姓　　名：李　伟
学　　科：发育生物学
电话/传真：+86-/+86-
电子邮件：liwei@ioz.ac.cn
通讯地址：北京市朝阳区大屯路甲3号院 中国科学院干细胞与再生医学创新研究院大楼
中国科学院动物研究所 干细胞与生殖生物学国家重点实验室 100101
更多信息：干细胞与细胞周期调控研究组

简历介绍：
　　李伟，博士，研究员，博士生导师，干细胞与生殖生物学国家重点实验室副主任。2006年获武汉大学理学学士学位，2012年获中国科学院大学理学博士学位。2013年入选中国科学院动物研究所“星辰研究员”计划并建立课题组，2016年评估优秀转任研究员。主要从事基因工程和干细胞等创新生物技术的研发，并利用这些新技术和模型揭示哺乳动物生殖与再生的基础调控规律，开发重大疾病的基因治疗。已发表SCI论文80余篇，其中作为通讯作者在Nature、Cell、Cell Stem Cell 等刊物发表论文多篇。获得国家自然科学基金委“优秀青年基金”、日本实验动物学会“国际奖”、中国科学院****、中国科学院“青年科学家奖”等资助和奖励。 研究领域：
　　基因组信息及其表达调控是生命多样性和复杂性的重要基础，也是疾病治疗和健康干预的重要靶标和手段。我们特别感兴趣结合基因工程、细胞工程和合成生物学等手段建立新的基因工程技术和细胞/动物模型，用于（1）揭示生殖与再生相关性状及其种间进化差异的调控机制；（2）设计和制造功能定制化的细胞；（3）重大疾病的基因治疗。 社会任职：
中国实验动物学会灵长类实验动物专业委员会 常务委员
中国医药生物技术协会基因编辑技术分会 常务委员
中国科学院青年创新促进会 会员
中国遗传学会青年委员会 委员
中国细胞生物学学会衰老细胞生物学分会 委员
获奖及荣誉：
承担科研项目情况：
　　国家重点研发计划项目，中国科学院“器官重建与制造”战略性先导科技专项（A类）项目等。 代表论著：
Mao J^#, Xu K^#, Han J^#, Feng G, Zhang Y^*, Li W^*. Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon. Protein Cell. 2020 Mar 19. doi: 10.1007/s13238-020-00702-0. [Epub ahead of print]
Teng F^#, Guo L^#, Cui T, Wang XG, Xu K, Gao Q, Zhou Q^*, Li W^*. (2019) CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity. Genome Biology. 2019 Jul 1;20(1):132. doi: 10.1186/s13059-019-1742-z.
Teng F^#, Li J^#, Cui T^#, Xu K, Guo L, Gao Q, Feng G, Chen C, Han D, Zhou Q^*, Li W^*. Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds. Genome Biology. 2019 Feb 5;20(1):15.
Li Y^#, Wang L^#, Zhang L^#, He Z^#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y, Zhou Q^*, Li W^*. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. Journal of Cell Biolology. 2019 May 6;218(5):1553-1563. doi: 10.1083/jcb.. Epub 2019 Feb 15.
Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W^*, Zhou Q^*. (2018) Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell 2018 Dec 13;175(7):1887-1901.
Teng F^#, Cui T^#, Feng G, Guo L, Xu K, Gao Q, Li T, Li J, Zhou Q, Li W^*. Repurposing CRISPR-Cas12b for mammalian genome engineering. Cell Discovery. 2018 Nov 27;4:63.
Zhang W^#, Wan H^#, Feng G^#, Qu J^#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W^*, Liu G^*, Hu B^*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. 2018 Nature 560(7720):661-665.
Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W^*, Zhou Q^*, Hu BY^*. (2018) Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell 23(5):665-676.
Wang X^#, Li T^#, Cui T^#, Yu D^#, Liu C^#, Jiang L, Feng G, Wang L, Fu R, Zhang X, Hao J, Wang Y, Wang L, Zhou Q^*, Li W^*, Hu B^*. (2018) Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Research. 28(1):126-129.
Xu K^#, Yang Y^#, Feng GH^#, Sun BF^#, Chen JQ^#, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q^*, Yang YG^*, Li W^*. (2017) Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Research. 27(9):1100-1114. (Cover story)
Li W^*, Zhou Q. (2017) New stem cell types for versatile applications. National Science Review 4(4):528-530.
Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W^*, Zhou Q^*. (2016) Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 164(1-2):279–292.
Wan HF^#, Feng CJ^#, Teng F^#, Yang SH^#, Hu BY, Niu YY, Xiang P, Fang WZ, Ji WZ, Li W^*, Zhao XY^*, Zhou Q^*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Research. (2015) 25(2):258-261.
Li W^#, Li X^#, Li TD^#, Jiang MG^#, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q^*. Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell. (2014) 14(3):404-414
Li W^#, Teng F^#, Li T, Zhou Q^*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nature Biotechnology. (2013) 31:684–686.
Li W^#, Shuai L^#, Wan H^#, Dong M^#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY^*, Zhou Q^*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature (2012) 490(7420):407-411.
Li W^#, Zhao XY^#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L^*, Zhou Q^*. iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Research. (2011) 21(3):550-553.
Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F^*, Zhou Q^*. iPS cells produce viable mice through tetraploid complementation. Nature (2009) 461(7260):86-90.
写给考生的话：
　　独立之精神，自由之思想。