姓名：杨慧 性别：女 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：帕金森病分子机制及诊治新途径 电子信箱：huiyang@ccmu.edu.cn


社会任职
1. 北京神经科学学会理事
2. 北京党外高级知识分子联谊会理事
3. 中国神经科学学会神经退行性疾病分会委员会委员
个人简历
1. 198709-199007:大连医科大学 硕士研究生
2. 199009-199307:荷兰阿姆斯特丹自由大学 访问
3. 199309-199409:美国科罗拉多州立大学 博士后
4. 199409-199609:首都医科大学神经科学研究所 副教授
5. 199609-199809:美国迈阿密大学 访问教授
6. 199810-200609:首都医科大学神经科学研究所 教授
7. 200610-:首都医科大学基础医学院神经生物系 教授
重要学术论文
1. Jia Liu, Weijin Liu, Ruolin Li， Hui Yang*.Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment. cells. 2019,8（7）:712.SCI
2. Jia Liu, Weijing Liu, Hui Yang*.Balancing Apoptosis and Autophagy for Parkinson's Disease Therapy: Targeting BCL2. ACS Chem. Neurosci.. 2019,10:792-802.SCI
3. Zhipeng Wang, Ge Gao, Chunli Duan, Hui Yang*.Progress of immunotherapy of anti-α-synuclein in Parkinson's disease. Biomedicine & Pharmacotherapy. 2019,115:108843.SCI
4. Lingling Lu, Huanzhen Jia, Ge Gao, Chunli Duan, Jing Ren, Yi Li and Hui Yang*.Pink1 Regulates Tyrosine Hydroxylase Expression and Dopamine Synthesis. Journal of Alzheimer's Disease. 2018,63:1361-1371.SCI
5. Weiwei Yang#,Xue Wang#, Jia Liu#, Chunli Duan, Ge Gao, Lingling Lu, Shun Yu, Hui Yang*.PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation . oncotarget. 2018,9(1):37-53.SCI
6. Hao Tian, Yongquan Lu, Jia Liu, Chunli Duan, Ge Gao, Hui Yang*.Leucine Carboxyl Methyltransferase Downregulation, and Protein Phosphatase Methylesterase Upregulation Contribute Towards the Inhibition of Protein Phosphatase 2A by α-Synuclein. Frontiers in Aging Neuroscience. 2018,10:e173 .SCI
7. Jia liu, Weijin Liu, Chunli Duan, Lingling, Lu, Ge Gao, Hui Yang*.Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. 2018,14(5):845-861.SCI
8. Jia Liu#, Xue Wang, Yongquan Lu, Chunli Duan, Ge Gao, Lingling Lu, Hui Yang*.Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy. Cell Death Dis. 2017,8(9):e3056.SCI
9. Lingling Lu. Shasha Zhao. Ge Gao. Xiaohong Sun. Huanying Zhao. Hui Yang*.DJ-1/PARK7, But Not Its L166P Mutant Linked to Autosomal Recessive Parkinsonism, Modulates the Transcriptional Activity of the Orphan Nuclear Receptor Nurr1 In Vitro and In Vivo. Mol Neurobiol. 2016,53：:7363-7374.SCI
10. Jia Liu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang and Hui Yang*.Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson’s disease model.. Oncotarget. 2016, 7(38): 60823-60843.SCI
11. Hao Wang, Jia Liu, Ge Gao, Xia Wu, Xiaomin Wang, Hui Yang*.Protection effect of piperine and piperlonguminine from Piper longum??L. alkaloids against rotenone induced neuronal injury. Brain Research . 2016,1639: 214-227.SCI
12. Yi Wang, Jia Liu, Min Chen, Tingting Du, Chunli Duan, Ge Gao, Hui Yang*.The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity. Int J Biochem Cell B. 2016,75 :34–44.SCI
