基本信息
孙黎女博导中国科学院海洋研究所
电子邮件： lsun@ms.qdio.ac.cn
通信地址： 青岛市南海路7号
邮政编码： 266071
部门/实验室：实验海洋生物学重点实验室
研究领域

招生信息
招生专业070703-海洋生物学
090801-水产养殖

招生方向微生物与免疫


教育背景1992-09--1999-01美国波士顿大学理学博士
1987-09--1990-06南开大学理学硕士
1983-09--1987-06南开大学理学学士

学历
学位

工作经历
工作简历2005-01~现在,中国科学院海洋研究所,研究员
1999-02~2003-11,英国牛津大学和美国哈佛大学,博士后
1992-09~1999-01,美国波士顿大学,理学博士
1991-09~1992-08,美国波士顿大学,Research assistant
1987-09~1990-06,南开大学,理学硕士
1983-09~1987-06,南开大学,理学学士

社会兼职2012-12-31-2017-12-31,山东省人大常委会委员,


教授课程海水养殖生物病害与防控
微生物与免疫学文献阅读
免疫学
Seminar
免疫学文献阅读
分子微生物学技术原理
基础分子微生物学


专利与奖励
奖励信息（1） 海水养殖鱼类细菌性疫病的免疫防控, 二等奖, 部委级, 2015

专利成果（ 1 ） 一种鱼类高迁移率族蛋白及其应用, 2015, 第 1 作者, 专利号: ZL0.9
（ 2 ） 一种含有未甲基化CpG的DNA序列（CpG-DNA）及其应用, 2015, 第 1 作者, 专利号: ZL2.9
（ 3 ） 一种海豚链球菌DNA疫苗及其应用, 2015, 第 1 作者, 专利号: ZL4.7
（ 4 ） 一种海豚链球菌细菌素及其应用, 2015, 第 1 作者, 专利号: ZL8.9
（ 5 ） 一种大菱鲆自然杀伤细胞增强因子表达载体的应用, 2015, 第 1 作者, 专利号: ZL20**
（ 6 ） 一种抗菌肽及其应用, 2015, 第 1 作者, 专利号: ZL20**
（ 7 ） 一种荧光假单胞菌TonB依赖型外膜受体及其应用, 2015, 第 1 作者, 专利号: ZL3X
（ 8 ） 基于大菱鲆铁调素的肽及其应用, 2016, 第 1 作者, 专利号: ZL1.X
（ 9 ） 条石鲷白细胞介素12亚基IL-12p40及其应用, 2016, 第 1 作者, 专利号: ZL3.1


