姓名：徐志卿 性别：男 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：神经递质受体和重大脑病 电子信箱：zhiqingx@ccmu.edu.cn


社会任职
1. 中国神经科学学会理事
2. 中国生理学会转化神经科学专业委员会
3. 北京神经科学学会副理事长
4. 北京海外高层次人才协会理事
5. 中国细胞生物学学会神经细胞生物学分会委员
6. 中国神经科学学会应激神经生物学分会主任委员
个人简历
1. 199112-199709:瑞典卡罗琳斯卡医学院神经科学系 博士生, 博士学位
2. 199709-199909:瑞典卡罗琳斯卡医学院神经科学系 博士后
3. 199909-200109:瑞典卡罗琳斯卡医学院医学生化和生物物理系 博士后
4. 200109-200707:瑞典卡罗琳斯卡医学院神经科学系 Forskare(研究员)
5. 200110-200912:中国科学院神经科学研究所 客座研究员
6. 200112-200712:华中科技大学 兼职教授
7. 200811-:首都医科大学神经生物学系 教授
8. 201001-:北京大学分子医学研究所 客座研究员
重要学术论文
1. Luo HJ, Liu ZJ, Liu B, Li H, Yang YT*, Xu ZQD* .Virus-mediated overexpression of ETS-1 in the ventral hippocampus counteracts depression-like behaviors in rats. Neurosci Bull. 2019,35(6):1035-1044.SCI
2. Jing B, Liu B, Li H, Lei JF, Wang ZJ, Yang YT, Sun PZ, Xue B, Liu H, Xu ZQD*..Within-subject test-retest reliability of the atlas-based cortical volume measurement in the rat brain: A voxel-based morphometry study. J Neurosci Methods. 2018,307:46-52.SCI
3. Bai YF, Ma HT, Liu LN, Li H, Li XX, Yang YT, Xue B, Wang D, Xu ZQD*.Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels. Biochem Biophys Res Commun. 2018, 503(1):79-85.SCI
4. Li H, Wang T, Shi CG, Yang YT, Li XX, Wu Y, Xu ZQD*.Inhibition of GALR1 in PFC Alleviates Depressive-Like Behaviors in Postpartum Depression Rat Model by Upregulating CREB-BNDF and 5-HT Levels. Front Psychiatry. 2018,9:588.SCI
5. Yang YT, Liu LT, Luo HJ, Li YT, Li H, Xu ZQD*..Characterization of the Rat GAL2R Promoter: Positive Role of ETS-1 in Regulation of the Rat GAL2R Gene in PC12 Cells. Mol Neurobiol. 2017,54(6):4421-4431.SCI
6. Mei Z, Yang YT*, Li Y, Yang FY, Li JF, Xing NZ, Xu ZQD*..Galanin suppresses proliferation of human U251 and T98G glioma cells via its subtype 1 receptor. Biol Chem. 2017,398(10):1127-1139.SCI
7. Yang YT#*, Li YT#, Di F, Cui JJ, Wang Y, Xu ZQD(徐志卿）*.Pokemon decreases the transcriptional activity of RARα in the absence of ligand. Biol Chem. 2017,398(3):331-340.SCI
8. Yang YT*, Cui JJ, Xue F, Overstreet AM, Zhan Y, Shan D, Li H, Li H, Wang Y, Zhang M, Yu C, Xu ZQD(徐志卿）*.Resveratrol represses Pokemon expression in glioma cells. Mol Neurobiol . 2016,53(2):1266-1278.SCI
9. Yang YT*#, Cui JJ#, Xue F, Zhang CF, Mei Z, Wang Y, Bi MJ, Shan DP, Meredith A, Li H, Xu ZQD（徐志卿）*.Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses.. BBA-Gene Regul Mech. 2015,1849(3):270-281.SCI
10. Keimpema E, Zheng K, Barde SS, Berghuis P, DobszayMB, Schnell R, Mulder J, Luiten PGM, Xu ZQD(徐志卿）, Runesson J, Langel U, Lu B, Tomas Hökfelt T, Harkany T. GABAergic Terminals Are a Source of Galanin to Modulate Cholinergic Neuron Development in the Neonatal Forebrain. Cerebral Cortex. 2014,24(12):3277-3288.SCI
11. Wang Y-J, Yang Y-T, Li H, Wang C-Y, Xu ZQD(徐志卿)*. Plasma galanin is a biomarker for symptom severity of major depressive disorder. . Int J Psychiat Med . 2014,48(2):109-119 .SCI
12. Liu LN, Zhu FP, Song MY, Zhang B, Kuo ST, Liu W, Li ML, Zhou L, Jiao RY, Liu B, Zhang XY, Wang CH, Wang SR, Yang H, Zhou Z and Xu ZQD（徐志卿）*.Effect of cocaine on ion channels and glutamatergic EPSCs in noradrenergic locus coeruleus neurons. J Mol Neurosci. 2014,53(3):345-351.SCI
13. Pan N, Bai Y, Yang Y, Hokfelt T, Xu ZQD（徐志卿）*.Activation of galanin receptor 2 stimulates large conductance Ca2+-dependent K+ (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells. Biochem Biophys Res Commun. 2014,446（1）:316-21.SCI