13. Huilin Zhang, Jia Liu, Xue Wang, Chunli Duan, Xiaomin Wang, Hui Yang*. V63 and N65 of overexpressed α-synuclein are involved in mitochondrial dysfunction. Brain Research. 2016, 1642 :308–318.SCI
14. Shanshan Gao, Chunli Duan, Ge Gao, Xiaoming Wang, Hui Yang*.Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. Int J Biochem Cell B. . 2015,64:25-33.SCI
15. Gao Hua, Lan Xiaolei, Yang Weiwei, Wang Hao, Zhu Yuangang, Liu Dongmei, Zhang Yazhuo*, Yang Hui*.Protein phosphatase 2A is involved in the tyrosine hydroxylase phosphorylation regulated by α-synuclein. Neurochemical Research. 2015,40:428-437.SCI
16. Chen Y, Yang W, Li X, Li X, Yang H, Xu Z, Yu S*.α-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca(2+) influx upon NMDA stimulation. Neuroscience. 2015,300:297-306.SCI
17. Ying Bi, Peng-Cheng Qu, Qing-Song Wang, Li Zheng, Hao-Long Liu, Rong Luo, Xiao-Qing Chen, Yin-Ying Ba, Xia Wu*, and Hui Yang*.Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson's disease.. Pharm. Biol. . 2015,53（10）:1516-1524 .SCI
18. Tingting Du, Le Wang, Chunli Duan, Lingling Lu, Jianliang Zhang, Ge Gao, Xiaobo Qiu, Xiaomin Wang, Hui Yang*.GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PP2A. Autophagy . 2015,11(10)::1803-1820.SCI
19. H. Zhang, C. Duan, H. Yang*.Defective Autophagy in Parkinson’s Disease: Lessons from Genetics. Molecular Neurobiology . 2015, 51 (1):: 89-104.SCI
20. Jiamei Shen, Tingting Du, Xue Wang, Chunli Duan, Ge Gao, Jianliang Zhang, Lingling Lu, Hui Yang*. α-Synuclein amino terminus regulates mitochondrial membrane permeability. Brain Research. 2014,159:14-26.SCI
21. Zhao Huanying, Gu Wei, Ye Ling, Yang Hui*. Biodistribution of PAMAM dendrimer conjugated magnetic nanoparticles in mice. . J Mater Sci Mater Med. . 2014, 25(3):769-776 .SCI
22. Zhao H, Gu W, Ye L, Yang H*.Biodistribution of PAMAM dendrimer conjugated magnetic nanoparticles in mice. J Mater Sci Mater Med. 2014, 25(3):769-776 .SCI
23. W. Yang, X. Wang, C. Duan, L. Lu, H. Yang*.Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex. Neurochemistry International. 2013,63(3) :180-194.SCI
24. Lu L, Zhang C, Cai Q, Lu Q, Duan C, Zhu Y, Yang H*.Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats. Acta Biochim Biophys Sin.. 2013,45（3）:170－178.SCI
25. Hua Gao, Weiwei Yang, Zhifeng Qi, Lingling Lu, Chunli Duan, Chunli Zhao, Hui Yang.* .DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK dependent mitophagy. J Mol Biol. . 2012,423:232－248.SCI
26. Jia Wei Zhu, Ji Fang Yuan, Hui Min Yang, Shu Ting Wang, Chen Guang Zhang, Li Li Sun, Hui Yang*, Hong Zhang*.Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity. Biochimie . 2012,94 :617-627 .SCI
27. Zhifeng Qi, Weiwei Yang, Tao Cui, Hua Gao, Chunli Duan, Lingling Lu, Chunli Zhao, Huanying Zhao, Hui Yang*. Loss of PINK1 function promotes autophagy via PP2A inactivation in dopaminergic cells and a murine model. . Neurochemistry International . 2011,59 (5):572-581.SCI
