基本信息
王华林男博导中国科学院武汉病毒研究所
电子邮件： h.wang@wh.iov.cn
通信地址： 湖北省武汉市小洪山中区44号
邮政编码： 430071

研究领域

招生信息
招生专业071005-微生物学

招生方向病毒学


教育背景
学历
学位

工作经历
工作简历2007-09~现在,中国科学院武汉病毒研究所,研究员
2002-04~2007-09,中国科学院武汉病毒研究所,副研究员
2000-07~2002-04,中国科学院武汉病毒研究所,助理研究员

社会兼职

教授课程

专利与奖励
奖励信息（1） 国家“”科技创新领军人才, 国家级, 2017
（2） 科技部2015年创新人才推进计划“中青年科技创新领军人才”, 部委级, 2015
（3） 湖北青年五四奖章, , 省级, 2012
（4） 国家科学基金, 部委级, 2012
（5） 湖北省自然科学奖, 一等奖, 省级, 2011
（6） 第二届武汉青年科技奖, , 市地级, 2010
（7） 湖北省自然科学奖, 二等奖, 省级, 2001
（8） 中国科学院院长奖学金, , 院级, 2000

专利成果（ 1 ） 高效表达SARS冠状病毒S蛋白的重组杆状病毒及构建。, 2010, 第 2 作者, 专利号: ZL 2007 1 **.9
（ 2 ） 重组杆状病毒AcBac△cc-GP41及其构建方法, 2011, 第 3 作者, 专利号: ZL 2007 1 **.0
（ 3 ） 一种用于检测乙型肝炎病毒的生物用品。, 2008, 第 1 作者, 专利号: ZL 2006 1 **.X
（ 4 ） 一种用于检测禽流感病毒H5N1亚型的液相芯片。, 2009, 第 1 作者, 专利号: ZL 2006 1 **.X
（ 5 ） 用于乙型肝炎病毒共价闭合DNA的检测用品及其应用, 2012, 第 3 作者, 专利号: ZL6.8
（ 6 ） 用液相芯片检测呼吸道传染病病原的引物和探针及方法, 2012, 第 1 作者, 专利号: ZL1.1


出版信息
发表论文（1）Interferon-γ-directed Inhibition of a Novel High-pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1.,Frontiers in Immunology,2019,第11作者
（2）The major hurdle for effective baculovirus transduction into mammalian cells is passing early endosomes,Journal of Virology,2019,第11作者
（3）Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.,Journal of Biological Chemistry,2019,第4作者
（4）Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo.,Protein & Cell,2018,第11作者
（5）Establishment of Baculovirus-Expressed VLPs Induced Syncytial Formation Assay for Flavivirus Antiviral Screening,Viruses,2018,第11作者
（6）Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice,Virologica Sinica,2018,第11作者
（7）Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus,Virologica Sinica,2018,第11作者
（8）The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly.,Journal of Virology,2018,第11作者
（9）HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability,Virologica Sinica,2018,第8作者
（10）Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus,Virologica Sinica,2018,第12作者
（11）Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea,Plos One,2018,第9作者
（12）Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes,Virologica Sinica,2018,第11作者
（13）Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.,The journal of bioogical chemistry,2017,第11作者
（14）HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability,Journal of General Virology,2017,第6作者
（15）A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus,Antiviral Research,2017,第10作者
（16）The roles of ebolavirus glycoproteins in viral pathogenesis.,Virol Sin,2016,第11作者
（17）Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus.,Virol Sin,2016,第5作者
（18）Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus.,Virol Sin,2016,第5作者
（19）Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus.,PLoS One,2016,第8作者
（20）P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33.,Virol Sin,2016,第6作者
（21）Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71.,Am J Clin Pathol,2016,第9作者
（22）Virus like particle-based vaccines against emerging infectious disease viruses,Virol Sin,2016,第5作者
（23）The Host Specificities of Baculovirus per os Infectivity Factors,PLoS One,2016,第7作者
（24）Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus.,Infect Genet Evol,2016,第7作者
（25）Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus.,J Gen Virol,2016,第11作者
（26）Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation.,J Virol,2015,第11作者
（27）An in vitro recombination-based reverse genetic system for rapid mutagenesis of structural genes of the Japanese encephalitis virus.,Virol Sin,2015,第4作者
（28）Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies.,Journal of Viroloy,2015,第11作者
（29）Glycoprotein E of the Japanese encephalitis virus forms virus-like particles and induces syncytia when expressed by a baculovirus.,Journal of General Virology,2015,第11作者
（30）The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus.,Plos One,2015,第11作者
（31）Identification and functional analysis of inter-subunit disulfide bonds of the F protein of Helicoverpa armigera nucleopolyhedrovirus.,Journal of General Virology,2014,第11作者
（32）Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform.,Journal of Molecular Cell biology,2014,第11作者
（33）Unraveling the entry mechanism of baculoviruses and its evolutionary implications.,Journal of Virology,2014,第11作者
（34）ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex.2012. ,Virology,2012,第4作者
（35）Betabaculovirus F Proteins Showed Different Efficiency when Rescuing the ,Virology.,2012,第11作者
（36）Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro.2012. ,J Gen Virol.,2012,第11作者
（37）AcMNPV efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH. ,Journal of Virology,2010,第11作者
（38）Partial Functional Rescue of HearNPV Infectivity by Substitution of F Protein with GP64 from AcMNPV.,Journal of Virology,2010,第11作者
（39）Specificity of baculovirus P6.9 basic DNA binding proteins and the critical role of the C-terminus in virion assembly., Journal of Virology,2010,第4作者
（40）The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus pseudotyped with baculovirus envelope fusion protein F.,Journal of Virology ,2008,第11作者
（41）A functional F analogue of Autographa californica nucleopolyhedrovirus GP64 from the Agrotis segetum granulovirus..,Journal of Virology ,2008,第11作者
（42）Mutagenesis and nuclear magnetic resonance analyses of the fusion peptide of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus F protein.,Journal of Virology ,2008,第11作者
（43）Green tea extract and its major component epigallocatechin gallate inhibits hepatitis B virus in vitro.,Antiviral Res,2008,第11作者

