基本信息
尹俊发 男 硕导 生态环境研究中心
电子邮件：jfyin@rcees.ac.cn
通信地址：北京市海淀区双清路18号
邮政编码：100085

研究领域
主要从事环境化学和分析化学领域的研究。近年来的研究包括：DNA损伤的高选择性和高灵敏度检测；功能性分子识别材料及环境纳米材料的研制及应用等。


招生信息
欢迎有分析化学、材料化学和生物化学专业背景的同学报考。

招生专业083001-环境科学
070302-分析化学

招生方向 功能性分子识别材料及环境纳米材料的研制及应用
DNA损伤的高选择性和高灵敏度检测
用于色谱和毛细管电泳分析的整体分离介质的研制

教育背景 2004-09--2007-06 中国科学院化学研究所 博士
2001-09--2004-06 河北大学化学与环境科学学院、药学院 硕士
1996-09--2000-06 河北大学化学与环境科学学院 学士

学历研究生

学位理学博士学位

代表性论著

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1. Junfa Yin, Shaokun Chen, Ning Zhang, Hailin Wang, Multienzyme Cascade Bioreactor for a 10 min Digestion of Genomic DNA into Single Nucleosides and Quantitative Detection of Structural DNA Modifications in Cellular Genomic DNA. ACS Appl. Mater. Interfaces, 2018, Doi: 10.1021/acsami.8b05399.
2. Tian Xu, Junfa Yin, Shaokun Chen, Dapeng Zhang, Hailin Wang, Elevated 8-oxo-7,8-dihydro-2'-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones. J. Environ. Sci., 2018, 63:133-139.
3. Danni Wu, Baodong Liu, Junfa Yin, Shuli Zhao, Qun Xu, Xi Chen, Hailin Wang, Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC-MS/MS. J. Chromatogr. B, 2017, 1064, 1-6.
4. Junfa Yin, Tian Xu, Ning Zhang, Hailin Wang, Three-Enzyme Cascade Bioreactor for Rapid Digestion of Genomic DNA into Single Nucleosides. Anal. Chem., 2016, 88, 7730-7.
5. Minjie Chen, Junfa Yin, Yong Liang, Fengbang Wang, Maoyong Song, Hailin Wang, Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish. Aquat. Toxicol., 2016, 174:54-60.
6. Maoyong Song, Fengbang Wang, Luzhe Zeng, Junfa Yin, Hailin Wang, Guibin Jiang, Co-exposure of carboxyl-functionalized single-walled carbon nanotubes and 17α-ethinylestradiol in cultured cells: effects on bioactivity and cytotoxicity. Environ. Sci. Technol., 2014, 48, 13978-84.
7. Junfa Yin, Zhixin Wang, Maoyong Song, Chao Zhao, Hailin Wang, Plastic antibody for DNA damages: Fluorescent imaging of BPDE-dG adducts in genomic DNA. Analyst, 2013, 138, 4958.
8. Chao Zhao, Ruichuan Yin, Junfa Yin, Dapeng Zhang, Hailin Wang, Capillary monolithic bioreactor of immobilized snake venom phosphodiesterase for mass spectrometry based oligodeoxynucleotide sequencing. Anal. Chem., 2012, 84, 1157.
9. Maoyong Song, Shaopeng Yuan, Junfa Yin, Xiaoli Wang, Zihui Meng, Hailin Wang, Guibin Jiang, Size-dependent toxicity of nano-C60 aggregates: more sensitive indication by apoptosis-related Bax translocation in cultured human cells. Environ. Sci. Technol., 2012, 46, 3457.
10. Junfa Yin, Zihui Meng, Yishan Zhu, Maoyong Song, Hailin Wang, Dummy molecularly imprinted polymer for selective screening of trace bisphenols in river water. Anal. Methods, 2011, 3, 173.
11. Junfa Yin, Yue Cui, Gengliang Yang, Hailin Wang, Molecularly imprinted nanotubes for enantio-selective drug delivery and controlled release. Chem. Commun., 2010, 46, 7688.
12. Junfa Yin, Zihui Meng, Mingjun Du, Cong Liu, Maoyong Song, Hailin Wang, Pseudo-template molecularly imprinted polymer for selective screening of trace β-lactam antibiotics in river and tap water. J. Chromatogr. A, 2010, 1217, 5420.
