姓名：张栋 性别：男 职称：研究员、教授 招生院所：附属友谊医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：内科学（消化系病）(博) 内科学（消化系病）(硕) 研究方向名称：移植免疫和自身免疫性疾病的研究 电子信箱：zhangd@ccmu.edu.cn


社会任职
个人简历
1. 199209-199707:首都医科大学 本科在读学习
2. 199709-200007:首都医科大学 硕士研究生学习
3. 200007-200407:首都医科大学附属北京友谊医院 任职普外科医师
4. 200109-200407:首都医科大学 博士研究生学习
5. 200407-200708:美国哈佛医学院 Beth Israel Deaconess医学中心 博士后学习
6. 200709-201012:美国匹兹堡大学医学院 任职助理教授
7. 201101-:首都医科大学附属北京友谊医院 任职研究员
8. 201212-:首都医科大学 任职教授
9. 201408-:移植耐受与器官保护北京市重点实验室 主任
重要学术论文
1. Jian Li#, Hong Tan#, Xiaona Zhou#, Chunpan Zhang, Hua Jin, Yue Tian, Xinyan Zhao, Xinmin Li, Xuelian Sun*, Meili Duan* and Dong Zhang*. .The protection of midazolam against immune mediated liver injury induced by lipopolysaccharide and galactosamine in mice. . Frontiers in Pharmacology. 2019,9:1528.SCI
2. Hua Jin#, Chunpan Zhang#, Hufeng Xu, Chengyang Sun, Xinyan Zhao, Dan Tian, Wen Shi, Yue Tian, Guangyong Sun and Dong Zhang*. .OX40 Expressed in Neutrophils Promotes Hepatic Ischemia-Reperfusion Injury. . JCI Insight. . 2019,4(21)::e129736. .SCI
3. Shuxiang Li, Tingting Lv, Chunpan Zhang, Tianqi Wang, Dan Tian, Guangyong Sun, Yan Wang, Xinyan Zhao, Weijia Duan, Sha Chen, Min Li, Hong Ma, Yuanyuan Kong, Hong You, Xiaojuan Ou, Guangyong Chen, Jianrong Su, Dong Zhang,* （共同通讯作者）and Jidong Jia*. .Alteration of liver-infiltrated and peripheral blood double-negative T-cells in primary biliary cholangitis. Liver International. . Liver International.. 2019,39(9): 1:1755-1767. .SCI
4. Dan Tian, Lu Yang, Song Wang, Yanbing Zhu, Wen Shi, Chunpan Zhang, Hua Jin, Yue Tian, Hufeng Xu, Guangyong Sun, Kai Liu, Zhongtao Zhang and Dong Zhang*.. Double negative T cells mediate Lag3-dependent antigen-specific protection in OVA-induced allergic asthma. . Nature Communications. . 2019,10(1):4246.SCI
5. Jian Li, Hong Tan, Xiaona Zhou, Chunpan Zhang, Hua Jin, Yue Tian, Xinyan Zhao, Xinmin Li, Xuelian Sun, Meili Duan* and Dong Zhang*..The protection of midazolam against immune mediated liver injury induced by lipopolysaccharide and galactosamine in mice. . Frontiers in Pharmacology.. 2019,9:1528.SCI
6. Tianqi Wang#, Guangyong Sun#, Yaning Wang, Shuxiang Li, Xinyan Zhao, Chunpan Zhang, Hua Jin, Dan Tian, Kai Liu, Wen Shi, Yue Tian and Dong Zhang*. .The immunoregulatory effects of CD8 T-cell derived perforin on diet-induced nonalcoholic steatohepatitis. . Faseb J. . 2019,33(7):8490-8503. .SCI
7. Kai Liu#, Huichu Ye#, Jin Zhou, Yue Tian, Hufeng Xu, Xuelian Sun*, Dong Zhang*. .Ox40 regulates the conversion and suppressive function of double-negative regulatory T cells. 2018 Sep 27;65:16-22. Int Immunopharmacol. 2018,65:16-22.SCI
8. Guangyong Sun, Xiaojing Sun, Wei Li, Kai Liu, Dan Tian, Yiran Dong, Xuelian Sun, Hufeng Xu and Dong Zhang*..Critical role of OX40 in the expansion and survival of CD4 T cell-derived double negative T cells. Cell Death Dis. 2018,9:616.SCI
