基本信息
吴雁 女 博导 国家纳米科学中心
电子邮件：wuy@nanoctr.cn
通信地址：北京市展春园
邮政编码：100080
部门/实验室：纳米生物效应与安全性研究室
研究领域

招生信息招生专业：高分子化学与物理、生物物理学、物理化学
研究方向：
高分子药物载体合成；多功能纳米生物材料制备； 纳米药物制备及输送研究；纳米药物生物效应研究； 纳米载体及纳米药物理化性质研究

教育背景 2000-09--2003-06 南开大学 博士学位

学历
学位

工作经历2003年8月-2005年8月复旦大学高分子系 博士后
工作简历 1995-09--2000-08 黑龙江省佳木斯大学药学系 副教授

社会兼职

教授课程 高分子纳米药物载体在生物医药领、 纳米技术在医药领域中的应用

专利与奖励授权专利：
（1）一种接枝聚合物及其制备方法和用途，2014. 5, 中国， ZL0.X （第一发明人）
(2) 羟丙基聚轮烷-磷脂聚合物及其制备方法和应用,2012.4, 中国，ZL 0.8 （第一发明人）
(3一种超支化聚合物及其制备方法和应用,2011.7, 中国， ZL 9.9 （第一发明人）
(4)环糊精-脂肪族聚酯-磷脂酰乙醇胺接枝聚合物及其制备方法,2013.4, 中国，ZL 2.3 （第一发明人）
(5) 一种聚(天冬氨酸-co-乳酸)-磷脂酰乙醇胺接枝聚合物及其制备方法和应用,2013.6, 中国，ZL 7.7 （第一发明人）
(6)一种纳米粒子及其制备方法和用途,2014.12,中国，ZL0.9 （第二发明人）
(7)一种药物组合物及其制备方法,2013.3,中国，ZL 6.1 （第二发明人）
(8) 一种药物组合物及其制备方法和应用,2013.5, 中国，ZL 0.6 （第二发明人）
(9) 药物组合物及其制备方法和应用, 2013.5, 中国，ZL 4.0 （第二发明人）