14. Wang M, Zhang N, Wang W, Wang B, Xu ZQ（徐志卿）, Yang Y.Expression and function of vascular endothelial growth inhibitor in aged porcine bladder detrusor muscle cells. Biogerontology. 2013,14:543-56.SCI
15. Jia W, Lu R, Jia G, Ni M, Xu Z（徐志卿）.Expression of pituitary tumor transforming gene (PTTG) in human pituitary macroadenomas. Tumour Biol. 2013,34(3):1559-67.SCI
16. Wang Y, Yang Y, Li H, Tie C, Li F, Xu ZQD(徐志卿)*, Wang C.Neuropeptide Y Variant (rs16139) Associated with Major Depressive Disorder in Replicate Samples from Chinese Han Population (Recommended by Faculty of 1000) . PLoS ONE . 2013,8(2):e57042.SCI
17. Wang GF, Shi CG, Sun MZ, Wang L, Wu SX, Wang HF, Xu ZQ（徐志卿）, Chen DM.Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL.. Cardiovasc Drugs Ther. 2013,27(3):199-10.SCI
18. Li H, Wang YJ, Yang YT, Zhang M, Zhang D, Wang C, Xu ZQD（徐志卿）*.Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population (Featured on MDLinx.com). Prog Neuro-Psychoph. 2013,45:7–10.SCI
19. Wang YJ, Li H, Yang YT, Tie CL, Li F, Xu Z-QD*（徐志卿）, Wang CY..Association of Galanin and Major Depressive Disorder in the Chinese Han Population. Plos one. 2013,8(5):e64617.SCI
20. Wang W, Zhang N, Zhu XH, He ZS, Wahafu W, Xu ZQD（徐志卿）*, Yang Y .Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly. Mol Med Report. 2012,6:434-8.SCI
21. Wardi-Le Maîtrea T, Xia S, Le Maîtrea E, Dun XP, Lu J, Ögrena SO, Hökfelt T, Xu ZQD(徐志卿）.Galanin receptor 2 overexpressing (GalR2OE) mice display an antidepressive-like phenotype: Possible involvement of the subiculum.. Neuroscience. 2011,190:270-88.SCI
22. Zheng K, An JJ, Yang F, Xu W, Xu ZQD（徐志卿）, Wu J, Hökfelt TG, Fisahn A, Xu B, Lu B .TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus. . Proc Natl Acad Sci U S A. 2011,108:17201-6 .SCI
23. Fu W, Le Maître E, Fabre V, Bernard JF, Xu Z-QD*（徐志卿）, Hökfelt T..Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain. J Comp Neurol. 2010,518(17):3464-2494.SCI
24. Fu W, Le Maıtre E, Fabre V, Bernard JF, Xu ZQD（徐志卿）*, Hökfelt T.Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain.. J Comp Neurol. 2010,518:3464–94.SCI
25. Shi CG, Wang LM, Wu Y, Wang P, Gan ZJ, Lin K, Jiang LX, Xu ZQD（徐志卿）, Fan M .Intranasal administration of nerve growth factor produces antidepressant-like effects in animals. Neurochem Res. 2010,35:1302-14.SCI
26. Vila-Porcile V, Xu ZQD（徐志卿）, Mailly P, Nagy F, Calas A, Hökfelt T, Landry M.Dendritic synthesis and release of the neuropeptide galanin: morphological evidence from studies on rat locus coeruleus neurons. J Comp Neurol. 2009,516:199–212.SCI
27. Shi TJ, Liu SX, Hammarberg H, Watanabe M, Xu ZQD（徐志卿）, Hökfelt T.Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc Natl Acad Sci U S A. 2008,105:20004-8.SCI
28. Xia S，Dun X-P，Hu P-S, Kjaer S, Zheng K, Qian Y, Solén C, Xu T, Fredholm B, Hokfelt T, and Xu Z-QD(徐志卿）* .Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus.. Proc Natl Acad Sci U S A. 2008,105:5609-13.SCI
29. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Chen XW, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu Z-Q D(徐志卿）, Zhou Z.Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci U S A. 2007,104:1401-1406.SCI
30. Lundstrom L, Sollenberg U, Brewer A, Kouya PF, Zheng K, Xu XJ, Sheng X, Robinson JK, Wiesenfeld-Hallin Z, Xu Z-Q D(徐志卿）, Hokfelt T, Bartfai T, Langel U.A galanin receptor subtype 1 specific agonist.. International journal of peptide research and therapeutics . 2005,11:17-27.SCI
31. Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu Z-QD(徐志卿）, Hokfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H, Walker MM, Durkin M, Artymyshyn RP, Smith KE, Jones KJ, Craig DA, Gerald CP, Brancheck TA .From The Cover: Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.. Proc Natl Acad Sci U S A . 2005,102:17489-17494.SCI
32. Xia S, Kjaer S, Zheng K, Hu PS, Xu T, Hokfelt T, Xu Z-Q D(徐志卿）*.Constitutive and ligand-induced internalization of EGFP-tagged galanin R2 and Rl receptors in PC12 cells.. Neuropeptides. 2005,39:173-178.SCI
33. Zheng K, Kuteeva E, Xia S, Bartfai T, Hokfelt T, Xu Z-Q D(徐志卿）*.Age-related impairments of synaptic plasticity in the lateral perforant path input to the dentate gyrus of galanin overexpressing mice.. Neuropeptides. 2005,39:259-267.SCI
34. Xia S, Kjaer S, Kang Z, Hu P-S, Bai L, Jia J, Rigler R, Pramanik A, Xu T, Hokfelt T, Xu Z-Q D(徐志卿）*.Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: Constitutive and ligand-induced internalization.. Proc Natl Acad Sci U S A . 2004,101:15207-15212.SCI
35. Xia S, Xu L, Bai L, Xu Z-Q D(徐志卿）, Xu, T.Labeling and dynamic imaging of synaptic vesicle-like microvesicles in PC12 cells using TIRFM analysis. . Brain Res. 2004,997:159-164.SCI
36. Bao L, Jin S-X, Zhang C, Wang L-H, Xu Z-Z, Zhang F-X, Wang L-C, Ning F-S, Cai H-J, Guan J-S, Xiao H-S, Xu Z-Q D, He C, Hokfelt T, Zhou Z and Zhang X.Activation of delta-opioid receptors induces receptor insertion and neuropeptide secretion.. Neuron. 2003,37:121-133.SCI
37. Fetissov S.O., Xu Z-Q D(徐志卿）, Byrne L.C., Hassani H., Ernfors P. and Hokfelt T.NPY targets in the hypothalamus.Nitric oxide synthesizing neurons express Y1 receptor. . J Neuroendocrinology . 2003,15:754-760.SCI
38. Kopp J, Xu Z-Q D(徐志卿）, Zhang X, Pedrazzini T, Herzog H, Kresse A, Wang H, Walsh J, Hokfelt T .Expression of neuropeptide Y1 receptor in the CNS of rat, wild type and Y1 receptor knock-out mouse. Focus on immunohistochemical localization. . Neuroscience . 2002,111:443-532.SCI
39. Ma X, Tong Y-G, Schmidt R, Brown W, Payza K, Hodzic L, Pou C, Godbout C, Hokfelt T, Xu Z-QD(徐志卿）*.Effects of galanin receptor agonists on locus coeruleus neurons.. Brain Res . 2001,919:169-174.SCI
40. Kokaia M, Holmberg K, Nanobashvili A, Xu Z-Q D(徐志卿）, Kokaia Z, Lendahl U, Hilke S, Theodorsson E, Kahl U, Bartfai T, Lindvall O, Hokfelt T.Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.. Proc Natl Acad Sci U S A . 2001,98:14006-14011.SCI
41. Lindgren N, Xu Z-Q D(徐志卿）, Herrere-Marschitz M, Haycock J, Goldstein M, Hokfelt T, Fisone G .Dopamine D2 receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum. Eur J Neurosci . 2001,13:773-780.SCI
42. Shi T-J S, Tandrup T, Bergman E, Xu Z-Q D(徐志卿）, Ulfhake B, Hokfelt T.Effect of peripheral nerve injury on neuronal cell numbers and neuropeptide expression in mouse dorsal root ganglia. . Neuroscience . 2001,105:249-263.SCI
43. Xu Z-Q D(徐志卿）*, Tong Y-G, Hokfelt T.Galanin enhances noradrenaline-induced outward current on locus coeruleus noradrenergic neurons. Neuroreport. 2001,12:1779-1782.SCI
44. Lindgren N, Xu Z-Q D(徐志卿）, Lindskog M, Herrere-Marschitz M, Goiny M, Haycock J, Goldstein M, Hokfelt T, Fisone G.Regulation of tyrosine hydroxylase activity and phosphorylation at Ser19 and Ser40 via activation of glutamate NMDA receptors in rat striatum.. J Neurochem . 2000,74:2470-2477.SCI