出版信息
发表论文（1）Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection,Dev Comp Immunol,2019,第11作者
（2）Description of Muricauda iocasae sp. nov., isolated from the deep sea sediment of South China Sea,Int J Syst Evol Microbiol,2019,第11作者
（3）pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection,Fish Shellfish Immunol.,2019,第11作者
（4）Histones and chymotrypsin-like elastases play significant roles in the antimicrobial activity of tongue sole neutrophil extracellular traps.,Fish Shellfish Immunol,2018,第11作者
（5）Internalization of large particles by turbot (Scophthalmus maximus) IgM+ B cells mainly depends on macropinocytosis.,Dev Comp Immunol,2018,第11作者
（6）Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin,archives of microbiology,2018,第11作者
（7）First characterization of two C-type lectins of the tubeworm Alaysia sp. from a deep-sea hydrothermal vent.,Dev Comp Immunol,2018,第11作者
（8）Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin,archives of microbiology,2018,第11作者
（9）Characterization of a teleost membrane-associated protein that is involved in the regulation of complement activation and bacterial infection.,Dev Comp Immunol,2018,第11作者
（10）Fictibacillus iocasae sp. nov., isolated from the deep-sea sediment in Pacmanus, Manus Basin,archives of microbiology,2018,第11作者
（11）Edwardsiella tarda Sip2: A serum-induced protein that is essential to serum survival, acid resistance, intracellular replication, and host infection,Front Microbiol,2018,第11作者
（12）Comparative metagenomic analysis of the microbial communities in the surroundings of Iheya north and Iheya ridge hydrothermal fields reveals insights into the survival strategy of microorganisms in deep-sea environments,J Mar Syst,2018,第11作者
（13）Bacterial communities associated with Shinkaia crosnieri from the Iheya North, Okinawa Trough: microbial diversity and metabolic potentials,J Mar Syst,2018,第11作者
（14）Transcriptome analysis reveals temperature-regulated antiviral response in turbot Scophthalmus maximus,Fish & Shellfish Immunology,2017,第11作者
（15）First characterization of fish CD22: An inhibitory role in the activation of peripheral blood leukocytes,Veterinary Immunology and Immunopathology,2017,第11作者
（16）A comparative study revealed first insights into the diversity and metabolisms of the microbial communities in the sediments of Pacmanus and Desmos hydrothermal fields,PLOS ONE,2017,第11作者
（17）Comparative transcriptome analysis of Rimicaris sp. reveals novel molecular features associated with survival in deep-sea hydrothermal vent,Scientific Reports,2017,第11作者
（18）A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish,Dev Comp Immunol,2017,第11作者
（19）Neutrophil extracellular traps of Cynoglossus semilaevis: production characteristics and antibacterial effect,Front Immunol.,2017,第11作者
（20）Description of Domibacillus iocasensis sp. nov., isolated from the deep sea sediment of Okinawa Trough, and emended description of the genus Domibacillus.,Int J Syst Evol Microbiol.,2017,第11作者
（21）Shewanella inventionis sp. nov., isolated from deep-sea sediment.,Int J Syst Evol Microbiol.,2017,第11作者
（22）Comparative metagenomic analysis of the microbial communities in the surroundings of Iheya north and Iheya ridge hydrothermal fields reveals insights into the survival strategy of microorganisms in deep-sea environments.,J Mar Syst.,2017,第11作者
（23）Description of Algoriphagus iocasae sp. nov., isolated from the deep sea sediment of Okinawa Trough.,Int J Syst Evol Microbiol.,2017,第11作者
（24）Bacterial communities associated with Shinkaia crosnieri from the Iheya North, Okinawa Trough: microbial diversity and metabolic potentials.,J Mar Syst.,2017,第11作者
（25）Comparative metagenomics reveals insights into the deep-sea adaptation mechanism of the microorganisms in Iheya hydrothermal fields.,World J Microb Biot.,2017,第11作者
（26）A teleost CD46 is involved in the regulation of complement activation and pathogen infection,Sci Rep,2017,第11作者
（27）Edwardsiella tarda-induced miRNAs in a teleost host: global profile and role in bacterial infection as revealed by integrative miRNA–mRNA analysis,Virulence,2017,第11作者
（28）Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis,International Journal of Molecular Sciences,2017,第11作者
（29）Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrinand Caveolin-Mediated Endocytosis to Endosome and Lysosome,Frontiers in Cellular and Infection Microbiology,2017,第11作者
（30）Bacillus iocasae sp. nov., isolated from Pacmanus hydrothermal field, Manus Basin,International Journal of Systematic and Evolutionary Microbiology,2017,第11作者
（31）A teleost bactericidal permeability-increasing protein kills Gram-negative bacteria, modulates innate immune response, and enhances resistance against bacterial and viral infection.,PLoS ONE,2016,第11作者
（32）Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: Signaling pathway and involvement in bacterial infection.,Fish Shellfish Immunol.,2016,第11作者
（33）pol-miR-731, a teleost miRNA upregulated by megalocytivirus, negatively regulates virus-induced type I interferon response, apoptosis, and cell cycle arrest.,Sci Rep.,2016,第11作者
