Zhaofeng Zheng
Tao Cheng
1 State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China;
2 Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;
3 Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, China;
4 Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin, China
Funds: CAMS Initiative for Innovative Medicine (2017-I2M-3-009, 2016-I2M-1-017)
the National Natural Science Foundation of China (81421002, 81730006, 81430004, 81670106, 81870086, 818110 1081)
and the CAMS Fundamental Research Funds for Central Research Institutes (2016GH3100001, 2018PT31005).
We appreciate insightful suggestions from Dr. Hideo Ema. This work was supported by grants from the National Key Research and Development Program of China (2016YFA0100600, 2017YFA0 103400)
Received Date: 2019-04-02
Rev Recd Date:2019-04-25
Publish Date:2020-01-10
Abstract
Abstract
Ever since hematopoietic stem cells (HSCs) were first identified half a century ago, their differentiation roadmap has been extensively studied. The classical model of hematopoiesis has long held as a dogma that HSCs reside at the top of a hierarchy in which HSCs possess self-renewal capacity and can progressively give rise to all blood lineage cells. However, over the past several years, with advances in single cell technologies, this developmental scheme has been challenged. In this review, we discuss the evidence supporting heterogeneity within HSC and progenitor populations as well as the hierarchical models revised by novel approaches mainly in mouse system. These evolving views provide further understanding of hematopoiesis and highlight the complexity of hematopoietic differentiation.Keywords: hematopoietic stem cell,
hierarchy,
heterogeneity,
differentiation
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