基本信息
孙蕾女 博士 研究员 中国科学院微生物研究所
电子邮件： sunlei362@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码： 100101


研究领域流感病毒致病机理、抗病毒天然免疫及抗病毒制品的研究。


招生信息
招生专业071005-微生物学

招生方向抗病毒天然免疫
分子病毒学


教育背景2000-07--2005-06扬州大学博士
1996-09--2000-06山东农业大学学士


工作经历
工作简历2019-10~现在,中国科学院微生物研究所,研究员
2011-08~2012-11,美国康奈尔大学医学院,访问助理教授
2009-06~现在,中国科学院微生物研究所,副研究员
2005-07~2009-06,中国科学院微生物研究所,助理研究员


教授课程医学病毒学


出版信息
发表论文（1）RIG-I 敲除293T 细胞系的建立及其对B 型流感病毒复 制的影响,生物工程学报,2019-09,通讯作者
（2）Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein,Frontiers in Microbiology,2019-08,通讯作者
（3）Naproxen exhibits broad anti-influenza virus activity in mice by impeding viral nucleoprotein nuclear export,Cell Reports,2019,通讯作者
（4）Latent Membrane Protein 1 of Epstein–Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway,Frontiers in Immunology,2018,第2作者
（5）胞外亲环素 A 对炎症发生的影响及其抗体在抑制炎症反应中的作用,生物工程学报,2018,通讯作者
（6）CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein,Virology,2018,通讯作者
（7）CypA Regulates AIP4-mediated M1 Ubiquitination of Influenza A Virus,Virologica Sinica,2018,通讯作者
（8）A promising IFN-deficient system to manufacture IFN-sensitive influenza vaccine virus,Frontiers in Cellular and Infection Microbiology,2018,通讯作者
（9）Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus,Virology,2018,通讯作者
（10）Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses,eLife,2017,通讯作者
（11）Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection,Journal of Virology,2016,第7作者
（12）脊椎动物Cyclophilin A肽基脯氨酰顺反异构酶活性及遗传变异分析,遗传,2016,通讯作者
（13）Threonine 80 phosphorylation of Non-structural protein NS1 regulates the replication of influenza a virus by reducing the binding affinity with RIG-I,Cellular Microbiology,2016,通讯作者
（14）Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism,Cellular Microbiology,2016,通讯作者
（15）Characteristics of Nucleocytoplasmic Transport of H1N1 Influenza A Virus Nuclear Export Protein,Journal of Virology,2014,第4作者
（16）Tyrosine 132 Phosphorylation of Influenza A Virus M1 Protein Is Crucial for Virus Replication by Controlling the Nuclear Import of M1,Journal of Virology,2013,第4作者
（17）Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein,PLos One,2012,第4作者
（18）Recombinant chicken interferon alpha inhibits H9N2 avian influenza virus replication in vivo by oral administration,Journal of Interferon Cytokine Research,2011,通讯作者
（19）Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice,Virology Journal,2011,通讯作者
（20）Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein,Virus Research,2010,第3作者
（21）Chicken cyclophilin A is an inhibitory factor to influenza virus replication,Virology Journal,2010,第4作者
（22）Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication,Cellular Microbiology,2009,第2作者
（23）Genetic correlation between H3N2 human and swine influenza viruses,Journal of Clinical Virology,2009,第1作者
（24）Genetic correlation between current circulating H1N1 swine and human influenza viruses,Journal of Clinical Virology,2009,通讯作者
（25）F gene recombination between genotype II and VII Newcastle disease virus,Virus Research,2008,第1作者
（26）Cloning and characterization of a novel feline IFN-omega,Journal of Interferon Cytokine Research,2007,第3作者
（27）A Massachusetts prototype like coronavirus isolated from wild peafowls is pathogenic to chickens,Virus Research,2007,第1作者