姓名：张宗德 性别：男 职称：研究员、教授 招生院所：胸科医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：免疫学(博) 免疫学(硕) 研究方向名称：分子生物学 电子信箱：zzd417@163.com


社会任职
个人简历
1. 198809-199107:北京职工医学院 学习 大专
2. 199309-199607:北京市结核病胸部肿瘤研究所 学习 硕士
3. 199808-199907:美国约翰·霍普金斯大学 访问
4. 200201-200310:美国佛罗里达大学医学院 博士后研究
5. 200409-200707:北京市结核病胸部肿瘤研究所 学习 博士
重要学术论文
1. Li Zihui #; Pan Liping#;LvLingna#; Li Jing; Jia Hongyan;Du Boping; Sun Qi; Zhang Zongde*.Diagnostic accuracy of droplet digital PCR analysis of cerebrospinal fluid for tuberculous meningitis in adult patients. Clin Microbiol Infect. 2020,26(2):213-219.SCI
2. Pan L, Zhang X, Jia H, Huang M, Liu F, Wang J, Du B, Wei R, Sun Q, Xing A, Li Q, Zhang Z*.Label-Free Quantitative Proteomics Identifies Novel Biomarkers for Distinguishing Tuberculosis Pleural Effusion from Malignant Pleural Effusion. Protemics Clinical Application. 2020,14(1):e**.SCI
3. Zhu CZ#, Hu BY#, Liu JW#, Cai Y, Chen XC, Qin DP, Cheng YX, Zhang ZD*.Anti-Mycobacterium tuberculosis Terpenoids from Resina Commiphora. Molecules. 2019,24(8):1475.SCI
4. Cao T#, Lyu L#, Jia H, Wang J, Du F, Pan L, Li Z, Xing A, Xiao J, Ma Y, Zhang Z*.A Two-way Proteome Microarray Strategy to Identify Novel Mycobacterium tuberculosis-human Interactors. Frontiers in Cellular and Infection Microbiology. 2019,9:65.SCI
5. Lyu L#, Zhang X# , Li C#, Yang T#, Wang J, Pan L, Jia H, Li Z, Sun Q, Yue L, Chen F*, Zhang Z*.Small RNA Profiles of Serum Exosomes Derived From Individuals With Latent and Active Tuberculosis. Frontiers in microbiology. 2019,10:1174.SCI
6. Jia H#, Pan L#, Wang G, Duan H, Song Z, Sun Q, Wei R, Du B, Xing A, Zhang Z*.Assessment of Interferon-Gamma Release Assay in Patients with Non-Tuberculous Mycobacteria Pulmonary Disease. Clinical Lab. 2019,65(10):1813-1818.SCI
7. Zhu C#, Cai Y#, Zhu J, Zhang L 1, Xing A, Pan L, Jia H, Mo S, Feng CG, Shen H, Chen X*, Zhang Z*.Histone deacetylase inhibitors impair the host immune response against Mycobacterium tuberculosis infection. Tuberculosis. 2019,118:1-9.SCI
8. Xiao J, Jia H, Pan L, Li Z, Lv L, Du B, Zhang L, Du F, Huang Y, Cao T, Sun Q, Wei R, Xing A, Zhang Z*.Application of the CRISPRi system to repress sepF expression in Mycobacterium smegmatis. INFECT GENET EVOL. 2019,7:183-190.SCI
