基本信息
吴东海 男 汉族 博导 广州生物医药与健康研究院
电子邮件：wu_donghai@gibh.ac.cn
联系电话：
手机号码：
通信地址：广州市萝岗区开源大道190号
邮政编码：501530

研究领域长期目标是研究脂肪酸代谢和脂肪细胞分化的分子机制，阐明代谢紊乱包括肥胖、糖尿病等病症的致病机理，并开发新型而有效的生物医药手段实现疾病的早期诊断和治疗。
研究重点在： 脂肪酸代谢调控；脂肪细胞分化及转分化；代谢疾病的诊断和治疗。
目前正在实施的研究项目包括：
1. CPT I 的功能研究
2.脂肪细胞分化及转分化的化学生物学研究；
3. 疾病相关蛋白的结构功能研究。

招生信息博士生：3人
硕士生：3人

招生专业071010-生物化学与分子生物学

招生方向诱导干细胞定向分化研究
脂肪细胞转分化研究
代谢疾病分子机理的研究

教育背景
学历-- 研究生

学位 -- 博士

出国学习工作

工作经历
工作简历1980 – 1984 北京师范大学生物系学士
1985 – 1990 美国德州西南医学中心生物化学与分子生物学博士
1990 – 1992 美国德州西南医学中心生物化学系，博士后
1992 – 1994 美国肯塔基大学生物化学系，助理研究教授
1994 – 1998 美国肯塔基大学生物化学系，助理教授
1998 – 2004 美国佛罗里达大学药学院药物化学系，助理教授
2004 – 至今 中国科学院广州生物医药与健康研究院，研究员

