1、招生信息2、教育背景3、工作经历4、教授课程5、专利与奖励6、出版信息7、科研活动8、合作情况9、指导学生
基本信息
孙黎 女 博导 中国科学院海洋研究所
电子邮件： lsun@ms.qdio.ac.cn
通信地址： 青岛市南海路7号
邮政编码： 266071
研究领域
招生信息

招生专业070703


招生方向鱼类免疫与病害（细菌、病毒）防治

教育背景1992-09--1999-01 美国波士顿大学 理学博士
1987-09--1990-06 南开大学 理学硕士
1983-09--1987-06 南开大学 理学学士


学历

学位
工作经历

工作简历2005-01~现在, 中国科学院海洋研究所, 研究员
1999-02~2003-11,英国牛津大学和美国哈佛大学, 博士后
1992-09~1999-01,美国波士顿大学, 理学博士
1991-09~1992-08,美国波士顿大学, Research assistant
1987-09~1990-06,南开大学, 理学硕士
1983-09~1987-06,南开大学, 理学学士


社会兼职
教授课程微生物与免疫学文献阅读
Seminar
免疫学
免疫学文献阅读
基础分子微生物学
分子微生物学技术原理

专利与奖励

奖励信息

专利成果
出版信息

发表论文（1） Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-？B-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus)., Dev Comp Immunol, 2015, 第 5 作者
（2） CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif., Dev Comp Immunol , 2015, 第 5 作者
（3） CD83 is required for the induction of protective immunity by a DNA vaccine in a teleost model, Dev Comp Immunol , 2015, 第 5 作者
（4） Edwardsiella tarda evades serum killing by preventing complement activation via the alternative pathway, Fish Shellfish Immunol, 2015, 第 5 作者
（5） Pseudomonas fluorescens: Fur is required for multiple biological properties associated with pathogenesis, Vet Microbiol, 2015, 第 5 作者
（6） Edwardsiella tarda Sip1: A serum-induced zinc metalloprotease that is essential to serum resistance and host infection., Vet Microbiol, 2015, 第 5 作者
（7） Edwardsiella tarda MliC: a lysozyme inhibitor that participates in pathogenesis in a manner that parallels Ivy, Infect Immun, 2015, 第 5 作者
（8） Pseudomonas fluorescens: iron-responsive proteins and their involvement in host infection., Vet Microbiol, 2015, 第 5 作者
（9） P247 and P523: two in vivo-expressed megalocytivirus proteins that induce protective immunity and are essential to viral infection, Plos ONE, 2015, 第 5 作者
（10） Edwardsiella tarda-regulated proteins in Japanese flounder (Paralichthys olivaceus): identification and evaluation of antibacterial potentials, J Proteomics, 2015, 第 5 作者
（11） Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection, Dev Comp Immunol, 2014, 第 5 作者
（12） Turbot (Scophthalmus maximus) hepcidin-1 and hepcidin-2 possess antimicrobial activity and promote resistance against bacterial and viral infection, Fish Shellfish Immunol, 2014, 第 5 作者
（13） Edwardsiella tarda Hfq: impact on host infection and global protein expression, Vet Res, 2014, 第 5 作者
（14） Streptococcus iniae SF1: complete genome sequence, proteomic profile, and immunoprotective antigens., Plos ONE, 2014, 第 5 作者
（15） Sil: a Streptococcus iniae bacteriocin with dual role as an antimicrobial and an immunomodulator that inhibits innate immune response and promotes S. iniae infection, Plos ONE, 2014, 第 5 作者
（16） In-depth profiling and analysis of host and viral microRNAs in Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus reveal involvement of microRNAs in host-virus interaction in teleost fish, BMC Genomics, 2014, 第 5 作者
（17） Nuclear factor 45 of tongue sole (Cynoglossus semilaevis): evidence for functional differentiation between two isoforms in immune defense against viral and bacterial pathogens, Dev Comp Immunol, 2014, 第 5 作者
（18） Poly(I:C) induces antiviral immune responses in Japanese flounder (Paralichthys olivaceus) that require TLR3 and MDA5 and is negatively regulated by Myd88, Plos ONE, 2014, 第 5 作者
（19） NKLP27: a teleost NK-lysin peptide that modulates immune response, induces degradation of bacterial DNA, and inhibits bacterial and viral infection, Plos ONE, 2014, 第 5 作者
