine Serum Albumin via Nonspecific Interactions Biomacromolecules, 2010, 11, 3158–316 Abstract pdf
31
 Zhang, G., Liu, Y., Liang, D. H., Gan, L. B., Li, Y. L. Facile Synthesis of Isomerically Pure Fullerenols and Formation of Spherical Aggregates from C60(OH)8 Angew. Chem. Int. Ed., 2010, 49, 5293-5295 Abstract pdf
30
 Lin, W. R., Zheng, C., Wan X. H., Liang, D. H., Zhou Q. F. Transition of Large Compound Micelles into Cylinders in Dilute Solution: Kinetic Study Macromolecules, 2010, 43, 5405–5410 Abstract pdf
29
 Gao, M., Jia, X. R., Li, Y., Liang, D. H., Wei, Y. Synthesis and Thermo-/pH- Dual Responsive Properties of Poly(amidoamine) Dendronized Poly(2-hydroxyethyl) Methacrylate Macromolecules, 2010, 43, 4314-4323 Abstract pdf
28
 Yan, J. J., Ji, W. X., Chen, E. Q., Li, Z. C., Liang, D. H. Effect of heating rate on thermo-induced aggregation of poly(ethylene oxide)-b-poly(N-isopropylacrylamide) in aqueous solutions Chinese Journal of Polymer Science, 2010, 28, 437-447 Abstract pdf
27
 Deng, L., Wang, C. H., Li, Z. C., Liang, D. H. Re-examination of the "Zipper Effect" in Hydrogen-Bonding Complexes Macromolecules, 2010, 43, 3004-3010 Abstract pdf
26
 Du F. S., Huang X. N., Chen G. T., Lin S. S., Liang D. H., Li Z. C. Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups. Macromolecules 2010, 43, 2474-2483 Abstract pdf
25
 Ke F. Y., Mo X. L., Yang R. M., Wang Y. M., Liang D. H. Polymer mixtures with enhanced compatibility and extremely low viscosity used as DNA separation media. Electrophoresis 2010, 31, 520-527 Abstract pdf
2009
24
 Zhang, X. W., Ke F. Y., Han J., Ye L., Liang D. H., Zhang A. Y., Feng Z. G. The self-aggregation behaviour of amphotericin B-loaded polyrotaxane-based triblock copolymers and their hemolytic evaluation. Soft Matter 2009, 5, 4797-4803 Abstract pdf
23
 Ke F. Y., Mo X. L., Liang D. H. Effect of Overlap Concentration and Persistence Length on DNA Separation in Polymer Solutions by Electrophoresis. Chinese Journal of Polymer Science 2009, 27, 601-610 Abstract pdf
22
 Ke F. Y., Mo X. L., Yang R. M., Wang Y. M., Liang D. H. Association of Block Copolymer in Nonselective Solvent. Macromolecules 2009, 42, 5339-5344 Abstract pdf
21
 Lin W. R., Zhang J., Wan X. H., Liang D. H., Zhou Q. F., Solvent-Induced Association and Micellization of Rod-Coil Diblock Copolymer. Macromolecules 2009, 42, 4090-4098 Abstract pdf
20
 Gao M., Jia X. R., Kuang G. C., Li Y., Liang D. H., Wei Y. Thermo- and pH-Responsive Dendronized Copolymers of Styrene and Maleic Anhydride Pendant with Poly(amidoamine) Dendrons as Side Groups. Macromolecules 2009, 42, 4273-4281 Abstract pdf
19
 Hu J., Wu Z. S., Yan J. J., Pang W. S., Liang D. H., Xu X. J. A promising approach for understanding the mechanism of Traditional Chinese Medicine by the aggregation morphology. Journal of Ethnopharmacology 2009, 123, 267-274 Abstract pdf
18
 Jiang L. X., Deng M. L., Wang Y. L., Liang D. H., Yan Y., Huang J. B. Special Effect of beta-Cyclodextrin on the Aggregation Behavior of Mixed Cationic/Anionic Surfactant Systems. Journal of Physical Chemistry B 2009, 113, 7498-7504 Abstract pdf
17
 Jiang L. X., Wang K., Ke F. Y., Liang D. H., Huang J. B. Endowing catanionic surfactant vesicles with dual responsive abilities via a noncovalent strategy: introduction of a responser, sodium cholate. Soft Matter 2009, 5, 599-606 Abstract pdf
16
 Huang X. N., Du F. S., Cheng J., Dong Y. Q., Liang D. H., Ji S. P., Lin S. S., Li Z. C. Acid-Sensitive Polymeric Micelles Based on Thermoresponsive Block Copolymers with Pendent Cyclic Orthoester Groups. Macromolecules 2009, 42, 783-790 Abstract pdf
