基本信息
王杰男博导中国科学院武汉物理与数学研究所
电子邮件： jie.wang@wipm.ac.cn
通信地址： 武汉市小洪山西30号
邮政编码： 430071

研究领域神经科学、磁共振成像/波谱


招生信息招收 生物医学工程类 硕士1名，博士1名

招生专业070302-分析化学
071010-生物化学与分子生物学
071006-神经生物学

招生方向核磁共振波谱/成像
神经科学与脑疾病


教育背景2007-10--2009-09耶鲁大学生物医学工程系联合培养博士
2004-09--2009-06兰州大学化学化工学院分析化学专业研究生博士
2000-09--2004-06兰州大学化学化工学院学士

学历2004-2009 兰州大学与耶鲁大学联合培养博士 分析化学/生物医学工程 导师：胡之德/Graeme F. Mason
2000-2004 兰州大学化学化工学院 化学 学士

学位博士

工作经历2017.10 中国科学院武汉物理与数学研究所 脑科学研究中心 研究员
2012.10 中国科学院武汉物理与数学研究所 磁共振应用部 副研究员
2009.12 中国科学院武汉物理与数学研究所 磁共振应用部 助理研究员
2010.10-2013.3 美国耶鲁大学放射诊断系 博士后

工作简历2017-10~现在,中国科学院武汉物理与数学研究所,研究员
2012-10~2017-10,中国科学院武汉物理与数学研究所,副研究员
2010-10~2013-03,耶鲁大学放射诊断系,博士后合作研究
2009-12~2012-10,中国科学院武汉物理与数学研究所,助理研究员

社会兼职

教授课程波谱与影像数据分析


专利与奖励
奖励信息（1） 第十七届国际磁共振生命会议优秀青年科学家奖, 一等奖, 其他, 2016

专利成果（ 1 ） 一种简易新型实验用麻醉机, 发明, 2014, 第 1 作者, 专利号: 9.9
（ 2 ） 一种核磁共振波谱谱峰对齐及谱峰提取方法, 发明, 2014, 第 1 作者, 专利号: 3.3
（ 3 ） 脊髓功能核磁共振信号分析软件[简称：SpinAnal]V1.0, 发明, 2018, 第 1 作者, 专利号: 2018SR087058
（ 4 ） 磁共振成像T2弛豫时间计算软件[简称：T2Cal], 发明, 2018, 第 1 作者, 专利号: 2018SR186113
（ 5 ） 荧光磁共振成像协同分析软件[简称：Fluo-MRIAnal]V1.0, 发明, 2017, 第 1 作者, 专利号: 2017SR075582
（ 6 ） 质谱谱峰配对分析软件[简称：MsPeakMatch]V1.0, 发明, 2016, 第 1 作者, 专利号: 2017SR075522