奖励信息

出版信息发表的代表性论文：
(1)Su, S.S.; Tian, Y.H.; Li, Y.Y.; Ding, Y.P.; Ji, T.J.; Wu, M.Y.; Wu, Y.*; Nie, G.J.*““Triple-Punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug Dosage and Improved Antitumor Efficacy ” ACS NANO 2015, 9, 1367-1378.
(2) Hu, K.L.; Zhou, H.G.; Liu, Y*; Liu, Z.; Liu, J.; Tang, J.L.; Li, J.Y.; Zhang, J, K.; Sheng, W.; Zhao, Y.L.; Wu, Y.*; Chen, C.Y.* “Hyaluronic acid functional amphipathic and redox-responsive polymer particles for co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells” Nanoscale 2015, 7, 8607-8618.
(3) Wang, S.H.; Cao, M.J.; Deng, X.W.; Xiao, X.Q.; Yin, Z.X.; Hu, Q.; Zhou, Z,X.; Zhang, F.; Zhang, R.R.; Wu, Y.*; Sheng, W.*; Zeng, Y.“Degradable Hyaluronic Acid/Protamine Sulfate Interpolyelectrolyte Complexes as miRNA-Delivery Nanocapsules for Triple-Negative Breast Cancer Therapy” Advanced Healthcare Materials 2015, 4,281-290.
(4) Zhang,R.R.; Liu, Y.H.; Yang, Z.W.; Li, Y.H.; Rong, X. X..; Wang, L.*; Guo, C.J.; Li, S.; Liu, J.X.*; Li, M.J.*; Wu, Y.*“Construction of nanoparticles based on amphiphilic PEI–PA polymers for bortezomib and paclitaxel co-delivery” RSC Adv. 2015, 5, 15453–15460
(5) Deng, X.W.; Cao, M.J.; Zhang, J.K.; Hu, K.L.; Yin,Z.X.; Zhou, Z.X.; Xiao, X.Q.; Yang, Y.S.; Sheng, W.*; Wu, Y.*; Zeng, Y.“ Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer” Biomaterials 2014, 35, 4333-4344.
(6) Li, S.L.; Hu, K.L.; Cao, W.P.; Sun, Y.; Sheng, W.; Li, F.; Wu, Y.*; Liang, X.J*. “pH-responsive biocompatible fluorescent polymer nanoparticles based on phenylboronic acid for intracellular imaging and drug delivery” Nanoscale 2014, 6, 13701–13709.
(7) Hu, L.M.*; Sun, Y.; Li, S.L.; Wang, X.L.; Hu, K.L.; Wang, L.R.; Liang, X.J.; Wu, Y.* “A Multifunctional carbon dots with high quantum yield for imaging and gene delivery” CARBON 2014, 67, 508 - 513.
(8) Nie, X.; Zhang, J.K.; Xu, Q.; Liu, X.G.; Li, Y.P.; Wu, Y.*; Chen, C.Y.*“ Targeting peptide iRGD-conjugated amphiphilic chitosan-co-PLA/DPPE drug delivery system for enhanced tumor therapy” J. Mater. Chem. B 2014, 2, 3232–3242.
(9) Zhao, C.Y.; Liu, X.G.; Liu, J.X.*; Yang, Z.W.; Rong, X.H.; Li, M.J.∗; Liang, X.J*; Wu, Y.* “Transferrin conjugated poly(γ-glutamic acid-maleimide-co-l-lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolaminecopolymer nanoparticles for targeting drug delivery” Colloids and Surfaces B: Biointerfaces 2014, 123, 787-796.
(10) Liu, X.G.; Su, S.S.; Wei, F.X.; Rong, X.H.; Yang, Z.W.; Liu, J.X.*; Li, M.J.*; Wu, Y.* “Construction of nanoparticles based on amphiphilic copolymers of poly(γ-glutamic acid co-L-lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolamine as a potential drug delivery carrier” Journal of Colloid and Interface Science 2014, 413, 54-64.
(11) Su, S.S.; Wang, H.; Liu, X.G.; Wu, Y.* ;.Nie, G.J.*.“iRGD-coupled responsive fluorescent nanogel for targeted drug delivery” Biomaterials, 2013, 34,3523-3533.
(12) Cao, M.J.; Deng, X.W.; Su, S.S.; Zhang, F.; Xiao, X.Q.; Hu, Q.; Fu, Y.W.; Yang, B.B.; Wu.Y.*; Sheng, W.*; Zeng, Y. “Protamine sulfate–nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells” Nanoscale 2013, 5, 12120 -12125.
(13) Wu, N.; Li, M.; Chen, Z. T.; Zhang, X.B.; Liu, H. Z.; Li, Z .; Guo, W.W.; Zhao, L.D.; Ren, L.L.; Li, J.N.; Yi, H.J.; Han, D.; Yang, W.Y.; Wu, Y.*; Yang, S.M.* “ In Vivo Delivery of Atoh1 Gene to Rat Cochlea Using a Dendrimer-Based Nanocarrier” J. Biomed. Nanotechnol. 2013, 9,1736-1745.
(14) Sun, Y.; Cao. W. P.; Li, S. L.; Jin, S.B.; Hu, K.L.; Hu, L.M.; Huang, Y.Y.; Gao, X.Y.; Wu, Y.*; Liang, X. J.*“Ultrabright and Multicolorful Fluorescence of Amphiphilic Polyethyleneimine Polymer Dots for Efficiently Combined Imaging and Therapy” SCIENTIFIC REPORTS 2013, 3, 3036-3041.
