姓名：张兰 性别：女 职称：研究员、教授 招生院所：附属宣武医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：药理学(博) 药理学(硕) 研究方向名称：神经药理学，老年药学，临床药理学 电子信箱：lanizhg@126.com


社会任职
1. 中西医结合学会临床药理与毒理专委会
2. 中国药理学会神经精神药理专业委员会常务委员
3. 中国药理学会抗衰老与老年痴呆专业委员会 主任委员
4. 中国药学会老年药学专业委员会委员
5. 中国老年学学会衰老与抗衰老科学委员会理事
6. 中国老年学学会老年医学委员会认知障碍专家委员会委员
7. 北京药理学会副理事长、秘书长
8. 中国老年保健医学研究会理事
9. 中国药理学会常务理事
10. 中国老年保健医学研究会老年合理用药分会副主任委员兼秘书长
11. 中国中西医结合学会实验医学专业委员会常务委员
12. 中国药理学会中药与天然药物药理专业委员会委员
13. 中关村玖泰药物临床试验技术创新联盟早期/BE专业委员会委员
14. 中国药学会科学传播专业委员会委员
15. 海峡两岸医药卫生交流协会医院药学专业委员会委员
16. 中国药学会医院药学委员
17. 中国智慧药学联盟
个人简历
1. 199109-199607:首都医科大学 本科学习
2. 199609-199907:首都医科大学宣武医院 硕士研究生学习
3. 199908-200609:首都医科大学宣武医院药物研究室 实习研究员,助理研究员
4. 200203-201412:首都医科大学宣武医院药物研究室 副研究员，副主任
5. 200209-200507:首都医科大学宣武医院 博士研究生学习
6. 200710-200903:美国哈佛医学院 博士后
7. 201410-:首都医科大学宣武医院药物研究室 研究员，主任
8. 201606-:国家药物临床试验机构 副主任
9. 201804-:首都医科大学宣武医院 药学部 主任
重要学术论文
1. Yan Gao#, Juntong Li, Shifeng Chu, Zhao Zhang, Naihong Chen, Lin Li∗, Lan Zhang∗.Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways. European Journal of Pharmacology. 2020,866:17281.SCI
2. Ming-Yang Wang#, Min Meng, Cui-cui Yang, Li Zhang, Ya-li Li, Lan Zhang*, Lin Li* ..Cornel iridoid glycoside improves cognitive impairment induced by chronic cerebral hypoperfusion via activating PI3K/Akt/GSK-3β/CREB pathway in rats.. Behavioural Brain Research. 2020,379:112319.SCI
3. Cuicui Yang#, Xunjie Bao, Li Zhang, Yali Li, Lin Li*, Lan Zhang*.Cornel iridoid glycoside ameliorates cognitive deficits in APP/ PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction. Ann Transl Med. 2020,-:-.SCI
4. Chaoying Hu#, Xiaoping Chen, Zirun Zhao, Dan Gao, Shili Gong, Lizhi Zhang,.A Two-Sequence, Four-Period, Crossover, Replicate Study to Demonstrate Bioequivalence of Warfarin Sodium Tablet in Healthy Chinese Subjects Under Fasting and Fed Conditions.. Clinical Pharmacology. 2020,-:-.SCI
5. Ping Liu#, Xinyu Bai, Tao Zhang, Limei Zhou, Jing Li, Lan Zhang*.The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome. . Ann Transl Med. 2019,7(24):811.SCI
6. Xian‑Zhe Dong#, Yan Song, Yu‑Pan Lu, Yuan Hu, Ping Liu*, Lan Zhan*.Sanguinarine inhibits the proliferation of BGC-823 gastric cancer cells via regulating miR-96-5p/miR-29c-3p and the MAPK/JNK signaling pathway. Journal of Natural Medicines. 2019,73:777-788.SCI
7. Chunhua Wang#, Chaoying Hu#, Dan Gao, Zirun Zhao, Xiaoping Chen, Xiao Hu, Shili Gong, Lin Li*, Lan Zhang*.Pharmacokinetics and bioequivalence of generic and branded abiraterone acetate tablet: a single-dose, open-label, and replicate designed study in healthy Chinese male volunteers. Cancer Chemotherapy and Pharmacology. 2019,83:509–517.SCI
