个人信息
李云琦 男 博导 长春应用化学研究所
电子邮件：yunqi@ciac.ac.cn
通信地址：长春市人民大街5625号
邮政编码：130022


研究领域
本课题组定位于应用基础研究，与前沿应用、先进材料研发紧密结合，利用多学科交叉方法，研究现有问题的科学本质，探索面向效率和性能提升的可行方案。具体侧重于以下两方面：

一、高分子复杂体系的基础研究
运用化学、物理、统计学结合计算机模拟与先进表征手段，研究含溶液、溶胶凝胶、功能膜等高分子复杂体系的性构关系，探索物质分布、微纳结构和相行为与材料性能的联系、增强机制及调控方法，为开发低成本、绿色环保的高性能材料提供理论基础和技术指导。
二、蛋白质复合物研究
运用化学、物理、生物信息学结合计算机模拟的多学科交叉方法，研究蛋白质与生物活性分子的相互作用、蛋白质复合物结构、聚集行为及其对健康的影响，建立预测构效关系的算法，研发可用于预防、抑制重大疾病的食品和药品。


招生信息本课题组热忱欢迎对高性能高分子复合材料开发；蛋白质复合物在促进生命健康，预防和抑制重大疾病方面感兴趣的研究生和博士后一起合作研究。 多学科交叉是本组的特点，具有化学、物理、生物学或应用数学等相关背景知识并对科研有浓厚兴趣的同学都可以前来寻找您的科学梦想。



招生专业方向 物理化学（含：化学物理）
高分子化学与物理
计算机化学
教育经历 2001-09--2007-05 中国科学院长春应用化学研究所 理学博士
1997-09--2001-07 南京大学 理学学士

工作经历

工作简历 2013-01--今 中国科学院长春应用化学研究所 研究员
2010-06--2012-11 罗格斯大学食品系 研究助理
2009-02--2010-05 堪萨斯大学应用生物信息学实验室 博士后
2007-05--2009-01 堪萨斯大学分子生物中心 博士后

专利与奖励

专利成果 （1） Fang J, Li Y, Middaugh CR METHODS AND SYSTEMS FOR DESIGNING STABLE PROTEINS ，发明，2010，第2作者，专利号：US Patent, **

学术成果1. Liu L, Chen W, & Li Y An overview of the proton conductivity of nafion membranes through a statistical analysis. J. Membr. Sci. 2016, 504:1-9.

2. Xiao J, Li YQ, Li J, Gonzalez AP, Xia QY, & Huang QR Structure, Morphology, and Assembly Behavior of Kafirin. J Agr Food Chem 2015, 63(1):216-224.

3. Xia SQ, Li YQ, Zhao Q, Li J, Xia QY, Zhang XM, & Huang QR Probing Conformational Change of Bovine Serum Albumin-Dextran Conjugates under Controlled Dry Heating. J Agr Food Chem 2015, 63(16):4080-4086.

4. Xia S, Li Y, Xia Q, Zhang X, & Huang Q Glycosylation of bovine serum albumin via Maillard reaction prevents epigallocatechin-3-gallate-induced protein aggregation. Food Hydrocolloids 2015, 43(0):228-235.

5. Tao YH, Chen XY, Jia F, Wang SX, Xiao CS, Cui FC, Li YQ, Bian Z, Chen XS, & Wang XH New chemosynthetic route to linear epsilon-poly-lysine. Chem Sci 2015, 6(11):6385-6391.

6. Shi C & Li Y Progress on the Application of Small-angle X-ray Scattering in the Study of Protein and Protein Complexes. Acta Polymerica Sinica 2015, 8:871-883.

7. Li Y & Huang Q (2015) Protein–polysaccharide complexes for effective delivery of bioactive functional food ingredients. in Nanotechnology and Functional Foods, eds Sabliov CM, Chen H, & Yada RY (John Wiley & Sons, Ltd), pp 224-246.

8. Hu B, Cui F, Yin F, Zeng X, Sun Y, & Li Y Caffeoylquinic acids competitively inhibit pancreatic lipase through binding to the catalytic triad. Int. J. Bio. Macromol. 2015, 80:529-535.

9. He Q, Xu T, Qian H, Zheng J, Shi C, Li Y, & Zhang S Enhanced proton conductivity of sulfonated poly(p-phenylene-co-aryl ether ketone) proton exchange membranes with controlled microblock structure. J. Power Sources 2015, 278(0):590-598.

10. Guan X, Hu X, Cui F, Li Y, Jing X, & Xie Z EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery. Macromol. Biosci. 2015, 15:1484-1489.