（34）First comparative analysis of the community structures and carbon metabolic pathways of the bacteria associated with Alvinocaris longirostris in a hydrothermal vent of Okinawa Trough.,PLoS ONE,2016,第11作者
（35）The global regulatory effect of Edwardsiella tarda Fur on iron acquisition, stress resistance, and host infection: a proteomics-based interpretation.,J Proteomics,2016,第11作者
（36）The serine protease autotransporter Tsh contributes to the virulence of Edwardsiella tarda,Vet Microbiol.,2016,第11作者
（37）Description of Domibacillus iocasensis sp. nov., isolated from the deep sea sediment of Okinawa Trough, and emended description of the genus Domibacillus.,Int J Syst Evol Microbiol.,2016,第11作者
（38）Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection.,Dev Comp Immunol.,2016,第11作者
（39）Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria.,Dev Comp Immunol.,2016,第11作者
（40）CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection.,Dev Comp Immunol.,2016,第11作者
（41）Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-？B-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus).,Dev Comp Immunol ,2015,第11作者
（42）CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif.,Dev Comp Immunol ,2015,第11作者
（43） CD83 is required for the induction of protective immunity by a DNA vaccine in a teleost model,Dev Comp Immunol ,2015,第11作者
（44）Edwardsiella tarda evades serum killing by preventing complement activation via the alternative pathway,Fish Shellfish Immunol ,2015,第11作者
（45）Pseudomonas fluorescens: Fur is required for multiple biological properties associated with pathogenesis,Vet Microbiol,2015,第11作者
（46）Edwardsiella tarda Sip1: A serum-induced zinc metalloprotease that is essential to serum resistance and host infection.,Vet Microbiol ,2015,第11作者
（47）Edwardsiella tarda MliC: a lysozyme inhibitor that participates in pathogenesis in a manner that parallels Ivy, Infect Immun,2015,第11作者
（48）Pseudomonas fluorescens: iron-responsive proteins and their involvement in host infection.,Vet Microbiol ,2015,第11作者
（49） P247 and P523: two in vivo-expressed megalocytivirus proteins that induce protective immunity and are essential to viral infection,Plos ONE,2015,第11作者
（50）Edwardsiella tarda-regulated proteins in Japanese flounder (Paralichthys olivaceus): identification and evaluation of antibacterial potentials, J Proteomics,2015,第11作者
（51）Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection,Dev Comp Immunol,2014,第11作者
（52）Turbot (Scophthalmus maximus) hepcidin-1 and hepcidin-2 possess antimicrobial activity and promote resistance against bacterial and viral infection,Fish Shellfish Immunol,2014,第11作者
（53） Edwardsiella tarda Hfq: impact on host infection and global protein expression,Vet Res,2014,第11作者
（54） Streptococcus iniae SF1: complete genome sequence, proteomic profile, and immunoprotective antigens.,Plos ONE,2014,第11作者
（55） Sil: a Streptococcus iniae bacteriocin with dual role as an antimicrobial and an immunomodulator that inhibits innate immune response and promotes S. iniae infection,Plos ONE,2014,第11作者
（56）In-depth profiling and analysis of host and viral microRNAs in Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus reveal involvement of microRNAs in host-virus interaction in teleost fish,BMC Genomics,2014,第11作者
（57）Nuclear factor 45 of tongue sole (Cynoglossus semilaevis): evidence for functional differentiation between two isoforms in immune defense against viral and bacterial pathogens,Dev Comp Immunol ,2014,第11作者
（58）Poly(I:C) induces antiviral immune responses in Japanese flounder (Paralichthys olivaceus) that require TLR3 and MDA5 and is negatively regulated by Myd88,Plos ONE,2014,第11作者
（59）NKLP27: a teleost NK-lysin peptide that modulates immune response, induces degradation of bacterial DNA, and inhibits bacterial and viral infection,Plos ONE ,2014,第11作者
（60） C7: a CpG oligodeoxynucleotide that induces protective immune response against megalocytivirus in Japanese flounder (Paralichthys olivaceus) via toll-like receptor 9-mediated signaling pathway,Dev Comp Immunol,2014,第11作者
（61）Antibacterial and antiviral properties of tongue sole (Cynoglossus semilaevis) high mobility group B2 protein are largely independent on the acidic C-terminal domain.,Fish Shellfish Immunol,2014,第11作者
（62）Characterization of a c-type lysozyme of Scophthalmus maximus: expression, activity, and antibacterial effect,Fish Shellfish Immunol.,2013,第11作者
（63）3.Chen C, Chi H, Sun B, Sun L. The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis.,Dev Comp Immunol,2013,第11作者
（64） Macrophage migration inhibitory factor of Sciaenops ocellatus regulates immune cell trafficking and is involved in pathogen-induced immune response,Dev Comp Immunol,2013,第11作者
（65） The C-reactive protein of tongue sole Cynoglossus semilaevis is an acute phase protein that interacts with bacterial pathogens and stimulates the antibacterial activity of peripheral blood leukocytes.,Fish Shellfish Immunol.,2013,第11作者
（66） Identification and characterization of a cell surface scavenger receptor cysteine-rich protein of Sciaenops ocellatus: bacterial interaction and its dependence on the conserved structural features of the SRCR domain,Fish Shellfish Immunol.,2013,第11作者
