基本信息
姚永刚男博导中国科学院昆明动物研究所
电子邮件： yaoyg@mail.kiz.ac.cn
通信地址： 云南省昆明市教场东路32号
邮政编码： 650223

研究领域人类神经精神疾病的遗传解析
树鼩基础生物学

招生信息
招生专业071007-遗传学
071009-细胞生物学

招生方向神经和免疫系统疾病
线粒体疾病
树鼩生物学


教育背景1997-09--2002-12中国科学院昆明动物研究所博士
1993-09--1997-07安徽师范大学理学学士

学历1993.09 - 1997.07安徽师范大学生物系，获学士学位
1997.09 - 2003.02 中国科学院昆明动物研究所/中国科学院研究生院，获博士学位

出国学习工作2001.05 - 2001.08 德国汉堡大学从事合作研究
2003.02 - 2004.09 约翰斯.霍普金斯大学医学院 (Johns Hopkins University School of Medicine) 从事博士后研究工作
2004.10 - 2008.01 美国国家卫生研究院心脏、肺和血液研究所(National Heart, Lung and Blood Institute, National Institutes of Health), Visiting Fellow

学位 -- 博士


工作经历
工作简历2007-12~现在,中国科学院昆明动物研究所,学科组负责人
2004-10~2008-01,NHLBI, NIH,Visiting Fellow
2003-02~2004-09,Johns Hopkins University School of Medicine,博士后

社会兼职2018-01-01-今,Associate editor of Journal of Alzheimer’s Disease,
2016-07-31-今,Editorial board member of Scientific Reports,
2015-07-30-2017-08-31,Associate editor of Science Bulletin,
2012-08-01-今,Receiving editor of Infection, Genetics and Evolution,
2012-01-01-今,Academic Editor of PLoS ONE,
2011-01-01-今,Associate editor of the Journal of Human Genetics ,
2010-12-01-今,《动物学研究》主编,
2010-10-01-今,Editorial board member of the Journal of Genetics and Genomics,


专利与奖励2010年 云南省有突出贡献优秀专业技术人才奖 二等奖
2009年 入选“新世纪百千万人才工程国家级人选”
2009年 云南青年五四奖章
2006年 国家自然科学奖二等奖; 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 第二获奖人.
2005年 云南省科学技术奖一等奖(自然科学类); 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 第二获奖人
2005年 全国百篇优秀博士论文
2004年 云南省科学技术奖三等奖(科学技术进步类); 项目名称: ß2肾上腺素受体遗传多态性与哮喘关系研究; 第四获奖人
2003年 云南省科学技术奖三等奖(科学技术进步类); 项目名称: 云南汉族系统性红斑狼疮与补体C4、C2基因相关性研究; 第四获奖人
2002年 中国科学院院长奖特别奖
2001年 德意志学术交流中心短期奖学金
2000年 中国科学院地奥奖学金和院长奖学金优秀奖