（20） C7: a CpG oligodeoxynucleotide that induces protective immune response against megalocytivirus in Japanese flounder (Paralichthys olivaceus) via toll-like receptor 9-mediated signaling pathway, Dev Comp Immunol, 2014, 第 5 作者
（21） Antibacterial and antiviral properties of tongue sole (Cynoglossus semilaevis) high mobility group B2 protein are largely independent on the acidic C-terminal domain., Fish Shellfish Immunol, 2014, 第 5 作者
（22） Characterization of a c-type lysozyme of Scophthalmus maximus: expression, activity, and antibacterial effect, Fish Shellfish Immunol., 2013, 第 5 作者
（23） 3.Chen C, Chi H, Sun B, Sun L. The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis., Dev Comp Immunol, 2013, 第 5 作者
（24） Macrophage migration inhibitory factor of Sciaenops ocellatus regulates immune cell trafficking and is involved in pathogen-induced immune response, Dev Comp Immunol, 2013, 第 5 作者
（25） The C-reactive protein of tongue sole Cynoglossus semilaevis is an acute phase protein that interacts with bacterial pathogens and stimulates the antibacterial activity of peripheral blood leukocytes., Fish Shellfish Immunol., 2013, 第 5 作者
（26） Identification and characterization of a cell surface scavenger receptor cysteine-rich protein of Sciaenops ocellatus: bacterial interaction and its dependence on the conserved structural features of the SRCR domain, Fish Shellfish Immunol., 2013, 第 5 作者
（27） Selection of normalization factors for quantitative real time RT-PCR studies in Japanese flounder (Paralichthys olivaceus) and turbot (Scophthalmus maximus) under conditions of viral infection, Vet Immunol Immunopathol., 2013, 第 5 作者
（28） Complete genome sequence and transcription profiles of the rock bream iridovirus RBIV-C1., Dis Aquat Org. , 2013, 第 5 作者
（29） SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop., Dev Comp Immunol. , 2013, 第 5 作者
（30） A NK-lysin from Cynoglossus semilaevis enhances antimicrobial defense against bacterial and viral pathogens. , Dev Comp Immunol. , 2013, 第 5 作者
（31） Comparative study of four flagellins of Vibrio anguillarum: vaccine potential and adjuvanticity., Fish Shellfish Immunol., 2013, 第 5 作者
（32） Overexpression of NF-？B inhibitor alpha in Cynoglossus semilaevis impairs pathogen-induced immune response., DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 第 5 作者
（33） A peptidoglycan recognition protein from Sciaenops ocellatus is a zinc amidase and a bactericide with a substrate range limited to Gram-positive bacteria., FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 5 作者
（34） CsCXCe1: a novel Cynoglossus semilaevis CXC chemokine that functions as a chemoattractant and an immunomodulator for peripheral blood leukocytes, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 第 5 作者
（35） Cynoglossus semilaevis thioredoxin: a reductase and an antioxidant with immunostimulatory property, CELL STRESS AND CHAPERONES, 2012, 第 5 作者
（36） Edwardsiella tarda DnaK: expression, activity, and the basis for the construction of a bivalent live vaccine against E. tarda and Streptococcus iniae, FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 5 作者
（37） A divalent DNA vaccine based on Sia10 and OmpU induces cross protection against Streptococcus iniae and Vibrio anguillarum in Japanese flounder, FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 5 作者
（38） Development and efficacy of an attenuated Vibrio harveyi vaccine candidate with cross protectivity against Vibrio alginolyticus., FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 5 作者
（39） Molecular characterization of Cynoglossus semilaevis CD28, FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 5 作者
