中文关键词:嵌段共聚物环境响应性自组装胶束药物控释 英文关键词:Block copolymers, Stimuli-responsive, Self-assembly, MicelleDrug controlled release 基金项目:国家自然科学基金项目(21676061)

作者	单位	E-mail
魏渊	广州大学精细化工研究所	13826072937@163.com
郑成	广州大学精细化工研究所	zhengcheng5512@163.com
毛桃嫣	广州大学精细化工研究所
林璟	广州大学精细化工研究所
凌慧	广州大学精细化工研究所

摘要点击次数:1989 全文下载次数:0 中文摘要: 近年来具有环境响应性的嵌段共聚物的研发受到了人们的广泛关注。该类型共聚物可以对外界环境刺激产生相应的结构、物理及化学性能的变化。根据外界环境刺激响应机理及类型的不同，可将其分为单一因素、双重因素以及三重因素刺激响应型嵌段聚合物三大类。针对每一类体系，本文重点综述了嵌段共聚物的设计合成、自组装以及应用等研究现状，并概括总结了各种有序聚集体（如胶束、囊泡等）随外界环境刺激（如pH值、温度、光、CO2、氧化还原剂等）所作出的响应性变化。最后，对智能型嵌段共聚物在药物控释、纳米容器制备、生物功能材料等方面潜在的应用价值和今后可能的发展方向进行了展望。 英文摘要: In recent years, the research of environmentally responsive block copolymers has attracted wide attention from researchers. The structure, physical and chemical properties of the copolymers responded to change, when they were stimulated by external environment. According to the different response mechanism and types of external stimuli, the stimulus-responsive block copolymers were classified into?three categories: single stimulus response, dual stimulus response and triple stimulus response. As for each type of system, this review discussed the design, synthesis, self-assembly and application of stimuli-responsive polymers in aqueous solution. Meanwhile, the various ordered aggregates (such as micelles, vesicles, etc.) changed with stimulus response (pH, temperature, light, CO2, redox agent, etc.) were summarized in detail. Finally, the potential application value of intelligent block copolymers in drug controlled release, the synthesis of nano container, biological functional materials and the possible development direction in the future were prospected. 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书Response to the reviewers -->