11. Cui F, Yang K, & Li Y Investigate the Binding of Catechins to Trypsin Using Docking and Molecular Dynamics Simulation. PLoS One 2015, 10(5):e**.

12. Chen W, Zhao H, Liu L, Chen J, Li Y, & An L Effects of Excluded Volume and Hydrodynamic Interaction on the Deformation, Orientation and Motion of Ring Polymers in Shear Flow. Soft Matter 2015, 11:5265-5273.

13. Chen W, Li Y, Zhao H, Liu L, Chen J, & An L Conformations and dynamics of single flexible ring polymers in simple shear flow. Polymer 2015, 64(0):93-99.

14. Li Y, Zhao Q, & Huang Q Understanding complex coacervation in serum albumin and pectin mixtures using a combination of the Boltzmann equation and Monte Carlo simulation. Carbohydr. Polym. 2014, 101(0):544-553.

15. Li Y, An L, & Huang Q Replica Exchange Monte Carlo Simulation of Human Serum Albumin–Catechin Complexes. J. Phys. Chem. B 2014, 118(35):10362-10372.

16. Duan XZ, Zhang R, Li YQ, Yang YB, Shi TF, An LJ, & Huang QR Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model. Eur Biophys J Biophy 2014, 43(8-9):377-391.

17. Duan XZ, Li YQ, Zhang R, Shi TF, An LJ, & Huang QR Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: Effects of chain rigidity. Eur Phys J E 2014, 37(8):71.

18. Li Y & Huang Q Influence of Protein Self-Association on Complex Coacervation with Polysaccharide: A Monte Carlo Study. J. Phys. Chem. B 2013, 117(9):2615-2624.

19. Li J, Li Y, Lee T-C, & Huang Q Structure and Physical Properties of Zein/Pluronic F127 Composite Films. J. Agric. Food Chem. 2013, 61(6):1309-1318.

20. Duan X, Zhang R, Li Y, Shi T, An L, & Huang Q Monte Carlo Study of Polyelectrolyte Adsorption on Mixed Lipid Membrane. J. Phys. Chem. B 2013, 117(4):989-1002.

21. Duan X, Li Y, Zhang R, Shi T, An L, & Huang Q Regulation of anionic lipids in binary membrane upon the adsorption of polyelectrolyte: A Monte Carlo simulation. AIP Adv. 2013, 3:062128.

22. Duan X, Li Y, Shi T, Huang Q, & An L Mutation induced structural variation in membrane proteins: Small but hard to catch. Chemical Research in Chinese Universities 2013, 29(5):1016-1021.

23. Li Y, Zhang J, Tai D, Russell Middaugh C, Zhang Y, & Fang J Prots: A fragment based protein thermo-stability potential. Proteins: Structure, Function, and Bioinformatics 2012, 80(1):81-92.

24. Li Y, Shi T, An L, & Huang Q Monte Carlo Simulation on Complex Formation of Proteins and Polysaccharides. J. Phys. Chem. B 2012, 116(10):3045-3053.

25. Li Y, Li J, Xia Q, Zhang B, Wang Q, & Huang Q Understanding the Dissolution of α-Zein in Aqueous Ethanol and Acetic Acid Solutions. J. Phys. Chem. B 2012, 116(39):12057-12064.

26. Li Y & Fang J PROTS-RF: A Robust Model for Predicting Mutation-Induced Protein Stability Changes. PLoS One 2012, 7(10):e47247.

27. Fang J, Li Y, & Middaugh CR METHODS AND SYSTEMS FOR DESIGNING STABLE PROTEINS 2012, US Patent ** (10/18/2012 ).

28. Li Y, Xia Q, Shi K, & Huang Q Scaling Behaviors of α-Zein in Acetic Acid Solutions. J. Phys. Chem. B 2011, 115(32):9695-9702.

29. Li Y, Fang Y, & Fang J Predicting residue-residue contacts using random forest models. Bioinformatics 2011, 27(24):3379-3384.

30. Li Y, Middaugh CR, & Fang J A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants. BMC Bioinformatics 2010, 11(1):62.

31. Li Y & Fang J Distance-dependent statistical potentials for discriminating thermophilic and mesophilic proteins. Biochem. Biophys. Res. Commun. 2010, 396(3):736-741.

32. Li Y & Zhang Y REMO: A new protocol to refine full atomic protein models from C-alpha traces by optimizing hydrogen-bonding networks. Proteins: Structure, Function, and Bioinformatics 2009, 76(3):665-676.

33. Li Y, Roy A, & Zhang Y HAAD: A Quick Algorithm for Accurate Prediction of Hydrogen Atoms in Protein Structures. PLoS One 2009, 4(8):e6701.