8. Mingyang Wang#, Xuesi Hua, Hongmei Niu, Zhengyu Sun, Li Zhang, Yali Li, Lan Zhang*, Lin Li*.Cornel Iridoid Glycoside Protects Against White Matter Lesions Induced by Cerebral Ischemia in Rats via Activation of the Brain-Derived Neurotrophic Factor/Neuregulin-1 Pathway. Neuropsychiatric Disease and Treatment. 2019,15:3327–3340.SCI
9. Xian‑Zhe Dong#, Zi‑Run Zhao, Yuan Hu, Yu‑Pan Lu, Ping Liu*, Lan Zhang*.LncRNA COL1A1-014 is involved in the progression of gastric cancer via regulating CXCL12-CXCR4 axis. Gastric Cancer. 2019,23(9688):1-13.SCI
10. Denglei Ma#, Yi Luo, Rui Huang, Zirun Zhao, Qi Wang, Lin Li,*, and Lan Zhang*.Cornel Iridoid Glycoside Suppresses Tau Hyperphosphorylation and Aggregation in a Mouse Model of Tauopathy through Increasing Activity of PP2A. Current Alzheimer Research. 2019,16:1-16.SCI
11. Xiaomin Yin, Chen Chen, Ting Xu, Lin Li*, Lan Zhang*. .Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3 pathway in cells and in APP/PS1 transgenic mice. Biochemical and Biophysical Research Communications. 2018,495(1)::672-678.SCI
12. Chaoying Hu#, Xiao Hu, Chunhua Wang, Zirun Zhao, Dan Gao, Xiaoping Chen, Dongli Zhou, Yue Huang, Lin Li*, Lan Zhang*.Bioequivalence and Pharmacokinetics of Bisoprolol-Amlodipine 5 mg/5 mg Combination Tablet versus Bisoprolol 5 mg Tablet and Amlodipine 5 mg Tablet: An Open-Label, Randomized, Two-Sequence Crossover Study in Healthy Chinese Subjects. Clin Drug Investig. 2018,38（12）:1145-1154.SCI
13. Cui-cui Yang, Xue-xian Kuai,Wen-bin Gao, Jian-chun Yu, Qi Wang, Lin Li, Lan Zhang*.Morroniside-induced PP2A activation antagonizes tau hyperphosphorylation in a cellular model of neurodegeneration. J Alzheimers Dis. . 2016,51(1):33-44.SCI
14. Denglei Ma, Yanqiu Zhu, Yanzheng Li, Cuicui Yang, Li Zhang, Yali Li, Lin Li* , Lan Zhang*..Beneficial effects of cornel iridoid glycoside on behavioral impairment and senescence status in SAMP8 mice at different ages.. Behavioural Brain Research. 2016,312::20-29.SCI
15. Wen-jing Tang, Deng-lei Ma, Cui-cui Yang, Li Zhang, Ya-li Li, Lan Zhang*, and Lin Li*. .Cornel iridoid glycoside improves locomotor impairment and decreases spinal cord damage in rats. . BioMed Research International. 2016,8：:1-12.SCI
16. PAN YANG, YUNQIAN GUAN, YALI LI, LI ZHANG, LAN ZHANG* and LIN LI* .Icariin promotes cell proliferation and regulates gene expression in human neural stem cells in vitro. . Molecular Medicine Reports. 2016,14::1316-1322.SCI
17. Zhang L*, Shen C, Chu J, Liu Y, Li YL, Zhang L, Li L*..Icariin reduces α-synuclein over-expression by promoting α-synuclein degradation. AGE. 2015,37（4）:9811.SCI
18. Cui-cui Yang, Lin Li, Sha-sha Zheng, Jie Lu, Li Zhang, Ya-li Li, Lan Zhang*..Cornel iridoid glycoside reduces infarct size measured by magnetic resonance imaging and improves neurological function after focal cerebral ischemia in rats. Chinese Journal of Integrative Medicine. 2015,2015:1-7.SCI
