基本信息
李磊男博导中国科学院动物研究所
电子邮件： lil@ioz.ac.cn
通信地址： 北京市朝阳区北辰西路一号院五号中国科学院动物研究所
邮政编码： 100101

研究领域基础医学

招生信息博士一名
招生专业100101-人体解剖与组织胚胎学

招生方向分子胚胎发育生物学


教育背景1999-04--2002-03日本群马大学博士学位
1990-09--1994-06中国农业大学学士学位

学历-- 研究生


学位 -- 博士

出国学习工作1998.4-2003.10， 日本群马大学，研修生，博士研究生，博士后
2003.10-2009.5， 美国国立卫生研究院，Visiting Fellow, Research Fellow

工作经历
工作简历2009-05~现在,中国科学院动物研究所,研究员
2003-10~2009-05,美国国立卫生研究院,Visiting/Research Fellow
2002-04~2003-10,日本群马大学生体调节研究所,外国人研究员
1998-05~1999-03,日本群马大学生体调节研究所,研修生
1994-07~1997-08,江西省明星企业集团,工程师

社会兼职

教授课程现代组织胚胎学及其技术应用
组织工程学
发育生物学
组织胚胎学
人体组织胚胎学
生殖生物学


专利与奖励
奖励信息（1） NIH Fellow Award for Research Excellent, , 其他, 2008
（2） NIDDK Nancy Nossal Fellowship Award, , 其他, 2007
（3） NIH Fellow Award for Research Excellent, , 其他, 2005

专利成果

论文发表


Wang X, Qin D, Lu X, Li L^*. An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese). Scientia Sinica Vitae. 2018 Jun; 48(6), 609-617.
Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology. 2018 May; 20(5): 535–540. doi: 10.1038/s41556-018-0087-2.
Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z^*, Li L^*. Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis. Biology Open. 2018, Mar; 7(3). bio032508.
Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L^*. ZBED3 participates in the subcortical maternal complex and regulates the distribution of organelles. Journal of Molecular Cell Biology. 2018 Feb; 10(1): 74-88.
Yu Y, Wang X, Zhang Z, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z^*, Li L^*. Inhibition of ERK promotes neuroectodermal commitment of EpiSCs by preventing self-renewal and primitive streak formation. Stem Cell Research & Therapy. 2018 Jan; 9(1): 2. doi: 10.1186/s13287-017-0750-8.
Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F. Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification. Nature Genetics. 2018 Jan; 50(1): 96-105.
Lu X, Gao Z, Qin D, Li L^*. A Maternal Functional Module in the Mammalian Oocyte-To-Embryo Transition. Trends in Molecular Medicine. 2017 Nov; 23 (11) 1014–1023.
Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S^*. MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. Journal of Endocrinology. 2017 Jul; 234(1):1-14. doi: 10.1530/JOE-16-0488.
Nie X, Lu X, Li L^*. First cell lineage specification in mammalian early development (in Chinese). Chinese Science Bulletin. 2017 May; 62(15), 1569-1577.
Liu W Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S*, Yi Z*, Li L*. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nature Communications. 2017 Jan 27; 8:14182.






Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, LiuW, Chen J^*, Yi Z^*, and Li L^*. Trp-Asp (WD) repeat domain 1 is Essentialfor Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. Journalof Biological Chemistry. 2017 Jan 27; 292(4):1438-1448. 2016 Dec 19. pii: jbc.M116.759886. [Epub aheadof print]
Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L^*. BTG4 is a keyregulator for maternal mRNA clearance during mouse early embryogenesis. Journalof Molecular Cell Biology. 2016 Aug; 8(4):366-8.
Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q^*,Li L^*. MicroRNA-127promotes primitive streak formation by targeting left-right determination factor2. Journalof Biological Chemistry. 2016Jun 3; 291(23):12126-35.
Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, LuX, Liu Y, Yu X, Wang H, Huang J, Yi Z,Gao S^*, Li L^*.Maternal BCAS2 protects genomic integrity in mouse early embryonic development.Development.2015 Nov 15; 142 (22):3943-53.
Zhao Z, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y , Zhang X-X,Wang H, Li L*. The roles of ERAS during cell lineage specification ofmouse early embryonic development. Open Biology. 2015 Aug; 5(8).
Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W,Li L, Zhang R, Zheng P. FiliaIs an ESC-Specific Regulator of DNA Damage Response and Safeguards GenomicStability. Cell Stem Cell. 2015 Apr 29.
Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J^*,Li L^*.Identification of a human subcortical maternal complex. Molecular Human Reproduction.2015 Apr; 21(4): 320-9.
Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, WangZ, Zheng P, Zhu M, Wang H, Sun QY, Dean J^*, Li L^*. The subcortical maternal complex controlssymmetric division of mouse zygotes by regulating F-actin dynamics. NatureCommunications. 2014Sep 11; 5:4887.
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q,Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B,Chen Q^*, Duan E^*, Wang H^*. Uterine Rbpj isrequired for embryonic-uterine orientation and decidual remodeling via Notchpathway-independent and -dependent mechanisms.Cell Research. 2014Aug; 24(8): 925-42.
Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J,Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F^*, Gao S^*,Wang H^*. Integral proteomic analysis of blastocysts reveals keymolecular machinery governing embryonic diapause and reactivation forimplantation in mice. Biology of Reproduction. 2014Mar; 90(3): 52, 1-11.
LiL^*, Lu X and Dean J^*. The maternal to zygotictransition in mammals. Molecular Aspects of Medicine. 2013Oct; 34(5): 919-38.
Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B,Li C, Dai Z, Hou N, Cheng X, Sun Q, LiL, Yang X^*, Fan Z^*. WASH inhibits autophagythrough suppression of Beclin 1 ubiquitination. The EMBO Journal. 2013Oct; 32(20): 2685-96.
Wang J, Xu M, Zhu K, LiL^*, Liu X^*. The N-terminus of FILIA forms anatypical KH domain with a unique extension involved in interaction with RNA. PLoS ONE.2012; 7(1): e30209.
Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q,Cooke HJ, Li L, Sun QY, Shi Q^*.Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouseoocytes. PLoS ONE. 2012; 7(1): e29735.
LiL^*, Zheng P and Dean J^*. Maternal control ofearly mouse development. Development. 2010Mar; 137(6): 859-70.
LiL^*, Baibakov B and Dean J. A subcortical maternal complexessential for pre-implantation mouse embryogenesis. Developmental Cell. 2008Sep; 15(3): 416-25.
OhsugiM, Zheng P, Baibakov B, Li L,Dean J^*. Maternally derived FILIA-MATER complex localizes asymmetricallyin cleavage-stage mouse embryos. Development. 2008 Jan; 135(2):259-69.
Ogata T, Li L,Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I^*.Promotion of b-CellDifferentiation by Conophylline in Fetal and Neonatal Rat Pancreas. Diabetes.2004 Oct; 53(10): 2596-2602.
LiL, Yi Z, Seno M, andKojima I^*. Activin A and Betacellulin: Effect on Regeneration ofPancreatic b-Cellsin Neonatal Streptozotocin-treated Rats, Diabetes. 2004 Mar; 53(3): 608-615.
LiL, Seno M, Yamada H,and Kojima I^*. Betacellulin Improved Glucose Metabolism by PromotingConversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treatedDiabetic Mice, Am J Physiol Endocrinol Metab. 2003 Sep; 285(3): E577-83.
LiL, Seno M, Yamada H,and Kojima I^*. Promotion of Beta-cell Regeneration by Betacellulinin 90% Pancreatectomized Rats. Endocrinology. 2001 Dec; 142(12): 5379-85.







































































科研活动科技部重大科学计划，国家自然基金面上项目，****

科研项目（ 1 ） “雌性生育力维持调节机制研究及生殖资源库建立”二级课题(2011CB944501)：雌性生殖细胞发生, 主持,国家级,2011-01--2015-12
（ 2 ） BCAS2 在小鼠早期胚胎发育过程中的生理功能及分子作用, 主持,国家级,2012-01--2015-12
（ 3 ） 蛋白复合体新组分SCMC5的鉴定、功能和分子作用机制研究, 主持,国家级,2015-01--2018-12
（ 4 ） 母源RNA降解和合子基因组激活的分子机制研究, 主持,国家级,2016-01--2020-12
（ 5 ） 卵泡形成及卵母细胞生长起始的分子机制, 主持,国家级,2011-01--2016-12
（ 6 ） BCAS2调控小鼠ES细胞增殖和围植入期胚胎发育的作用机制, 主持,国家级,2018-01--2021-11
（ 7 ） 人类胚胎着床调控及相关重大妊娠疾病发生机制, 主持,国家级,2017-07--2020-12
（ 8 ） 获得性性状的生殖传递机制, 主持,国家级,2018-12--2021-12

参与会议

合作情况
项目协作单位

指导学生已指导学生
宇兴江博士研究生071008-发育生物学
徐倩华博士研究生071008-发育生物学
朱恺博士研究生071008-发育生物学
马怀孝硕士研究生071008-发育生物学
余洋博士研究生071008-发育生物学
肖翼博士研究生071008-发育生物学
高征博士研究生071008-发育生物学
卢绪坤博士研究生100101-人体解剖与组织胚胎学
马海霞博士研究生071008-发育生物学
林宇轩硕士研究生071008-发育生物学
马怀孝博士研究生100101-人体解剖与组织胚胎学
何波博士研究生100101-人体解剖与组织胚胎学
现指导学生
秦丹丹博士研究生100101-人体解剖与组织胚胎学
王晓晓博士研究生100101-人体解剖与组织胚胎学
全裕军博士研究生100101-人体解剖与组织胚胎学
任伟倩硕士研究生100101-人体解剖与组织胚胎学
张嘉祺博士研究生100101-人体解剖与组织胚胎学
聂晓庆博士研究生100101-人体解剖与组织胚胎学
王琪智硕士研究生100101-人体解剖与组织胚胎学