（40） Inv1: an Edwardsiella tarda invasin and a protective immunogen that is required for host infection., FISH AND SHELLFISH IMMUNOLOGY, 2012, 第 5 作者
（41） Edwardsiella tarda Eta1: an in vivo-induced antigen that is involved in host infection, INFECTION AND IMMUNITY, 2012, 第 5 作者
（42） Construction and evaluation of a live vaccine against Edwardsiella tarda and Vibrio harveyi: laboratory vs mock field trial, Vaccine, 2011, 第 5 作者
（43） Edwardsiella tarda DnaJ is a virulence-associated molecular chaperone with immunoprotective potential, Fish and Shellfish Immunology , 2011, 第 5 作者
（44） A pathogenic Vibrio harveyi lineage causes recurrent disease outbreaks in cultured Japanese flounder (Paralichthys olivaceus) and induces apoptosis in host cells, Aquaculture, 2011, 第 5 作者
（45） Ferritin M of Cynoglossus semilaevis: an iron binding protein and a broad-spectrum antimicrobial that depends on the integrity of the ferroxidase center and nucleation center for biological activity., Fish and Shellfish Immunology , 2011, 第 5 作者
（46） An inflammatory CC chemokine of Cynoglossus semilaevis is involved in immune defense against bacterial infection, Fish and Shellfish Immunology , 2011, 第 5 作者
（47） Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus)., Fish and Shellfish Immunology , 2011, 第 5 作者
（48） HtpG is involved in the pathogenesis of Edwardsiella tarda, Veterinary Microbiology, 2011, 第 5 作者
（49） A multivalent killed whole-cell vaccine induces effective protection against Edwardsiella tarda and Vibrio anguillarum., Fish and Shellfish Immunology , 2011, 第 5 作者
（50） Suppressor of cytokine signaling 3 inhibits head kidney macrophage activation and cytokine expression in Scophthalmus maximus, Developmental and Comparative Immunology , 2011, 第 5 作者
（51） The tissue factor pathway inhibitor 1 of Sciaenops ocellatus possesses antimicrobial activity and is involved in the immune response against bacterial infection, Developmental and Comparative Immunology , 2011, 第 5 作者
（52） The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation, Developmental and Comparative Immunology , 2011, 第 5 作者
（53） CXCL8 of Scophthalmus maximus: expression, biological activity, and immunoregulatory effect, Developmental and Comparative Immunology , 2011, 第 5 作者
（54） Construction and analysis of the immune effect of an Edwardsiella tarda DNA vaccine encoding a D15-like surface antigen, Fish and Shellfish Immunology, 2011, 第 5 作者
（55） Identification and analysis of the tissue factor pathway inhibitor 2 of Sciaenops ocellatus. , Fish and Shellfish Immunology , 2011, 第 5 作者
（56） The g-type lysozyme of Scophthalmus maximus has a broad substrate spectrum and is involved in the immune response against bacterial infection, Fish and Shellfish Immunology , 2011, 第 5 作者
（57） Comparative study of the immune effect of an Edwardsiella tarda antigen in two forms: subunit vaccine vs DNA vaccine., Vaccine, 2011, 第 5 作者
（58） A bivalent Vibrio harveyi DNA vaccine induces strong protection in Japanese flounder (Paralichthys olivaceus), Vaccine, 2011, 第 5 作者
（59） Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus)., Fish and Shellfish Immunology , 2011, 第 5 作者
（60） Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property, Fish and Shellfish Immunology , 2011, 第 5 作者


发表著作
科研活动

科研项目（ 1 ）鱼类疫病免疫防治的系统疫苗学原理与技术途径, 主持, 国家级, 2012-01--2016-12
（ 2 ）鱼类致病性荧光假单胞菌铁调控系统的识别、功能分析及其在病害防治中的应用探索, 主持, 国家级, 2013-01--2016-12
（ 3 ）迟缓爱德华氏菌关键免疫逃逸因子及其作用机制和应用潜能, 主持, 国家级, 2014-01--2018-12
（ 4 ）热液生态系统生物群落特征, 主持, 部委级, 2013-11--2017-12


参与会议
合作情况

项目协作单位
指导学生