姓名：范明 性别：男 职称：研究员、教授 招生院所：脑重大疾病研究院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：神经损伤修复调节机制与干预措施 电子信箱：fanmingchina@126.com


社会任职
1. 全国应用生理专业委员会主任委员
2. 亚太地区高原医学会常务理事
3. 中国神经科学会常务理事
个人简历
1. 197610-198007:北京第二医学院医疗四系 学生
2. 198009-198307:军事医学科学院 硕士
3. 198509-198807:军事医学科学院 博士
4. 1989-1993:军事医学科学院基础医学研究所 副研究员
5. 1993-:军事医学科学院基础医学研究所 研究员
6. 2006-:首都医科大学 客座教授
重要学术论文
1. Wei W, Wang X, Gong Q, Fan M, Zhang J..Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau.. AJNR Am J Neuroradiol. 2017,38(3):553-560.SCI
2. Li X, Jin T, Zhang M, Yang H, Huang X, Zhou X, Huang W, Qin L, Kang L, Fan M, Li S..Genome-wide association study of high-altitude pulmonary edema in a Han Chinese population.. Oncotarget. 2017,-:-.SCI
3. Wang Y, Liu H, Lin Y, Liu G, Chu H, Zhao P, Yang X, Zheng T, Fan M, Zhou X, Meng J, Sun C..Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke.. Sci Rep. 2017,5;7:40137.SCI
4. Li D, Zhang L, Huang X, Liu L, He Y, Xu L, Zhang Y, Zhao T, Wu L, Zhao Y, Wu K, Wu Y, Fan M, Zhu L..WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation.. Neurosci Bull. . 2017,-:-.SCI
5. Li D, Zhang L, Xu L, Liu L, He Y, Zhang Y, Huang X, Zhao T, Wu L, Zhao Y, Wu K, Li H, Yu X, Zhao T, Gong S, Fan M, Zhu L..WIP1 phosphatase is a critical regulator of adipogenesis through dephosphorylating PPARγ serine 112.. Cell Mol Life Sci. 2017,74(11):2067-2079..SCI
6. Zhang J, Chen J, Fan C, Li J, Lin J, Yang T, Fan M..Alteration of Spontaneous Brain Activity After Hypoxia-Reoxygenation: A Resting-State fMRI Study.. High Alt Med Biol.. 2017,18(1):20-26.SCI
7. Ding XF, Wang HJ, Qian L, Hu ZY, Feng SF, Wu Y, Yang HH, Wu HT, Fan WH, Fan M..Cpne5 is Involved in Regulating Rodent Anxiety Level.. CNS Neurosci Ther. 2017,23(3):266-268.SCI
8. Zhou Y, Huang X, Zhao T, Qiao M, Zhao X, Zhao M, Xu L, Zhao Y, Wu L, Wu K, Chen R, Fan M, Zhu L..Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.. Brain Behav Immun. 2017,S0889-1591(17):30115-0..SCI
9. Zhao M, Huang X, Cheng X, Lin X, Zhao T, Wu L, Yu X, Wu K, Fan M, Zhu L..Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats.. PLoS One. 2017,12(3):e**.SCI
10. Zhang J, Chen J, Yu Q, Fan C, Zhang R, Lin J, Yang T, Fan M..Alteration of spontaneous brain activity in COPD patients.. Int J Chron Obstruct Pulmon Dis. 2016,28;11:1713-9.SCI
11. Chen J, Lin IT, Zhang H, Lin J, Zheng S, Fan M, Zhang J..Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study.. Brain Imaging Behav. 2016,10(2):464-76.SCI
12. Zhang K, Zhao T, Huang X, He Y, Zhou Y, Wu L, Wu K, Fan M, Zhu L..Dissolved oxygen concentration in the medium during cell culture: Defects and improvements.. Cell Biol Int. . 2016,40(3):354-60.SCI
13. Chen X, Zhao T, Huang X, Wu L, Wu K, Fan M, Zhu L..Intermittent hypoxia maintains glycemia in streptozotocin-induced diabetic rats.. Cell Stress Chaperones.. 2016,21(3):515-22.SCI
