姓名：刘桂友 性别：男 职称：副教授 招生院所：脑重大疾病研究院 招生类型：科学学位(硕) 招生专业：神经生物学(硕) 研究方向名称：阿尔茨海默病的遗传易感性 电子信箱：liuguiyou1981@163.com


社会任职
1. Aging Dis编委
2. J Alzheimers Dis副主编
3. Sci Rep编委
4. 美国国际衰老与疾病学会委员
5. 中国微循环学会神经保护与康复专业委员会青年委员
个人简历
1. 200609-200907:哈尔滨医科大学生物信息科学与技术学院 硕士研究生
2. 201602-201907:哈尔滨工业大学生命科学与技术学院 博士研究生
3. 201907-:首都医科大学北京脑重大疾病研究院 任职
重要学术论文
1. Longcai Wang#, Yanchun Qiao#, Haihua Zhang, Yan Zhang, Jiao Hua, Shuilin Jin, Guiyou Liu*. .Circulating vitamin D levels and Alzheimer’s disease: a Mendelian randomization study in IGAP and UK Biobank. Journal of Alzheimer’s Disease. 2020,73(2):609-618.SCI
2. Haihua Zhang, Tao Wang, Zhifa Han, Longcai Wang, Yan Zhang, Lijun Wang*, Guiyou Liu*..Impact of vitamin D binding protein levels on Alzheimer’s disease: a Mendelian randomization study. Journal of Alzheimer’s Disease. 2020,74(3):991-998.SCI
3. Guiyou Liu#,*, Haihua Zhang, Bian Liu, Tao Wang, Zhifa Han, Xunming Ji*..Rs** variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer’s disease patients compared with controls. Acta Neuropathol. 2020,【未填写卷（期）】:doi: 10.1007/s00401-020-02135-9.SCI
4. Guiyou Liu, Shuilin Jin, Qinghua Jiang..Interleukin 6 receptor and inflammatory bowel disease: a Mendelian randomization study.. Gastroenterology. 2019,156(3):823-824.SCI
5. Guiyou Liu, Yang Hu, Zhifa Han, Shuilin Jin, Qinghua Jiang*. . Genetic variant rs** regulates SIM1 gene expression in human brain hypothalamus.. Proc Natl Acad Sci U S A.. 2019,116(9):3347-3348.SCI
6. Chang-Juan Wei#, Pan Cui#, He Li, Wen-Jing Lang, Gui-You Liu*, Xiao-Feng Ma*.Shared genes between Alzheimer’s disease and ischemic stroke.. CNS Neuroscience & Therapeutics. 2019,25(8):855-864.SCI
7. Guiyou Liu, Yang Hu, Qinghua Jiang. .Population difference and disease status affect the association between genetic variants and gene expression. Gastroenterology. 2019,157(3):894-896.SCI
8. Guiyou Liu*, Haihua Zhang, Bian Liu, Xunming Ji*..Rs** regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer’s disease.. Brain. 2019,142(11):e61.SCI
9. Guiyou Liu, Yi Zhao, Jing-yi Sun, Bao-liang Sun*. .Parkinson’s disease risk variant rs** regulates the expression of INPP5K and CRK in human brain tissues. Neuroscience Bulletin. 2019,35(2):365-368.SCI
10. Yan Zhang#, Longcai Wang#, Haiyang Jia, Mingzhi Liao, Xiaoyun Chen, Jianyong Xu, Yunjuan Bao, Guiyou Liu*. .Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk. . Journal of the Neurological Sciences. 2018,15;390:162-165.SCI
11. Guiyou Liu, Shuilin Jin, Yang Hu, Qinghua Jiang*..Disease status affects the association between rs** and the expression of Alzheimer’s disease susceptibility gene TRIB3. Proc Natl Acad Sci U S A. 2018,115(45):E10519-E10520.SCI
12. Guiyou Liu*, Tao Wang, Rui Tian, Meng Luo, Yang Hu, Zhifa Han, Pingping Wang, Wenyang Zhou, Peng Ren, Jian Zong, Shuilin Jin*, Qinghua Jiang*. .Alzheimer’s disease risk variant rs** regulates GAB2 and NARS2 expression in human brain tissues. Journal of Molecular Neuroscience. 2018,66(1):37-43.SCI
13. Linna Zhao#, Di Liu#, Zhaoyang Wang, Jingxu, Yang chen, Guiyou Liu*, Yongshuai Jiang*. .The framework for population epigenetic study. Briefings in Bioinformatics. 2018,1;19(1):89-100.SCI
14. Guiyou Liu, Shuilin Jin, Yang Hu, Tao Wang, Rui Tian, Zhifa Han, Dandan Xu, Qinghua Jiang*. .Circulating vitamin E levels and Alzheimer’s disease: a Mendelian randomization study.. Neurobiology of Aging. 2018,72:189.e1-189.e9.SCI
