基本信息
严飞 博导中国科学院深圳先进技术研究院
电子邮件： fei.yan@siat.ac.cn
通信地址： 深圳市南山区西丽大学城学苑大道1068号
邮政编码： 518055

部门/实验室：合成所（筹）
研究领域
1、超声造影剂及其生物医学应用；
2、声控细菌治疗


招生信息
招收细胞生物学，生物化学与分子生物学，生物医学工程相关专业的学生



















招生专业071009-细胞生物学
083100-生物医学工程

招生方向重大疾病的分子诊断与治疗
超声分子影像


教育背景2004-09--2007-06四川大学细胞生物学博士
2001-09--2004-06西南大学生物化学与分子生物学硕士
1997-09--2001-06江西农业大学学士


工作经历
2016.01~ 今,中国科学院深圳先进技术研究院,研究员
2011.08~2016.12,中国科学院深圳先进技术研究院,副研究员
2009.12~2011.07,中国科学院深圳先进技术研究院,助理研究员
2008.09~2010.08,清华大学深圳研究生院,博士后



教授课程

专利与奖励
专利成果（ 1 ） 靶向载药超声微泡及其制备方法, 发明, 2011, 第 2 作者, 专利号: CN A
（ 2 ） 聚乙二醇1000维生素E琥珀酸酯修饰的己内酯-乳酸-羟基乙酸共聚物及其应用, 发明, 2010, 第 1 作者, 专利号: CN A
（ 3 ） 一种联合治疗肿瘤的基因药物及其应用, 发明, 2012, 第 2 作者, 专利号: 9.6
（ 4 ） 制备含氢气微泡水溶液的方法，其产品及应用, 发明, 2012, 第 2 作者, 专利号: 3.9


