Yuqing Chen
Peijun Zhang
Liyuan Cui
Jiayi Zhang
1 Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China;
2 Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China
Abstract
Abstract
70%-80% of our sensory input comes from vision. Light hit the retina at the back of our eyes and the visual information is relayed into the dorsal lateral geniculate nuclei (dLGN) and primary visual cortex (V1) thereafter, constituting the image-forming visual circuit. Molecular cues are one of the key factors to guide the wiring and refinement of the image-forming visual circuit during pre-and post-embryonic stages. Distinct molecular cues are involved in different developmental stages and nucleus, suggesting diverse guidance mechanisms. In this review, we summarize molecular guidance cues throughout the image-forming visual circuit, including chiasm determination, eye-specific segregation and refinement in the dLGN, and at last the reciprocal connections between the dLGN and V1.Keywords: molecular guidance cue, optic chiasm, dLGN, thalamocortical axons, corticothalamic projection
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