15. Guiyou Liu, Yan Zhang, Longcai Wang, Jianyong Xu, Xiaoyun Chen, Yunjuan Bao, Yang Hu, Shuilin Jin, Rui Tian, Weiyang Bai, Wenyang Zhou, Tao Wang, Zhifa Han, Jian Zong, Qinghua Jiang*..Alzheimer's Disease rs** Variant Regulates EPHA1 Gene Expression Specifically in Human Whole Blood. Journal of Alzheimer’s Disease. 2018,61(3):1077-1088.SCI
16. Yang Hu, Shuilin Jin, Liang Cheng, Guiyou Liu*, Qinghua Jiang*..Autoimmune disease variants regulate GSDMB gene expression in human immune cells and whole blood.. Proc Natl Acad Sci U S A. 2017,114(38):E7860-E7862.SCI
17. Guiyou Liu#, Yang Hu#, Shuilin Jin, Qinghua Jiang*..Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.. Proc Natl Acad Sci U S A.. 2017,114(6):E906-E907.SCI
18. Guiyou Liu, Jing-yi Sun, Meiling Xu, Xiao-yi Yang*, Bao-liang Sun*. .SORL1 variants show different association with early onset and late onset Alzheimer’s disease risk. Journal of Alzheimer’s Disease. 2017,58(4):1121-1128.SCI
19. Guiyou Liu#, Fang Zhang#, Yongshuai Jiang, Yang Hu, Zhongying Gong, Shoufeng Liu, Xiuju Chen, Qinghua Jiang*, Junwei Hao*. .Integrating genome-wide association studies and gene expression data highlights disregulated multiple sclerosis risk pathways. Multiple Sclerosis Journal. 2017,23(2):205-212.SCI
20. Guiyou Liu#, Yining Xu#, Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Qinghua Jiang*. .PICALM rs** variant confers susceptibility to Alzheimer’s disease in Chinese population. Molecular Neurobiology. 2017,54(5):3131-3136.SCI
21. Keshen Li, Qinghua Jiang, Anding Xu, Guiyou Liu. .REST rs** variant does not confer susceptibility to Alzheimer’s disease. Annals of Neurology. 2016,78(5):835-6.SCI
22. Guiyou Liu, Qinghua Jiang*. .Alzheimer's disease CD33 rs** variant does not contribute to cognitive performance.. Proc Natl Acad Sci U S A. 2016,113(12):E1589-90.SCI
23. Guiyou Liu, Yang Hu, Shuilin Jin, Fang Zhang, Qinghua Jiang*, Junwei Hao*. .Cis-eQTLs regulate reduced LST1 and NCR3 expression and contribute to increased autoimmune disease risk.. Proc Natl Acad Sci U S A. 2016,113(42):E6321-E6322.SCI
24. Zimin Xiang#, Meiling Xu#, Mingzhi Liao#, Yongshuai Jiang, Qinghua Jiang, Rennan Feng, Liangcai Zhang, Guoda Ma, Guangyu Wang, Zugen Chen, Bin Zhao, Tiansheng Sun*, Keshen Li*, Guiyou Liu*. .Integrating genome-wide association study and brain expression data highlights cell adhesion molecules and purine metabolism in Alzheimer’s disease.. Molecular Neurobiology. 2015,52(1):514-21.SCI
25. Hongyuan Chen#, Guihua Wu#, Yongshuai Jiang, Rennan Feng, Mingzhi Liao, Liangcai Zhang, Guoda Ma, Zugen Chen, Bin Zhao*, Keshen Li*, Chunjiang Yu*, Guiyou Liu*..Analyzing 54936 samples supports the association between CD2AP rs** polymorphism and Alzheimer’s disease susceptibility. Molecular Neurobiology. Molecular Neurobiology. 2015,52(1):1-7.SCI
26. Xingwang Li#, Ning Shen#, Shuyan Zhang#, Jiafeng Liu, Qinghua Jiang, Mingzhi Liao, Rennan Feng, Liangcai Zhang, Guangyu Wang, Guoda Ma, Haihong Zhou, Zugen Chen, Yongshuai Jiang*, Bin Zhao*, Keshen Li*, Guiyou Liu*..CD33 rs** polymorphism contributes to Alzheimer’s disease susceptibility in Chinese, European and North American populations.. Molecular Neurobiology. 2015,52(1):414-21.SCI
27. Guiyou Liu..No association of TREM1 rs** and TREM2 rs** with Alzheimer’s disease. Annals of Neurology. 2015,78(4):659.SCI
28. Hong Shang#, Guiyou Liu#, Yongshuai Jiang, Jin Fu, Benping Zhang, Rongrong Song, Weizhi Wang*. .Pathway analysis of two amyotrophic lateral sclerosis GWAS highlights shared genetic signals with Alzheimer’s disease and Parkinson’s disease. Molecular Neurobiology. 2015,51(1):361-9.SCI