45. Xu Z-Q D(徐志卿)*, Ma X, Soomets U, Langel U, Hokfelt T.Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons.. Proc Natl Acad Sci U S A. 1999,96:14583-14587.SCI
46. Xu Z-Q D(徐志卿）, Shi TJ, Hokfelt T.Galanin/GMAP- and NPY-like immunoreactivities in locus coeruleus and noradrenergic nerve terminals in the hippocampal formation and cortex with notes on the galanin-R1 and -R2 receptors. . J Comp Neurol . 1998,392:227-251.SCI
47. Shi TJ, Holmberg K, Xu Z-Q D(徐志卿）, Steinbusch H, de Vente J, Hokfelt T.Effect of peripheral nerve injury on cGMP and nitric oxide synthase levels in rat dorsal root ganglia: time course and coexistence.. Pain. 1998,78:171-180.SCI
48. Xu Z-Q D(徐志卿）, Zhang X, Pieribone VA, Grillner S, Hokfelt T.Galanin-5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors.. Neuroscience . 1998,87:79-94.SCI
49. Xu Z-Q D(徐志卿）, Lew JY, Harada K, Aman K, Goldstein M, Deutch A, Haycock JW, Hokfelt T.Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies.. Neuroscience . 1998,82:727-738.SCI
50. Xu Z-Q D(徐志卿）*, Bartfai T, Langel U, Hokfelt T.Effects of three galanin analogs on the outward current evoked by galanin in locus coeruleus.. Ann N Y Acad Sci . 1998,863:459-465.SCI
51. Xu Z-Q D(徐志卿）*, de Vente J, Steinbusch H, Grillner S, Hokfelt T .The NO-cGMP pathway in the rat locus coeruleus: electrophysiological, immunohistochemical and in situ hybridization studies.. Eur J Neurosci. 1998,10:3508-3516.SCI
52. Shi TJ, Zhang X, Holmberg K, Xu Z-Q D(徐志卿）, Hokfelt T. Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation.. Neurosci Lett . 1997,237:57-60.SCI
53. Xu Z-Q D(徐志卿）, Zhang X, Grillner S, Hokfelt T.Electrophysiological studies on rat dorsal root ganglion neurons after peripheral axotomy: changes in responses to neuropeptides.. Proc Natl Acad Sci U S A. 1997,94:13262-13266.SCI
54. Xu Z-Q D(徐志卿）* and Hokfelt T.Expression of galanin and nitric oxide synthase in subpopulations of serotonin neurons of the rat dorsal raphe nucleus.. J Chem Neuroanat . 1997,13:169-187.SCI
55. Yamada K, Xu Z-Q(徐志卿）, Zhang X, Gustafsson L, Hulting AL, de Vente J, Steinbusch HW, Hokfelt T.Nitric oxide synthase and cGMP in the anterior pituitary gland: effect of a GnRH antagonist and nitric oxide donors.. Neuroendocrinology . 1997,65:147-156.SCI
56. Bao L, Kopp J, Zhang X, Xu Z-Q D(徐志卿）, Zhang LF, Wong H, Walsh J, Hokfelt T. Localization of neuropeptide Y Y1 receptors in cerebral blood vessels. Proc Natl Acad Sci U S A . 1997,94:12661-12666.SCI
57. Xu Z-Q(徐志卿）, Shi TJ, Landry M, Hokfelt T .Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation.. Neuroreport . 1996,8:237-242 .SCI
58. Xu Z-Q(徐志卿）, Shi TJ, Hokfelt T.Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos.. Proc Natl Acad Sci U S A. 1996,93:14901-14905.SCI
59. Pieribone VA, Xu Z-Q(徐志卿）, Zhang X, Grillner S, Bartfai T, Hokfelt T.Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience. 1995,64:861-874.SCI
60. Zhang X, Xu Z-Q(徐志卿）, Bao L, Dagerlind A, Hokfelt T.Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomy. J Neurosci . 1995,15:2733-2747.SCI
61. Xu Z-Q(徐志卿）, Pieribone VA, Zhang X, Grillner S, Hokfelt T.A functional role for nitric oxide in locus coeruleus: immunohistochemical and electrophysiological studies. Exp Brain Res. 1994,98:75-83.SCI
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重要奖项