9. Pan L#, Liu F#, Zhang J, Li J, Jia H, Huang M, Liu X, Chen W, Ding Z, Wang Y, Du B, Wei R, Sun Q, Xing A, Zhang Z*.Genome-wide miRNA analysis identifies potential biomarkers in distinguishing tuberculous and viral meningitis. Frontiers in Cellular and Infection Microbiology. 2019,9:323.SCI
10. Du F, Xie L, Zhang Y, Gao F, Zhang H, Chen W, Sun B, Sha W, Fang Y, Jia H, Xing A, Du B, Zheng L, Gao M, Zhang Z*.Prospective Comparison of QFT-GIT and T-SPOT.TB Assays for Diagnosis of Active Tuberculosis. Sci Rep. 2018,8(1):5582.SCI
11. Li Z, Du B, Li J, Zhang J, Zheng X, Jia H, Xing A, Sun Q, Liu F, Zhang Z*.Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis. Clin Chi Acta. 2017,466:38-45.SCI
12. Lv L, Li C, Zhang X, Ding N, Cao T, Jia X, Wang J, Pan L, Jia H, Li Z, Zhang J, Chen F, Zhang Z*.RNA Profiling Analysis of the Serum Exosomes Derived from Patients with Active and Latent Mycobacterium tuberculosis Infection.. Front Microbiol. 2017,8:1051.SCI
13. Pan L, Wei N, Jia H, Gao M, Chen X, Wei R, Sun Q, Gu S, Du B, Xing A, Zhang Z*..Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection. Oncotarget. 2017,8(68):112907-112916.SCI
14. 贾红彦、潘丽萍、张宗德.医务人员结核潜伏感染相关问题. 中华结核和呼吸杂志. 2016,39(1):16-20.核心期刊
15. 孙会姗. 潘丽萍. 贾红彦.杜凤娇. 郑立恒 .刘秋月. 张宗德.结核分枝杆菌潜伏感染特异性蛋白标志物的血浆蛋白质组学研究. 中华结核呼吸杂志. 2016,39(7):519-523 .核心期刊
16. 杜凤娇. 张治国. 高铁杰. 刘忠泉. 陈曦 .曹廷明. 贾红彦. 邢爱英. 杜博平 .张宗德.北京市昌平区某高校大学新生结核潜伏感染调查. 实用预防医学. 2016,23(9):1039-42.核心期刊
17. 肖婧，张宗德，申阿东.CRISPR-Cas9系统在真核细胞领域内的研究进展. 标记免疫分析与临床. 2016,23(10) :1218-1225.核心期刊
18. 刘洋,郭艳玲,杨丽梅,班武娟,孙琦,张宗德.环介导等温扩增技术检测肺结核患者感染铜绿假单胞菌的临床应用研究. 中华临床医师杂志（电子版）. 2016,10(12):1723-1726.核心期刊
19. Zheng LH1, Jia HY, Liu XJ, Sun HS, Du FJ, Pan LP, Huang HR, Zhang ZD.Modified cytospin slide microscopy method for rapid diagnosis of smear-negative pulmonarytuberculosis. Int J Tuberc Lung Dis. 2016,20(4):456-61.SCI
20. Du F, Zhang Z, Gao T, Liu Z, Jia H, Xing A, Du B, Sun Q, Cao T, Zhang Z.Diagnosis of latent tuberculosis by ELISPOT assay and tuberculin skin test. Med Mal Infect. 2016,46(3):150-3.SCI
21. Jia H, Pan L, Du B, Sun Q1, Wei R, Xing A1, Du F, Sun H1, Zhang Z.Diagnostic performance of interferon-γ release assay for lymph node tuberculosis. Diagn Microbiol Infect Dis. 2016,85(1):56-60.SCI
22. 潘丽萍，贾红彦，张宗德*.医务人员结核分枝杆菌潜伏感染的相关问题.. 中华结核和呼吸杂志. 2016,39（1）:16-20.核心期刊
23. Jia H, Pan L, Du B, Sun Q, Wei R, Xing A, Du F, Sun H, Zhang Z*.Diagnostic performance of interferon-γ release assay for lymph node tuberculosis. Diagn Microbiol Infect Dis. 2016,85（1）:56-60.SCI