28. Tao Cui, Chunxiang Fan, Li Gu, Hua Gao, Qi Liu, Tao Zhang, Zhifeng Qi, Chunli Zhao, Huanying Zhao, Qing Cai, Hui Yang*.Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells. Brain Research . 2011,1394 :1-13.SCI
29. Ling Zhang,* Hui Yang,* Huanying Zhao, Chunli Zhao..Calcium-related signaling pathways contributed to dopamine-induced cortical neuron apoptosis.. Neurochemistry International. 2011,58(3) :281-294.SCI
30. Yuangang Zhu, Chunli Duan#, LiLv, Hua Gao, Chunli Zhao, Shun Yu, Kenji Ueda, Piu Chan, Hui Yang*..α–Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator.. INT J BIOCHEM CELL B. . 2011,43 (5):732-741.SCI
31. Bo Wu, Qi Liu, Chunli Duan, Yaohua Li, Shun Yu, Piu Chan, Kenji Uéda, Hui Yang*.Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells.. Acta Histochemica . 2011,113 : 32-35 .SCI
32. Lu LL, Gu L, Liang Y, Yang H*.Dual effects of alpha-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells. Science China-Life Sciences . 2010,53 (5):590-597 .SCI
33. Jingxian Yu, Huanying Zhao, Ling Ye*, Hui Yang*. Shuting Ku, Nan Yang and Ning Xiao.Effect of surface functionality of magnetic silica nanoparticles on the cellular uptake by glioma cells in vitro. Journal of Materials Chemistry. 2009,19 :1265–1270.SCI
34. Li Gu, Tao Cui, Chunxiang Fan, Huanying Zhao, Chunli Zhao, Lingling Lu, Hui Yang*..Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress. Biochem. Bioph. Res. Co.. 2009,383 :469–474.SCI
35. Na Li, Hui Yang*, Lingling Lu, Chunli Duan, Chunli Zhao, Huanying Zhao.Comparison of the labeling efficiency of BrdU, DiI and FISH labeling techniques in bone marrow stromal cells. Brain Research . 2008,1215 :11-19.SCI
36. Dongmei Liu, Ling Jin, Hao Wang, Huanying Zhao Chunli Zhao Hui Yang*.RNA interference mediated silencing of α-synuclein in MN9D cells and its effects on cell viability. Neurosci Bull . 2008,24 (2) :96-104.无
37. Fengqing Ji, Yi Wang, Haimei Sun, Juan Du, Danni Wang, Huanying Zhao, Deyi Duan*, Hui Yang*, and Qunyuan Xu.Human Umbilical Cord Blood-Derived Non- Hematopoietic Stem Cells Suppress T-lymphocyte Proliferation and CD4, CD8 expression. Journal of Neuroimmunology. 2008,197(2): 99–109.SCI
38. Ling Jin Hui Yang*.a-Synuclein aggregation and Parkinson’s Disease: factors affecting the aggregation of a-Synuclein. Prog. Biochem. Biophys. 2006,33（4）:321-328.SCI
39. Duan Chun-li,SUN Xiao-hong,JI Man YANG Hui*. Effects of glutamate and MK–801 on the metabolism of dopamine in the striatum of normal and parkinsonian rats.. Acta physiologica sinica. 2005,57(1):71-76.SCI
主编或副主编的著作/译著
重要奖项
1. 一种丝氨酸129位磷酸化alpha-突触核蛋白聚集体的ELISA检测方法 中国发明专利 2017.7
2. 北京科技进步一等奖 帕金森病的发病机制、预警和干预研究 一等奖 201511
3. 国家发明专利 来自荜茇的提取物及其制备方法与应用 发明专利 201109
4. 永生化大鼠骨髓基质细胞系及其制备方法 中国发明专利号：3.1 2010
5. 腺相关病毒介导三基因细胞表达系统， 中国发明专利，CN7.X， 2009
6. 国务院政府特殊津贴专家 2004
7. 教育部高等学校优秀骨干教师 2003
8. 北京市优秀跨世纪人才资助奖励 2001