13. Junfa Yin, Yuling Song, Zhixin Wang, Hailin Wang, Fabrication and fluorescence imaging of human low-density lipoprotein coatings for highly efficient capillary electrophoresis separation of basic proteins. Electrophoresis, 2009, 30, 1362.
14. Junfa Yin, Lijuan Wang, Xiaoyi Wei, Gengliang Yang, Hailin Wang, P-tert-Butylcalix[8]arene-bonded silica monoliths for liquid chromatography. J. Chromatogr. A, 2008, 1188, 199.
15. Junfa Yin, Gengliang Yang, Hailin Wang, Yi Chen, Macroporous polymer monoliths fabricated by using a metal-organic coordination gel template. Chem. Commun., 2007, 44, 4614.
16. Junfa Yin, Sumin Wang, Guanqun Yang, Gengliang Yang, Yi Chen, Molecularly imprinted solid-phase extraction for rapid screening of mycophenolic acid in human plasma. J. Chromatogr. B, 2006, 844, 142.
17. Junfa Yin, Gengliang Yang, Sumin Wang, Yi Chen, Purification and determination of stachyose in Stachys Sieboldii Miq. by high-performance liquid chromatography with evaporative light scattering detection. Talanta, 2006, 70, 208.
18. Junfa Yin, Gengliang Yang, Yi Chen. Rapid and efficient chiral separation of nateglinide on monolithic molecularly imprinted polymer. J. Chromatagr. A, 2005, 1090, 68.
19. Junfa Yin, Gengliang Yang, Yihua Zhang, Haiyan Liu, Yi Chen, Molecular recognition in in-situ nateglinide imprinted chiral stationary phase. Acta Chimica Sinica, 2004, 62, 1922.
20. Song Maoyong, Jiang Guibin, Yin Junfa, Wang Hailin, Inhibition of polymerase activity by pristine fullerene nanoparticles can be mitigated by abundant proteins. Chem. Commun., 2010, 46, 1404.
21. Zhixin Wang, Xiaoli Wang, Shengquan Liu, Junfa Yin, Hailin Wang, Fluorescently Imaged Particle Counting Immunoassay for Sensitive Detection of DNA Modifications. Anal. Chem., 2010, 82, 9901.
22. Gao Haiyan, Guo Fangqiu, Feng Feng, Yin Junfa, Song Maoyong, Wang Hailin, Improved preparation and identification of aristolochic acid-DNA adducts by solid-phase extraction with chromatography-tandem mass spectrometry. J. Environ. Sci., 2009, 21, 1769.
23. Zhixin Wang, Chao Wang, Junfa Yin, Tao Li, Maoyong Song, Meiling Lu, Hailin Wang, Focusing and stabilization of bis-intercalating dye–DNA complexes for high-sensitive CE-LIF DNA analysis. Electrophoresis, 2008, 29, 4454.
24. Feng Feng, Junfa Yin, Maoyong Song, Hailin Wang, Preparation, identification and analysis of stereoisomeric anti-benzo[a]pyrene diol epoxide–deoxyguanosine adducts using phenyl liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection. J. Chromatogr. A, 2008, 1183, 119.
25. Xiaoyi Wei, Junfa Yin, Gengliang Yang, Chunxia He, Yi Chen, On-line solid-phase extraction with a monolithic weak cation-exchange column and simultaneous screening of a1-adrenergic receptor antagonists in human plasma. J. Sep. Sci., 2007, 30, 2851.????????????????
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科研活动（1）原子转移自由基聚合法制备新型分子印迹纳米膜包覆型毛细管整体柱，主持，国家级，2009-01--2011-12
（2）纳米材料与技术在水中污染物选择性消除中的应用基础研究，参与，国家级，2009-08--2012-12
（3）松花江水体污染生态风险评估关键技术研究，参与，国家级，2009-07--2012-06
（4）重大环境污染事件特征污染物实验室检测技术系统，参与，国家级，2008-03--2011-06

合作情况
项目协作单位

工作经历2007年--至今 中国科学院生态环境研究中心 环境化学与生态毒理学国家重点实验室