34. Song J, Shi T, Li Y, Chen J, & An L Rigidity effect on phase behavior of symmetric ABA triblock copolymers: A Monte Carlo simulation. J. Chem. Phys. 2008, 129(5):054906.

35. Li Y, Lee J, Lal J, An L, & Huang Q Effects of pH on the Interactions and Conformation of Bovine Serum Albumin: Comparison between Chemical Force Microscopy and Small-Angle Neutron Scattering. J. Phys. Chem. B 2008, 112(12):3797-3806.

36. Zhu Y, Ma Z, Li Y, Cui J, & Jiang W Monte Carlo simulation of the compatibility of graft copolymer compatibilized two incompatible homopolymer blends: Effect of graft structure. J. Appl. Polym. Sci. 2007, 105(3):1591-1596.

37. Wang X, Li Y, Wang YW, Lal J, & Huang Q Microstructure of beta-lactoglobulin/pectin coacervates studied by small-angle neutron scattering. J. Phys. Chem. B 2007, 111(3):515-520.

38. Song J, Li Y, Huang Q, Shi T, & An L Monte Carlo simulation on symmetric ABA/AB copolymer blends in confined thin films. J. Chem. Phys. 2007, 127(9):094903.

39. Li Y, Shi T, An L, Lee J, Wang X, & Huang Q Effects of polar group saturation on physical gelation of amphiphilic polymer solutions. J. Phys. Chem. B 2007, 111(42):12081-12087.

40. Li Y, Shi T, Sun Z, An L, & Huang Q Investigation of sol-gel transition in pluronic F127/D2O solutions using a combination of small-angle neutron scattering and Monte Carlo simulation. J. Phys. Chem. B 2006, 110(51):26424-26429.

41. Li Y, Huang Q, Shi T, & An L How does solvent molecular size affect the microscopic structure in polymer solutions? J. Chem. Phys. 2006, 125(4):044902.

42. Li Y, Huang Q, Shi T, & An L Effects of chain flexibility on polymer conformation in dilute solution studied by lattice Monte Carlo simulation. J. Phys. Chem. B 2006, 110(46):23502-23506.

43. Liao Y, Su Z, Ye X, Li Y, You J, Shi T, & An L Kinetics of Surface Phase Separation for PMMA/SAN Thin Films Studied by in Situ Atomic Force Microscopy. Macromolecules 2005, 38(2):211-215.

44. Li Y, Sun Z, Su Z, Shi T, & An L The effect of solvent size on physical gelation in triblock copolymer solutions. J. Chem. Phys. 2005, 122(19):194909.

45. Li Y, Sun Z, Shi T, & An L Conformation studies on sol-gel transition in triblock copolymer solutions. J. Chem. Phys. 2004, 121(2):1133-1140.
科研活动

科研项目 （1） 科学院百人计划，主持，部委级，2014-12--2017-12
（2） 蛋白茶多酚复合物的分子模拟和小角X光散射研究，主持，国家级，2014-01--2017-12
（3） 长春应用化学研究所启动经费，主持，研究所（学校）级，2013-01--2013-05


参与会议 （1） 大分子复杂体系中的小角X光散射实验与计算，中国化学会2014年大分子体系理论、模拟与计算研讨会，2014-06，李云琦
（2） 血清蛋白-儿茶素复合物的计算机模拟研究 ，2013 年全国高分子学术论文报告会，2013-10，李云琦
（3） Understanding the pathway and driving force of protein/polysaccharide complex coacervation，2012-03，Y.Q. Li, Q.R. Huang

课题组成员现指导学生

杨科成 硕士研究生 070304-物理化学

刘伦洋 硕士研究生 085216-化学工程

孔祥鑫 硕士研究生 085216-化学工程

汤海峰 博士研究生 070304-物理化学
课题组成员
陈文多，助理研究员 wdchen@ciac.ac.cn
崔凤超，助理研究员 fccui@ciac.ac.cn
史册， 实习研究员 ceshi@ciac.ac.cn
汤海峰，博士研究生 tanghaifeng@ciac.ac.cn
杨科成，博士研究生 kcyang@ciac.ac.cn
刘伦洋，硕士研究生 lyliu@ciac.ac.cn
孔祥鑫，硕士研究生 bnnkong@ciac.ac.cn
韩迎春，硕士研究生 ychan1218@ciac.ac.cn

习士霞，联培研究生，xishixia@ciac.ac.cn

刘婷丽，本科毕设 tlliu@ciac.ac.cn
石振，博士后
刘佳音，助理研究员
曹威， 联培研究生
张帅， 联培研究生
郭建宝，本科毕设
张忠， 本科毕设