14. Fan C, Zhao Y, Yu Q, Yin W, Liu H, Lin J, Yang T, Fan M, Gesang L, Zhang J..Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure.. Sci Rep. 2016,16;6:33596.SCI
15. 4.Huang X, Zhou Y, Zhao T, Han X, Qiao M, Ding X, Li D, Wu L, Wu K, Zhu L*, Fan M*.A method for establishing the high-altitude cerebral edema (HACE) model by acute hypobaric hypoxia in adult mice. J Neurosci Methods.. 2015,30（245）:178-81.SCI
16. 3.Di Y, He YL, Zhao T, Huang X, Wu KW, Liu SH, Zhao YQ, Fan M*, Wu LY*, Zhu L*.Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy.. Mol Med. . 2015,19（21）:420-9.SCI
17. Ding XF, Zhao YQ, Fan WH, Wu LY, Huang X, Wang F, He YL, Liu SH, Wu Y, Zhao T, Wu Y, Zhu LL, Fan M..Gene transfer into the both sides of postnatal cerebral cortex using tweezer electrode. CNS Neurosci Ther. . 2013,19(3):197-8. .SCI
18. Wang Y, Yang J, Li H, Wang X, Zhu L, Fan M, Wang X..Hypoxia promotes dopaminergic differentiation of mesenchymal stem cells and shows benefits for transplantation in a rat model of Parkinson's disease.. PLoS One. . 2013,8(1):e54296.SCI
19. Ding XF, Zhao YQ, Hu ZY, Lin K, Wang F, Liu SH, Wu Y, Wu LY, Zhao T, Huang X, Wu Y, Zhu LL, Fan WH, Fan M.Efficient gene transfer into neonatal mouse brain using electroporation. Neurochem Res.. 2012,37(7):1392-8. .SCI
20. Xiong L, Wang F, Huang X, Liu ZH, Zhao T, Wu LY, Wu K, Ding X, Liu S, Wu Y, Zhao Y, Zhu LL, Fan M.DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia. FEBS J. . 2012,279(23):4318-26.SCI
21. 1.Xin Huang, Jia Sun, Tong Zhao, Kuiwu Wu, Kazutada Watanabe, Zhi-Cheng Xiao, Lingling Zhu, Ming Fan.Loss of NB-3 aggravates cerebral ischemia by impairing neuron survival and neurite growth.. Stroke. 2012,42: 2910-2916.SCI
22. 2.XiangLi, XuWang, Peng Zhang, Lingling Zhu, Tong Zhao, Shuhong Liu, Yan Wu, Xiaoping Chen, Ming Fan..Extracellular signal-regulated kinase1/2 mitogen-activated protein kinase pathway is involved in inhibition of myogenic differentiation of myoblasts by hypoxia. Exp Physiol, . 2011, 061382: 1-8.SCI
23. Zhu LL, Zhao T, huang X, Fan M. Gene expression profiles and metabolic changes in embryonic neural progenitor cells under low oxygen.. Cell Reprogram.. 2011, 13(2): :113-20..SCI
24. 5.Xin Huang, Ling-ling Zhua, Tong Zhao, Li-ying Wu, Kui-wu Wu, Melitta Schachner, Zhi-Cheng Xiao, Ming Fan..CHL1 negatively regulates the proliferation and neuronal differentiation of neural progenitor cells through activation of the ERK1/2MAPK pathway.. Molecular and Cellular Neuroscience . 2011,; 46::296–307..SCI
25. 7.Jun-Xia Zheng, Yang Zheng, Hui Zhi, Yi Dai, Nai-Li Wang, Yan-Xiong Fang, Zhi-Yun Du, Kun Zhang , Ming-Ming Li, Li-Ying Wu, Ming Fan..New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia. Molecules . 2011,16,: 6206-6214.SCI
26. Li MM, Wu LY, Zhao T, Xiong L, Huang X, Liu ZH, Fan XL, Xiao CR, Gao Y, Ma YB, Chen JJ, Zhu LL, Fan M.The protective role of 5-HMF against hypoxic injury. Cell Stress Chaperones. 2011,16(3)::267-73.SCI