发表论文



1. Xu Z, Liu Hi*, Tian H, Yan F*. Real-time imaging tracking of engineered macrophages as ultrasound-triggered cell bombs for cancer treatment. Adv Funct Mater. 2020, **.
2. Chen Y, Liang Y, Jiang P, Li F, Yu B*, Yan F*. Lipid/PLGA Hybrid microbubbles as a versatile platform for noninvasive image-guided targeted drug delivery. ACS Appl Mater Interfaces. 2019; 11(45):41842-41852.
3. Yang C, Du M, Yan F*, Chen Z*. Focused ultrasound improves NK-92MI cells infiltration into tumors. Front Pharmacol. 2019; 10: 326.
4. Tayier B, Deng Z, Wang Y, Wang W, Mu Y*, Yan F*. Biosynthetic nanobubbles for targeted gene delivery by focused ultrasound. Nanoscale, 2019; 11(31):14757-14768.
5. Xie Y, Chen Y, Zhang L, Wu M, Deng Z, Yang Y, Wang J, Lv Q, Zheng H, Xie M*, Yan F*. Ultrasound molecular imaging of lymphocyte-endothelium adhesion cascade in acute cellular rejection of cardiac allografts. Transplantation, 2019; 103(8):1603-1611.
6. Li F, Wang Y, Mo X, Deng Z, Yan F*. Acoustic characteristics of biosynthetic bubbles for ultrasound contrast imaging. Langmuir, 2019; 35(31):10213-10222.
7. Mo X, Yan F*, Zhang B*. Molecular ultrasound monitoring of early artery injury after carotid balloon angioplasty. Front. Pharmacol. 2019; 9:1569.
8. Wu M, Zhang H, Tie C, Yan C, Deng Z, Wan Q, Liu X, Yan F*, Zheng H*. MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma. Nature Communications, 2018; 9(1):4777.
9. Wu M, Chen W, Chen Y, Zhang H, Liu C, Deng Z, Sheng Z, Chen J, Liu X, Yan F*, Zheng H*. Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment. Adv Sci (Weinh). 2018; 5(4):**.
10. Zhang R, Yan F*, Chen Y*. Exogenous physical irradiation on titania semiconductors: materials chemistry and tumor-specific nanomedicine. Adv Sci (Weinh). 2018; 5(12):**.
11. Yan F, Sun Y, Mao Y, Wu M, Deng Z, Li S, Liu X, Xue L*, Zheng H*. Ultrasound Molecular imaging of atherosclerosis for early diagnosis and therapeutic evaluation through leucocyte-like multiple targeted microbubbles. Theranostics, 2018; 8(7):1879-1891.
12. Zhang N^#, Yan F^#, Liang X, Wu M, Shen Y, Chen M, Xu Y, Zou G, Jiang P, Tang C, Zheng H, Dai Z. Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy. Theranostics, 2018; 8(8):2264-2277.
13. Yu J, Chen Z*, Li Y, Du M, Yan F*, Zheng H. Echogenic chitosan nanodroplets for spatiotemporally controlled gene delivery. J Biomed Nanotechnol. 2018,14, 1384-1395.
14. Zhang J, Wang S, Deng Z, Li L, Tan G, Liu X, Zheng H, Yan F*. Ultrasound-triggered drug delivery for breast tumor therapy through irgd-targeted paclitaxel-loaded liposome-microbubble complexes. J Biomed Nanotechnol. 2018,14, 1-11.
15. Pan M, Zhang Y, Deng Z, Yan F*, Hong G*. Noninvasive and local delivery of adenoviral-mediated herpes simplex virus thymidine kinase to treat glioma through focused ultrasound-induced blood-brain barrier opening in rats. J Biomed Nanotechnol. 2018;14(12):2031-2041.
16. Wang X^#, Yan F^#, Liu X^#, Wang P, Shao S, Sun Y, Sheng Z, Liu Q, Lovell JF, Zheng H. Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins. J Control Release. 2018; 286:358-368.
17. Li F, Li D*, Yan F*. Improvement of detection sensitivity of microbubbles as sensors to detect ambient pressure. Sensors (Basel). 2018;18(12). pii: E4083.
18. Yu J, Chen Z*, Yan F*. Advances in mechanism studies on ultrasonic gene delivery at cellular level. Prog Biophys Mol Biol. 2018; S0079-6107(18)30109-3.
19. Yan F*, Song Z, Du M, Klibanov AL. Ultrasound molecular imaging for differentiation of benign and malignant tumors in patients. Quant Imaging Med Surg. 2018, 8(11):1078-1083.
20. Wang X, Liu X, Li Y, Wang P, Feng X, Liu Q, Yan F*, Zheng H*. Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome. Biomaterials. 2017; 141:50-62.
21. Shen Y, Pi Z, Yan F*, Yeh C, Zeng X, Diao X, Hu Y, Chen S, Chen X*, Zheng H. Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma. Int J Nanomedicine, 2017:12 5613–5629.
22. Li Y, Wu M, Zhang N, Tang C, Jiang P, Liu X, Yan F*, Zheng H. Mechanisms of enhanced antiglioma efficacy of polysorbate 80-modified paclitaxel-loaded PLGA nanoparticles by focused ultrasound. J Cell Mol Med. 2018; 22(9):4171-4182.
23. Yan F, Wang S, Yang W*, Goldberg SN, Wu H, Duan WL, Deng ZT, Han HB, Zheng HR*. Tumor-penetrating Peptide-integrated Thermally Sensitive Liposomal Doxorubicin Enhances Efficacy of Radiofrequency Ablation in Liver Tumors. Radiology. 2017:162405.
24. He Y, Zhang B, Chen Y, Jin Q, Wu J, Yan F*, Zheng H. Image-Guided Hydrogen Gas Delivery for Protection from Myocardial Ischemia-Reperfusion Injury via Microbubbles. ACS Appl Mater Interfaces. 2017; 9(25):21190-21199.
25. Zhang L, Sun Z, Ren P, You M, Zhang J, Fang L, Wang J, Chen Y, Yan F*, Zheng H*, Xie M*. Localized delivery of shRNA against PHD2 protects the heart from acute myocardial infarction through ultrasound-targeted cationic microbubble destruction. Theranostics, 2017;7(1):51-66.
26. Deng Z, Xiao Y, Pan M, Li F, Duan W, Meng L, Liu X, Yan F*, Zheng H*. Hyperthermia-triggered drug delivery from iRGD-modified temperaturesensitive liposomes enhances the anti-tumor efficacy using high intensity focused ultrasound. J Control Release. 2016, 243:333-341.
27. Yan F^#, Duan W^#, Li Y*, Wu H, Zhou Y, Pan M, Liu H, Liu Xin, Zheng H*. NIR-laser-controlled drug release from DOX/IR-780-loaded temperature-sensitive-liposomes for chemo-photothermal synergistic tumor therapy. Theranostics, 2016; 6(13):2337-2351.
28. Ma M^#; Yan F^#; Yao M; Wei Z; Zhou D; Yao H; Zheng H*; Chen H*; Shi J. Template-free synthesis of hollow/porous organosilica-Fe3O4 hybrid nanocapsules towards MRI-guided high intensity focused ultrasound therapy. ACS Applied Materials & Interfaces, 2016; 8(44):29986-29996.
29. Yan F^#, Wu H^#, Liu H, Deng Z, Liu H, Duan W, Liu X*, Zheng H*. Molecular imaging-guided photothermal/photodynamic therapy against tumor by iRGD-modified indocyanine green nanoparticles. J Control Release. 2016;224:217-28.






发表著作

科研活动
科研项目（ 1 ） 基于iRGD靶向载药脂质体-微泡复合体的超声成像引导给药治疗肿瘤的研究, 主持,国家级,2014-01--2017-12
（ 2 ） 载氢气微泡的超声可视化传递及其治疗心肌缺血再灌注损伤的研究, 主持,国家级,2016-01--2019-12


合作情况
项目协作单位

指导学生