24. Zheng L, Jia H,Liu X, Sun H, Du F, Pan L, Huang H, Zhang Z*.Modified cytospin slide microscopy method for rapid diagnosis of smear-negative pulmonary tuberculosis. Int J Tuberc Lung Dis. 2016,20（4）:456-461.SCI
25. Du F, Zhang Z, Gao T, Liu Z, Jia H, Xing A, Du B, Sun Q, Cao T, Zhang Z*.Diagnosis of latent tuberculosis by ELISPOT assay and tuberculin skin test. Med Mal Infect. 2016,46（3）:150-153.SCI
26. Pan L, Jia H, Liu F, Sun H, Gao M, Du F, Xing A, Du B, Sun Q, Wei R, Gu S, Zhang Z*.Risk Factors for False-negative T-SPOT.TB Assay Results in Patients with Pulmonary and Extra-pulmonary TB. Journal of infection. 2015,70（4）:367-380.SCI
27. Xu Y, Zhang Z*, Sun Z*..Drug resistance to Mycobacterium tuberculosis: from the traditional Chinese view to modern systems biology. Crit Rev Microbiol. 2015,41（3）:399-410.SCI
28. 石国民，喻容，彭雪峰，石燕，聂英，齐志强，陈拥军，向延根，刘忠泉* .基因芯片技术在结核分枝耐药检测及菌种鉴定中的应用. 中国防痨杂志. 2015,37（1):66-73.核心期刊
29. 潘丽萍，贾红彦，刘菲，高孟秋，孙会姗，杜博平，孙琦，邢爱英，魏荣荣，张宗德*.γ-干扰素释放试验对不同年龄组疑似肺结核的辅助诊断价值.. 中华结核和呼吸杂志. 2015,38（12）:892-896.核心期刊
30. 刘洋，郭艳玲，姜广路，孙琦，郑素华，张宗德*.不同靶点环介导等温扩增技术对结核分枝杆菌检测的比较研究. 中国防痨杂志. 2015,3（8）:843-847.核心期刊
31. 刘洋,郭艳玲,姜广路,孙琦,邢爱英,张宗德* .环介导等温扩增技术在结核性胸膜炎快速诊断中的应用. 临床肺科杂志. 2015,20（4）:583-585.核心期刊
32. 李泰明，杨幸远，蒙青林，刘晓玫，张霞，张春，张宗德*.表达结核分枝杆菌热休克蛋白16.3的U937细胞蛋白组学分析.. 中华结核和呼吸杂志. 2015,38（1）:34-38.核心期刊
33. 徐玉辉，张宗德*.结核分枝杆菌耐乙胺丁醇分子机制的研究进展.. 肺结核与肺部健康杂志. 2015,4(2):133-136.核心期刊
34. Xia Zhang, Fei Liu, Qi Li, Hongyan Jia, Liping Pan, Aiying Xing, Shaofa Xu , Zongde Zhang*.A proteomics approach to the identification of plasma biomarkers for latent tuberculosis infection. Diagnostic Microbiology and Infectious Disease. 2014, 79:432–437.SCI
35. Jinghui Wang, Yujie Dong, Yiran Cai, Lijuan Zhou, Shafei Wu, Guimei Liu, Dan Su, Xi Li, Na Qin, Jingying Nong, Hongyan Jia, Quan Zhang, Jing Mu, Xuan Zeng, Haiqing Zhang, Shucai Zhang, Zongde Zhang*.Clinicopathologic characteristics of ALK rearrangement in primary lung adenocarcinoma with identified. J Cancer Res Clin Oncol. 2014,140:453-460.SCI
36. Jinghui Wang, Yiran Cai, Yujie Dong, Jingying Nong, Lijuan Zhou, Guimei Liu, Dan Su, Xi Li, Shafei Wu, Xuejing Chen, Na Qin, Xuan Zeng, Haiqing Zhang, Zongde Zhang*, Shucai Zhang*. Clinical Characteristics and Outcomes of Patients with Primary Lung Adenocarcinoma Harboring ALK Rearrangements Detected by FISH, IHC, and RT-PCR. Plos One. 2014,9(7):e101551.SCI