出版信息
发表论文（1）Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese.,American Journal of Human Genetics, 102: 794 - 805,2018,通讯作者
（2）Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer’s disease research?,Journal of Alzheimer’s Disease, 61: 1015 - 1028,2018,通讯作者
（3）A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China.,British Journal of Dermatology, 178: 931 - 939.,2018,通讯作者
（4）A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease.,Alzheimer's & Dementia, 14: 215 - 229.,2018,通讯作者
（5）The Arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese.,Molecular Neurobiology, 55: 1217 - 1226.,2018,通讯作者
（6）SZDB: A database for schizophrenia genetic research.,Schizophrenia Bulletin,43: 459 - 471.,2017,通讯作者
（7）The OPA1 gene mutations are frequent in Han Chinese patients with suspected optic neuropathy.,Molecular Neurobiology, 54: 1622 - 1630.,2017,通讯作者
（8）Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia.,Journal of Genetics and Genomics, 44: 295-306.,2017,通讯作者
（9）Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine,Autophagy, 13: 1496 - 1511,2017,通讯作者
（10）The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China,Journal of Dermatological Science, 88: 349 - 356.,2017,通讯作者
（11）Leber hereditary optic neuropathy: a mitochondrial disease unique in many ways.,Handbook of Experimental Pharmacology, 309 - 336.,2017,通讯作者
（12）mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia.,Molecular Neurobiology, 54: 4343 - 4352.,2017,通讯作者
（13）Female-specific effect of the BDNF gene on Alzheimer's disease.,Neurobiology of Aging, 53: 192.e11 - 192.e19.,2017,通讯作者
（14）Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?,Zoological Research, 38: 118 - 126.,2017,通讯作者
（15）Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring.,Cell Research, 27: 241 - 252.,2017,通讯作者
（16）Rare genetic variants of the transthyretin gene are associated with Alzheimer’s disease in Han Chinese.,Molecular Neurobiology, 54: 5192 - 5200,2017,通讯作者
（17）Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew.,Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955,2016,通讯作者
（18）PLD3 in Alzheimer's disease: a modest effect as revealed by updated association and expression analyses.,Molecular Neurobiology, 53: 4034–4045,2016,通讯作者
（19）Mitochondrial DNA haplogroup A decreases the risk of drug addiction but conversely increases the risk of HIV-1 infection in Chinese addicts.,Molecular Neurobiology, 53: 3873-3881,2016,通讯作者
（20）CFH variants affect structural and functional brain changes and genetic risk of Alzheimer's disease.,Neuropsychopharmacology, 41: 1034-1045,2016,通讯作者
（21）Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile.,Journal of Dermatological Science, 82: 18-27,2016,通讯作者
（22）Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia.,Schizophrenia Research, 171: 200-206,2016,通讯作者
（23）Complement factor H and susceptibility to major depressive disorder in Han Chinese.,British Journal of Psychiatry, 208(5): 446-452,2016,通讯作者
（24）Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis).,Developmental and Comparative Immunology, 60: 127-138,2016,通讯作者
（25）Validating GWAS-identified risk loci for Alzheimer’s disease in Han Chinese populations.,Molecular Neurobiology,53(1): 379-390,2016,通讯作者
（26）Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.,Scientific Reports, 6: 37086,2016,通讯作者
（27）Was ADH1B under selection in European populations?,The American Journal of Human Genetics, 99: 1217 - 1219,2016,第3作者
（28）Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China.,Infection, Genetics and Evolution, 45: 105 - 110,2016,通讯作者
（29）Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy.,Journal of Dermatological Science, 84: 322-329,2016,通讯作者
（30）Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication.,Cell Research, 26: 556-573,2016,第10作者
（31）Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese.,Molecular Neurobiology, 53: 4883-4892,2016,通讯作者
（32）Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.,Genes & Immunity 16(2): 112-119,2015,通讯作者
（33）Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?,Scientific Reports, 5: 11076,2015,通讯作者
（34）Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation,Autophagy, 11: 1745-1759,2015,通讯作者
（35）Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China,Journal of Dermatological Science, 80: 133-141,2015,通讯作者
（36）Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis).,Developmental and Comparative Immunology, 52(1): 58-68,2015,通讯作者
（37）Common variants of IRF3 conferring risk of schizophrenia,Journal of Psychiatric Research, 64: 64-73,2015,通讯作者
（38）Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimers disease in Han Chinese.,Neurobiology of Aging, 36: 1604.e7-1604.e16,2015,通讯作者
（39）Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina.,Gene, 571: 279-285,2015,通讯作者
（40）Mitochondrial DNA mutations in single human blood cells.,Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 779: 68 - 77,2015,第1作者
（41）Common variants in the MKL1 gene confer risk of schizophrenia.,Schizophrenia Bulletin, 41: 715-727,2015,第7作者
（42）Caveats about interpretation of ancient chicken mtDNAs from northern China.,Proceedings of the National Academy of Sciences of the United States of America, 112: E1970- E1971,2015,第3作者
（43）Identification of PSEN1 mutations p.M233L and p.R352C in Han Chinese families with early-onset familial Alzheimer's disease.,Neurobiology of Aging, 36: 1602.e3-1602.e6,2015,通讯作者
（44）Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese.,Molecular Genetics and Genomics, 290: 585-592,2015,通讯作者
（45）Tree shrew database (TreeshrewDB): a knowledge base for Chinese tree shrew genome biology,Scientific Reports, 4: 7145,2014,通讯作者
（46）No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese.,Neuroscience Letters, 566: 210-215,2014,通讯作者
（47）No association of the LRRK2 genetic variants with Alzheimers disease in Han Chinese individuals.,Neurobiology of Aging, 35: 444.e5-444.e9,2014,通讯作者
（48）Diverse interleukin-7 mRNA transcripts in Chinese tree shrew (Tupaia belangeri chinensis).,PLoS One, 9(6): e99859,2014,通讯作者
（49）Promoter variant rs** on the neural cell adhesion molecule 1 gene conferring risk of schizophrenia in Han Chinese.,Schizophrenia Research, 160: 88-96,2014,通讯作者
（50）Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia.,Journal of Psychiatric Research, 57: 84-89,2014,通讯作者
