基本信息
黄河男硕导中国科学院上海药物研究所
电子邮件： hhuang@simm.ac.cn
通信地址： 上海市浦东张江祖冲之路555号
邮政编码：

研究领域

招生信息
招生专业100706-药理学

招生方向化学生物学，蛋白质组学，表观遗传学，药物化学


教育背景2004-09--2010-06中国科学院上海药物研究所药物设计学博士
2000-09--2004-06同济大学理学学士

学历
学位

工作经历
工作简历2019-01~现在,中国科学院上海药物研究所,研究员
2015-09~2019-01,美国芝加哥大学,研究助理
2012-11~2015-08,美国芝加哥大学,博士后
2010-08~2012-10,美国西北大学,博士后
2004-09~2010-06,中国科学院上海药物研究所,药物设计学博士
2000-09~2004-06,同济大学,理学学士

社会兼职

教授课程

专利与奖励
奖励信息（1） 中国科学院院长优秀奖, 院级, 2010
（2） 上海市高等学校优秀毕业生, 省级, 2010
（3） Eli Lilly亚洲优秀学位论文, 一等奖, 其他, 2010
（4） 首届中华医药澳门论坛最佳论文奖, 其他, 2009
（5） 第六届世界华人药物化学会议优秀墙报奖, 其他, 2008

专利成果（ 1 ） Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors, 2017, 第 2 作者, 专利号: US**B2
（ 2 ） Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors, 2016, 第 2 作者, 专利号: US**B2
（ 3 ） Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition., 2015, 第 3 作者, 专利号: US**B2
（ 4 ） Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors., 2014, 第 2 作者, 专利号: US**B2
（ 5 ） Selective neuronal nitric oxide synthase inhibitors., 2013, 第 3 作者, 专利号: US**B2


出版信息
发表论文（1）p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.,Mol Cell,2018,第1作者
（2）Lysine benzoylation is a histone mark regulated by SIRT2.,Nat Commun,2018,第1作者
（3）Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway.,Cell Res,2018,第1作者
（4）Quantitative crotonylome analysis expands the roles of p300 in the regulation of lysine crotonylation pathway.,Proteomics,2018,第11作者
（5）Structure of p300 in complex with acyl-CoA variants.,Nat Chem Biol,2017,第4作者
（6）2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae.,Proc Natl Acad Sci USA,2017,第5作者
（7）Metabolic Regulation of Gene Expression by Histone Lysine-X modification,Mol Cell,2016,第5作者
（8）Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.,Mol Cell,2016,第8作者
（9）Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.,Mol Cell,2016,第3作者
（10）TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions.,Mol Cell,2016,第5作者
（11）Quantitative Proteomic Analysis of Histone Modifications,Chem Rev,2015,第1作者
（12）Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation,,Mol Cell,2015,第3作者
（13）Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors,J Med Chem,2015,第7作者
（14）SnapShot: Histone Modifications.,Cell,2014,第1作者
（15）Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5.,Cell Metab,2014,第9作者
（16）Silverman RB. Potent and Selective Double-headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma.,J Med Chem,2014,第1作者
（17）Arylazanyl pyrazolone derivatives as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis.,J Med Chem,2013,第3作者
（18）Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase.,J Med Chem,2013,第1作者
（19）Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.,J Am Chem Soc,2012,第1作者
（20）Iron deprivation caused by a novel iron chelator thiosemicarbazone-24 suppresses hepatocellular carcinoma in vitro and in vivo.,Clin Cancer Res,2011,第1作者
（21）A class of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity,,J Med Chem,2010,第1作者
（22）PH006, a novel and highly potent Src kinase inhibitor, suppresses tumor growth and metastasis in vitro and in vivo.,Breast Cancer Res Tr,2010,第1作者
（23）Ligand-free Iron/Copper Cocatalyzed N-Arylations of Aryl Halides with Amines under Microwave Irradiation,,Green Chem,2010,第2作者
（24）Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors,Eur J Med Chem,2009,第1作者
（25）A Simple and Efficient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature,,J Org Chem,2009,第1作者
（26）Microwave-assisted Synthesis of Quinazolinone Derivatives by Efficient and Rapid Iron-Catalyzed Cyclization in Water,,Green Chem,2009,第6作者
（27）Efficient Iron/Copper Cocatalyzed Alkynylation of Aryl Iodides with Terminal Alkynes,J Org Chem,2008,第1作者
（28）Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides,J Org Chem,2008,第1作者
（29）Efficient Copper-Promoted N-Arylations of Aryl Halides with Amines,J Comb Chem,2008,第1作者
（30）Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines,Org Lett,2008,第2作者

发表著作

科研活动
科研项目
参与会议（1）Lysine benzoylation is a new type of histone mark regulated by SIRT22018-06-03
（2）Quantitative Proteomic Approach Reveals Landscape of the Regulatory Elements for Lysine β-hydroxybutyrylation2017-06-04
（3）Landscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway2017-04-25
（4）Lysine β-hydroxybutyrylation is a new type of protein post-translational modification associated with diverse pathophysiology2016-06-05


合作情况
项目协作单位

指导学生