37. 邢爱英, 刘忠泉, 杜博平, 孙琦, 贾红彦, 魏荣荣, 刘洋, 曹廷明, 杜凤娇, 古淑香, 马玙, 张宗德*.结核分枝杆菌复苏因子对结核性胸腔积液中结核分枝杆菌生长促进作用 的探索. 中国防痨杂志. 2014,36(5):369-374.核心期刊
38. Qing-Lin Meng, Fei Liu, Xing-Yuan Yang, Xiao-Mei Liu, Xia Zhang, Chun Zhang, Zong-De Zhang*.Identification of latent tuberculosis infection-related microRNAs in human U937 macrophages expressing Mycobacterium tuberculosis Hsp16.3. BMC Microbiology. 2014,14:37.SCI
39. Liu F, Du FJ, Jia HY, Pan LP, Zhang X, Xing AY, Du BP, Sun Q, Nie LH, Li H, Liu RM, Ma Y, Zhang ZD*..Inadequate values from an interferon-gamma release assay for smear-negative tuberculosis in a high-burden setting.. Int J Tuberc Lung Dis. . 2014,18(12):1496-1501.SCI
40. Jinghui Wang, Jingying Nong, Hongyan Jia, Na Qin, Xi Li, Hui Zhang, Quan Zhang, Zongde Zhang*, and Shucai Zhang*.Jinghui Wang, Jingying Nong, Hongyan Jia, Na Qin, Xi Li, Hui Zhang, Quan Zhang, Zongde Zhang, and Shucai Zhang. Efficacy and predictors of EGFR tyrosine kinase inhibitors in Chinese advanced lung adenocarcinoma: analyses of 253 cases from a single institute. Oncol Res. 2014,21(5):237-46.SCI
41. 邢爱英, 刘忠泉, 杜博平, 孙琦, 贾红彦, 魏荣荣, 刘洋, 曹廷明, 杜凤娇, 古淑香, 张宗德*.血清结核分枝杆菌复苏因子抗体检测方法的建立及其在肺结核诊断的应用. 中华结核和呼吸杂志. 2014,37(5):137-138.核心期刊
42. 刘菲, 张霞, 杜凤娇, 潘丽萍, 刘洋, 贾红彦, 邢爱英, 杜博平, 孙琦, 古淑香, 张宗德.*.γ-干扰素释放试验检测胸腔积液对诊断结核性胸膜炎的初步探讨. 中华结核和呼吸杂志. 2014,37(5):323-327.核心期刊
43. 贾红彦, 潘丽萍, 杜博平, 孙琦, 邢爱英, 杜凤娇, 张宗德*.γ-干扰素释放试验中两种细胞计数方法的对比分析. 临床军医杂志. 2014,42(7):749-751.核心期刊
44. .贾红彦, 潘丽萍, 刘菲, 杜博平, 孙琦, 邢爱英, 杜凤娇, 马玙, 张宗德*.结核分枝杆菌感染T细胞斑点试验对淋巴结结核的辅助诊断价值研究. 中国防痨杂志. 2014,36(6):467-471.核心期刊
45. 刘菲, 张宗德*.微小RNA在感染性疾病及结核病中的研究进展. 中华结核和呼吸杂志. 2014,37(5):205-208.核心期刊
46. Zhang X, Jia H, Liu F, Pan L, Xing A, Gu S, Du B, Sun Q, Wei R, Zhang Z*.Prevalence and Risk Factors for Latent Tuberculosis Infection among Health Care Workers in China: A Cross-Sectional Study. PLoS One. 2013,8(6):e66412.
47. Application of Hyperbranched Rolling Circle Amplification for Direct Detection of Mycobacterium Tuberculosis in Clinical Sputum Specimens Liu Y, Guo YL, Jiang GL, Zhou SJ, Sun Q, Chen X, Chang XJ, Xing AY, Du FJ, Jia HY, Zhang ZD*.Application of Hyperbranched Rolling Circle Amplification for Direct Detection of Mycobacterium Tuberculosis in Clinical Sputum Specimens. PLoS One. 2013,8(6):e64583.SCI
48. 杜凤娇， 傅瑜，吴雪琼，李亮，高静韬，张宗德*.结核分枝杆菌RD1 区编码蛋白ELISPOT辅助诊断活动性结核病的应用价值. 临床肺科杂志. 2012,17（2）:264-266.