9. Guangyong Sun#, Hua Jin#, Chunpan Zhang#, Hua Meng#, Xinyan Zhao, Dan Wei, Xiaojuan Ou, Qianyi Wang, Shuxiang Li, Tianqi Wang, Xiaojing Sun, Wen Shi, Dan Tian, Kai Liu, Hufeng Xu, Yue Tian, Xinmin Li, Wei Guo, Jidong Jia, Zhongtao Zhang* and Dong Zhang*. .OX40 regulates both innate and adaptive immunity and promotes nonalcoholic steatohepatitis.. Cell Reports. 2018,25(13):3786-3799.SCI
10. Bing Liu#, Hengchi Yu#, Guangyong Sun#, Xiaojing Sun, Hua Jin, Chunpan Zhang, Wen Shi, Dan Tian, Kai Liu, Hufeng Xu, Xinmin Li, Jie Yin, Xu Hong* and Dong Zhang*.OX40 promotes obesity-induced adipose inflammation and insulin resistance. . 2017 Oct; 74( 20): 3827–3840. Cell Mol Life Sci. . 2017,74( 20):3827–3840.SCI
11. Xiaojing Sun, Chunpan Zhang, Hua Jin, Guangyong Sun, Yue Tian, Wen Shi, Dong Zhang*.Flow cytometric analysis of T lymphocyte proliferation in vivo by EdU incorporation. Int Immunopharmacol. . 2016,41:56-65.SCI
12. Tianhui Liu，Min Cong, Guangyong Sun, Ping Wang, Yue Tian, Wen Shi, Xinmin Li, Hong You, Dong Zhang*.Combination of double negative T cells and anti-thymocyte serum reverses type 1 diabetes in NOD mice. Journal of Translational Medicine. 2016,14(1):57. doi: 10.1186/s12967-016-0815-y.SCI
13. Xinyan Zhao, Guangyong Sun, Xiaojing Sun, Dan Tian, Kai Liu, Tianhui Liu, Min Cong, Hufeng Xu, Xinmin Li, Wen Shi, Yue Tian, Jingyi Yao, Hongbo Guo and Dong Zhang* .A novel differentiation pathway from CD4+ T cells to CD4- T cells for maintaining immune system homeostasis. Cell Death & Disease. 2016,7:e2193. doi: 10.1038/cddis.2016.83.SCI
14. Min Cong, Tianhui Liu, Dan Tian, Hongbo Guo, Ping Wang, Kai Liu, Jun Lin, Yue Tian, Wen Shi, Hong You, Jidong Jia and Dong Zhang* .Interleukin-2 enhances the regulatory functions of CD4+ T cell-derived CD4-CD8- double negative T cells. J Interferon Cytokine Res. 2016,36(8):499-505 .SCI
15. Wenxia Li,Yue Tian,Zhao Li, Jie Gao,Wen Shi,Jiye Zhu,Dong Zhang*.Ex vivo converted double negative T cells suppress activated B cells. International Immunopharmacology. 2014,20:146-149.SCI
16. Dong Zhang, Miaoda Shen, Allison Mikita, Wensheng Zhang, Yun Liu, Quan Liu, Yifan Dai, Chenyu Zhang, Shusen Zheng, Xin Xiao Zheng*.Targeting Uncoupling Protein-2: A Novel Strategy to Improve Islet Graft Function. . Cell Transplantation. 2011,20（3）:421-9.SCI
17. Dong Zhang, Wensheng Zhang, Yong Wang, Yun Liu, Quan Liu，Yan Tian, Timothy W. Ng, Vijay S Gorantla, Fadi Lakkis, Xin Xiao Zheng*.Adoptive cell therapy using antigen-specific CD4(-)CD8 (-) T regulatory cells to prevent autoimmune diabetes and promote islet allograft survival in NOD mice.. Diabetologia. . 2011,54(8):2082-92.SCI
18. Dong Zhang, Alberto Sanchez-Fueyo, Kensaku Kawamoto, Sophoclis P. Alexopoulos, Wensheng Zhang, Xin Xiao Zheng*.Th1 to Th2 Immune Deviation Facilitates, But Does Not Cause, Islet Allograft Tolerance in Mice. . Cytokine. 2010,51(3):311-9.SCI
19. Dong Zhang, Wei Yang, Nicolas Degauque, Yan Tian, Allison Mikita, Xin Xiao Zheng*.New differentiation pathway for double-negative regulatory T-cells that regulates the magnitude of immune responses.. Blood. 2007,109(9):4071-9.SCI
主编或副主编的著作/译著
重要奖项
1. 北京市海外高层次人才认定（海聚工程） 其他省级科技奖 特等奖 201209
2. 青年奖（美国器官移植学会颁发） 其他省级科技奖 特等奖 200805