出版信息
发表论文（1）Effect of myocardial ischemic preconditioning on ischemia-reperfusion stimulation-induced activation in rat thoracic spinal cord with functional MRI,International Journal of Cardiology,2019,第1作者
（2）Comprehensive Profiling of Fecal Metabolome of Mice by Integrated Chemical Isotope Labeling-Mass Spectrometry Analysis,Analytical Chemistry,2018,第6作者
（3）Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics,Talanta,2018,第1作者
（4）Fluorescence self-quenching assay for the detection of target collagen sequences using a short probe peptide,Talanta,2018,第5作者
（5）1H NMR-based metabolomics for discrimination of rice from different geographical origins of China,Journal of Cereal Science,2017,第2作者
（6）Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice,Mol Ther,2017,其他（合作组作者）
（7）Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain,Sci Rep-Uk,2017,第4作者
（8）Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle,Front Neural Circuit,2017,第7作者
（9）WS2 and MoS2 biosensing platforms using peptides as probe biomolecules,Sci Rep-Uk,2017,第6作者
（10）Fluorescence self-quenching assay for the detection of target collagen sequences using a short probe peptide,Talanta,2017,第5作者
（11）NMRSpec: An integrated software package for processing and analyzing one dimensional nuclear magnetic resonance spectra,Chemometr Intell Lab,2017,通讯作者
（12）Specific patterns of spinal metabolites underlying alpha-Me-5-HT-evoked pruritus compared with histamine and capsaicin assessed by proton nuclear magnetic resonance spectroscopy,BBA-Mol Basis Dis,2017,通讯作者
（13）Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats,Oncotarget,2017,通讯作者
（14）Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics,Talanta,2017,通讯作者
（15）Determination of Histamine by High-Performance Liquid Chromatography After Precolumn Derivatization with o-Phthalaldehyde-Sulfite,Journal of Chromatographic Science,2016,通讯作者
（16）Compositional differences among Chinese soy sauce types studied by C-13 NMR spectroscopy coupled with multivariate statistical analysis,Talanta,2016,第4作者
（17）Characterization of cationic starch flocculants synthesized by dry process with ball milling activating method,Int J Biol Macromol,2016,第5作者
（18）Characterization and Comparison of Commercial Chinese Cereal and European Grape Vinegars Using H-1 NMR Spectroscopy Combined with Multivariate Analysis,中国化学(英文版),2016,第2作者
（19）High Morphologic Plasticity of Microglia/Macrophages Following Experimental Intracerebral Hemorrhage in Rats,Int J Mol Sci,2016,第4作者
（20）Simultaneous Determination of Arginine and Citrulline in Gourd Fruits and Melons by High Performance Liquid Chromatography with Electrochemical Detection,Food Anal Method,2016,第5作者
（21）Determination of Whiteners in Cosmetics by Microdialysis and High-Performance Liquid Chromatography,Analytical Letters,2015,通讯作者
（22）Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome,Journal of Proteomics,2014,通讯作者
（23）Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure,PNAS,2013,第1作者
（24）Metabolic products of [2-13C]Ethanol in the rat brain after chronic ethanol exposure,Journal of Neurochemistry,2013,第1作者
（25）Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking,Neuropharmacology,2013,第4作者
（26）Amyloid-beta Deposition and Olfactory Dysfunction in an Alzheimer’s Disease Model,Journal of Alzheimer’s Disease,2013,第4作者
（27）An ethanol vapor chamber for small animals,Alcoholism: Clinical and Experimental Research,2012,第1作者
（28）Metabolic products of [1-13C] ethanol in the awake rat brain,Alcoholism: Clinical and Experimental Research,2012,第1作者
（29）An ethanol vapor chamber system for small animals,Journal of Neuroscience Methods,2012,第1作者
（30）大脑能量代谢和神经传递动力学的NMR测定方法,NMR method for determining energy metabolism and neurotransmission kinetics in brain,Chinese Journal of Magnetic Resonance,2010,第1作者
（31）Regional metabolite levels and turnover in the awake rat brain under the influence of nicotine,Journal of Neurochemistry,2010,第1作者
（32）Quantitative structure-retention relationships models for the prediction of the reversed-phase HPLC gradient retention based on the Heuristic Method and Support Vector Machine,Journal of Chromatographic Science,2009,第2作者
（33）Prediction of relative sensitivity of the olfactory and nasal trigeminal chemosensory systems for a series of the volatile organic compounds based on local lazy regression method,Sensors and Actuators B: Chemical,2009,第2作者
（34）Classification Structure Activity Relationship (CSAR) Studies for Prediction of Genotoxicity of Thiophene Derivatives,Toxicology Letters,2008,第2作者
（35）Prediction of retention times of peptides in RPLC by using radial basis function neural networks and projection pursuit regression,Chemometrics and Intelligent Laboratory Systems,2008,第2作者
（36）Quantitative Structure Activity Relationship (QSAR) Studies for Prediction of the Inhibition of Matrix Metalloproteinase Inhibitors Based on the Combination of Projection Pursuit Regression and Grid Search method,Chemometrics and Intelligent Laboratory Systems,2008,第2作者
（37）Quantitative Structure-Retention Relationship study of the constituents of saffron aroma in SPME-GC-MS based on the Projection Pursuit Regression method,Talanta,2008,第2作者
（38）A novel quantitative structure - activity relationship method to predict the affinities of MT3 melatonin binding site,European Journal of Medicinal Chemistry,2008,第2作者
（39）Prediction of fungicidal activities of rice blast disease based on least squares support vector machines and project pursuit regression,Journal of Agricultural and Food Chemistry,2008,第2作者
（40）Novel approaches to predict the retention of histidine-containing peptides in immobilized metal-affinity chromatography,Proteomics,2008,第3作者
（41）Prediction of retention indices of drugs based on immobilized artificial membrane chromatography by using projection pursuit regression and local lazy regression,Journal of Separation Science,2008,第3作者
（42）Using Classification Structure Pharmacokinetic Relationship (CSPR) method to Predict Drug Bioavailability Based on Grid-Search Support Vector Machine,Analytica Chimica Acta,2007,第1作者
（43）Prediction of Surface Tension for Common Compounds Based on Novel Methods Using Heuristic Method and Support Vector Machine,Talanta,2007,第1作者
（44）Study on the Structure-Activity Relationship of New Anti-HIV Nucleoside Derivatives Based on the Support Vector Machine Method,QSAR and Combinatorial Science,2007,第1作者
（45）Quantitative Structure-Activity Relationship study on a series of novel ligands binding to central benzodiazepine receptor by using the combination of Heuristic Method and Support Vector Machines,QSAR and Combinatorial Science,2007,第3作者
（46）Prediction of the Power Rotation of the Amino Acid Based on the Quantitative Structure-Property Relationship Method,Chinese Journal of Analytical Chemistry,2006,第1作者

发表著作

科研活动
科研项目（ 1 ） 活体动物大脑中能量代谢和神经传递动力学参数的定量测定方法, 主持,国家级,2012-01--2014-12
（ 2 ） 基于脑网络研究脑内长期乙醛蓄积诱发脑损伤的多层次表征, 主持,国家级,2018-01--2021-12
（ 3 ） 新型降压药物研发及其疗效的多模态磁共振成像评估, 主持,市地级,2018-01--2019-12
（ 4 ） 第三届全国神经环路示踪技术培训班, 主持,部委级,2018-01--2018-12
（ 5 ） 活体脑多光子显微结构与功能成像关键技术研究, 参与,国家级,2015-01--2017-12
（ 6 ） 光遗传技术在情感和记忆神经回路调控研究中的应用, 参与,国家级,2012-01--2015-12
（ 7 ） 气味相关的两个大脑半球之间的联系, 参与,国家级,2016-10--2019-09
（ 8 ） 神经回路结构研究新技术新方法及其应用, 参与,部委级,2012-01--2017-06
（ 9 ） 第四届神经环路技术高级培训班, 主持,部委级,2019-01--2019-12

参与会议（1）Acute and Chronic Energetic Effects of Alochol on the BrainJie Wang, Lihong Jiang, Graeme F. Mason2013-02-16
（2）An ethanol vapor chamber for small animals1.Jie Wang, Lihong Jiang, Hongying Du, Graeme F. Mason2012-06-24
（3）Metabolic products of [1-13C] ethanol in the awake rat brain2.Jie Wang, Peter C. Nicholas, Daniel Kim, Xiaoxian Ma, Ting-Kai Li, Jeffrey M. Macdonald, Fulton T. Crews, Graeme Mason2012-06-24


合作情况
项目协作单位

指导学生