1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
宋林生 男 博导 中国科学院海洋研究所
电子邮件： lshsong@ms.qdio.ac.cn
通信地址： 青岛市南海路7号生物楼115室
邮政编码： 266000
研究领域
招生信息

招生专业070703


招生方向免疫学基础及应用

教育背景1991-09--1994-08 南开大学 博士
1987-09--1990-08 南开大学 硕士
1983-09--1987-08 南开大学 学士


学历

学位
工作经历

工作简历1998-07~现在, 中国科学院海洋研究所, 研究员
1996-07~1998-07,中国科学院海洋研究所, 博士后
1991-09~1994-08,南开大学, 博士
1990-09~1996-09,南开大学, 讲师、副教授
1987-09~1990-08,南开大学, 硕士
1983-09~1987-08,南开大学, 学士


社会兼职2013-01-01-今,SCI期刊Peer J 编委,
2013-01-01-今,SCI期刊PLoS One 编委,
2012-02-01-今,SCI 期刊Developmental and Comparative Immunology编委 ,
2009-12-01-今,天津市水产养殖与生态重点实验室学术委员会主任,
2009-01-01-今,国际期刊《Fish and shellfish immunology》编委, 编委
2008-01-01-今,国家贝类产业技术体系岗位科学家,
2007-10-01-今,中国海洋与湖沼学会贝类学分会理事,
2006-10-01-今,《微生物通报》编委,
2004-01-01-今,《动物学杂志》编委,

教授课程
专利与奖励

奖励信息（1）扇贝凝集素功能多样性的分子基础,省级,2013
（2）我国重要经济虾蟹类的免疫与内分泌学基础研究,省级,2011
（3）重要水产养殖无脊椎动物免疫防御的分子机制,部委级,2011
（4）扇贝模式识别受体结构与功能的研究,部委级,2010


专利成果（ 1 ）一种对水产动物有免疫增强活性的CpG寡聚核苷酸及其制备和应用,2010,第 2 作者,专利号: **1.0
（ 2 ）中华绒螯蟹半胱氨酸蛋白酶抑制剂EsCystatin基因编码蛋白及应用,2010,第 1 作者,专利号: **8.1
（ 3 ）中华绒鳌蟹Crustin-2基因及其重组蛋白的应用,2010,第 1 作者,专利号: ZL 2009 1 **.8
（ 4 ）一种具有抑菌活性的抗脂多糖因子的制备及应用,2010,第 1 作者,专利号: **6.4
（ 5 ）一种具抑菌活性的中华绒螯蟹乳清酸蛋白的制备和应用,2010,第 1 作者,专利号: **.8
（ 6 ）病原相关分子模式免疫检测芯片及其制备方法与应用,2010,第 1 作者,专利号: **2.X

