Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus va

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Xingdong Zhou1,3,
Hui Wang2,
Qun Ji3,
Mingjuan Du3,
Yuexia Liang1,
Huanhuan Li1,
Fan Li1,
Hang Shang1,
Xiujuan Zhu2,
Wei Wang3,
Lichun Jiang3,
Alexey V. Stepanov4,
Tianyu Ma1,
Nanxin Gong1,
Xiaodong Jia5,
Alexander G. Gabibov4,
Zhiyong Lou6,,,
Yinying Lu5,,,
Yu Guo1,,,
Hongkai Zhang1,3,,,
Xiaoming Yang2,,
1 State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China;
2 Beijing Institute of Biological Products Company Limited, Beijing 100176, China;
3 Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China;
4 M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia 117997;
5 Comprehensive Liver Cancer Center, The 5th Medical Center of PLA General Hospital, Beijing 100039, China;
6 MOE Key Laboratory of Protein Science&Collaborative Innovation Center of Biotherapy, School of Medicine, Tsinghua University, Beijing 100084, China
Funds: This work was supported by the National Key Research and Development Plan of China (grant numbers: 2018YFE0200400 and 2017YFA0504801), the Fundamental Research Funds for the Central Universities, Nankai University (grant numbers ZB19100123, 63191212 and 63191316), ShanghaiTech University Shanghai Institute for Advanced Immunochemical Studies (SIAIS) research funding and Russian Scientific Foundation (grant number 17-74-30019). The authors declare no competing interests.

Publish Date:2021-09-27

Abstract

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