姓名：陈德喜 性别：男 职称：研究员、教授 招生院所：北京佑安医院 招生类型：科学学位(博) 科学学位(硕) 招生专业：生物化学与分子生物学(博) 生物化学与分子生物学(硕) 研究方向名称：肝病（肝炎及肝癌）发病机制及生物治疗研究 电子信箱：dexichen@ccmu.edu.cn


社会任职
1. 美国肿瘤学会active member
2. 国家自然基金委重大项目评审专家组成员；《临床肝胆病杂志》，《北京医药》等杂志编委
3. 中国肿瘤微创治疗技术创新战略联盟常委委员
4. Aging & Disease杂志编委
5. 《精准医学杂志》编委
个人简历
1. 198209-198707:包头医学院 医学本科
2. 198708-199009:包头医学院 工作
3. 199009-199307:包头医学院 医学硕士
4. 199308-199409:包头医学院 工作
5. 199409-199707:北京医科大学 博士学习
6. 199709-200011:匹兹堡大学医学院 博士后
7. 200012-200208:Legacy Medical Research Center, Oregon, OHSU 工作
8. 200209-200609:俄勒冈医科大学 工作
9. 200610-201307:首都医科大学附属北京佑安医院 性病艾滋病实验室主任
10. 201011-:北京市肝病研究所 常务副所长
重要学术论文
1. Yabo Ouyang#, Jiming Yin#,Wenjing Wang#，Hongbo Shi, Ying Shi, Bin Xu, Luxin Qiao, Yingmei Feng,Lijun Pang, Feili Wei1i,Xianghua Guo,Ronghua Jin*, Dexi Chen* .Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19（DOI:10.1093/cid/ciaa462）. Clinical Infectious Diseases. 2020,-:-.SCI
2. Zhang Y#, Gao Y#, Qiao L#, Wang W, Chen D*.Inflammatory Response Cells During Acute Respiratory Distress Syndrome in Patients With Coronavirus Disease 2019 (COVID-19). Ann Intern Med. 2020,10.7326:/L20-0227.
3. Yang T, Gao Y, Liu D, Wang Y, Wu J, Liu X, Shi Y, Chen D*.ASPP2 enhances chemotherapeutic sensitivity through the down-regulation of XIAP expression in a p53 independent manner in hepatocellular carcinoma. Biochemical and Biophysical Research Communications. 2019,508(3):769-774.SCI
4. Xiaoni Liu, Shuang Wang, Jianji Xu, Buxin Kou, Dexi Chen, Yajie Wang, Xiaoxin Zhu*.Extract of Stellerachamaejasme L(ESC) inhibits growth and metastasis of human hepatocellular carcinoma via regulating microRNA expression. BMC Complementary and Alternative Medicine. 2018,18(1):99.SCI
5. Kai Liu#,Jiyoung Lee#,Ja Yeon Kim,Linya Wang,Yongjun Tian,Stephanie T. Chan,Cecilia Cho,Keigo Machida,Dexi Chen,Jing-Hsiung James Ou*.Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells.. Molecular Cell. 2017,68(2):281-292.SCI
6. Liu Z, Zang Y, Qiao L, Liu K, Ouyang Y, Zhang Y, Chen D*.ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons. Sci Rep. 2016,6:33378.SCI
7. Shi Y#, Wang J#, Wang Y, Wang A, Guo H, Wei F, Mehta SR, .A novel mutant 10Ala/Arg Together With Mutant 144Ser/Arg of Hepatitis B Virus X Protein Involved in Hepatitis B Virus-Related Hepatocarcinogenesis in HepG2 Cell Lines. Cancer Lett. 2016,371(2):285-.
8. Liu K#, Shi Y#, Guo XH, Ouyang YB, Wang SS, Liu DJ, Wang AN, Li N*, Chen DX..Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria. . Cell Death and Disease. 2014,5(2):e1078.SCI
9. Yulin Zhang#, Fengli Song#, Ziyun Gao#, Wei Ding, Luxin Qiao, Sufang Yang, Xi Chen*, Ronghua Jin*, Dexi Chen*.Long-Term Exposure of Mice to Nucleoside Analogues Disrupts Mitochondrial DNA Maintenance in Cortical Neurons. PLoS One. 2014,9(1):e85637.SCI
10. Liu K#, Shi Y#, Guo X, Wang S, Ouyang Y, Hao M, Liu D, Qiao L, Li N, Zheng J, Chen D*..CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2.. Cell Death and Disease. 2014,5(1):e1323.SCI
11. Kai Liu#, Jinli Lou#, Tao Wen, Jiming Yin, Bin Xu, Wei Ding, Anna Wang, Daojie Liu, Chao Zhang, Dexi Chen*, Ning Li.Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX. Liver International. 2013,33(10):1566-1574.SCI
12. Liu K#, Sun Y#, Liu D, Yin J, Qiao L, Shi Y, Dong Y, Li N, Zhang F, Chen D*.Mitochondrial toxicity studied with the PBMC of children from the Chinese National Pediatric Highly Active Antiretroviral Therapy Cohort. Plos One. 2013,8（2）:e57223.SCI
13. Shi Y, Wei F, Hu D, Li Q, Smith D, Li N, Chen D*.Mutations in the major hydrophilic region (MHR) of Hepatitis B virus genotype C in North China. J Med Virol. 2013,84(12):1901-6.SCI
