基本信息
尹文兵男博导中国科学院微生物研究所
电子邮件： yinwb@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码： 100101

研究领域

招生信息
招生专业071005-微生物学

招生方向 真菌天然产物发现，基因调控，合成生物学



教育背景 2006-06--2009-09 德国马尔堡大学 博士
2002-09--2005-07 首都师范大学 硕士
1998-09--2002-07 山西师范大学 学士


工作经历
工作简历 2014-01--今 中国科学院微生物研究所 研究员
2012-11--2014-01 美国加州大学洛杉矶分校 博士后
2009-10--2012-10 美国威斯康辛大学麦迪逊分校 研究助理

社会兼职

教授课程

专利与奖励
奖励信息 （1） 国家优秀自费留学生奖学金，国家级，2008

专利成果

出版信息
发表论文（1）Duplication of a Pks gene cluster and subsequent functional diversification facilitate environmental adaptation in Metarhizium species,PloS Genet.,2018,第8作者
（2）Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans,Org. Biomol. Chem.,2018,通讯作者
（3）A new regulator RsdA mediating fungal secondary metabolism has a detrimental impact on asexual development in Pestalotiopsis fici,Environ. Microbiol.,2018,通讯作者
（4）Rational design for heterologous production of aurovertin-type compounds in Aspergillus nidulans,Appl. Microbiol. Biotechnol.,2018,通讯作者
（5）Asperorydines A–M: prenylated tryptophan-derived alkaloids with neurotrophic effects from Aspergillus oryzae,J Org Chem,2018,第8作者
（6）Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi,Chem. Sci,2018,通讯作者
（7）Identification and characterization of a membrane-bound sesterterpene cyclase from Streptomyces somaliensis.,J. Nat. Prod,2018,第8作者
（8）Trichodermatides E and F from fungus Trichoderma applanatum,J. Asian Nat. Prod. Res.,2018,通讯作者
（9）Rational design for fungal laccase production in the model host Aspergillus nidulans,SCIENCE CHINA Life Sciences,2018,通讯作者
（10）Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds,Appl. Microbiol. Biotechnol.,2018,通讯作者
（11）Genetic manipulation of the COP9 signalosome subunit PfCsnE leads to the discovery of pestaloficins in Pestalotiopsis fici,Org Lett.,2017,通讯作者
（12）Decalin-containing tetramic acids and 4-hydroxy-2-pyridones with antimicrobial and cytotoxic activity from the fungus coniochaeta cephalothecoides collected in Tibetan Plateau (Medog),J Org Chem,2017,第10作者
（13）Versicoamides F–H, prenylated indole alkaloids from Aspergillus tennesseensis,Org Lett.,2017,第9作者
（14）Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes,Appl. Microbiol. Biotechnol.,2017,第5作者
（15）Regio- and stereospecific O-glycosylation of phenolic compounds catalysed by a fungal glycosyltransferase from Mucor hiemalis,Adv. Synth. Catal.,2017,通讯作者
（16）Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii,Org. Lett.,2017,通讯作者
（17）Discovery and characterization of the UbiA proteins as a new family of diterpene cyclases in bacteria and fungi,Angew. Chem. Int. Ed.,2017,第10作者
（18）Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum,Mycology (TMYC),2017,第8作者
（19）A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici,Mol. Microbiol.,2017,通讯作者
（20）COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici,SCIENCE CHINA Life Sciences,2017,通讯作者
（21）Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp Collected in the Tibet Plateau Region,Eur. J. Org. Chem.,2016,第7作者
（22）Bioactive sesquiterpenes from the edible mushroom flammulina velutipes and their biosynthetic pathway confirmed by genome analysis and chemical evidence,J. Org. Chem.,2016,第10作者
（23）Functional analysis of the nitrogen metabolite repression regulator gene nmrA in Aspergillus flavus,Frontiers Microbiol.,2016,第4作者
（24）A new species of Trichoderma hypoxylon harbours abundant secondary metabolites,Sci. Rep.,2016,通讯作者
（25）Polyketide production of pestaloficiols and macrodiolide ficiolides revealed by manipulations of epigenetic regulators in an endophytic fungus.,Org. Lett.,2016,通讯作者
（26）Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining.,PLoS Pathog,2016,通讯作者
（27）Efficient biosynthesis of fungal polyketides containing the dioxabicyclo-octane ring system.,J. Am. Chem. Soc.,2015,第4作者
（28）Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α-glucosidase.,J. Nat. Prod.,2015,第4作者
（29）Structurally diverse sesquiterpenes produced by a Chinese Tibet fungus Stereum hirsutum and their cytotoxic and immunosuppressant activities.,Org. Lett.,2015,第4作者
（30）Gloeophyllins A?J, cytotoxic ergosteroids with various skeletons from a Chinese Tibet fungus Gloeophyllum abietinum.,Org. Lett.,2015,第4作者
（31）From taxonomy and industry to genetics: Fungal Biology in China.,Fungal Genet Biol.,2015,通讯作者
（32）Epigenetic genome mining of an endophytic fungus leads to pleiotropic biosynthesis of natural products,Angew. Chem. Int. Ed.,2015,第4作者
（33）The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici,Fungal Genet. Biol. ,2015,通讯作者
（34）Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products,BMC Genomics,2015,第4作者
（35）Farming of a defensive fungal mutualist by an attelabid weevil.,ISME J.,2015,第4作者
（36）A Carbonate-forming Baeyer-Villiger Monooxygenase.,Nature Chem. Biol.,2014,第4作者
（37）Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus.,Front. Microbiol.,2014,第4作者
（38）The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus,PloS One,2013,第3作者
（39）Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans,ACS Synth. Biol.,2013,第1作者
（40）A nonribosomalpeptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus,J. Am. Chem. Soc.,2013,第1作者
（41）bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans,Microbiology-SGM,2013,第1作者
（42）An Aspergillus nidulansbZIP response pathway hardwired for defensive secondary metabolism operates through aflR,Mol. Microbiol.,2012,第1作者
（43）Transcriptional regulatory elements in fungal secondary metabolism,J. Microbiol.,2011,第1作者
（44）Preparation of pyrrolo[2,3-b]indoles carrying a ？-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT,Org. Biomol. Chem.,2010,第1作者
（45）Reconstruction of pyrrolo[2,3-b]indoles carrying an a-configured reverse C3-dimethylallyl moiety by using recombinant enzymes,Org. Biomol. Chem. ,2010,第1作者
（46）Stereospecific synthesis of aszonalenins by using two prenyltransferases,Org. Biomol. Chem. ,2009,第1作者
（47）Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaATcatalyses the acetylation of fumigaclavine B,ChemBioChem,2009,第4作者
（48）Acetylaszonalenin biosynthesis in Neosartorya fischeri: Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation,J. Biol. Chem.,2009,第1作者
（49）Indole prenyltransferases from fungi: a new enzyme group with high potential for the production of prenylated indole derivatives,Curr. Med. Chem.,2009,第3作者
（50） Reinvestigation of a cyclic dipeptide N-prenyltransferase reveals rearrangement of N-1 prenylated indole derivatives,Chembiochem,2008,第1作者
（51）CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation,ChemBioChem ,2007,第1作者


科研活动
科研项目 （1） “****”启动，主持，院级级，2014-01--2015-07

参与会议

合作情况
项目协作单位

指导学生