基本信息
李于男博导中国科学院上海营养与健康研究所
电子邮件： liyu@sibs.ac.cn
通信地址： 上海市岳阳路320号
邮政编码：
部门/实验室：营养科学研究所
研究领域

招生信息
招生专业071003-生理学
100104-病理学与病理生理学
083100-生物医学工程

招生方向胰岛素抵抗、2型糖尿病、非酒精性脂肪性肝病和肥胖等代谢性疾病的病理生理学机制研究


教育背景2004-04--2008-08加拿大圭尔夫大学分子及细胞生物系博士
2000-09--2003-08天津科技大学生物工程系硕士
1996-09--2000-08天津科技大学生物工程系学士

学历
学位

工作经历
工作简历2017-01~现在,中国科学院上海营养与健康研究院,研究员
2013-01~2016-12,中国科学院上海生命科学研究院营养所,研究员
2009-03~2013-01,美国波士顿大学Whitaker心血管病研究所,博士后
2008-09~2009-02,加拿大圭尔夫大学分子及细胞生物系,博士后
2004-07~2008-04,加拿大圭尔夫大学分子及细胞生物系,兼职助教
2004-04~2008-08,加拿大圭尔夫大学分子及细胞生物系,博士
2000-09~2003-08,天津科技大学生物工程系,硕士
1996-09~2000-08,天津科技大学生物工程系,学士

社会兼职

教授课程营养与生理学
营养学


专利与奖励
奖励信息
专利成果（ 1 ） 两步发酵法生产酵母胞外海藻糖, 2003, 第 4 作者, 专利号: CN**.3
（ 2 ） 一种绿茶组合物在改善饮食诱导的代谢紊乱中的应用, 2016, 第 1 作者, 专利号: 1.7
（ 3 ） CREBZF在治疗、预防和诊断代谢性疾病中的应用, 2017, 第 1 作者, 专利号: CN6.5
（ 4 ） CREBZF在治疗、预防和诊断代谢性疾病中的应用, 2017, 第 1 作者, 专利号: PCT/CN2017/087688