19. Cong Shen, Fang-ling Sun, Ru-yi Zhang, Lan Zhang*, Lin Li*..Tetrahydroxystilbene glucoside ameliorates memory and movement functions, protects synapses and inhibits α-synuclein aggregation in hippocampus and striatum in aged mice. Restorative Neurology and Neuroscience. 2015,33(4) :531-541.SCI
20. Lan Zhang, Bailiu Ya, Pan Yang, Fangling Sun, Li Zhang, Yali Li, Lin Li*..Impact of carotid atherosclerosis combined with hypercholesterolemia on cerebral microvessles and brain parenchyma in a new complex rat model.. Neurochem Res. 2014,39::653–660.SCI
21. Lan Zhang, Cong Shen, Jin Chu, Ruyi Zhang, Yali Li, Lin Li* .Icariin decreases the expression of APP and BACE-1 and reduces the beta-amyloid burden in an APP transgenic mouse model of Alzheimer’s Disease . International Journal of Biological Sciences. 2014,10(2)：:181-191.SCI
22. Lan Zhang, Hui Ding, Dan-Hui Wang, Yan-Li Zhang, Andrius Baskys, Piu Chan, Yu Zhong, Yan-Ning Cai*..Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson’s disease in the Han Chinese population. PLoS ONE. 2013,8（8）:e70935.SCI
23. Cui-cui Yang, Xue-xian Kuai, Ya-li Li, Li Zhang, Jian-chu Yu, Lin Li*, Lan Zhang*.Cornel iridoid glycoside attenuates tau phosphorylation by inhibition of PP2A demethylation. Evidence based Complementary and Alternative Medicine. 2013,2013:108486.SCI
24. Jin N, Qian N, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F..CREB Regulates the Expression of Neuronal Glucose Transporter 3: a mechanism leading to impaired brain glucose uptake in Alzheimer’s disease.. Nucleic Acid Res.. 2013,41（5）:3240–3256.SCI
25. Lan Zhang, Qin-gling Lin, Lu Lu, Cui-cui Yang, Ya-Li Li, Fangling Sun, Yanning Cai*, Lin Li*. .Tissue-specific modification of clock methylation in aging mice.. European Review for Medical and Pharmacological Sciences . 2013,17(14) :1874-1880.SCI
26. Lan Zhang*, Shun Yu, Ruyi Zhang,Ying Xing, Yaohua Li, Lin Li*. .Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease. Restorative Neurology and Neuroscience. 2013,31（1）:41-52.SCI
27. Lan Zhang#, Qingling Lin#, Hui Ding, Danhui Wang, Yanning Cai*.Promoter methylation of seven clock genes in total leukocytes from different-aged healthy subjects. Biological Rhythm Research. 2012,43（6）:631-637.SCI
28. Wei Li, Yan-qi Chu, Lan Zhang, Lin-lin Yin, Lin Li..Ginsenoside Rg1 attenuates tau phosphorylation in SK-N-SH induced by Aβ-stimulated THP-1 supernatant and the involvement of p38 pathway activation. . Life Science. 2012,91::809-815 .SCI