发表著作

科研活动
科研项目（ 1 ） Ⅱ型包膜病毒的入侵机制, 主持,国家级,2010-01--2014-12
（ 2 ） 新发和突发传染病病原快速诊断和高通量检测技术平台建设, 主持,国家级,2009-01--2010-12
（ 3 ） 杆状病毒和昆虫细胞间的相互作用, 参与,国家级,2008-01--2012-12
（ 4 ） 昆虫病毒感染关键步骤的分子机理研究, 参与,国家级,2009-01--2013-12
（ 5 ） 棉铃虫病毒结构蛋白组成和相互作用关系以及调控BV/ODV形成的分子机制的研究, 参与,国家级,2006-12--2010-12
（ 6 ） 以沙坦类药物为探针研究血管紧张素Ⅱ受体AT1分子间相互作用机制, 参与,国家级,2009-01--2011-12
（ 7 ） 杆状病毒膜融合蛋白介导病毒入侵的分子机制研究, 主持,国家级,2012-01--2015-12
（ 8 ） 我国重要自然宿主及媒介昆虫的病毒病原调查, 主持,国家级,2013-05--2018-04
（ 9 ） 病毒与宿主相互作用的分子机理, 参与,国家级,2014-01--2016-12
（ 10 ） 湖北省重大人才工程高端人才引领培养计划：病毒感染及入侵机制的研究, 主持,省级,2013-01--2017-12
（ 11 ） 快速检测技术和产品研发, 主持,部委级,2016-01--2018-12
（ 12 ） 杆状病毒口服感染的分子机制研究, 主持,市地级,2016-07--2018-12
（ 13 ） 病毒与宿主相互作用的分子机理, 参与,国家级,2017-01--2019-12
（ 14 ） 第三批国家“”科技创新领军人才, 主持,国家级,2018-01--2020-12
（ 15 ） 生物安全关键技术研发, 主持,国家级,2018-08--2021-06

参与会议（1）Mutagenesis and functional analysis of N-linked glycosylations of the major envelope fusion protein of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus第44届无脊椎动物病理学年会王华林2011-08-07
（2）无第29届美国病毒学会年会无2010-07-17


合作情况
项目协作单位

指导学生