姓名：柳柯 性别：男 职称：研究员、教授 招生院所：附属友谊医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：耳鼻咽喉科学(博) 耳鼻咽喉科学(硕) 研究方向名称：耳神经生物学；耳科重大疾病发病机制与临床干预 电子信箱：liuke@ccmu.edu.cn


社会任职
个人简历
1. 198409-198907:中国医科大学 本科阶段学习
2. 198908-199609:中国医科大学附属第一医院耳鼻咽喉-头颈外科 住院医师，助教
3. 199209-199507:中国医科大学 硕士阶段学习
4. 199609-200005:中国医科大学附属第一医院耳鼻咽喉-头颈外科 主治医师，讲师
5. 199809-200407:中国医科大学 博士阶段学习
6. 200005-200210:美国纽约哥伦比亚大学医学院神经生物及行为研究中心 访问
7. 200211-200402:美国哥伦比亚大学医学院外科所属实验室 博士后
8. 200410-200503:加拿大麦克马斯特大学生物系 博士后
9. 200505-200605:中国医科大学附属第一医院耳鼻咽喉-头颈外科 主治医师，讲师
10. 200606-200910:中国医科大学附属第一医院耳鼻咽喉-头颈外科 副教授，副主任医师
11. 200911-201107:解放军总医院耳鼻咽喉研究所 博士后
12. 201109-201610:解放军总医院耳鼻咽喉研究所 研究员
13. 201610-:首都医科大学附属北京友谊医院 教授，主任医师
重要学术论文
1. Zhang W., Peng Z., Yu S., Song Q-L., Qu T-F., Liu K.*, Gong S-S*..Exposure to sodium salicylate disrupts VGLUT3 expression in cochlear inner hair cells and contributes to tinnitus. Physiol Res. 2020,69(1):181-190.SCI
2. Guo Bin., Guo Qing., Wang Zhan., Shao Jian-Bo., Liu Ke., Du Zheng-De.*, Gong Shu-Sheng*..D-Galactose-induced oxidative stress and mitochondrial dysfunction in the cochlear basilar membrane: an in vitro aging model.. Biogerontology. 2020,undefined:1-13.SCI
3. Han Shuguang., Du Zhengde., Liu Ke.*, Gong Shusheng*..Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses.. Neurosci. Lett.. 2020,725(2020):1-9.SCI
4. Wei Wei., Shi Xi., Xiong Wei., He Lu., Du Zheng-De., Qu Tengfei., Qi Yue., Gong Shu-Sheng., Liu Ke.*, Ma Xiulan*.RNA-seq profiling and co-expression network analysis of long noncoding RNAs and mRNAs reveal novel pathogenesis of noise-induced hidden hearing loss.. Neuroscience. 2020,434(2020):120-135.SCI
5. Luo Yangtuo., Qu Tengfei., Song Qingling., Qi Yue., Yu Shukui., Gong Shusheng., Liu Ke.*, Jiang Xuejun*.Repeated Moderate Sound Exposure Causes Accumulated Trauma to Cochlear Ribbon Synapses in Mice. Neuroscience. 2020,429:173-184.SCI
6. Xiong Wei., Wei Wei., Qi Yue., Du Zhengde., Qu Tengfei., Liu Ke.*, Gong Shusheng*..Autophagy is Required for Remodeling in Postnatal Developing Ribbon Synapses of Cochlear Inner Hair Cells. Neuroscience. 2020,431:1-16.SCI
7. He Lu., Guo Jing-Ying., Qu Teng-Fei., Wei Wei., Liu Ke., Peng Zhe., Wang Guo-Peng.*, Gong Shu-Sheng*.Cellular origin and response of flat epithelium in the vestibular end organs of mice to Atoh1 overexpression. . Hear. Res.. 2020,391(2020):1-10.SCI
8. Du Zheng-De., Han Shu-Guang., Qu Teng-Fei., Guo Bin., Yu Shu-Kui., Wei Wei., Feng Shuai., Liu Ke.*, Gong Shu-Sheng*.Age-related insult of cochlear ribbon synapses: An early-onset contributor to D-galactose-induced aging in mice. Neurochem. Int. 2019,133:1-8.SCI
9. Qi Y, Yu S, Du Z, Qu T, He L, Xiong W, Wei W, Liu K*, Gong S*. . Long-Term Conductive Auditory Deprivation During Early Development Causes Irreversible Hearing Impairment and Cochlear Synaptic Disruption. . Neuroscience. 2019,406:345-355.SCI
10. Du ZD, Yu S, Qi Y, Qu TF, He L, Wei W, Liu K*, Gong SS*..NADPH oxidase inhibitor apocynin decreases mitochondrial dysfunction and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging model in rats. . Neurochem Int.. 2019,124:31-40.SCI
11. Qu Tengfei., Qi Yue., Yu Shukui., Du Zhengde., Wei Wei., Cai Aoling., Wang Jie., Nie Binbin., Liu Ke.*, Gong Shusheng*..Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram. . Neuroscience. 2019,408:31-45.SCI
12. Du, Z.-D., Wei, W., Yu, S., Song, Q.-L., Liu, K.*, Gong, S.-S*..NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats. Neural Plasticity. 2019,2019:1-9.SCI
13. Du, Z.-D., He, L., Tu, C., Guo, X.-A., Yu, S., Liu, K., Gong, S*..Mitochondrial DNA 3,860-bp Deletion Increases with Aging in the Auditory Nervous System of C57BL/6J Mice.. Orl. 2019,81:92-100.SCI