29. Yu Y, Zhang L#(张兰，共同第一作者), Li X, Run X, Liang Z, Li Y, Liu Y, Lee M, Iqbal I, Iqbal K, Vocadlo D, Liu F, Gong C..Differential effects of an O-GlcNAcase inhibitor on Tau phosphorylation. . PLoS ONE. 2012,7(4):e35277.SCI
30. Bai-liu Ya, Lan Zhang#(共同第一作者), Li Zhang, Yali Li, Lin Li.5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain ischemia.. Neural Regen Res. 2012,7(22):1722-1728.SCI
31. Lin-lin Yin, Li-li Lin, Lan Zhang, Lin Li..Epimedium flavonoids ameliorate experimental autoimmune encephalomyelitis in rats by modulating neuroinflammatory and neurotrophic responses. Neuropharmacology. 2012,63 :851-862.SCI
32. Bailiu Ya, Lan Zhang#; Li Zhang, Yali Li, Lin Li*.5 hydroxymethyl 2 furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain Ischemia. Neural Regeneration Research. 2012,7(22):1722-1728.SCI
33. 刘莹，李林，张兰*.二苯乙烯苷对基因转染PC12细胞突触核蛋白过表达和泛素-蛋白酶体系统的影响. 中国药学杂志. 2012,47(1):34-39.核心期刊
34. 李延峥，李林，张兰（通讯作者）*.快速老化小鼠SAMP8 在阿尔茨海默病研究中的应用. 中国康复理论与实践. 2012,18(12):1119-1122.核心期刊
35. Lan Zhang, Qingling Lin, Hui Ding, Danhui Wang, Yanning Cai.Promoter methylation of seven clock genes in total leukocytes from different-aged healthy subjects. Biological Rhythm Research. 2012,43(6):631-637.SCI
36. 李林,张兰..中药治疗阿尔茨海默病的作用特点. 生物化学与生物物理进展. 2012,39(8)::816-828.核心期刊
37. Fang-ling Sun, Lan Zhang, Ru-yi Zhang and Lin Li*. .Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. European Journal of Pharmacology. 2011,660:283-290.SCI
38. 张兰，刘芳，万岁桂，贾建平，李林.阿尔茨海默病转线粒体DNA细胞模型胞浆钙稳态的改变. 首都医科大学学报. 2011,32（1）:67-72.核心期刊
39. 刘莹，张兰，李雅莉，李林.淫羊藿苷对基因转染PC-12细胞α-突触核蛋白过表达和泛素-蛋白酶体系统的影响. 首都医科大学学报. 2011,32（1）:79-83.核心期刊
40. Ruiqin Yao, Lan Zhang, Xiaoli Li, Lin Li*..Effects of Epimedium flavanoids on proliferation and differentiation of neural stem cells in vitro. Neurological Research . 2010,32（7）:736-742.SCI
41. Li-hong Zhao, Yue-xia Ding, Lan Zhang, Lin Li*.Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats. European Journal of Pharmacology. 2010,647（1-3）:68–74.SCI
42. 王蓉，赵志炜，张丽，张兰，李林.参乌胶囊及其有效成分二苯乙烯苷对老年大鼠海马神经元突触体素表达的影响. 首都医科大学学报. 2010,31（1）:60-64.核心期刊
43. Bai-liu Ya, Chun-yang Li, Lan Zhang, Wen Wang, Lin Li*.Cornel iridoid glycoside inhibits inflammation and apoptosis in brains of rats with focal cerebral Ischemia. Neurochem Res. 2010,35(5):773-778.SCI
44. 叶翠飞，张丽，张兰，李林*.参乌胶囊对东莨菪碱模型大鼠学习记忆能力和脑内胆碱能系统的影响. 中国药学杂志. 2010,45(9):661-664.核心期刊
45. 王蓉，唐玉，张丽，赵志炜，张兰，李林*.大鼠海马神经元突触超微结构的增龄变化. 中国比较医学杂志. 2009,19（4）:18-22.核心期刊
46. Ruiqin Yao, Lan Zhang, Wen Wang, Lin Li*.Cornel Iridoid Glycoside Promotes Neurogenesis and Angiogenesis and Improves Neurological Function after Stroke in Rats. Brain Research Bull. 2009,79(1):69-76.SCI
47. 唐静，刘小艳，张兰，王育琴*，史录文.老年脑梗死住院患者治疗用药的对照研究老年脑梗死住院患者治疗用药的对照研究. 中国药学杂志. 2009,44（2）:155-157.核心期刊
48. 张兰，邢颖，叶翠飞，李林*，董奇.二苯乙烯苷对不同时程APP转基因拟痴呆小鼠脑内ERK蛋白表达及磷酸化的影响. 中国康复理论与实践. 2009,15（8）:723-727.核心期刊