49. 贾红彦，兰汀隆，刘菲，杜凤娇，魏荣荣，杜博平，邢爱英，孙琦，秦世炳* 张宗德*.酶联免疫斑点试验在骨关节结核中的辅助诊断价值. 北京医学. 2012,34(10):867-870.
50. 曹廷明.结核分枝杆菌Rv1512 基因的特异性和克隆表达. 临床肺科杂志. 2011,1612:1887.
51. 杜凤娇 张宗德* .酶联免疫斑点术和流式细胞术检测7干扰素对结核性胸膜炎的辅助诊断价值. 中华检验医学杂志. 2011,34（7）:617.核心期刊
52. Yang Liu,Zong-de Zhang*.CREB Is a Positive Transcriptional Regulator of Gamma Interferon in Latent but Not Active Tuberculosis Infections.. Clinical and Vaccine Immunology . 2010,17(9):1377-1380.SCI
53. 郑晓静，张宗德*.多位点可变数量串联重复序列分析在北京家族结核分枝杆菌基因分型中的应用及位点筛选 . 临床肺科杂志. 2010,15(7):957-961.核心期刊
54. 邢爱英,刘忠泉，张宗德*.结核分枝杆菌复苏因子D基因在真核细胞中的表达 . 临床肺科杂志. 2010,15(11):1560-1562.核心期刊
55. 刘洋，张宗德*.肺结核患者环腺苷酸反应元件结合蛋白与γ干扰素基因启动子区的关系. 中华结核和呼吸杂志. 2010,33(7)::500-504.核心期刊
56. 曹廷明,张宗德*.结核分枝杆菌Rv2352c基因的克隆表达及其抗原活性鉴定 . 中国防痨杂志. 2010,32(10):627-632.核心期刊
57. 邢爱英，张宗德*.结核分枝杆菌复苏因子E-DNA疫苗对BALB/C小鼠免疫效应的研究. 中国实用医学杂志. 2010,26(23):4259-4261.核心期刊
58. 马丽萍,张宗德*.结核病不同抗原酶联免疫斑点检测的影响因素分析 . 中国防痨杂志. 2010,32(10):643-645.核心期刊
59. 刘忠泉,张宗德*.结核分枝杆菌复苏因子E基因在真核细胞中的表达及鉴定. 国际呼吸杂志. 2010,30(24):1490-1494.核心期刊
60. 杜凤娇 张宗德*.结核分枝杆菌RD1区编码蛋白在结核病诊断中的潜在价值. 中国医学科学院学报. 2009,31（4）:511.核心期刊
61. 刘菲，张宗德*.酶联免疫斑点检测斑点形成细胞在结核潜伏感染诊断中的价值. 中华检验医学杂志. 2009,32(8):900-904.核心期刊
62. 刘菲，张宗德*.酶联免疫斑点检测和结核菌素试验在初治肺结核中的辅助诊断价值. 中国医学科学院学报. 2009,31(4):443-448.核心期刊
63. 刘菲，张宗德*.不同抗原的酶联免疫斑点检测技术对结核病的辅助诊断价值比较. 中华结核和呼吸杂志. 2009,32(11):838-841.核心期刊
64. 张宗德*，李自慧.结核分枝杆菌体内诱导基因的筛选及初步分析. 中华医学杂志 . 2008,88(3):189-193.核心期刊
65. 张宗德*，邢爱英.噻唑蓝和刃天青法在一线抗结核药物药敏试验中的应用. 中华检验医学杂志. 2008,31(9):989-992.核心期刊
66. 张宗德*，贾红彦.对氨水杨酸耐药与结核分枝杆菌胸苷酸合成酶基因突变的研究. 中华结核和呼吸杂志. 2007,30(9):683-688.核心期刊
主编或副主编的著作/译著
1. 《非结核分枝杆菌病诊断与治疗》,副主编,人民卫生出版社,201901
2. 《结核杆菌分子生物学》,主编,人民军医出版社,201004
重要奖项
1. 结核病诊疗关键技术的创新性研究与应用 北京市科技奖 二等 201412