姓名：陈伟 性别：男 职称：教授 招生院所：附属天坛医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 神经生物学(硕) 研究方向名称：药物筛选与脑卒中康复研究 电子信箱：w.chen@duke.edu


社会任职
个人简历
1. 198309-198707:复旦大学 学士
2. 198709-199007:中国预防医学科学院 医学硕士
3. 199409-199906:俄亥俄州托莱多大学生物系 博士
4. 199907-200306:杜克大学霍华德休斯研究所 博士后
5. 200307-201206:杜克大学医学中心 助理教授
6. 201101-:首都医科大学附属北京天坛医院 特聘专家
7. 2012-:杜克大学医学中心 副教授
重要学术论文
1. Barella LF, Rossi M, Zhu L, Cui Y, Mei FC, Cheng X, Chen W, Gurevich VV, Wess J.β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion. J Clin Invest. 2019,130:3732-3737.SCI
2. Wang J, Ren XR, Piao H, Zhao S, Osada T, Premont RT, Mook RA Jr, Morse MA, Lyerly HK, Chen W*.Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy. Biochem J. 2019,476(3):535-546.SCI
3. Wang J, Mook RA Jr, Ren XR, Zhang Q, Jing G, Lu M, Spasojevic I, Lyerly HK, Hsu D, Chen W*.Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018,26(20):5435-5442.SCI
4. Chen W#, Mook RA Jr, Premont RT, Wang J..Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018,41:89-96.SCI
5. Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W*.Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth. Nanoscale. 2017,9(34):12709-12717.SCI
6. Mook RA Jr, Ren XR, Wang J, Piao H, Barak LS, Kim Lyerly H, Chen W*.Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.. Bioorganic & Medicinal Chemistry. 2017,25(6):1804-1816.SCI
7. Chen G, Xie RG, Gao YJ, Xu ZZ, Zhao LX, Bang S, Berta T, Park CK, Lay M, Chen W, Ji RR..b-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration ofpersistent pain. NATURE COMMUNICATIONS. 2016,87:207-15.SCI
8. Minyong Chen, Akhil Hegde, Yeon Ho Choi, Barbara S Theriot, Richard T Premont1, Wei Chen, Julia K L Walker* .Genetic Deletion of b-Arrestin-2 and the Mitigation of EstablishedAirway Hyperresponsiveness in a Murine Asthma Model. American Journal of Respiratory Cell and Molecular Biology. 2015,53:348-358.SCI
9. Robert A. Mook, Jr., Jiangbo Wang, Xiu-Rong Ren, Minyong Chen, Ivan Spasojevic, Larry S. Barak, H. Kim Lyerly, and Wei Chen*.Structure-Activity studies of Wnt/-betacatenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.. Bioorganic & Medicinal Chemistry. 2015,23(17):5829-38.SCI
10. Ren X, Wang J, Osada T, Mook R, Morse M, Lyerly K, Chen W*.Perhexiline promotes HER3 ablation throughreceptor internalization and inhibits tumor growth. Breast Cancer Research. 2015,15:17-20.SCI
主编或副主编的著作/译著
重要奖项