Zhikun Li
Qi Zhou
Wei Li
1 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
2 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China;
3 University of Chinese Academy of Sciences, Beijing 100049, China
Funds: This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA16030400), the National Basic Research Program of China (Grant No. 2014CB964800), the National Natural Science Foundation of China (Grant Nos. 31621004, 31422038), the National Key Research and Development Program (Grant No. 2017YFA0103803), CAS Key Projects (Grant No. QYZDY-SSWSMC022, QYZDB-SSW-SMC002).
Received Date: 2019-02-26
Rev Recd Date:2019-03-29
Publish Date:2020-01-10
Abstract
Abstract
Diploidy is the typical genomic mode in all mammals. Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells, which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale. To date, a multitude of haploid stem cell types from mouse, rat, monkey and humans have been derived, as more are in development. They have been applied in high-throughput genetic screens and mammalian assisted reproduction. Here, we review the generation, unique properties and broad applications of these remarkable cells.Keywords: haploidy,
parthenogenetic,
androgenetic,
stem cells,
diploidization,
functional genomics,
imprinting
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