14. Yu SK, Du ZD, Song QL, Qu TF, Qi Y, Xiong W, He L, Wei W, Gong SS*, Liu K*.Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea.. J Vis Exp.. 2019,（147）:1-9.SCI
15. Li Sijun., Yu Shukui., Ding Tonghui., Yan Aihui., Qi Yue., Gong Shusheng., Tang Siquan.*, Liu Ke*..Different patterns of endocytosis in cochlear inner and outer hair cells of mice.. Physiol Res. 2019,68(4):659-665.SCI
16. Le Yang#,DaiShi Chen#,TengFei Qu,TongHui Ding,AiHui Yan,Pinggui Gong,Yunyi Liu,Junjun Zhang,ShuSheng Gong,ShiMing Yang,Hong Peng*,Ke Liu*.Maximal number of pre-synaptic ribbons are formed in cochlear region corresponding to middle frequency in mice. Acta Oto-Laryngologica. 2018,138(1):25-30.SCI
17. Guo Jing-Ying., He Lu., Qu Teng-Fei., Liu Yu-Ying., Liu Ke., Wang Guo-Peng.*, Gong Shu-Sheng*..Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice. . J Vis Exp. 2018,（135）:1-8.SCI
18. Shi Xi., Zhang Yan., Qiu Shiwei., Zhuang Wei., Yuan Na., Sun Tiantian., Gao Jian*., Qiao Yuehua*., Liu Ke*. A Novel GJB2 compound heterozygous mutation c.257C>G (p.T86R)/c.176del16 (p.G59A fs*18) causes sensorineural hearing loss in a Chinese family.. J. Clin. Lab. Anal.. 2018,32（7）:1-7.SCI
19. Yu Shukui., Li Zhongxuan., Zhang Wei., Du Zhengde., Liu Ke., Yang Denghua., Gong Shusheng*..Isolation and characterization of endothelial colony-forming cells from mononuclear cells of rat bone marrow.. Exp. Cell Res. 2018,370（1）:116-126.SCI
20. Wei Sun, Shiming Yang, Ke Liu*, Richard J. Salvi*.Hearing loss and auditory plasticity. Hearing Research. 2017,347(2017):1-2.SCI
21. Zhao N, Tai X, Zhai L, Shi L, Chen D, Yang B, Ji F, Hou K, Yang S, Gong S, Liu K*.Unitary Ototoxic Gentamicin Exposure Dose not Disrupt the Function of Outer Hair Cells in Mice. Acta Oto-Laryngologica. 2017,137(8):842-849.SCI
22. Wang H, Zhao N, Yan K, Liu X, Zhang Y, Hong Z, Wang M, Yin Q, Wu F, Lei Y, Li X, Shi L, Liu K*.Inner hair cell ribbon synapse plasticity might be molecular basis of temporary hearing threshold shifts in mice. International Journal of Experimental Pathology. 2015,8(7):8680-8691.SCI
23. Liu K, Chen D, Guo W, Yu N, Wang X, Ji F, Hou Z, Yang WY, Yang S*.Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal. Molecular Neurobiology. 2015,52(3):1680-1689.SCI
24. Shi L#, Liu K#, Wang H, Zhang Y, Hong Z, Wang M, Wang X, Jiang X, Yang S*.Noise induced reversible changes of cochlear ribbon synapses contribute to temporary hearing loss in mice. Acta Oto-Laryngologica. 2015,135(11):1093-1102.SCI
25. Liu Ke., Ji Fei., Yang Guan., Hou Zhaohui., Sun Jianhe., Wang Xiaoyu., Guo Weiwei., Sun Wei., Yang Weiyan., Yang Xiao., Yang Shiming*..SMAD4 Defect Causes Auditory Neuropathy Via Specialized Disruption of Cochlear Ribbon Synapses in Mice.. Mol. Neurobiol. 2015,53（8）:5679-5691.SCI
26. Liu K, Ji F, Xu Y, Wang X, Hou Z, Yang S*..MyosinVIIa and otoferlin in cochlear inner hair cells have distinct response to ototoxic exposure . Acta Oto-Laryngologica. 2014,134(6):564-570.SCI
27. Ji F, Li JN, Liu K, Jiao QS, Sun L, Hong MD, Chen AT, Li SY, Yang SM*.NRT test in auditory neuropathy patients with cochlear implants. Acta Oto-Laryngologica. 2014,134(9):930-942.SCI
28. Liu K#, Shi C#, Sun Y#, Xu Y, Shi L, Shi L, Wang X, Ji F, Hou Z, Yang S*.Dynamic Distribution of Ototoxic Gentamicin Entry into Inner Hair Cells of Mice. Acta Oto-Laryngologica. 2014,134(4):345-351.SCI
29. Liu K, Jiang X, Shi C, Shi L, Yang B, Shi L, Xu Y, Yang W, Yang S*.Cochlear Inner Hair Cell Ribbon Synapse is the Primary Target of Ototoxic Aminoglycoside Stimuli. Molecular Neurobiology. 2013,48(3):647-654.SCI
主编或副主编的著作/译著
重要奖项
1. 药物性聋发病机制和精准干预及人工耳蜗研发 辽宁省科学技术奖励 三等奖 201712
2. 药物性聋发病机制和精准干预及人工耳蜗研发 辽宁医学科技奖 二等奖 201710
3. 耳蜗传入神经突触可塑性改变在耳聋发生过程中的作用及临床应用 其他省级科技奖 三等奖 201503