2008
15
 Lin Y. Y., Han X., Cheng X. H., Huang J. B., Liang D. H., Yu C. L. pH-Regulated Molecular Self-Assemblies in a Cationic-Anionic Surfactant System: From a "1-2" Surfactant Pair to a "1-1" Surfactant Pair. Langmuir 2008, 24, 13918-13924 Abstract pdf
14
 Chen K. Q., Liang D. H., Tian J., Shi L. Q., Zhao H. Y., In-situ polymerization at the interfaces of micelles: A "grafting from" method to prepare micelles with mixed coronal chains. Journal of Physical Chemistry B 2008, 112, 12612-12617 Abstract pdf
13
 Liu J. H., Yan J. J., Chen E. Q., Lam J. W. Y., Dong Y. P., Liang D. H., Tang B. Z. Chain helicity of a poly(phenylacetylene) with chiral centers between backbone and mesogenic groups on side chains. Polymer 2008, 49, 3366-3370 Abstract pdf
12
 Ren L. X., Ke F. Y., Chen Y. M., Liang D. H., Huang J. Supramolecular ABA triblock copolymer with polyrotaxane as B block and its hierarchical self-assembly. Macromolecules 2008, 41, 5295-5300 Abstract pdf
11
 Huang X. N., Du F. S., Liang D. H., Lin S. S., Li Z. C. Stereochemical effect of trans/cis isomers on the aqueous solution properties of acid-labile thermoresponsive polymers. Macromolecules 2008, 41, 5433-5440 Abstract pdf
10
 Yan J. J., Ji W. X., Chen E. Q., Li Z. C., Liang D. H. Association and aggregation behavior of poly(ethylene oxide)-b-poly (N-isopropylacrylamide) in aqueous solution. Macromolecules 2008, 41, 4908-4913 Abstract pdf
9
 Ji W. X., Yan J. J., Chen E. Q., Li Z. C., Liang D. H. In situ and online monitoring polymerization-induced micellization. Macromolecules 2008, 41, 4914-4919 Abstract pdf
8
 Qin A. J., Lam J. W. Y., Jim C. K. W., Zhang L., Yan J. J., Haussler M., Liu J. Z., Dong Y. Q., Liang D. H., Chen E. Q., Jia G. C., Tang B. Z. Hyperbranched polytriazoles: Click polymerization, regioisomeric structure, light emission, and fluorescent patterning. Macromolecules 2008, 41, 3808-3822 Abstract pdf
7
 Zhuang Y., Yan J. J., Zhu W., Chen L. R., Liang D. H., Xu X. J. Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine? Journal of Ethnopharmacology 2008, 117, 378-384 Abstract pdf
6
 Bai Y., Gao W. P., Yan J. J., Ma Y. G., Liang D. H., Li Z. C., Han B. Y., Yang W. T., Chen E. Q. Co-aggregation process of poly(ethylene oxide)-b-polybutadiene/poly(acrylic acid) based on evolution of interpolymer hydrogen bonding in solutions. Polymer 2008, 49, 2099-2106 Abstract pdf
5
 Fan H. M., Han F., Liu Z., Qin L., Li Z. C., Liang D. H., Ke F. Y., Huang J. B., Fu H. L. Active control of surface properties and aggregation behavior in amino acid-based Gemini surfactant systems. Journal of Colloid and Interface Science 2008, 321, 227-234 Abstract pdf
4
 Zhang H., Lin W. R., Liu A. H., Yu Z. N., Wan X. H., Liang D. H., Zhou Q. F. Solvent effect on the aggregation behavior of rod-coil diblock copolymers. Langmuir 2008, 24, 3780-3786 Abstract pdf
3
 Lu T., Huang J. B., Liang D. H. Salt effect on microstructures in cationic gemini surfactant solutions as studied by dynamic light scattering. Langmuir 2008, 24, 1740-1744 Abstract pdf
2
 Lin S., Du F. S., Wang Y., Ji S. P., Liang D. H., Yu L., Li Z. C. An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems. Biomacromolecules 2008, 9, 109-115 Abstract pdf
2007
1
 Yu Z. Q., Liu J. H., Yan J. J., Liu X. B., Liang D. H., Lam J. W. Y., Dong Y. P., Li Z. C., Chen E. Q., Tang B. Z. Sheetlike side-chain liquid crystalline polyacetylenes forming monolayer lamellae in dilute solutions. Macromolecules 2007, 40, 8342-8348 Abstract pdf
2007之前