27. 3.Wu LY, Ma ZM, Fan XL, Zhao T, Liu ZH, Huang X, Li MM, Xiong L, Zhang K, Zhu LL, Fan M.The anti-necrosis role of hypoxic preconditioning after acute anoxia is mediated by aldose reductase and sorbitol pathway in PC12 cells. Cell Stress Chaperones. 2010,15(4)::387-94.SCI
28. 2.Shi CG, Wang LM, Wu Y, Wang P, Gan ZJ, Lin K, Jiang LX, Xu ZQ, Fan M..Intranasal administration of nerve growth factor produces antidepressant-like effects in animals. Neurochem Res. 2010,35(9)::1302-14.SCI
29. 1.Zhao YQ, Gao JT, Liu SH, Wu Y, Lin MT, Fan M.Geranylgeranylacetone preconditioning may attenuate heat-induced inflammation and multiorgan dysfunction in rats. J Pharm Pharmacol. 2010,62(1)::99-105.SCI
30. 5.Liu S, Tian Z, Yin F, Zhao Q, Fan M.Generation of dopaminergic neurons from human fetal mesencephalic progenitors after co-culture with striatal-conditioned media and exposure to lowered oxygen.. Brain Res Bull.. 2009,80(1-2)::62-8.SCI
31. Wu HT,Fan J,Zhu LL,Fan M.Sema4C Expression in Neural Stem/Progenitor Cells and in Adult Neurogenesis Induced by Cerebral Ischemia.. J mol neurosci. 2009,【未填写卷（期）】:【未填写起止页码】.SCI
32. Zhang L,Zheng SS,Wu HT,Wu Y,Liu SH,Fan, M,Zhang, J*.Identification of BLyS (B Lymphocyte Stimulator),a Non-Myelin-Associated Protein, as a Functional Ligand for Nogo-66 Receptor.. The Journal of Neuroscience. 2009,29(19):6348–6352.SCI
33. 11.Jing XT, Wu HT, Wu Y, Ma X, Liu SH, Wu YR, Ding XF, Peng XZ, Qiang BQ, Yuan JG, Fan WH, Fan M.DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells. Cell Mol Neurobiol.. 2009,29(1)::55-67.SCI
34. Cancer Invest.Expression and functional roles of Smad1 and BMPR-IB in glioma development. Cancer Invest. 2009,27(7)::734-40.SCI
35. 10.Zhang K, Zhao T, Huang X, Liu ZH, Xiong L, Li MM, Wu LY, Zhao YQ, Zhu LL, Fan M.Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain. Cell Stress Chaperones. 2009,14(4)::407-15.SCI
36. 9.Xiong L, Zhao T, Huang X, Liu ZH, Zhao H, Li MM, Wu LY, Shu HB, Zhu LL, Fan M.Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells.. Cell Stress Chaperones. 2009,14(2)::183-92.SCI
37. 8.Wu H, Fan J, Zhu L, Liu S, Wu Y, Zhao T, Wu Y, Ding X, Fan W, Fan M.Sema4C expression in neural stem/progenitor cells and in adult neurogenesis induced by cerebral ischemia. J Mol Neurosci. 2009,39(1-2)::27-39.SCI
38. 6.Gao JT, Liu SH, Yan YE, Wu Y, Wu HT, Xing C, Ge XM, Wang H, Zhao YQ, Fan M. Quinacrine protects neuronal cells against heat-induced injury.. Cell Biol Int. 2009,33(8)::874-81.SCI
39. Lei Xiong, Tong Zhao, Xin Huang, Ling-ling Zhu*, Ming Fan*. .Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells. . Cell Stress and Chaperones. 2009,14:183-192.SCI
40. kuan zhang, Tong Zhao, Xin Huang, Ling-ling Zhu, Ming Fan..Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain.. Cell Stress and Chaperones. 2009,【未填写卷（期）】:【未填写起止页码】.SCI