社会兼职

教授课程专业综述(生物类）2007—2008学年秋季学期


专利与奖励
奖励信息
专利成果

出版信息
发表论文近5年内发表的部分论文：
1. Y.Wang, J.B. Lam, K.S.L. Lam, J. Liu, M.C. Lam, R.L.C. Hoo, D.Wu, G.J.S. Cooper, and A. Xu (2006) Adiponectin Modulates the Glycogen Synthase Kinase-3B/B-Catenin Signaling Pathway and Attenuates Mammary Tumorigenesis of MDA-MB-231 Cells in Nude Mice. Cancer Res. 66(23): 11462 - 11470
2. K.K. Y. Cheng, K. S. L .Lam, Y.Wang, C. David, H.Yu，D.Wu, C. Wong, , and A.Xu (2007) Adiponectin-induced eNOS activation and Nitric Oxide Production are Mediated by APPL1 in Endothelial Cells Diabetes. 56(5):1387-94
3. Y. Gao, Y.Zhou, A.Xu and D.Wu (2008) Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells Biol. Pharm. Bull. 31(9);1716-22.
4. Y.Yang, Y.Wang, K. S. L .Lam, M. Yau, K.K. Y. Cheng, J. Zhang, W. Zhu, D.Wu and A.Xu (2008) Suppression of the Raf/MEK/ERK Signaling Cascade and Inhibition of Angiogenesis by the Carboxyl Terminus of Angiopoietin-like Protein 4 ATVB. 28(5):835-40
5. A.Xu, H.Wang, R.Hoo, P.Vanhoutte, Y.Wang, D.Wu, W.Chu, G.Qin and K. S. L .Lam (2009) Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice Endocrinology. 150(2):625-33.
6. Y.Luo, X.Kong, A.Xu, S. Jin and D. Wu (2009) Expression, purification and characterization of human recombinant interleukin 7. Protein Expression and Purification 63:1-4.
7. X,Gao, W.Chen, X.Kong, A,Xu,Z.Wang,G.Sweeney and D.Wu (2009) Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake Diabetologia 52(5):912-20.
8. M. Yau, Y.Wang, K.S.L. Lam, J. Zhang, D. Wu and A. Xu (2009) A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase through disrupting the enzyme dimerization J. Biol. Chem. 284: 11942 – 11952
9. Y.Zhou, D.Wang, Q.Zhu, X. Gao, A.Xu and D.Wu (2009) Inhibitory effects of a novel AMP-activated protein kinase activator, A769662, on adipogenic differentiation of 3T3-L1 cells Biol. Pharm. Bull. Jun; 32(6):993-8.
10. Z. Shi, N. Liang, K. Li, S. Guo, J. Liu, A. Xu, X. Li and D. Wu (2009) Expression, purification and crystallization of SH3 domain of human AHI1 in Escherichia coli Acta Crystal F. 65(Pt 4):361-3.
11. H. Li, D. Wang, A. Xu, S. Li, S. Jin and D. Wu (2009) High level expression and purification of active recombinant human interleukin-8 in Pichia pastoris Protein Expression and Purification 68:60-4.
12. X. Hui, W. Zhu, Y.Wang, K.S.L. Lam, J. Zhang, D. Wu, E. Kraegen, Y. Li and A. Xu (2009) Major Urinary Protein-1 Increases Energy Expenditure And Improves Glucose Intolerance Through Enhancing Mitochondrial Function In Skeletal Muscle of Diabetic Mice J. Biol. Chem. 284: 14050 - 14057.
13. X. Hui, Y. Li, Z. Zhou, K.S.L. Lam, Y.Xiao, D.Wu, K.Ding,Y.Wang P.M.Vanhoutte and A. Xu (2010) Adipocyte fatty acid binding protein mediates inflammatory response in macrophages through a positive feedback loop involving c-Jun N-terminal kinases and activator protein-1 J. Biol. Chem. 285(14):10273-80.
14. W. Lian, D. Wu, D.V. Lim and S. Jin (2010) Sensitive Detection of Multiplex Toxins Using Antibody Microarray Anal. Biochem. 401(2):271-9.
15. L. Wen, J. Liu, Y. Chen and D. Wu (2010) Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis BBRC. 396(2):419-24.
16. L. Wen, Y. Yang, Y. Wang, A. Xu, D. Wu and Y. Chen (2010) Appl1 is Essential for the Survival of Xenopus Pancreas, Duodenum, and Stomach Progenitor Cells Developmental Dynamics. 239(8):2198-207.
17. M. Zhou, A. Xu, K. S. L. Lam, P. K. H. Tam, C. Che, L. Chan, I. Lee, D. Wu and Y. Wang (2010) Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin J. Hepatol. 53(6):1108-16.
17. H. Li, Y. Wang, A. Xu, S. Li, S. Jin and D. Wu (2010) Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris FEMS. 11(2):160-7.
18. X. Ren, L. Duan, Q. He, Z. Zhang, Y. Zhou, D. Wu, J. Pan, D. Pei and K. Ding (2010) Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway Med Chem. Lett. In press.
19. C. Bichsel, D.K.Neeld, T. Hamazaki, D. Wu, L. Chang, L. Yang, N. Terada and S. Jin (2011) Bacterial Delivery of Nuclear Proteins into Pluripotent and Differentiated Cells PLOSone. 6(1):e16465.
20. X. Gao, K. Li, X. Hui, X. Kong, G. Sweeney, Y. Wang, A. Xu, M. Teng, P. Liu and D. Wu (2011) Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocytes dysfunction through suppression of c-Jun N-terminal kinase Biochem.J. In press.
21. M. Park, B. Youn, X. Zheng, D.Wu, A.Xu, and G.Sweeney (2011) Adiponectin prevents hypoxia/reoxygenation-induced apoptosis in cardiomyocytes via AdipoR1/APPL1 signaling PLOSone. 6(4):e19143.
22. X. Liu, X. Huang, W. Lin, D. Wang, Y. Diao, H. Li, X. Hui, Y. Wang, A. Xu, D. Wu and K. Ding (2011) New Aromatic Substituted Pyrazoles as Selective Inhibitors of Human Adipocyte Fatty Acid-Binding Protein Bioorganic & Med Chem. Lett. In press. DOI 10.1016/j.bmcl. 2011.03.063
23. H. Li, X. Gao, Y. Zhou, N. Li, C. Ge, X. Hui, Y. Wang, A. Xu, S. Jin and D. Wu (2011) High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli Protein Expression and Purification In press. 10.1016/j.pep.2011.03.013
24. 59. S. Gao, G. Zhu, X. Gao, D. Wu, P. Carrasco, N. Casals, F. Hegardt, T. Moran, and G. Lopaschuk (2011) Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding PNAS, accepted.

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