（67） Selection of normalization factors for quantitative real time RT-PCR studies in Japanese flounder (Paralichthys olivaceus) and turbot (Scophthalmus maximus) under conditions of viral infection, Vet Immunol Immunopathol.,2013,第11作者
（68）Complete genome sequence and transcription profiles of the rock bream iridovirus RBIV-C1., Dis Aquat Org. ,2013,第11作者
（69）SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop.,Dev Comp Immunol. ,2013,第11作者
（70）A NK-lysin from Cynoglossus semilaevis enhances antimicrobial defense against bacterial and viral pathogens. ,Dev Comp Immunol. ,2013,第11作者
（71）Comparative study of four flagellins of Vibrio anguillarum: vaccine potential and adjuvanticity.,Fish Shellfish Immunol.,2013,第11作者
（72）Overexpression of NF-？B inhibitor alpha in Cynoglossus semilaevis impairs pathogen-induced immune response.,DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,第11作者
（73）A peptidoglycan recognition protein from Sciaenops ocellatus is a zinc amidase and a bactericide with a substrate range limited to Gram-positive bacteria.,FISH AND SHELLFISH IMMUNOLOGY,2012,第11作者
（74）CsCXCe1: a novel Cynoglossus semilaevis CXC chemokine that functions as a chemoattractant and an immunomodulator for peripheral blood leukocytes,DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,第11作者
（75）Cynoglossus semilaevis thioredoxin: a reductase and an antioxidant with immunostimulatory property,CELL STRESS AND CHAPERONES,2012,第11作者
（76）Edwardsiella tarda DnaK: expression, activity, and the basis for the construction of a bivalent live vaccine against E. tarda and Streptococcus iniae,FISH AND SHELLFISH IMMUNOLOGY,2012,第11作者
（77）A divalent DNA vaccine based on Sia10 and OmpU induces cross protection against Streptococcus iniae and Vibrio anguillarum in Japanese flounder,FISH AND SHELLFISH IMMUNOLOGY,2012,第11作者
（78）Development and efficacy of an attenuated Vibrio harveyi vaccine candidate with cross protectivity against Vibrio alginolyticus.,FISH AND SHELLFISH IMMUNOLOGY,2012,第11作者
（79）Molecular characterization of Cynoglossus semilaevis CD28,FISH AND SHELLFISH IMMUNOLOGY,2012,第11作者
（80）Inv1: an Edwardsiella tarda invasin and a protective immunogen that is required for host infection.,FISH AND SHELLFISH IMMUNOLOGY,2012,第11作者
（81）Edwardsiella tarda Eta1: an in vivo-induced antigen that is involved in host infection,INFECTION AND IMMUNITY,2012,第11作者
（82）Construction and evaluation of a live vaccine against Edwardsiella tarda and Vibrio harveyi: laboratory vs mock field trial,Vaccine,2011,第11作者
（83）Edwardsiella tarda DnaJ is a virulence-associated molecular chaperone with immunoprotective potential,Fish and Shellfish Immunology ,2011,第11作者
（84）A pathogenic Vibrio harveyi lineage causes recurrent disease outbreaks in cultured Japanese flounder (Paralichthys olivaceus) and induces apoptosis in host cells,Aquaculture,2011,第11作者
（85） Ferritin M of Cynoglossus semilaevis: an iron binding protein and a broad-spectrum antimicrobial that depends on the integrity of the ferroxidase center and nucleation center for biological activity.,Fish and Shellfish Immunology ,2011,第11作者
（86）An inflammatory CC chemokine of Cynoglossus semilaevis is involved in immune defense against bacterial infection,Fish and Shellfish Immunology ,2011,第11作者
（87）Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus).,Fish and Shellfish Immunology ,2011,第11作者
（88）HtpG is involved in the pathogenesis of Edwardsiella tarda,Veterinary Microbiology,2011,第11作者
（89）A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum.,Fish and Shellfish Immunology ,2011,第11作者
（90）Suppressor of cytokine signaling 3 inhibits head kidney macrophage activation and cytokine expression in Scophthalmus maximus,Developmental and Comparative Immunology ,2011,第11作者
（91）The tissue factor pathway inhibitor 1 of Sciaenops ocellatus possesses antimicrobial activity and is involved in the immune response against bacterial infection,Developmental and Comparative Immunology ,2011,第11作者
（92）The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation,Developmental and Comparative Immunology ,2011,第11作者
（93）CXCL8 of Scophthalmus maximus: expression, biological activity, and immunoregulatory effect,Developmental and Comparative Immunology ,2011,第11作者
（94）Construction and analysis of the immune effect of an Edwardsiella tarda DNA vaccine encoding a D15-like surface antigen,Fish and Shellfish Immunology,2011,第11作者
（95）Identification and analysis of the tissue factor pathway inhibitor 2 of Sciaenops ocellatus. ,Fish and Shellfish Immunology ,2011,第11作者
（96）The g-type lysozyme of Scophthalmus maximus has a broad substrate spectrum and is involved in the immune response against bacterial infection,Fish and Shellfish Immunology ,2011,第11作者
（97）Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: subunit vaccine vs DNA vaccine.,Vaccine,2011,第11作者
（98）A bivalent Vibrio harveyi DNA vaccine induces strong protection in Japanese flounder (Paralichthys olivaceus),Vaccine,2011,第11作者
（99）Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus).,Fish and Shellfish Immunology ,2011,第11作者
（100）Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property,Fish and Shellfish Immunology ,2011,第11作者

