基本信息
教育经历
工作经历
研究概述
发表文章

曹鹏博士
北京生命科学研究所研究员

Peng Cao, Ph.D. Assistant Investigator, NIBS, Beijing, China

Phone: 86--8565

Fax: 86-

E-mail: caopeng@nibs.ac.cn


教育经历
Education
2000年 北京大学生命科学学院理学学士
B.Sc. Peking University, China
2005年 中国科学院生物物理研究所理学博士
Ph.D., Neurobiology, Institute of Biophysics, CAS

工作经历
Professional Experience
2016-Present
北京生命科学研究所 研究员

Assistant Investigator, National Institute of Biological Sciences, Beijing

2012-2016年
中国科学院生物物理研究所 研究员

Principle Investigator, Institute of Biophysics, CAS

2008-2012年
美国斯坦福大学医学院/霍华德休斯医学研究所 助理研究员

Research Associate, HHMI at Stanford University

2005-2008年
美国贝勒医学院分子生理及生物物理系 博士后

Postdoctoral Associate, Baylor College of Medicine



研究概述
Research Description
研究方向： 脑功能和脑疾病的神经环路基础 人类在发育、成熟和衰老的进程中，不断受到各类脑疾病的困扰。课题组以小鼠为动物模型，重点解析自闭症、情感障碍和老年痴呆三类典型脑疾病的生物大分子、突触和神经环路基础。除使用常规手段（例如光遗传学和电生理记录）外，我们还开发新型囊泡分子工具，以刻画神经环路联结，并对神经环路的活动进行实时监测和精细操控。我们希望以此发现新的神经环路，揭示其工作机理，并探索它们在脑疾病干预策略中的应用。
In this laboratory, we are studying two major classes of brain disease: neurodegenerative disorders and neuropsychiatric disorders, using methods including molecular genetics, electrophysiology, live-cell imaging, behavioral analysis, neural stem cell biology, deep sequencing and drug virtual screening. We are warmly inviting talented students and scholars with different background to join us!

Selected Publications


1. Congping Shang, Aixue Liu, Dapeng Li, Zhiyong Xie, Zijun Chen, Meizhu Huang, Yang Li, Yi Wang, Wei Shen, Peng Cao^CA, A subcortical excitatory circuit for sensory-triggered predatory hunting in mice. Nature Neuroscience 22(6):909-920 (2019)

2. Congping Shang, Zijun Chen, Aixue Liu, Yang Li, Jiajing Zhang, Baole Qu, Fei Yan, Yaning Zhang, Weixiu Liu, Zhihui Liu, Xiaofei Guo, Dapeng Li, Yi Wang, Peng Cao^CA, Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice. Nature Communications 9(1):1232 (2018)

3. Zhihui Liu, Zijun Chen, Congping Shang, Fei Yan, Yingchao Shi, Jiajing Zhang, Baole Qu, Hailin Han, Yanying Wang, Dapeng Li, Thomas Südhof^CA, Peng Cao^CA, IGF1-dependent synaptic plasticity of mitral cells in olfactory memory during social learning. Neuron 95: 106–122 (2017)

4. Congping Shang, Zhihui Liu, Zijun Chen, Yingchao Shi, Su Liu, Dapeng Li, Qian Wang, Peng Cao^CA, A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice. Science 348: 1472-77 (2015)

5. Peng Cao^CA, Xiaofei Yang, and Thomas Südhof^CA, Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins. The Journal of Neuroscience 33, 1714-27 (2013)

6. Peng Cao, Anton Maximov, and Thomas Südhof, Activity-dependent IGF1 exocytosis is controlled by the Ca2+-sensor synaptotagmin 10. Cell 145, 300–311 (2011).

Other Publications

7. Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li Wei Shen. Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nature Neuroscience 22(6):921-932 (2019)

8. Yonglu Tian, Chaojuan Yang, Yaxuan Cui, Feng Su, Yongjie Wang, Yangzhen Wang, Peijiang Yuan, Shujiang Shang, Hao Li, Jizong Zhao, Desheng Zhu, Shiming Tang, Peng Cao, Yunbo Liu, Xunli Wang, Liecheng Wang, Wenbo Zeng, Haifei Jiang, Fei Zhao, Minhua Luo, Wei Xiong, Zilong Qiu, Xiang-Yao Li, Chen Zhang, An excitatory neural assembly encodes short-term memory in the prefrontal cortex. Cell Reports22 (7): 1734-1744 (2018)

9. Xiaofei Yang, Peng Cao and Thomas Südhof, Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proceedings of National Academy of Sciences U S A. 110, 20777-82 (2013)

10. Zhiping Pang, Wei Xu, Peng Cao and Thomas Südhof. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Journal of Biological Chemistry. 285, 33930-9 (2010)

11. Zhiping Pang, Peng Cao, Wei Xu and Thomas Südhof. Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. The Journal of Neuroscience 30, 4132-42 (2010)

12. Yan Yang, Peng Cao, Yang Yang, and Shu-Rong Wang, Corollary discharge circuits for saccadic modulation of the pigeon visual system. Nature Neuroscience 11, 595-602 (2008).

13. Daoying Hu, Peng Cao, Edda Thiels, Charleen Chu, Gang-Yi Wu, Tim Oury, Eric Klann. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiology of Learning and Memory 87, 372-84 (2007)

14. Peng Cao, Yan Yang, Yang Yang and Shu-Rong Wang. Differential modulation of thalamic neurons by optokinetic nuclei in the pigeon. Brain Research 1069, 159-65 (2006)

15. Peng Cao, Yong Gu, and Shu-Rong Wang, Visual neurons in the pigeon brain encode the acceleration of stimulus motion. The Journal of Neuroscience 24, 7690–7698 (2004).

16. Quan Xiao, Peng Cao, Yong Gu and Shu-Rong Wang Visual responses of neurons in the pretectal nucleus lentiformis mesencephali to moving patterns within and beyond receptive fields in pigeons. Brain Behavior and Evolution 57, 80-6 (2001)