出版信息

发表论文（1） A conserved zinc finger transcription factor GATA involving in the hemocyte production of scallop Chlamys farreri, Fish Shellfish Immunol, 2014, 第 5 作者
（2） The immunomodulation of a novel tumor necrosis factor (CgTNF-1) in oyster Crassostrea gigas, Dev Comp Immunol, 2014, 第 5 作者
（3） Maternal immune transfer in mollusc, Dev Comp Immunol, 2014, 第 5 作者
（4） The promotion of cytoskeleton integration and redox in the haemocyte of shrimp Litopenaeus vannamei after the successive stimulation of recombinant VP28, Dev Comp Immunol, 2014, 第 5 作者
（5） A new fibrinogen-related protein from Argopecten irradians (AiFREP-2) with broad recognition spectrum and bacteria agglutination activity, Fish Shellfish Immunol , 2014, 第 5 作者
（6） The modulation of catecholamines on immune response of scallop Chlamys farreri under heat stress, GenerComp Endocrino, 2014, 第 5 作者
（7） The essential roles of core binding factors CfRunt and CfCBFβ in hemocyte production of scallop Chlamys farreri, Dev Comp Immunol, 2014, 第 5 作者
（8） The specifically enhanced cellular immune responses in Pacific oyster (Crassostrea gigas) against secondary challenge with Vibrio splendidus, Dev Comp Immunol, 2014, 第 5 作者
（9） Acetylcholine modulates the immune response in Zhikong scallop Chlamys farreri, Fish Shellfish Immunol , 2014, 第 5 作者
（10） A low-density lipoprotein receptor-related protein (LRP)-like molecule identified from Chlamys farreri participated in immune response against bacterial infection, Fish Shellfish Immunol , 2014, 第 5 作者
（11） The immune responses triggered by CpG ODNs in shrimp Litopenaeus vannamei are associated with LvTolls, Dev Comp Immunol , 2014, 第 5 作者
（12） The protein expression profile in hepatopancreas of scallop Chlamys farreri under heat stress and Vibrio anguillarum challenge, Fish Shellfish Immunol , 2014, 第 5 作者
（13） The immunomodulation of inducible hydrogen sulfide in Pacific oyster Crassostrea gigas, Dev Comp Immunol , 2014, 第 5 作者
（14） A high mobility group box 1 (HMGB1) gene from Chlamys farreri and the DNA-binding ability and pro-inflammatory activity of its recombinant protein, Fish Shellfish Immunol , 2014, 第 5 作者
（15） A double WAP domain-containing protein from Chinese mitten crab Eriocheir sinensis with antimicrobial activities against Gram-negative bacteria and yeast, Dev Comp Immunol, 2012, 第 5 作者
（16） A novel C1qDC protein acting as pattern recognition receptor in scallop Argopecten irradians, Fish Shellfish Immunol, 2012, 第 5 作者
（17） The phenoloxidase activity and antibacterial function of a tyrosinase from scallop Chlamys farreri, Fish Shellfish Immunol, 2012, 第 5 作者
（18） An iodothyronine deiodinase from Chlamys farreri and its induced mRNA expression after LPS stimulation, Fish Shellfish Immunol, 2012, 第 5 作者
（19） The expression of dopa decarboxylase and dopamine beta hydroxylase and their responding to bacterial challenge during the ontogenesis of scallop Chlamys farreri, Fish Shellfish Immunol, 2012, 第 5 作者
（20） The arginine kinase in Zhikong scallop Chlamys farreri is involved in immunomodulation, Dev Comp Immunol, 2012, 第 5 作者
（21） Association of CfLGBP gene polymorphism with disease susceptibility/resistance of Zhikong scallop (Chlamys farreri) to Listonella anguillarum, Fish Shellfish Immunol, 2012, 第 5 作者
（22） A novel cold-regulated cold shock domain containing protein from scallop Chlamys farreri with nucleic acid-binding activity, PLoS One, 2012, 第 5 作者
（23） Alternation of immune parameters and cellular energy allocation of Chlamys farreri under ammonia-N exposure and Vibrio anguillarum challenge, Fish Shellfish Immunol, 2012, 第 5 作者
（24） The immunomodulation of acetylcholinesterase in zhikong scallop Chlamys farreri, PLoS One, 2012, 第 5 作者
（25） A multi-CRD C-type lectin with broad recognition spectrum and cellular adhesion from Argopectenirradians, Dev Comp Immunol, 2012, 第 5 作者
（26） A gamma-aminobutyrate type A receptor-associated protein involved in the immune response of Eriocheir sinensis, Int J Immunogenet, 2012, 第 5 作者
（27） A macrophage migration inhibitory factor like gene from scallop Chlamys farreri: Involvement in immune response and wound healing., Dev Comp Immunol, 2011, 第 5 作者
（28） A dopamine beta hydroxylase from Chlamys farreri and its induced mRNA expression in the haemocytes after LPS stimulation., Fish Shellfish Immunol, 2011, 第 5 作者
（29） A novel type III crustin (CrusEs2) identified from Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol, 2011, 第 5 作者
（30） A dopa decarboxylase modulating the immune response of scallop Chlamys farreri., PLoS One, 2011, 第 5 作者
（31） A TRAF and TNF receptor-associated protein (TTRAP) in mollusk with endonuclease activity., Dev Comp Immunol, 2011, 第 5 作者
（32） An interleukin-2 enhancer binding factor 2 homolog involved in immune response from Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol., 2011, 第 5 作者
（33） A monoamine oxidase from scallop Chlamys farreri serving as an immunomodulator in response against bacterial challenge., Dev Comp Immunol, 2011, 第 5 作者
（34） C-type lectin in Chlamys farreri (CfLec-1) mediating immune recognition and opsonization., PLoS One, 2011, 第 5 作者
（35） A novel C-type lectin from bay scallop Argopecten irradians (AiCTL-7) agglutinating fungi with mannose specificity., Fish Shellfish Immunol, 2011, 第 5 作者
（36） A galectin with quadruple-domain from bay scallop Argopecten irradians is involved in innate immune response., Dev Comp Immunol, 2011, 第 5 作者
（37） A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri., Dev Comp Immunol, 2011, 第 5 作者
（38） A novel scavenger receptor-cysteine-rich (SRCR) domain containing scavenger receptor identified from mollusk mediated PAMP recognition and binding., Dev Comp Immunol, 2011, 第 5 作者
（39） A macrophage migration inhibitory factor like gene from scallop Chlamys farreri: Involvement in immune response and wound healing., Dev Comp Immunol, 2011, 第 5 作者
（40） AiCTL-6, a novel C-type lectin from bay scallop Argopecten irradians with a long C-type lectin-like domain., Fish Shellfish Immunol, 2011, 第 5 作者
（41） Identification and characterization of a Cystatin gene from Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol, 2010, 第 5 作者
（42） Peptidoglycan recognition protein of Chlamys farreri (CfPGRP-S1) mediates immune defenses against bacterial infection., Dev Comp Immunol., 2010, 第 5 作者
（43） CfLGBP, a pattern recognition receptor in Chlamys farreri involved in the immune response against various bacteria., Fish Shellfish Immunol, 2010, 第 5 作者
（44） An ancient C-type lectin in Chlamys farreri (CfLec-2) that mediate pathogen recognition and cellular adhesion., Dev Comp Immunol, 2010, 第 5 作者
（45） cDNA cloning and mRNA expression of a selenium-dependent glutathione peroxidase from Zhikong scallop Chlamys farreri., Comp Biochem Physiol B Biochem Mol Biol, 2010, 第 5 作者
（46） A Dicer-1 gene from white shrimp Litopenaeus vannamei: expression pattern in the processes of immune response and larval development., Fish Shellfish Immunol., 2010, 第 5 作者
（47） The second anti-lipopolysaccharide factor (EsALF-2) with antimicrobial activity from Eriocheir sinensis., Dev Comp Immunol, 2010, 第 5 作者
（48） AiC1qDC-1, a novel gC1q-domain-containing protein from bay scallop Argopecten irradians with fungi agglutinating activity., Dev Comp Immunol, 2010, 第 5 作者
（49） Cflec-5, a pattern recognition receptor in scallop Chlamys farreri agglutinating yeast Pichia pastoris., Fish Shellfish Immunol., 2010, 第 5 作者
（50） Molecular characterization and expression of a crustin-like gene from Chinese mitten crab, Eriocheir sinensis., Dev Comp Immunol, 2010, 第 5 作者
（51） An inhibitor kappaB homologue from bay scallop Argopecten irradians., Fish Shellfish Immunol, 2010, 第 5 作者
（52） Two novel secreted ferritins involved in immune defense of Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol, 2010, 第 5 作者
（53） Two novel secreted ferritins involved in immune defense of Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol, 2010, 第 5 作者
（54） Protective immunity induced by CpG ODNs against white spot syndrome virus (WSSV) via intermediation of virus replication indirectly in Litopenaeus vannamei., Dev Comp Immunol., 2010, 第 5 作者
（55） An immune responsive multidomain galectin from bay scallop Argopectens irradians., Fish Shellfish Immunol, 2010, 第 5 作者
（56） A putative endocrine factor SIBD (single insulin binding domain protein) involved in immune response of Chinese mitten crab Eriocheir sinensis., Fish Shellfish Immunol, 2010, 第 5 作者
（57） AiCTL-6, a novel C-type lectin from bay scallop Argopecten irradians with a long C-type lectin-like domain., Fish Shellfish Immunol, 2010, 第 5 作者
（58） The involvement of HSP22 from bay scallop Argopecten irradians in response to heavy metal stress, Mol Biol Rep., 2010, 第 5 作者
（59） The involvement of suppressors of cytokine signaling 2 (SOCS2) in immune defense responses of Chinese mitten crab Eriocheir sinensis., Dev Comp Immunol, 2010, 第 5 作者
（60） The first molluscan TCTP in Venerupis philippinarum: molecular cloning and expression analysis., Fish Shellfish Immunol., 2010, 第 5 作者
（61） Identification of two small heat shock proteins with different response profile to cadmium and pathogen stresses in Venerupis philippinarum., Cell Stress Chaperones, 2010, 第 5 作者
（62） Molecular cloning and expression of a Relish gene in Chinese mitten crab Eriocheir sinensis., International Journal of Immunogenetics, 2010, 第 5 作者