41. Yu S， Zhao T，Fan ming.Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes.. Brain research. 2008,23:22-9.SCI
42. Wu LY,Wang Y,Fan M.The role of hypoxia in the differentiation of P19 embryonal carcinoma cells into dopaminergic neurons.. Neurochem Res. 2008,33:2118-2125.SCI
43. Qiang Sun1, Yan Zhang1, Guang Yang2, Xiaoping Chen3, Yingai Zhang1, Guojun Cao2,.Transforming growth factor-b-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Research Nucleic Acids Research. 2008,【未填写卷（期）】:1-10.SCI
44. Xuan Wang, Haitao Wu, Zhenxing Zhang, Shuhong Liu, Jian Yang, Xiaoping Chen, Ming Fan, Xiaomin Wang..Effects of Interleukin-6, Leukemia Inhibitory Factor, and Ciliary Neurotrophic Factor on the Proliferation and Differentiation of Adult Human Myoblasts.. Cell Mol Neurobiol. 2008,28:113–124.SCI
45. Yi-Yuan Tang, Yinghua Ma, Junhong Wang, Yaxin Fan, Shigang Feng, Qilin Lu, Qingbao Yu, Danni Sui, Mary K. Rothbart, Ming Fan and Michael I. .Posner Short-term meditation training improves attention and self-regulation . PNAS. 2008,104:**–17156.SCI
46. Zhao T,Zhang cui-ping,Lingling Zhu,Fan Ming.Hypoxia-driven proliferation of embryonic neural stem/progenitor cells--role of hypoxia-inducible transcription factor-1alpha.. FEBS J. 2008,275(8):1824-34.SCI
47. Ding X，Fan W，Fan M.Localization and cellular distribution of CPNE5 in embryonic mouse brain.. Brain research. 2008,11:20-8.SCI
48. Tang YY,Ma YH,Fan YX, Feng HB,WangJH,Feng SG,Lu QL,Hu B,Lin Y,Li J,Zhang Y,Wang Y,Zhou L,Fan M* .Central and autonomic nervous system interaction is altered by short-term meditation. . Proc Natl Acad Sci U S A. 2008,105:5609-5613.SCI
49. Peng Zhang , Xiaoping Chen , Ming Fan.Signaling mechanisms involved in disuse muscle atrophy. Med Hypotheses. 2007,69: 310–321..SCI
50. Haitao Wu, Xuan Wang, Shuhong Liu, Wenhong Fan*, Ming Fan* .Sema4C participates in the myogenic differentiation in vivo and in vitro through p38 MAPK pathway. . Eur. J. Cell Biol.. 2007,86:331-344.SCI
51. 【未填作者】.Pathophysiological factors underlying heatstroke . Med Hypotheses. 2006,22(2):118-123.SCI
52. 【未填作者】.Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro. . Mol Biol Cell.. 2005,16(7):3140-51.SCI
53. 【未填作者】.Neurogenesis in the adult rat brain after intermittent hypoxia. . Brain Res. . 2005,1055(1-2):1-6.SCI
54. Lingling Zhu, Liying Wu and Ming Fan..Effects of hypoxia on proliferation and differentiation of neural stem cells. Mol Neurobiology. 2005,31(1-3):231-242 .SCI
55. Jing XT,Wu HT,Fan M.DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells.. cell mol neurobiol. 2002,29:55-67.SCI
主编或副主编的著作/译著
1. 《神经科学进展（第三册） 》,主编,高等教育出版社,2004
2. 《神经科学进展（第二册） 》,主编,高等教育出版社,2003
3. 《特殊环境生理学 》,副主编,军事医学出版社,2003
4. 《蛋白质技术手册 》,主编,科学出版社,2000
重要奖项
1. 适度低氧促进脑损伤修复的途径与应用方案 军队科技进步 二等奖 201211
2. NGF临床研究 北京市科技进步奖 三等 2008
3. 兴奋毒性脑损害干预研究 辽宁省科技进步一等奖 2004
4. 神经营养因子的系列研究 北京市科技进步二等奖 2003
5. 海马神经元缺氧损伤机制及保护措施的研究 军队科技进步二等奖 1999
6. 人脑源性神经营养因子基因工程及其生物学作用的研究 军队科技进步二等奖 1998