29. Shuyan Zhang#, Donghui Zhang#, Yongshuai Jiang, Lina Wu, Hong Shang, Jiafeng Liu, Rennan Feng, Mingzhi Liao, Liangcai Zhang, Yong Liu, Guiyou Liu* , Keshen Li*. .CLU rs** polymorphism contributes to Alzheimer’s disease susceptibility in Caucasian and Asian populations.. Journal of Neural Transmission. 2015,122 (3):433-9.SCI
30. Ning Shen#, Bin Chen#, Yongshuai Jiang, Rennan Feng, Mingzhi Liao, Liangcai Zhang, Fujun Li, Guoda Ma, Zugen Chen, Bin Zhao*, Keshen Li*, Guiyou Liu*..An updated analysis with 85,939 samples confirms the association between CR1 rs** polymorphism and Alzheimer’s disease.. Molecular Neurobiology. 2015,51(3):1017-23.SCI
31. Xinjie Bao#, Gengfeng Liu#, Yongshuai Jiang, Qinghua Jiang, Mingzhi Liao, Rennan Feng, Liangcai Zhang, Guoda Ma, Shuyan Zhang, Zugen Chen, Bin Zhao, Renzhi Wang*, Keshen Li*, Guiyou Liu*..Cell adhesion molecules pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer’s disease brains. Neurobiology of Aging. 2015,36(10):2904.e1-7.SCI
32. Guiyou Liu#, Xinjie Bao#, Yongshuai Jiang, Mingzhi Liao, Qinghua Jiang, Rennan Feng, Liangcai Zhang, Guoda Ma, Zugen Chen, Guangyu Wang, Renzhi Wang*, Bin Zhao*, Keshen Li*. .Identifying the association between Alzheimer’s disease and Parkinson’s disease using genome-wide association studies and protein-protein interaction network. Molecular Neurobiology. 2015,52(3):1629-36.SCI
33. Guiyou Liu*, Keshen Li.CHCHD2 and Parkinson’s disease. The Lancet Neurology. 2015,14(7):679-80.SCI
34. Guiyou Liu*, Xinjie Bao, Renzhi Wang..Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains. Proc Natl Acad Sci U S A. 2015,112(30):E3975.SCI
35. Guiyou Liu#, Haiyang Wang*,#, Jiafeng Liu#, Jingbo Li, Hali Li, Guoda Ma, Yongshuai Jiang, Zugen Chen, Bin Zhao, Keshen Li*. .The CLU Gene rs** Variant is Significantly Associated with Alzheimer’s Disease in Caucasian and Asian Populations.. NeuroMolecular Medicine. 2014,16(1):52-60.SCI
36. Guiyou Liu#,*, Lifen Yao#, Jiafeng Liu#, Yongshuai Jiang, Guoda Ma, The Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Zugen Chen, Bin Zhao, Keshen Li*. .Cardiovascular disease contributes to Alzheimer’s disease: evidence from large-scale genome-wide association studies. . Neurobiology of Aging. 2014,35(4):786-92.SCI
37. Guiyou Liu#,*, Fujun Li#, Shuyan Zhang#, Yongshuai Jiang, Guoda Ma, Hong Shang, Jiafeng Liu, Rennan Feng, Liangcai Zhang, Mingzhi Liao, Bin Zhao, Keshen Li*. .Analyzing large-scale samples confirms the association between the ABCA7 rs** polymorphism and Alzheimer’s disease susceptibility. . Molecular Neurobiology. 2014,50(3):757-64.SCI
38. Guiyou Liu#, Shuyan Zhang#, Zhiyou Cai, Guoda Ma, Liangcai Zhang, Yongshuai Jiang, Rennan Feng, Mingzhi Liao, Zugen Chen, Bin Zhao*, Keshen Li*. .PICALM Gene rs** Polymorphism Contributes to Alzheimer’s disease in an Asian Population.. NeuroMolecular Medicine. 2013,15(2):384-8.SCI
39. Guiyou Liu#, Shuyan Zhang#, Zhiyou Cai, You Li, Lili Cui, Guoda Ma, Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Mingzhi Liao, Zugen Chen, Bin Zhao*, Keshen Li*..BIN1 gene rs744373 polymorphism contributes to Alzheimer’s disease in East Asian population. . Neuroscience Letters. 2013,7;544:47-51.SCI
40. Liu Guiyou*, Jiang Yongshuai, Wang Ping, Feng Rennan, Jiang Nan, Chen Xiaoyun, Song Hui, Chen Zugen*..Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies. . Journal of Neurochemistory. 2012,120(1):190-8.SCI
主编或副主编的著作/译著
重要奖项