出版信息
发表论文（1）Han Yamei#, Hu Zhimin#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene,Nature Communications,2019,第11作者
（2）Yang Yunzhi#, Ma Fengguang#, Liu Z, Su Q, Liu Y, Liu Z, Li Y*. The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3,Journal of Biological Chemistry,2019,第11作者
（3）Wu Rong, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*. The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex,Cell Metabolism,2019,第7作者
（4）Xiao Fei, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals,Molecular Metabolism,2019,第7作者
（5）Zhang Hao, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin X-M*. Dynamic mtorc1-tfeb feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply,Autophagy,2018,第9作者
（6）刘雨笑，张菲菲，李于*.肝脏CREBZF通过抑制Insig活性促进胰岛素诱导的脂质合成并加重饮食诱导的胰岛素抵抗小鼠的肝脏脂质沉积,临床肝胆病杂志,2018,第11作者
（7）Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y*. Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice.,Hepatology,2018,第11作者
（8）Sun Yixuan, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q, Chen X, Gao J, Bian H, Tan Y, Li Y*, Gao X. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21.,British journal of pharmacology,2018,第11作者
（9）Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M. DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease.,Hepatology,2018,第5作者
（10）Cui Aoyuan, Hu Z, Han Y, Yang Y, Li Y*. Optimized Analysis Of In Vivo and In Vitro Hepatic Steatosis.,Journal of Visualized Experiments,2017,第11作者
（11）Chen Liqun, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, and Wang Y. Fasting-induced hormonal regulation of lysosomal function.,Cell Res,2017,第7作者
（12）Sun Yixuan, Yuan X, Zhang F, Han Y, Chang X, Xu X, Li Y, and Gao X. Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells.,Scientific Reports,2017,第7作者
（13）崔奥媛, 李于*. 成纤维细胞生长因子21的前世今生：胰岛素增敏机制与临床研究,中华糖尿病杂志,2017,第11作者
（14）Zhuo Shu, Yang M, Zhao Y, Chen X, Zhang F, Li N, Yao P, Zhu T, Mei H, Wang S, Li Y, Chen S, Le Y. Microrna-451 negatively regulates hepatic glucose production and glucose homeostasis by targeting glycerol kinase mediated gluconeogenesis.,Diabetes,2016,第12作者
（15）Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1.,Hepatology,2016,第11作者
（16）Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, Han Y, Gao J, Sun Y, Liu Z, Yang Z, Le Y, Gao X, Dong LQ, Gao X, Li Y*. Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice through Peroxisome Proliferator-Activated Receptor Alpha.,Diabetes,2016,第11作者
（17）龚琦, 张菲菲, 韩亚美, 李于*. FGF21的代谢调控及临床应用.,中国细胞生物学学报,2015,第11作者
（18）Li Y*, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M*, Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.,Gastroenterology,2014,第11作者
（19）Li Y, Xu S, Jiang B, Cohen RA, Zang M. Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.,PLoS ONE,2013,第1作者
（20）Li Y*, Wong K, Walsh K, Gao B, Zang M*. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.,Journal of Biological Chemistry,2013,第11作者
（21）DenBoer LM, Iyer A, McCluggage ARR, Li Y, Martyn AC, Lu R. JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation.,Biochim Biophys Acta,2013,第4作者
（22）Tan Z, Zhou L, Li Y, Cui Y, Xiang Q, Lin G, and Wang T. E2 - BSA activates caveolin-1 via PI3K/ERK1/2 and lysosomal degradation pathway and contributes to EPC proliferation.,Int J Cardiol.,2012,第3作者
（23）Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JJ, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, and Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in Diet-Induced insulin-resistant mice.,Cell Metabolism,2011,第1作者
（24）Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.,FASEB Journal,2011,第1作者
（25）Audas TE, Li Y, Liang G, and Lu R. A novel protein, Luman/CREB3 recruitment factor (LRF), inhibits Luman activation of the unfolded protein response.,Molecular and Cellular Biology,2008,第2作者
（26）Liang G, Audas TE, Li Y, Cockram GP, Dean JD, Martyn AC, Kokame K, and Lu R. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.,Molecular and Cellular Biology,2006,第3作者

发表著作

科研活动
科研项目（ 1 ） 中科院重点部署项目 慢性和急性干预实验肝脏代谢指标检测分析, 主持,部委级,2017-01--2020-12
（ 2 ） 国家自然科学基金面上项目 核受体RARβ调控肝脏脂质沉积和胰岛素抵抗的机制研究, 主持,国家级,2017-01--2020-12
（ 3 ） 国家自然科学基金面上项目 转录因子CREBZF调节肝脏糖异生和控制糖代谢平衡的机制研究, 主持,国家级,2015-01--2018-12
（ 4 ） 国家自然科学基金面上项目 肝脏SIRT1通过FGF21调节酮体生成和能量代谢的机制研究, 主持,国家级,2013-01--2016-12
（ 5 ） 基于新型代谢因子CREBZF的抗糖尿病药物新靶标的研究, 主持,部委级,2019-01--2020-09
（ 6 ） 糖尿病发病机理及代谢异常生物标志物与个体化诊疗研究, 主持,国家级,2017-09--2019-12
（ 7 ） 肝脏再生及重建小鼠模型的建立及应用, 主持,省级,2019-05--2022-04