发表著作

科研活动
科研项目（ 1 ） 鱼类疫病免疫防治的系统疫苗学原理与技术途径, 主持,国家级,2012-01--2016-12
（ 2 ） 鱼类致病性荧光假单胞菌铁调控系统的识别、功能分析及其在病害防治中的应用探索, 主持,国家级,2013-01--2016-12
（ 3 ） 迟缓爱德华氏菌关键免疫逃逸因子及其作用机制和应用潜能, 主持,国家级,2014-01--2018-12
（ 4 ） 热液生态系统生物群落特征, 主持,部委级,2013-11--2017-12
（ 5 ） 海水养殖鱼类中性粒细胞胞外陷阱：产生特征、抗感染免疫以及作用机制, 主持,国家级,2016-01--2019-12
（ 6 ） 青岛海洋科学与技术国家实验室 “鳌山人才”卓越科学家计划项目, 主持,国家级,2016-01--2018-12
（ 7 ） 山东省重点研发计划 "海水绿色养殖环境监控和生态修复关键技术研究与示范", 参与,省级,2016-11--2018-11
（ 8 ） 深海特殊生境微生物组及其与环境的互作研究, 主持,部委级,2017-01--2018-12
（ 9 ） 病毒和细菌共诱导的多效型牙鲆microRNA及其功能解析和应用探索, 主持,国家级,2018-01--2022-12
（ 10 ） 深海病原微生物的认知与应用, 主持,研究所（学校）,2017-07--2018-06
（ 11 ） 深潜区生物多样性及功能研究, 主持,省级,2016-01--2017-12
（ 12 ） 水产动物疫病发生的分子基础与免疫机制, 主持,国家级,2018-12--2022-12
（ 13 ） 深海极端环境微生物资源的挖掘和生物安保探索, 主持,部委级,2019-01--2022-12

参与会议

合作情况
项目协作单位

指导学生