Bota Cui
Xingxiang He
Yuqiang Nie
Kaichun Wu
Daiming Fan
Study Group FMT-standardization
1. Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing fzhang@njmu. edu. cn 210011, China
2. Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing 211166, China
3. Division of Microbiotherapy, Sir Run Run Shaw Hospital, Nanjing Medical University, Nanjing 211166, China
4. Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China
5. Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China
6. State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China
7. National Clinical Research Center for Digestive Diseases, Xi'an 710032, China
Funds: This work was supported by publically donated Intestine Initiative; Jiangsu Province Medicine Creation Team and Leading Talents project (Faming Zhang); National Natural Science Foundation of China (Grant Nos. 81670495 and 81600417) and National Center for Clinical Research of Digestive System Diseases (2015BAI13B07).
More InformationCorresponding author: Faming Zhang, fzhang@njmu.edu.cn
Received Date: 2018-02-28
Accepted Date:2018-04-08
Publish Date:2018-01-01
Abstract
Abstract
Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gutbrain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future. Here, we review the changing concept of microbiota transplantation from FMT to selective microbiota transplantation, methodology development of FMT and stepup FMT strategy based on literature and state experts' perspectives.Keywords: selective microbiota transplantation,
microbiome,
bacteria,
Clostridium difficile,
inflammatory bowel disease,
step-up fecal microbiota transplantation,
perspectives
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