49. 褚燕琦，张兰，王文，李玮，张丽，李林*.山茱萸环烯醚萜苷对蛋白磷酸酶抑制剂冈田酸拟阿尔茨海默病细胞模型的抗凋亡作用. 中国药房. 2009,20（18）:1364-1367.核心期刊
50. 姚瑞芹，张丽，张兰，王文，艾厚喜，李林*.山茱萸环烯醚萜苷对局灶性脑缺血模型大鼠BDNF及其受体TrkB表达的影响. 中国药理学通报. 2009,25(11):1535-6.核心期刊
51. Xiaoqin Run, Zhihou Liang, Lan Zhang, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong*.Anesthesia induces phosphorylation of tau. . Journal of Alzheimer’s Disease. 2009,16::619-626.SCI
52. 刘莹，李林，杨慧，李雅莉，张兰*.二苯乙烯苷对过度表达α-synuclein 蛋白的转基因cos-7细胞株的影响. 中国康复理论与实践. 2008,14（4）:338-340.核心期刊
53. 张丽，叶翠飞，张兰*，李雅莉，杨东旭，王文，李林.山茱萸环烯醚萜苷对血栓形成和凝血功能的影响. 中药新药与临床药理. 2008,19（5）:363-366.核心期刊
54. 楚晋，李林，叶翠飞，刘莹，亚白柳，阎晓媛，张兰*.淫羊藿黄酮对APP转基因小鼠学习记忆及Beta-amyloid生成的影响. 中国科学技术大学学报. 2008,38（4）:339-348.核心期刊
55. 张兰，李林*，安文林，薛冰.山茱萸拮抗线粒体缺陷致神经细胞微管及微管相关蛋白表达异常. 中国药理学通报. 2007,23（3）:358-364.核心期刊
56. 赵玲，张兰，李雅莉，张丽，李林*.5-羟甲基糠醛对脑缺血再灌注模型小鼠学习记忆及脑部自由基的影响. 中国药房. 2007,18（13）:974-976.核心期刊
57. 张兰，于顺，邢颖，叶翠飞，陈彪，李林*.APP转基因拟痴呆小鼠模型脑内α-synuclein的增龄改. 中国病理生理杂志. 2007,23（12）:2289-2294.核心期刊
58. 李雅莉，赵玲，李林，张兰*.二苯乙烯苷对缺糖缺氧致海马神经元凋亡的影响. 中国新药杂志. 2007,16（20）:1670-1673.核心期刊
59. Lan ZHANG, Ying XING, Cui-fei YE, Hou-xi AI, Hai-feng WEI, Lin LI*.Learning-memory deficit with aging in APP transgenic mice of Alzheimer’s disease and intervention by using tetrahydroxy -stilbene glucoside. Behavioural Brain Research. 2006,173(2):246-254.SCI
60. 邢颖，张兰，李林*.二苯乙烯苷对APP转基因小鼠学习记忆能力和脑内β-淀粉样肽表达的影响. 中国新药杂志 . 2006,15（7）:510-513.核心期刊
61. 张兰，邢颖，赵玲，叶翠飞，艾厚喜，李林*.不同时程APP转基因小鼠学习记忆改变及参乌胶囊、二苯乙烯苷的干预作用. 中国行为医学科学. 2006,15（3）:193-196.核心期刊
62. 邢颖，张兰，李林*.参乌胶囊抑制阿尔茨海默病模型小鼠脑内β-淀粉样肽生成的机制研究. 中国老年学杂志. 2006,26（7）:924-926.核心期刊
63. 邢颖，张兰，李林*.参乌胶囊对APP转基因小鼠学习记忆能力及脑β-淀粉样肽含量的影响. 中国康复理论与实践. 2005,11(5):161-163.核心期刊
64. 张兰，叶翠飞，褚燕琦，李斌，李林*.二苯乙烯苷对鹅膏蕈氨酸致痴呆大鼠模型脑内胆碱能系统的影响. 中国药学杂志. 2005,40（10）:749-752.核心期刊
65. 张兰，李林*，李雅莉.何首乌有效成分二苯乙烯甙对神经细胞保护作用的机制. 中国临床康复. 2004,8（1）:118-120.核心期刊
66. 张兰，张如意，李林*，王蓉，叶翠飞，盛树立.微泵恒速灌注叠氮钠对大鼠脑内胆碱及单胺能递质含量改变. 中国康复理论与实践. 2003,9（9）:536-539 .核心期刊
67. Zhang Lan,Liu Fang,Jia Jian-ping,Li Lin*.Development of mtDNA-transfused cell model of Alzheimer’s disease and application in pharmacological study on Chinese herb components. Brain Aging. 2003,3(4):29-35.
68. 张兰，李林*, 李斌，丰艳，叶翠飞，张丽,陆华宝.中药参乌胶囊对老年大鼠学习记忆及海马组织学的影响. 中国康复理论与实践. 2002,8(9):516-519.核心期刊
69. 张兰，张如意，李林*, 王辉，熊杰.亨廷顿病大鼠行为学改变及中药962胶囊干预. 中国行为医学科学 . 2002,11(3):243-246.核心期刊
主编或副主编的著作/译著
1. 《实用临床药物学》,主编,中国医药科技出版社,201809
2. 《老年人合理用药与抗衰老药》,副主编,人民卫生出版社,201203
重要奖项
1. 痴呆与轻度认知障碍的流行病学、发病机制和诊治应用研究 国家科技进步二等奖 二等奖 201312
2. 5-羟甲基糠醛(HMF)在制备防治神经退行性疾病和认知损害的药品和保健品中的用途 山茱萸提取物、其提取方法以及在制备药物及保健品中的用途 国家发明专利授权 200611
3. 5-羟甲基糠醛类用于制备神经系统用药的用途 5-羟甲基糠醛类用于制备神经系统用药的用途 国家发明专利授权 200605
4. 补肾中药治疗老年性痴呆的实验研究与技术平台的建立 北京市科学技术一等奖 省部级一等奖 200602
5. 山茱萸提取物、其提取方法以及在制备药物及保健品中的用途 “5-羟甲基糠醛(HMF)在制备防治神经退行性疾病和认知损害的药品和保健品中的用途” 国家发明专利授权 200602