Yiguo Wang
MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
Funds: This work was supported by grants from National Natural Science Foundation of China (Grant Nos. 31500956, 31625014, 31471127, 31621063, and 31322027) and National Key Research Program of China (2016YFC1304803).
Received Date: 2017-03-02
Rev Recd Date:2017-04-04
Abstract
Abstract
The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.Keywords: mTOR,
mTORC1,
lipogenesis,
lipophagy
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