（51）A matrilineal genetic legacy from the last glacial maximum confers susceptibility to schizophrenia in Han Chinese.,Journal of Genetics and Genomics, 41: 397-407,2014,通讯作者
（52）Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese.,Genes and Immunity, 15: 506-510,2014,通讯作者
（53）Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.,Gene, 546: 263-270,2014,通讯作者
（54）Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens.,Gene, 545: 226-232,2014,通讯作者
（55）The positively selected genes of the locomotion system in Chinese tree shrew (Tupaia belangeri chinensis).,Zoological Research, 35: 240-248,2014,通讯作者
（56）Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China.,Molecular Psychiatry 18(6):638-9.,2013,通讯作者
（57）No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese.,Psychiatric Genetics, 23(1): 29-32,2013,通讯作者
（58）Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.,Stem Cell Research, 10: 361-370,2013,通讯作者
（59）Genome of the Chinese tree shrew.,Nature Communications, 4: 1426,2013,通讯作者
（60）Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China.,Human Genetics, 132: 629-640,2013,通讯作者
（61）Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-druplex ligands.,FEBS Lett. 587(11):1656-62,2013,通讯作者
（62）An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination.,Mitochondrion, 13: 360-363,2013,通讯作者
（63）Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport.,Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 751-752: 36-41,2013,通讯作者
（64）Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families.,Molecular Vision, 19: 1631-1638,2013,通讯作者
（65）Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from Southwest China.,PLoS One, 8(7): e67577,2013,通讯作者
（66）Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin.,Autophagy, 9: 1395-1406,2013,通讯作者
（67）Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: implication for using tree shrew as an alternative experimental animal to primates in biomedical research.,Journal of Genetics and Genomics, 39: 131-137,2012,通讯作者
（68）Mitochondrial DNA mutation m.10680G/A is associated with Leber hereditary optic neuropathy in Chinese patients.,Journal of Translational Medicine, 10: 43,2012,通讯作者
（69）Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.,Human Genetics, 131: 1251-1260,2012,通讯作者
（70）Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.,PLoS ONE, 7(6): e38848,2012,通讯作者
（71）Presence of mutation m.14484T/C in a Chinese family with maternally inherited essential hypertension but no expression of LHON.,Biochimica et Biophysica Acta-Molecular Basis of Disease, 1822: 1535-1543,2012,通讯作者
（72） Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G/A and Leber hereditary optic neuropathy.,Molecular Vision, 18: 3087-3094,2012,通讯作者
（73）Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny.,Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 709-710:15-20,2011,通讯作者
（74）Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients.,PLoS ONE, 6(11): e27750,2011,通讯作者
（75）MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations. ,Mitochondrion, 11: 351-356,2011,通讯作者
（76）Is mitochondrial tRNA-phe variant m.593T/C a synergistically pathogenic mutation in Chinese LHON families with m.11778G/A,PLoS ONE, 6: e26511,2011,通讯作者
（77）Identification of mutation c.632G/A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier disease., International Journal of Dermatology, 50: 1366-1370,2011,通讯作者
（78）Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkins lymphoma in Chinese patients.,Annals of Hematology, 90: 1137-1144,2011,通讯作者
（79）Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese. ,Behavioral and Brain Functions 6: 75 (doi:10.1186/1744-9081-6-75),2010,通讯作者
（80）Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C.,PLoS ONE, 5(10): e13426,2010,通讯作者
（81）The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells.,Human Mutation, 31: 538-543,2010,通讯作者
（82）No association between the SNPs (rs** and rs**) in the PARL gene and LHON in Chinese patients with m.11778G-A.,Human Genetics, 128: 465-468,2010,通讯作者
（83）mtDNA data-mining in GenBank needs surveying.,American Journal of Human Genetics, 85: 929-933,2009,第1作者
（84）The exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searches.,Human Mutation, 30: 191-196,2009,通讯作者
（85）Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber Hereditary Optic Neuropathy in Chinese families with the m.11778G→A mutation.,American Journal of Human Genetics, 83: 760-768,2008,通讯作者
（86）Pseudo-mitochondrial genome haunts disease studies.,Journal of Medical Genetics, 45: 769-772,2008,通讯作者
（87）A homogenous nature of Chinese native duck matrilineal pool.,BMC Evolutionary Biology, 8: 298,2008,通讯作者
（88）Population phylogenomic analysis of mitochondrial DNA in wild boars and domestic pigs revealed multiple domestication events in East Asia.,Genome Biology, 8:R245,2007,第2作者
（89）Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation.,Stem Cells, 25:2670-2676,2007,第1作者
（90）Mitochondrial DNA sequence variation in single cells from leukemia patients.,Blood, 109: 756-762,2007,通讯作者
（91）Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background.,Human Molecular Genetics, 16: 286-294,2007,第1作者
（92）Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations.,Human Molecular Genetics, 15: 2076-2086,2006,第4作者
（93）A reappraisal of complete mtDNA variation in East Asian families with hearing impairment.,Human Genetics, 119: 505-515,2006,通讯作者
（94）Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism.,FEBS Letters, 579: 1227-1234,2005,第1作者
（95）Different matrilineal contributions to genetic structure of ethnic populations in Silk-Road region in China.,Molecular Biology and Evolution, 21: 2265-2280,2004,第1作者
（96）To trust or not to trust an idiosyncratic mitochondrial data set.,American Journal of Human Genetics, 72: 1341-1346,2003,通讯作者
（97）Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA.,Molecular Biology and Evolution, 20: 214-219,2003,第1作者
（98）Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences.,American Journal of Human Genetics, 73: 671-676,2003,第2作者
（99）Phylogeographic differentiation of mitochondrial DNA in Han Chinese.,American Journal of Human Genetics, 70: 635-651,2002,第1作者
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