Paola Romagnoli
Joost P. M. van Meerwijk
CPTP, Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France
Funds: dicale” (FRM-DEQ20160334920), the “Agence Nationale pour la Recherche” (ANR-16-CE15-0015-01), and the IdEx Toulouse.
We thank the members of the TMIT team for critical discussions on the topic of the involvement of cytokines in thymic Treg development. This work was financially supported by the “Fondation pour la Recherche Mé
Received Date: 2017-02-06
Rev Recd Date:2017-05-04
Publish Date:2019-01-08
Abstract
Abstract
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immunesystem to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-β in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.Keywords: regulatory T cells,
thymus,
differentiation,
IL-2,
IL-15
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