14. Li L#, Jin R#, Zhang X, Lv F, Liu L, Liu D, Liu K, Li N, Chen D*.Oncogenic activation of GPC3 by c-Myc in human hepatocellular carcinoma. Hepatology. 2012,56(4):1380-90.SCI
15. Zhang Y, Shi Y, Qiao L, Sun Y, Ding W, Zhang H, Li N, Chen D*.Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures.. brain research. 2012,1431:13-22.SCI
16. Liu L, Zhao Q, Wei F, Yuan L, Zhang Y, Qiao L, Shi Y, Li N, Chen D*.Genetic analysis of HIV type 1 env gene in cerebrospinal fluid and plasma of infected Chinese paid blood donors.. AIDS Res Hum Retroviruses. 2012,28(1):106-9.SCI
17. Zhang Y, Wang M, Li H, Zhang H, Shi Y, Wei F, Liu D, Liu K, Chen D*.Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders. Brain Res. 2012,1458:1-11.SCI
18. Zhang Y, Qiao L, Ding W, Wei F, Zhao Q, Wang X, Shi Y, Li N, Smith D, Chen D*.An initial screening for HIV-associated neurocognitive disorders of HIV-1 infected patients in China.. J Neurovirol. 2012,18:120-126.SCI
19. 张玉林, 石英, 乔录新, 张宏海, 孙玉, 丁渭, 张彤, 吴昊, 陈德喜*.司他夫定中枢神经毒性研究.. 中华传染病杂志. 2012,30(1):4-9.核心期刊
20. Wei F, Wang X, Liu L, Gao R, Shi Y, Zhang Y, Qiao L, Chen D*.Characterization of HIV type 1 env gene in cerebrospinal fluid and blood of infected Chinese patients.. AIDS Res Hum Retroviruses. 2011,27(7):793-6.SCI
21. Jin R, Sun Y, Qi X, Zhang H, Zhang Y, Li N, Ding W, Chen D*.E2F1 is involved in DNA single-strand break repair through cell-cycle-dependent upregulation of XRCC1 expression.. DNA Repair. 2011,10(9):926-33.SCI
22. Shi Y, Sun S, Liu Y, Li J, Zhang T, Wu H, Chen X, Chen D*, Zhou Y*.Keratin 18 phosphorylation as a progression marker of chronic hepatitis B.. Virol J.. 2010,24:7-70.SCI
23. Zhang H#, Zang Y#, Sun Y, Jin R, Wu H, Wang M, Li N, Chen D*.A new approach utilizing real-time qPCR to detect in vitro base excision repair.. DNA Repair . 2010,5;9(8):898-906.SCI
24. Kampa KM, Acoba JD, Chen D, Gay J, Lee H, Beemer K, Padiernos E, Boonmark N, Zhu Z, Fan AC, Bailey AS, Fleming WH, Corless C, Felsher DW, Naumovski L, Lopez CD..Apoptosis Stimulating Protein of p53 (ASPP2) Heterozygous Mice Are Tumor Prone and Have Attenuated Cellular Damage-Response Thresholds. Proc Natl Acad Sci U S A. 2009,106(11):4390-4395.SCI
25. Wu Yasong*, Li Ning, * Zhang Tong, Wu Hao, Huang Chun, Chen Dexi*..Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine. Mutation Research. 2009,664:28-38.SCI
26. Huang Chun, Wu Hao, Zhang Honghai, Li Ning, Wu Yasong, Dexi Chen*..CCl3L1 preventing gp120-induced neuron death via CREB cell signal pathway. Brain Research. 2009,1257:75-88.SCI
27. Chen D, Yu Z, Zhu Z, Lopez CD..E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair. J Biol Chem. 2008,283(22):15381-15389.SCI
28. Li N, Wu H, Yang S, Chen D*..Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair. DNA Repair (Amst) . 2007,6(9) :1297-1306.SCI
29. Chen D, Padiernos E, Ding F, Lossos IS, Lopez CD..The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells.. Cancer Research. 2006,66（7）:3485-3494.SCI
30. D Chen, E Padiernos, F Ding, I S Lossos and C D Lopez*..Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene. Cell Death & Differation. 2005,12(4):358-368.SCI
31. Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP..Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem.. 2003,85(3):670-679.SCI
32. Chen D, Minami M, Henshall DC, Meller R, Kisby G, Simon RP..Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia.. J Cereb Blood Flow Metab.. 2003,23(1):88-98.SCI
主编或副主编的著作/译著
重要奖项
1. 噬血细胞综合征快速诊断体系和挽救治疗技术的建立及推广应用 北京市科学技术奖 三等 201711
2. 荧光实时定量PCR法检测题外碱基切除修复的研究 丰台区科学技术奖 二等 201209
3. 第四届北京市归国人员创新创业特别贡献奖 201205
4. 艾滋病影像学与病理基础研究 北京市科学技术奖 三 2012
5. 艾滋病影像学与病理基础研究 中华医学科技奖 二等 2011
6. 趋化性细胞因子CCL3L1与HIV-1易感性和融合蛋白与多克隆抗体的研制 丰台区科学技术奖 三等 200804