发表著作（ 1 ）双壳贝类免疫, Bivalve immunity. Invertebrate immunity., Landes Bioscience and Springer Science, 2010-06, 第 1 作者
（ 2 ）无脊椎动物免疫, Bivalve immunity. Invertebrate immunity, Landes Bioscience and Springer Science, 2010-06, 第 1 作者

科研活动

科研项目（ 1 ）对虾的抗病及免疫物质应用原理与途径, 主持, 国家级, 2006-10--2010-10
（ 2 ）重要生产性状关键基因的发掘与应用技术, 主持, 国家级, 2006-10--2010-11
（ 3 ）农业部贝类产业技术体系病害防控岗位专家, 主持, 国家级, 2008-11--2015-10
（ 4 ）扇贝免疫识别的分子机制, 主持, 国家级, 2008-01--2011-12
（ 5 ）扇贝免疫防御的分子机制, 主持, 国家级, 2009-12--2012-12
（ 6 ）海水养殖动物主要病毒性疫病爆发机理与免疫防治的基础研究, 主持, 国家级, 2012-01--2016-12


参与会议（1）第10届海峡两岸细胞生物学学术研讨会 第10届海峡两岸细胞生物学学术研讨会 宋林生 2014-04-23
（2）The Preliminary Study on the Molecular Mechanism of Immune Defense in Scallop Linsheng Song, Lingling Wang, Limei Qiu, Huan Zhang 2011-04-20
（3）Identification and characterization of genes involved in immune system of scallops Linsheng Song 2010-11-18
（4）The immunity system of scallop. Linsheng Song 2010-10-12
（5）The catecholaminergic modulation of the immune response in scallops Chlamys farreri. Zhi Zhou 2010-10-08
（6） C-type lectin in Chlamys farreri (CfLec-3) mediates immune recognition and opsonization Jialong Yang 2010-10-08
（7）The complement-like molecules identified from scallops Lingling Wang 2010-10-08
（8）Protective immunity induced by CpG ODNs against white spot syndrome virus (WSSV) via intermediation of virus replication indirectly in Litopenaeus vannamei Ying Zhang 2010-06-20

合作情况

项目协作单位
指导学生