参与会议（1）CREBZF as a novel target of glucose sensing signaling in the control of adaptive thermogenesis in the adipose tissue. American Diabetes Association 79th Scientific Sessions, Oral presentation, June 7-11, 2019, San Francisco, California.2019-06-07
（2）Myeloid CREBZF couples inflammatory signals to systemic insulin resistance by regulating immune response of the adipose tissue. American Diabetes Association 79th Scientific Sessions, Oral presentation, June 7-11, 2019, San Francisco, California2019-06-07
（3）A Novel Metabolic Regulator CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig. 9th Chinese American Diabetes Association Scientific Meeting, Oral Presentation, June 20-22, 2018, Orlando, Florida2018-06-20
（4）Molecular Controls of Lipid Metabolism and Nonalcoholic Fatty Liver Disease. 2018 Queenstown Molecular Biology Meetings in Shanghai2018-03-22
（5）bZIP Transcription Factor CREBZF Functions as a Novel Metabolic Regulator in the Control of Hepatic Steatosis in Diet-Induced Insulin Resistant Mice. American Diabetes Association 77th Scientific Sessions, Oral presentation, San Diego, California.2017-06-09
（6）Hepatic SIRT1 Deficiency Abolishes Berberine-Mediated Augmentation of Autophagy and Reduction of Hepatic Steatosis in Diet-Induced Obesity Mice. American Diabetes Association 77th Scientific Sessions, Poster presentation, San Diego, California.2017-06-09
（7）Overview of Metabolism and Fatty Liver. 26th Conference of Asian Pacific Association for the Study of the Liver (APASL), Invited Speaker, February 15-19, 2017, Shanghai, China.2017-02-19
（8）Overview of Metabolism and Fatty Liver. 26th Conference of Asian Pacific Association for the Study of the Liver (APASL), Invited Speaker, Shanghai, China.2017-02-15
（9）A novel mechanism for fibroblast growth factor 21 to regulate hepatic insulin sensitivity via inhibiting mammalian target of rapamycin complex 1. American Diabetes Association 76th Scientific Sessions, Moderated Poster Discussion, New Orleans, Louisiana.2016-06-10
（10） ATF6 directly increases peroxisome proliferator-activated receptor alpha activity to reduce hepatic steatosis in mice. American Diabetes Association 76th Scientific Sessions, Moderated Poster Discussion, New Orleans, Louisiana.2016-06-10
（11）FGF21 in Control of Hepatic Insulin Sensitivity. 7th Chinese American Diabetes Association Scientific Meeting, Oral Presentation, New Orleans, Louisiana.2016-06-09
（12）Fibroblast growth factor 21 improves hepatic insulin sensitivity and controls glucose homeostasis. New Advances in Metabolism Research Symposium, Duke-NUS Medical School, Invited Speaker, Singapore.2016-04-20
（13） Hepatic SIRT1 Stimulates Fibroblast Growth Factor 21 to Improve Hepatic Insulin Sensitivity and Control Glucose Homeostasis. American Diabetes Association 75th Scientific Sessions, Poster Presentation, Boston, Massachusetts.2015-06-05
（14） The Unfolded Protein Response Regulates Hepatic Fatty Acid Metabolism and Hepatic Steatosis through Peroxisome Proliferator-Activated Receptor Alpha. American Diabetes Association 75th Scientific Sessions, Poster Presentation, Boston, Massachusetts.2015-06-05
（15） mTOR mediates metabolic effects of FGF21 on insulin sensitivity in mice. American Diabetes Association 74th Scientific Sessions, Oral Presentation, San Francisco, California.2014-06-13
（16）RARβ functions as a novel downstream regulator of SIRT1 that protects against metabolic disorders in diet-induced obesity mice. American Diabetes Association 73th Scientific Sessions, Oral Presentation, Chicago, Illinois.2013-06-21
（17）Transcriptional Regulation of Fasting Inducible Hormone FGF21 by Retinoic Acid Receptor β in the Liver. American Diabetes Association 72nd Scientific Sessions, Oral Presentation, Philadelphia, Pennsylvania.2012-06-08
（18）Loss of SIRT1 in Liver Suppresses FGF21 Expression and Inhibits Fatty Acid Oxidation and Ketogenesis, Leading to Decreased Energy Expenditure and Increased Susceptibility of Obesity in Mice. American Diabetes Association 72nd Scientific Sessions, Poster Presentation, Philadelphia, Pennsylvania.2012-06-08


合作情况
项目协作单位

指导学生