Yi Li
Yang Liu
Jianwei Qu
Wen Cao
Enfan Zhang
Jingsong He
Zhen Cai
1 Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China;
2 Institution of Hematology, Zhejiang University, Hangzhou 310006, China
Funds: This work was supported by the Funds for the National Natural Science Foundation of China (Grant No. 81700201), Zhejiang Key Research and Development Project (2020C03014), National Major Scientific and Technological Special Project for “Significant New Drug Development” (2018ZX09733-003).
Received Date: 2020-04-09
Abstract
Abstract
Cytokines are secreted by various cell types and act as critical mediators in many physiological processes, including immune response and tumor progression. Cytokines production is precisely and timely regulated by multiple mechanisms at different levels, ranging from transcriptional to post-transcriptional and posttranslational processes. Monocyte chemoattractant protein-1 induced protein 1 (MCPIP1), a potent immunosuppressive protein, was first described as a transcription factor in monocytes treated with monocyte chemoattractant protein-1 (MCP-1) and subsequently found to possess intrinsic RNase and deubiquitinase activities. MCPIP1 tightly regulates cytokines expression via various functions. Furthermore, cytokines such as interleukin 1 beta (IL-1B) and MCP-1 and inflammatory cytokines inducer lipopolysaccharide (LPS) strongly induce MCPIP1 expression. Mutually regulated MCPIP1 and cytokines form a complicated network in the tumor environment. In this review, we summarize how MCPIP1 and cytokines reciprocally interact and elucidate the effect of the network formed by these components in cancer-related immunity with aim of exploring potential clinical benefits of their mutual regulation.Keywords: MCPIP1,
cytokines,
cancer-related immunity,
RNase,
deubiquitinase
PDF全文下载地址:
http://www.protein-cell.org/article/exportPdf?id=da2c60f6-bdcf-4a47-9488-eb2488933877&language=en