(15) Han, S.Y.; Li,M.J.*; Liu, X.G.; Gao, H.X.; Wu, Y.* “Construction of amphiphilic copolymer nanoparticles based on gelatin as drug carriers for doxorubicin delivery “ Colloids and Surfaces B: Biointerfaces 2013,102,833-841.
(16) Wang, H.; Wu, Y.; Zhao, R. F.; Nie, G. J*. “Engineering the Assemblies of Biomaterial Nanocarriers for Delivery of Multiple Theranostic Agents with Enhanced Antitumor Ef？cacy” Advanced materials, 2013, 25, 1616-1622.
(17) Han, S.Y.; Liu, Y. X.; Nie, X.; Xu, Q.; Jiao, F.; Li, W.; Zhao,Y.L.; Wu, Y.*; Chen, C.Y.* “Efficient Delivery of Antitumor Drug to the Nucleus of Tumor Cells by Amphiphilic Biodegradable Poly(L-Aspartic Acid co-Lactic Acid)/DPPE Co-Polymer Nanoparticles”Small 2012, 8,1596-1606.
(18) Xu, Q.; Liu, Y.X.; Su, S.S.; Li, W.; Chen, C.Y.*; Wu, Y.* “Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles” Biomaterials 2012, 33, 1627-1639.
(19) Ma, X.W.; Wang, H.; Jin, S.B.; Wu, Y.*; Liang, X. J.* “Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-poly (lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity” International Journal of Nanomedicine 2012,7,1313-1328.
(20) Wu, Y.; Jiao, F.; Han, S.Y.; Fan, T.F.; Liu, Y.; Li, W.; Hu, L.M.; Zhao, Y..; Chen, C.Y*.“Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy” Nanomedicine: Nanotechnology, Biology, and Medicine 2011,7,945-954.
(21)Wang, H.; Han, S.Y.; Sun, J.H.*; Fan, T.F.; Tian, C.X.; Wu, Y.* “Preparation of dextran-poly(lactide)–1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer and its micellar characteristics” Carbohydrate Polymers 2011, 83, 1408-1413.
(22) Fan, T.F.; Li, M.J.; Wu, X.M.*; Li, M.; Wu, Y.* “Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as nticancer drug carriers” Colloids and Surfaces B: Biointerfaces 2011, 88, 593-600.
(23)Wang, T.W.; Li, M.J.; Gao, H.X.; Wu, Y.* “Nanoparticle carriers based on copolymers of poly(e-caprolactone) and hyperbranched polymers for drug delivery” Journal of Colloid and Interface Science 2011, 353, 107-115.
(24)Wang, T.W.; Zhang, C.L.; Liang, X. J.; Liang, W.; Wu,Y.*“Hydroxypropyl-β-Cyclodextrin Copolymers and Their Nanoparticles as Doxorubicin Delivery System” Journal of Pharmaceutical Sciences 2011, 100, 1067-1079.
(25) Miao, Q.H.; Xu, D.X.; Wang, Z.; Xu, L.; Wang, T.W.; Wu, Y.*; Lovejoy, D.B.; Kalinowski, D.S.; Richardson, D.R.*; Nie, G.J.*; Zhao, Y.L. “Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents” Biomaterials 2010, 31, 7364-7375.
(26)Wang,T.W.; Xu, Q.; Wu, Y.*; Zeng, A.J.; Li, M.J.; Gao, H. X.“Preparation of dextran-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) copolymer and its micellar characteristics”Carbohydrate Polymers 2010, 80,303-307.
(27) Wu, Y.; Jiang, P.*; Jiang, M.; Wang, T.W.; Guo, C.F.; Xie, S.S.*; Wang, Z.L.* “The shape evolution of gold seeds and gold@silver core–shell nanostructures” Nanotechnology 2009, 20, 305602 (10pp).
(28) Jiang, M.; Wang, T.W.; Xu, Q.; Wu, Y.* “Novel Amphiphilic Hyperbranched Poly (amine-ester) Copolymers Nanoparticles as Protein Drug Delivery” Mini-Reviews in Medicinal Chemistry, 2009, 9,1342-1356.
(29) Gu, J.X.; Xia, F.; Wu, Y.*; Qu, X. Z.*; Yang, Z.Z.; Jiang, L.“ Programmable delivery of hydrophilic drug using dually responsive hydrogel cages” Journal of Controlled Release, 2007, 117, 396-402.
(30)Wu, Y.; Guo, J.; Yang, W.L.*; Wang, C.C.; Fu, S.K. “Preparation and characterization of chitosan-poly(acrylic acid) polymer magnetic microspheres” Polymer 2006, 47, 5287-5294.
发表著作

科研活动科研项目：
阿霉素联合调控DNA损伤反应的miRNA靶向治疗脑胶质瘤多功能纳米粒子构建,国家自然科学基金，主持，75万元，2015年1月-2018年12月；
多功能纳米载体携载紫杉醇对海马神经元影响的分子机制研究，国家自然科学基金，主持，70万元，2013年1月-2016年12月；

科研项目 （1） 基于纳米技术的药物新剂型改善肿瘤治疗效果的应用基础研究，参与，国家级，2010-01--2015-12
（2） 应用纳米技术解决新型抗艾滋病药物的若干关键科学问题，参与，国家级，2009-01--2014-12


合作情况与301医院、同仁医院、军事医学科学院、农业科学院都有密切合作，
项目协作单位

指导学生已指导学生
徐清硕士研究生070304-物理化学
现指导学生
邵磊厚硕士研究生080502-材料学
李宪磊硕士研究生080502-材料学
赵彩艳博士研究生070304-物理化学

指导学生苏世帅 博士研究生 070304-物理化学